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Featured Florence Business Hotels

See all 90 Hotels in Florence
The Inn at the Crossroads

The Inn at the Crossroads

128 West Main Street, Lake City
2.5 out of 5.0
4.6 out of 5 (100 reviews)
Wonderful StaffThis hotel was an wonderful option for this area. Well apportioned with a reasonable breakfast and dinner selection. The restaurant/bar in the hotel was quite convenient. The only problem was the heat didn't work. But the staff made certain that I had extra blankets. Offers were made to move me, ...
  Dec 11, 2017

$109

$109
Days Inn Florence Near Civic Center

Days Inn Florence Near Civic Center

140 Dunbarton Dr, Florence
3.0 out of 5.0
3.2 out of 5 (984 reviews)
Showing it's age.I found the mattress to be worn out and the whole facility could use some upkeep.
  Nov 30, 2017

$55

$55
Fairfield Inn by Marriott Hartsville

Fairfield Inn by Marriott Hartsville

200 S 4th St, Hartsville
3.0 out of 5.0
4.4 out of 5 (162 reviews)
Close to family in Hartsville.Close to family in SC....microwave was a plus with refrig...especially after Thansgiving leftovers.
  Nov 24, 2017

$99

$99
Holiday Inn Ex Hotel & Suites Florence I-95 & I-20 Civic Ctr

Holiday Inn Ex Hotel & Suites Florence I-95 & I-20 Civic Ctr

3440 W Radio Dr, Florence
3.0 out of 5.0
4.5 out of 5 (361 reviews)
I’ve stayed in hotels everywhere. I’ll take the Holiday Inn express rooms anyday. So comfortable. Really!
  Nov 18, 2017

$110

$110
TownePlace Suites by Marriott Florence

TownePlace Suites by Marriott Florence

2650 Hospitality Boulevard, Florence
4.0 out of 5.0
4.7 out of 5 (158 reviews)
Loved itThe staff were extremely friendly and helpful. The breakfast was more than we expected and 24hr coffee? How can you beat it! Nice workout room and a laundry. It had everything we needed and was convenient to everything with many places to eat in walking distance. Will definitely go there again.
  Nov 19, 2017

$101

$101
Best Western Executive Inn

Best Western Executive Inn

1534 Highway 38 W, Latta
3.0 out of 5.0
3.6 out of 5 (146 reviews)
Excellent. Found hotel clean, comfortable and friendly. It was also quiet. It is in a rural area right off of 95.
  Nov 22, 2017

$90

$90
Country Inn & Suites By Carlson Florence

Country Inn & Suites By Carlson Florence

1739 Mandeville Rd, Florence
3.0 out of 5.0
4.2 out of 5 (1,157 reviews)
Great place to stay for this area. Newer hotel. Ive stayed at several, this is my favorite.
  Dec 3, 2017

$88

$88
Ramada Inn Florence

Ramada Inn Florence

1819 West Lucas Street, Florence
3.0 out of 5.0
3.1 out of 5 (894 reviews)
It was a very good experience. Staff was very friendly and accommodating.
  Nov 18, 2017

$55

$55
Super 8 Florence SC

Super 8 Florence SC

1832 1/2 Lucas Street, I95 Exit 164, Florence
2.5 out of 5.0
3.4 out of 5 (245 reviews)
Great value.Comfortable room, Great shower. Desk services very friendly and helpful.
  Aug 29, 2017

$59

$59
Baymont Inn & Suites Florence

Baymont Inn & Suites Florence

1826 W Lucas Street, Florence
2.5 out of 5.0
3.7 out of 5 (1,327 reviews)
Nice hotel for a overnight stayGot to hotel to check in a there was a mix up with my reservation. Expedia or Baymont had put the room under someone elses name. The staff was very understanding and helped us solve the problem. We had to call Expedia and my daughter talked with a very nice lady who called the hotel and straightened ...
  Dec 9, 2017

$56

$56
Suburban Extended Stay Hotel

Suburban Extended Stay Hotel

1914 W Lucas St, Florence
2.5 out of 5.0
3.0 out of 5 (354 reviews)
Nice hotel, close to the race track.The room was fine. It was disappointing to see the remnants from the fire.
  Sep 6, 2017

$42

$42
Palmetto Inn Florence

Palmetto Inn Florence

3311 Meadors Road, Florence
3.0 out of 5.0
3.1 out of 5 (93 reviews)
Nice hotel/locationOur room was nicely cleaned. The front desk staff were excellent, friendly and able to answer all my questions. The microwave was missing from my room and once I informed the front desk they quickly put one in.
  Sep 8, 2015

$55

$55
Comfort Suites

Comfort Suites

2120 West Lucas Street, Florence
3.0 out of 5.0
4.5 out of 5 (246 reviews)
Great room for the priceConvenient to interstate and a good variety of restaurants
  Dec 10, 2017

$88

$88
Abingdon Manor - Country Inn & Restaurant

Abingdon Manor - Country Inn & Restaurant

307 Church St, Latta
4.0 out of 5.0
5.0 out of 5 (6 reviews)
There is little to do in the surrounding area. All things are at least an hours drive away. Pretty area especially for weddings or intimate gatherings
  Apr 2, 2017

$199

$199
Americas Best Value Inn

Americas Best Value Inn

3024 TV Road, Florence
2.5 out of 5.0
2.5 out of 5 (116 reviews)
Nice hotel right by the I 95Very clean and nice rooms. Rate is pretty reasonable.
  Mar 9, 2015

$63

$63
Americas Best Value Inn

Americas Best Value Inn

27 Charlene Ln, Bishopville
2.5 out of 5.0
3.3 out of 5 (34 reviews)
Perfect place to stop for a rest. Everything was perfect , the breakfast could of been a little better. That was the only reason for 4 stars.
  Jul 30, 2016

$58

$58
Best Western Inn

Best Western Inn

1808 W Lucas Street, Florence
3.0 out of 5.0
3.6 out of 5 (105 reviews)
Easy quick stop off the highway The hotel was fine, nice check in and the rooms were fine. One word of advice, if you stop on a Sunday night, do not expect to have a “drink” to unwind after your trip. You can’t buy alcohol near here either in the convenience store or even in the Ruby Tuesday next door - no alcohol on Sunday!
  Nov 27, 2017

$67

$67
Courtyard by Marriott Florence

Courtyard by Marriott Florence

2680 Hospitality Blvd, Florence
3.5 out of 5.0
4.4 out of 5 (105 reviews)
Nice hotel, quiet and just 1 mile from highway.Very pleasant experience; only wish breakfast were complimentary.
  Nov 22, 2017

$124

$124
Days Inn Dillon

Days Inn Dillon

823 Radford Blvd, Dillon
2.5 out of 5.0
2.7 out of 5 (173 reviews)
It Wasn't BadThere was a very serious incident that I will not share details about. I will say that hotel staff and management handled it IMMEDIATELY. The rooms could smell a little better. The first room I was in didn't smell fresh. I know they cleaned the room, I saw them but maybe new products may help! Other ...
  Sep 18, 2017

$56

$56
Days Inn Lake City

Days Inn Lake City

170 S Ron Mcnair Blvd, Lake City
2.5 out of 5.0
3.1 out of 5 (107 reviews)
Nice stay few issue with the coffee maker. Breakfast sausage should have been cook try put in mic melted the form bowl. Too many hands .
  Oct 26, 2017

$85

$85
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