Defiance Vacation Rentals

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Vacation Rentals in Defiance

The St. Charles Guest House, lovely historic home, fun for families and groups

St. Charles Historic District
10.0 out of 10, Exceptional, (135)
"House is so charming and a home away from home! The historical home and town were literally the vacation I will cherish! Game room was a hit!I highly recommend for any family that plans to visit St. Charles, MO!"
United States
Schererville A.
The St. Charles Guest House, lovely historic home, fun for families and groups

Studio Condo on the Water @ Innsbrook

Wright City
9.8 out of 10, Exceptional, (39)
"Had a good golf day wonderful place to stay "
United States
david c.
$177 nightly
The price is $183
Nov 16 - Nov 17
Total with taxes and fees
Studio Condo on the Water @ Innsbrook

Madison House 2 -Walk to Main St

St. Charles Historic District
7.8 out of 10, Good, (7)
"Poor communication with property owner we told him of issues including two ceiling fans not working missing lightbulbs broken coffee maker unusable backyard due to negligence old stove and broken chair in backyard dirty back porch he responded on the first day he would bring lightbulbs and never came even though he said he lived one block away "
United States
Tom B.
$224 nightly
The price is $252
Nov 16 - Nov 17
Total with taxes and fees
Madison House 2 -Walk to Main St

Cozy Clark Suite in Frenchtown Saint Charles

St. Charles Historic District
9.6 out of 10, Exceptional, (11)
"Awesome place to stay"
United States
paul
$266 nightly
The price is $266
Nov 15 - Nov 16
Total with taxes and fees
Cozy Clark Suite in Frenchtown Saint Charles

Authentic Log cabin with something for everyone!

Marthasville
9.6 out of 10, Exceptional, (375)
"Very beautiful place to stay. We really enjoyed the lake. "
United States
Kristi W.
Authentic Log cabin with something for everyone!

Stunning 1890's Home - Sleeps 8!

St. Charles Historic District
10.0 out of 10, Exceptional, (87)
"The house is beautiful, in a great location, and has all the amenities of home. Definitely glad we stayed here instead of a nearby hotel."
United States
Emily D.
$372 nightly
The price is $381
Nov 18 - Nov 19
Total with taxes and fees
Stunning 1890's Home - Sleeps 8!

The Hare Suite at Divine Otter

St. Charles Historic District
9.4 out of 10, Exceptional, (12)
"This is such a cute place. Highly recommend. Very relaxing while also all kinds of shopping and dining options. There was a water main break our first few hrs into the stay. Host was great responded fast to any questions we had. "
United States
Pam
The Hare Suite at Divine Otter

Historic Main Street Heritage Retreat

4.0 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (36)
"No complaints here, would definitely stay here again! "
United States
Adrienne R.
Historic Main Street Heritage Retreat

1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!

St. Charles Historic District
10.0 out of 10, Exceptional, (209)
"Nice view of the Mississippi in the morning. Just off of the main street in old town St Charles, this place was perfect for our needs."
United States
Ralph
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!

Cozy Cottage, we're told it's heavenly!

Marthasville
10.0 out of 10, Exceptional, (208)
"Small but very cozy cabin in a very private spot. Still had all the conveniences and close to town. "
United States
Kathie H.
Cozy Cottage, we're told it's heavenly!

St. Charles 1860's Gem - Sleeps 6!

St. Charles Historic District
9.8 out of 10, Exceptional, (130)
"Great location to historic St. Charles! Lots of room and it was a great stay!"
United States
brooke c.
$239 nightly
The price is $239
Nov 17 - Nov 18
Total with taxes and fees
St. Charles 1860's Gem - Sleeps 6!

5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1

St. Charles Historic District
9.2 out of 10, Wonderful, (11)
"Comfortable home in a convenient location."
United States
Troy B.
$247 nightly
The price is $278
Nov 16 - Nov 17
Total with taxes and fees
5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1

Honky Tonk Hideaway

St. Charles Historic District
9.2 out of 10, Wonderful, (10)
"We were in town for a concert and loved our stay here. Great location very close to restaurants and bars. Very safe area. Had a very private back patio next to a creek which made morning coffee even better. Place was clean and had all the necessities. We will stay here again."
United States
LAURIE P.
$288 nightly
The price is $294
Nov 23 - Nov 24
Total with taxes and fees
Honky Tonk Hideaway

The Lewis & Clark Hangout

St. Charles Historic District
9.0 out of 10, Wonderful, (19)
"Nice place and wonderful host"
United States
Faisal I.
$378 nightly
The price is $425
Nov 16 - Nov 17
Total with taxes and fees
The Lewis & Clark Hangout

The Otter Suite at Divine Otter

St. Charles Historic District
9.0 out of 10, Wonderful, (6)
"We absolutely loved this place! I would recommend this place. We had one issue but it was resolved. If you have children, I would probably stay somewhere else. There are bars all around and gets loud at night but it does get really quiet after 1:30 a.m. The property manager was absolutely amazing and is very quick to respond to your needs. "
United States
kim F.
The Otter Suite at Divine Otter

Home Near Main Street-Covered Patio-Hot Tub!

Saint Charles
9.8 out of 10, Exceptional, (25)
"The interior is super clean, showers all very nice, and beds seemed like they have never been slept in. I highly recommend this place, the kitchen is well suited for cooking anything! "
United States
Sam R.
$468 nightly
The price is $478
Nov 16 - Nov 17
Total with taxes and fees
Home Near Main Street-Covered Patio-Hot Tub!

Victorian Gem Steps from Main St - Sleeps 9 & Pets

St. Charles Historic District
9.8 out of 10, Exceptional, (19)
"Excellent home, lots of room for a big family gathering. One block From Main Street. Parking in alley and garage makes easy access. Would stay here again."
United States
Ardith B.
$629 nightly
The price is $700
Nov 30 - Dec 1
Total with taxes and fees
Victorian Gem Steps from Main St - Sleeps 9 & Pets

Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort

Innsbrook
10.0 out of 10, Exceptional, (69)
"This Chalet was Great, Beautiful clear lake, Peaceful. Has everything you could possibly need. We Highly recommend this cozy Chalet."
United States
Tammy S.
Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort

Value Suites Extended Stay - St Louis

3.0 star property
Maryland Heights
7.0 out of 10, Good, (1110)
"Close to the city, very comfortable and has a full kitchen which is nice."
United States
Anonymous traveler
$453 nightly
The price is $525
Nov 15 - Nov 16
Total with taxes and fees
Value Suites Extended Stay - St Louis

Cowboy Cabin, come sit under the trees

Marthasville
10.0 out of 10, Exceptional, (208)
"It was amazing! The dogs were so sweet and just so welcoming. The place was very neat and awesome!!! It’s so quiet and peaceful."
United States
Caden W.
Cowboy Cabin, come sit under the trees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Find out more about Defiance

Everything you need to know about Defiance vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Defiance vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Defiance vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Defiance vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Defiance. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Defiance in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $183 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Defiance rentals

At Expedia, we put the best Defiance vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Defiance rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Defiance vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Defiance. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find vacation rentals in Defiance?

Yes, there are vacation rentals close to popular sights in Defiance, or you can choose a more secluded option if you're looking for relaxation. Defiance is known for its wineries and parks.

What are some of the best vacation home rentals that Defiance has to offer?

The St. Charles Guest House, lovely historic home, fun for families and groups: This vacation home rental outside of Defiance is located on a river and has a fireplace, a selection of games, and air-conditioning to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

How many vacation rentals will I find in Defiance?

With 4 Expedia vacation rentals, you're sure to find just the right place for your Defiance stay.

What’s there to see and do in Defiance?

August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Yellow Farmhouse Winery and Chandler Hill Vineyards.

What’s a vacation rental in Defiance like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Defiance. Vacation rentals feature amenities like laundry facilities and kitchens so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of security away from shared hotel elevators and busy front desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great option for families.