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Featured Downtown San Francisco Independent Hotels

See all 177 Hotels in Downtown San Francisco
Hotel Whitcomb

Hotel Whitcomb

1231 Market St, San Francisco
3.5 out of 5.0
3.1 out of 5 (3,216 reviews)
A Historic Hotel In A Less Than Historic Area Overall, I like this hotel. It's beautiful, having been built in the early 1900s, so the rooms are … - 

$149

$149
Serrano Hotel

Serrano Hotel

405 Taylor St, San Francisco
4.0 out of 5.0
3.9 out of 5 (1,635 reviews)
value Well the hotel is in the Tenderloin so ya it's a little rough, but be smart about it. It is just at … - 

$178

$178
The Westin St. Francis San Francisco on Union Square

The Westin St. Francis San Francisco on Union Square

335 Powell Street, San Francisco
4.0 out of 5.0
4.1 out of 5 (1,837 reviews)
Beautiful historic hotel in the heart of San Franc It was a wonderful experience staying at the St. Francis. WE really loved learning about all the hi … - 

$249

$249
Hotel Nikko San Francisco

Hotel Nikko San Francisco

222 Mason St, San Francisco
4.0 out of 5.0
4.3 out of 5 (2,779 reviews)
Good location near Union Square, restaurants, shopping. Comfortable clean Hotel - 

$232

$232
San Francisco Marriott Marquis

San Francisco Marriott Marquis

780 Mission Street, San Francisco
4.0 out of 5.0
4.4 out of 5 (1,659 reviews)
First visit to San Francisco Great place. Close to everything. Arrived on Saturday morning and but room wasn't going to be ready … - 

$208

$208
Palace Hotel, a Luxury Collection Hotel, San Francisco

Palace Hotel, a Luxury Collection Hotel, San Francisco

2 New Montgomery St, San Francisco
5.0 out of 5.0
4.5 out of 5 (1,545 reviews)
Close to everything! The lobby was very elegant and fancy and the amenities in the room are almost complete (no tootbrus … - 

$235

$235
Grand Hyatt San Francisco Union Square

Grand Hyatt San Francisco Union Square

345 Stockton St, San Francisco
4.0 out of 5.0
4.3 out of 5 (1,387 reviews)
Very nice hotel. Great location too. Check-in was very quick. Front desk person was able to find a nice room facing Union Square for us … - 

$209

$209
Fairmont San Francisco

Fairmont San Francisco

950 Mason Street Atop Nob Hill, San Francisco
5.0 out of 5.0
4.4 out of 5 (2,069 reviews)
Timeless Class! The Fairmont San Francisco has such a storied past yet has all the modern amenities you need. I sta … - 

$254

$254
Handlery Union Square Hotel

Handlery Union Square Hotel

351 Geary St, San Francisco
3.5 out of 5.0
3.9 out of 5 (1,603 reviews)
Very nice hotel close to everything the Handlery is a family owned hotel, and it has just enough of everything to please a traveller. T … - 

$179

$179
Monarch Hotel

Monarch Hotel

1015 Geary St, San Francisco
2.0 out of 5.0
3.0 out of 5 (1,069 reviews)
Perfect location to visit the Masonic We stayed here so we could easily walk to the Masonic for a concert. This was easily achievable. Th … - 

$101

$101
San Francisco Marriott Union Square

San Francisco Marriott Union Square

480 Sutter Street, San Francisco
4.0 out of 5.0
4.3 out of 5 (772 reviews)
Great hotel. Will return! Awesome staff and room was great. Very comfy!! My room was spacious and comfortable. Room service w … - 

$199

$199
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

424 Clay St, San Francisco
4.0 out of 5.0
4.1 out of 5 (1,419 reviews)
Downtown close to street cars & short ride to Fisherman"s Wharf & cable cars. Reasonable price for … - 

$159

$159
Hotel Union Square

Hotel Union Square

114 Powell St, San Francisco
3.5 out of 5.0
3.6 out of 5 (799 reviews)
Super convenient location. Nice update. Small sink but tube is big enough. Noisy due to the window in the bathroom. I could he … - 

$157

$157
Bartlett Bunkhouse

Bartlett Bunkhouse

240 O'Farrell St, San Francisco
2.5 out of 5.0
4.0 out of 5 (51 reviews)
Budget Hotel - no, really a budget hotel OK, Hotel prices are somewhere between shocking and gouging. So on a recent trip to San Francisco, … - 

$129

$129
Omni San Francisco Hotel

Omni San Francisco Hotel

500 California St, San Francisco
4.5 out of 5.0
4.7 out of 5 (1,652 reviews)
Lovely hotel in great location Very comfortable hotel in convenient location for Terminal 1, Chinatown and Nob Hill. Good transpor … - 

$242

$242
Hyatt Regency San Francisco

Hyatt Regency San Francisco

5 Embarcadero Center, San Francisco
4.0 out of 5.0
4.3 out of 5 (1,306 reviews)
Excelente location This is a very good hotel. Clean and comfortable. Nice staff. Walking distance to many attractions … - 

$199

$199
Stanford Court San Francisco

Stanford Court San Francisco

905 California Street, San Francisco
4.0 out of 5.0
4.1 out of 5 (1,214 reviews)
San Fran stay over we were passing through san fran and wanted a nice place for a quick stop. This hotel got lots of g … - 

$160

$160
The Pickwick Hotel

The Pickwick Hotel

85 5th St, San Francisco
3.5 out of 5.0
3.6 out of 5 (765 reviews)
Close to Everything Comfortable and quiet lodging at a reasonable price and close to everything San Franciscan - 

$149

$149
Clift

Clift

495 Geary St, San Francisco
4.0 out of 5.0
4.1 out of 5 (1,458 reviews)
I was disappointed that they do not even put a pitcher of water in the room. Also the hall ways are … - 

$191

$191
Kimpton Sir Francis Drake Hotel

Kimpton Sir Francis Drake Hotel

450 Powell Street, San Francisco
4.0 out of 5.0
3.8 out of 5 (1,584 reviews)
Great downtown location We enjoyed all the fabulous shopping that is walking distance from the hotel as well as the great r … - 

$200

$200
Map

Recently booked Downtown San Francisco hotels

Fitzgerald Hotel
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Parc 55 San Francisco - A Hilton Hotel
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Kensington Park Hotel
3.5 out of 5.0
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Palace Hotel, a Luxury Collection Hotel, San Francisco
5.0 out of 5.0
Last booking: 26 minutes ago
San Francisco Inn
2.0 out of 5.0
Last booking: 26 minutes ago
Hotel Whitcomb
3.5 out of 5.0
Last booking: 28 minutes ago

Independent Downtown San Francisco Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in Downtown San Francisco, San Francisco. Known for well-appointed rooms and friendly, personalized service, each of the top Independent Downtown San Francisco hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Downtown San Francisco Independent locations may even offer extra little benefits and discounts for frequent travelers.