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Hotel Spero$136
Hotel Spero$136Hotel Whitcomb$119
Hotel Whitcomb$119Chancellor Hotel on Union Square$161
Chancellor Hotel on Union Square$161Handlery Union Square Hotel$149
Handlery Union Square Hotel$149The Pickwick Hotel$159
The Pickwick Hotel$159Hotel Vertigo$197
Hotel Vertigo$197Mystic Hotel$155
Mystic Hotel$155Adante Hotel, a C-Two Hotel$139
Adante Hotel, a C-Two Hotel$139Calista Organic Hotel$137
Calista Organic Hotel$137King George Hotel - A Greystone Hotel$120
King George Hotel - A Greystone Hotel$120The Andrews Hotel$149
The Andrews Hotel$149Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in Downtown San Francisco, San Francisco. Known for well-appointed rooms and friendly, personalized service, each of the top Independent Downtown San Francisco hotels guarantees an unparalleled level of comfort and quality.
You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Downtown San Francisco Independent locations may even offer extra little benefits and discounts for frequent travelers.