The hotel is very nearby the train station (walking distance) which is convenient. However, it is a bit of a walk from the city center / tourist destinations. It is still within walking distance, however, they do offer a shuttle (during certain hours) to a main palazzo to make the stay more pleasant. There were a few streets that I didn't love to walk past to get to / from, however I was never in danger. There are little food options nearby, but what I did find was good.
The hotel itself is beautiful. The lobby, service, breakfast, room, views etc were spectacular and were above and beyond what was expected. I would absolutely recommend staying here if you want the cleanliness, comfort and safety with your stay. The only slight downfall is the location to Florence's "hot spots".