Edisto Vacation Rentals

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Our top choices for Edisto vacation rentals

Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
Bowman
10.0 out of 10, Exceptional, (30)
"Will stay again."
United States
Robert B.
$147 nightly
The price is $163
Dec 12 - Dec 13
Total with taxes and fees
Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

Nene’s Cozy Corner

Nene’s Cozy Corner
Orangeburg
7.8 out of 10, Good, (14)
"Overall, our stay was good. We loved having the comfort and space. It was quiet and still convenient to the places we needed to visit. "
United States
Natasia W.
Nene’s Cozy Corner

Country Resting Spot just off I95. 12 miles west on hwy 6.

Country Resting Spot just off I95. 12 miles west on hwy 6.
Elloree
9.4 out of 10, Exceptional, (21)
"Great place for our family to stop on our way to Florida. It had ample parking, pet friendly, and very comfortable country retreat! "
United States
Jackie M.
$162 nightly
The price is $180
Dec 14 - Dec 15
Total with taxes and fees
Country Resting Spot just off I95. 12 miles west on hwy 6.

Secluded Cabin Retreat with Hot Tub, for Family Get Away

Secluded Cabin Retreat with Hot Tub, for Family Get Away
orangeburg
9.8 out of 10, Exceptional, (149)
"Traveling to the area for a family wedding and the cabin was the perfect place to stay to be close to the festivities!"
United States
Kristine G.
Secluded Cabin Retreat with Hot Tub, for Family Get Away

2 Mi to SC State & Claflin: Townhome w/ Patio!

2 Mi to SC State & Claflin: Townhome w/ Patio!
3.0 star property
Orangeburg
2 Mi to SC State & Claflin: Townhome w/ Patio!

Tranquil Getaways W/Heated Pool and Fishing

Tranquil Getaways W/Heated Pool and Fishing
Elloree
8.4 out of 10, Very Good, (6)
"Great property the pool was so fun! Mostly stayed on the property and lounged around for a nice relaxing stay!"
United States
Tori P.
$189 nightly
The price is $210
Jan 2 - Jan 3, 2026
Total with taxes and fees
Tranquil Getaways W/Heated Pool and Fishing

Saint Matthews Outlaw Gameroom w/ Fire Pit!

Saint Matthews Outlaw Gameroom w/ Fire Pit!
3.0 star property
Saint Matthews
Saint Matthews Outlaw Gameroom w/ Fire Pit!

Fully furnished cozy 2-bedroom apartment on quiet lot in Orangeburg, SC

Fully furnished cozy 2-bedroom apartment on quiet lot in Orangeburg, SC
Orangeburg
Fully furnished cozy 2-bedroom apartment on quiet lot in Orangeburg, SC

Your 4 bedroom 3 full bathroom Orangeburg Oasis awaits!!!!

Your 4 bedroom 3 full bathroom Orangeburg Oasis awaits!!!!
Orangeburg
Your 4 bedroom 3 full bathroom Orangeburg Oasis awaits!!!!

Spacious Stylish One Bedroom Apartment

Spacious Stylish One Bedroom Apartment
Elloree
8.0 out of 10, Very Good, (1)
"Very nice home! Pictures are as advertised and the home was very clean. The area surrounding the home is dilapidated, however, the home is very nice. The only two issues with the house are 1) the walls are very thin and you can hear the road noise and every step the people above take very clearly. 2) there is an issue with the municipal pipes of the town and my last night of the stay the water in the shower and bathroom sink was coming out yellow. Overall a very nice option in this small town."
United States
Joshua S.
$260 nightly
The price is $289
Dec 12 - Dec 13
Total with taxes and fees
Spacious Stylish One Bedroom Apartment

Private Pond & Large Yard: Unique Cabin in Norway!

Private Pond & Large Yard: Unique Cabin in Norway!
3.0 star property
Norway
Private Pond & Large Yard: Unique Cabin in Norway!

Beautiful brick home w/ large porch and 3 bedrooms

Beautiful brick home w/ large porch and 3 bedrooms
Bowman
9.0 out of 10, Wonderful, (4)
"Nice and quiet property. It served us well for the weekend "
United States
Mick S.
$253 nightly
The price is $280
Dec 15 - Dec 16
Total with taxes and fees
Beautiful brick home w/ large porch and 3 bedrooms

Walk to SC State University & Claflin: Cozy Home

Walk to SC State University & Claflin: Cozy Home
2.0 star property
Orangeburg
Walk to SC State University & Claflin: Cozy Home

Charming Bamberg Home Near Medical Centers!

Charming Bamberg Home Near Medical Centers!
3.0 star property
Bamberg
Charming Bamberg Home Near Medical Centers!

Centally located w/ coffee bar, theatre/gameroom

Centally located w/ coffee bar, theatre/gameroom
Orangeburg
10.0 out of 10, Exceptional, (18)
"Charming house that was perfect for our group of six. "
United States
Grant S.
Centally located w/ coffee bar, theatre/gameroom

Rural, Woods, Activities Galore, Educational & Fun

Rural, Woods, Activities Galore, Educational & Fun
North
9.8 out of 10, Exceptional, (8)
"Great property. Very well stocked with anything you could imagine for a great stay. The Urban Roost was a cool place to see. "
United States
Lori R.
Rural, Woods, Activities Galore, Educational & Fun

Secluded Retreat With hot tub ideal to fish and relax on private pond

Secluded Retreat With hot tub ideal to fish and relax on private pond
Orangeburg
9.8 out of 10, Exceptional, (37)
"Came here with friends, it was a nice house with great view! Would come again!!!"
United States
Leonardo M.
Secluded Retreat With hot tub ideal to fish and relax on private pond

RayneBow Royalty

RayneBow Royalty
2.0 star property
Orangeburg
RayneBow Royalty

Modern apartment overlooking historic downtown Elloree, SC.

Modern apartment overlooking historic downtown Elloree, SC.
Elloree
$119 nightly
The price is $132
Dec 31 - Jan 1, 2026
Total with taxes and fees
Modern apartment overlooking historic downtown Elloree, SC.

Private entrance charming room with clawfoot tub.

Private entrance charming room with clawfoot tub.
Elloree
4.0 out of 10, (1)
"This pains me to write because this could’ve been a great little stopping point, however the bathtub was actually filthy. It smelled like urine and there is a dark grey film that needs to be scrubbed off. I get that old tubs can have stains but these are not stains and could’ve been removed with cleaner and elbow grease. I had camped for a week and just wanted to take a nice hot bath; I did not get to take one. Also I would add a sign for the cottage because it was confusing as to which door it...
United States
Gregory P.
$190 nightly
The price is $211
Dec 12 - Dec 13
Total with taxes and fees
Private entrance charming room with clawfoot tub.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Edisto Hotel Reviews

Find out more about Edisto

Everything you need to know about Edisto vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Edisto vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Edisto vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Edisto vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Edisto. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Edisto in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $132 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Edisto rentals

At Expedia, we put the best Edisto vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Edisto rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Edisto vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Edisto. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Are there vacation rentals in Edisto?

Yes, you can find vacation rentals close to well known sights in Edisto, or you can choose a secluded option if you're looking for a relaxing stay.

What's the top vacation rental that Edisto has to offer?

Nene’s Cozy Corner: This vacation home rental near Edisto has air-conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings.

What can I see and do in Edisto?

While exploring the area, visit family-friendly sights like I.P. Stanback Museum & Planetarium, or get outside and enjoy nature at Edisto Memorial Gardens. Claflin University and South Carolina State University are a couple of places you'll find in the larger area.

What are vacation rentals like in Edisto?

Vacation rentals are private accommodations you can stay in for a few days or a quick weekend in Edisto. Vacation rentals offer extras like WiFi and washers and dryers so you'll feel just like you're at home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of privacy away from public hotel elevators and busy lobbies while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a popular choice for family trips or small group gatherings.