Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys Independent Hotels

See all 699 Hotels in Florida Keys
24 North Hotel Key West

24 North Hotel Key West

3820 North Roosevelt Boulevard, Key West
4.5 out of 5.0
4.1 out of 5 (1,067 reviews)
very nice hotel close enough to downtown key west lost my key card a couple times eh sh** happens right? they had no problem in replacing it cleaning … - 

$161

$161
Southernmost Beach Resort

Southernmost Beach Resort

1319 Duval Street, Key West
4.5 out of 5.0
4.5 out of 5 (3,114 reviews)
Nice hotel room I purchased a superior queen room with a veranda but it looks at the back of the lobby. This is a v … - 

$194

$194
Ibis Bay Beach Resort

Ibis Bay Beach Resort

3101 N. Roosevelt Blvd, Key West
3.0 out of 5.0
3.7 out of 5 (1,610 reviews)
On the water Clean, comfortable room with a peaceful water view. Prompt shuttle to town was a big plus. Friendly … - 

$143

$143
Oceans Edge Key West Resort, Hotel & Marina

Oceans Edge Key West Resort, Hotel & Marina

5950 Peninsular Avenue, Key West
4.5 out of 5.0
4.5 out of 5 (311 reviews)
Amazing!!! Absolutely stunning hotel! Beautiful rooms, grounds, and views. - 

$166

$166
Sheraton Suites Key West

Sheraton Suites Key West

2001 S Roosevelt Blvd, Key West
4.0 out of 5.0
4.3 out of 5 (2,094 reviews)
Nice hotel This hotel is nice. The shuttle is very useful to go to downtown. - 

$151

$151
Hilton Garden Inn Key West,The Keys Collection

Hilton Garden Inn Key West,The Keys Collection

3850 N Roosevelt Blvd, Key West
4.0 out of 5.0
4.1 out of 5 (343 reviews)
Just 1 night. Check-in was quick. Didn't even fill anything out. Room was clean, well decorated, and quiet. Showe … - 

$146

$146
The Gates Hotel Key West

The Gates Hotel Key West

3824 N Roosevelt Blvd, Key West
4.5 out of 5.0
4.3 out of 5 (1,076 reviews)
Nice Hotel -- Beautiful Poor and Bar Area The Gates is a nice hotel at the very north end of Key West. The have a shuttle that runs every hou … - 

$169

$169
Silver Palms Inn

Silver Palms Inn

830 Truman Ave, Key West
4.0 out of 5.0
4.4 out of 5 (2,471 reviews)
Great location! Perfect location to be able to get to Duval St. You are a bit away from the action but it is very a … - 

$179

$179
The Marker Waterfront Resort Key West

The Marker Waterfront Resort Key West

200 William Street, Key West
4.0 out of 5.0
4.5 out of 5 (853 reviews)
Great Resort Valet parking is sweet, however know that there is a $30/day parking fee on top of the $35/day reso … - 

$175

$175
Margaritaville Key West Resort & Marina

Margaritaville Key West Resort & Marina

245 Front Street, Key West
4.5 out of 5.0
4.3 out of 5 (170 reviews)
Beautiful hotel and experience We were given an upgrade for no apparent reason except good customer service and kindness. It was a … - 

$231

$231
The Southernmost Inn-Adults Only

The Southernmost Inn-Adults Only

525 United Street, Key West
2.5 out of 5.0
4.1 out of 5 (849 reviews)
Nice hotel, friendly staff, good breakfast. We had a great time. The staff was very friendly. The folks at the front desk were very accommodati … - 

$179

$179
Lime Tree Bay Resort

Lime Tree Bay Resort

68500 Overseas Hwy, Long Key
4.0 out of 5.0
4.1 out of 5 (526 reviews)
Great trip. I only wish the pool had been heated like the website said. - 

$116

$116
Marina Del Mar Resort and Marina

Marina Del Mar Resort and Marina

527 Caribbean Drive, Key Largo
2.5 out of 5.0
3.6 out of 5 (1,859 reviews)
Pluses and minuses This is an older property in a beautiful setting next to a marina. Our room was somewhat small, but … - 

$119

$119
Heron House Court - Adult Only

Heron House Court - Adult Only

412 Frances St, Key West
3.5 out of 5.0
4.4 out of 5 (1,344 reviews)
Convient location The hotel staff were personable and helpful. The staff made our stay enjoyable. Expect a lot of int … - 

$149

$149
Heron House - Adult Only

Heron House - Adult Only

512 Simonton St, Key West
4.0 out of 5.0
4.3 out of 5 (1,507 reviews)
Very nice place to stay, close to everything in Key West. Rooms were very nice & clean. Staff very … - 

$149

$149
La Concha Hotel & Spa

La Concha Hotel & Spa

430 Duval St, Key West
4.5 out of 5.0
4.1 out of 5 (1,777 reviews)
Great location. Very posh! Wonderful experience with the hotel overall, staff, atmosphere, everything was beautiful. For the l … - 

$195

$195
Drift Hotel

Drift Hotel

95320 Overseas Hwy, Key Largo
3.0 out of 5.0
3.9 out of 5 (15 reviews)
Clean, quiet Hotel with room for some improvements Check in was not the standard expected businesslike event I am used to. Pleasant greeting by the la … - 

$129

$129
Fairfield Inn & Suites by Marriott Key West, Keys Collection

Fairfield Inn & Suites by Marriott Key West, Keys Collection

3852 North Roosevelt Boulevard, Key West
3.5 out of 5.0
4.0 out of 5 (885 reviews)
Only problem was the elevator was broke and for someone with knee issues it was not fun with the st … - 

$149

$149
NYAH Key West-Adults Only

NYAH Key West-Adults Only

420 Margaret Street, Key West
2.5 out of 5.0
4.4 out of 5 (822 reviews)
Little KW Gem This place is incredible. Super clean. Awesome, helpful staff. - 

$159

$159
Skipjack Resort & Marina

Skipjack Resort & Marina

19 Sombrero Blvd, Marathon
3.5 out of 5.0
4.2 out of 5 (151 reviews)
Convenient and Close to Everything on Marathon With the very real and impending threat of Hurricane Irma looming, I was in need of a room for the … - 

$169

$169
Map

Recently booked Florida Keys hotels

Sea Dell Motel
2.5 out of 5.0
Last booking: 1 minute ago
Almond Tree Inn
3.5 out of 5.0
Last booking: 6 minutes ago
Coconut Mallory Resort And Marina By Kees Vacations
0.0 out of 5.0
Last booking: 13 minutes ago
Heron House Court - Adult Only
3.5 out of 5.0
Last booking: 14 minutes ago
The Gates Hotel Key West
4.5 out of 5.0
Last booking: 46 minutes ago
24 North Hotel Key West
4.5 out of 5.0
Last booking: 1 hour ago
Captain Pips Marina & Hideaway
3.5 out of 5.0
Last booking: 6 hours ago
Holiday Inn Express Hotel & Suites Marathon
3.0 out of 5.0
Last booking: 6 hours ago
Fairfield Inn & Suites by Marriott Key West, Keys Collection
3.5 out of 5.0
Last booking: 7 hours ago

Independent Florida Keys Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in Florida Keys, Florida. Known for well-appointed rooms and friendly, personalized service, each of the top Independent Florida Keys hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Florida Keys Independent locations may even offer extra little benefits and discounts for frequent travelers.