Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys Independent Hotels

See all 1,047 Hotels in Florida Keys
Oceans Edge Key West Resort, Hotel & Marina

Oceans Edge Key West Resort, Hotel & Marina

5950 Peninsular Avenue, Key West
4.0 out of 5.0
4.5 out of 5 (333 reviews)
Very Nice Hotel it is not close to a Beach. We went here to just relax and you will get all of that here.. It was great services friendly just … - 

$179

$179
Ibis Bay Beach Resort

Ibis Bay Beach Resort

3101 N. Roosevelt Blvd, Key West
3.0 out of 5.0
3.7 out of 5 (1,608 reviews)
Great place for the laid backed hammocks, beach great food - 

$239

$239
Margaritaville Key West Resort & Marina

Margaritaville Key West Resort & Marina

245 Front Street, Key West
4.5 out of 5.0
4.2 out of 5 (189 reviews)
Great location Very expensive. Great location, convenient to downtown - 

$254

$254
Silver Palms Inn

Silver Palms Inn

830 Truman Ave, Key West
3.5 out of 5.0
4.4 out of 5 (1,815 reviews)
Overpriced Nice hôtel overpriced. Very helpful and presant staff. Noisy roof first floor close to the pool. So … - 

$153

$153
The Southernmost Inn-Adults Only

The Southernmost Inn-Adults Only

525 United Street, Key West
3.0 out of 5.0
4.1 out of 5 (868 reviews)
Cozy inn We stayed at the Inn in mid October. Our 1st hotel had issues post hurricane so we found this place … - 

$184

$184
Lime Tree Bay Resort

Lime Tree Bay Resort

68500 Overseas Hwy, Long Key
4.0 out of 5.0
4.1 out of 5 (548 reviews)
Would definitely stay here again! Beautiful view! Staff was friendly and helpful! - 

$165

$165
Heron House Court - Adult Only

Heron House Court - Adult Only

412 Frances St, Key West
3.5 out of 5.0
4.4 out of 5 (1,361 reviews)
Lovely guest house with super friendly staff I usually prefer larger hotels, but in Key West guesthouses are the more common & more affordable w … - 

$189

$189
NYAH Key West-Adults Only

NYAH Key West-Adults Only

420 Margaret Street, Key West
3.0 out of 5.0
4.4 out of 5 (830 reviews)
3 days 2 nights of an awesome experience. Will aga Excellent price and staff where excellent. Will stay over and over again. - 

$199

$199
Southwinds Motel

Southwinds Motel

1321 Simonton Street, Key West
2.0 out of 5.0
3.9 out of 5 (784 reviews)
Great location with friendly staff Lovely room close to the southern most point. Front desk staff were exceptionally helpful and alway … - 

$208

$208
Seashell Motel & Key West Hostel

Seashell Motel & Key West Hostel

718 South Street, Key West
2.0 out of 5.0
2.7 out of 5 (658 reviews)
Best deal in key west Great staff great facilities close to everything it is the best deal financially in key west. I wou … - 

$118

$118
Marina Del Mar Resort and Marina

Marina Del Mar Resort and Marina

527 Caribbean Drive, Key Largo
3.0 out of 5.0
3.6 out of 5 (1,854 reviews)
nice and clean. great restuarant next door. canal view. - 

$169

$169
Skipjack Resort & Marina

Skipjack Resort & Marina

19 Sombrero Blvd, Marathon
3.5 out of 5.0
4.2 out of 5 (157 reviews)
nice place to stay Great place to stay - we went snorkeling in Marathon and we stayed here and it was very nice. Every … - 

$199

$199
Heron House - Adult Only

Heron House - Adult Only

512 Simonton St, Key West
3.5 out of 5.0
4.3 out of 5 (1,519 reviews)
Beautiful and great price! We've stayed at several places around Old Town Key West, and this was definitely the most beautiful … - 

$159

$159
Creekside Inn Islamorada

Creekside Inn Islamorada

90611 Old Highway, Islamorada
3.0 out of 5.0
3.5 out of 5 (654 reviews)
Nice place to stay. Room is clean and smells good. It’s perfect if you’re not in a rush and want to … - 

$125

$125
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

2600 Overseas Hwy, Marathon
4.5 out of 5.0
4.5 out of 5 (1,050 reviews)
Last minute trip to the Keys Decided the day before we left to get away for a few days from the extreme cold. We had never been … - 

$249

$249
The Pelican Key Largo Cottages

The Pelican Key Largo Cottages

99340 Overseas Highway, Key Largo
2.0 out of 5.0
3.7 out of 5 (784 reviews)
Nice location. Some things could be better. Cottages on a beach. I stayed there overnight and the staff was great. I liked the little cottage f … - 

$120

$120
Drift Hotel

Drift Hotel

95320 Overseas Hwy, Key Largo
3.0 out of 5.0
4.1 out of 5 (21 reviews)
Cozy, quaint little gem with direct access to the we just stayed here for two days and absolutely loved it! Quaint little place with direct access to … - 

$139

$139
Bayside Inn Key Largo

Bayside Inn Key Largo

99490 Overseas Hwy, Key Largo
3.0 out of 5.0
3.0 out of 5 (1,758 reviews)
Great location, resort. Secluded, mostly clean place, great friendly staff. Walking distance to some cafes, and stores. - 

$159

$159
Chelsea House Hotel - Key West

Chelsea House Hotel - Key West

709 Truman Ave, Key West
3.0 out of 5.0
4.2 out of 5 (600 reviews)
Beautiful Hotel with lots of common areas This is a boutique hotel set up in an old house, everything is in good condition and the staff is v … - 

$224

$224
Amara Cay Resort

Amara Cay Resort

80001 Overseas Hwy, Islamorada
4.0 out of 5.0
4.3 out of 5 (1,208 reviews)
We loved the whole atmosphere and kindness of staff. - 

$233

$233
Map

Recently booked Florida Keys hotels

Southwinds Motel
2.0 out of 5.0
Last booking: 2 hours ago
NYAH Key West-Adults Only
3.0 out of 5.0
Last booking: 4 hours ago
Paradise Inn Key West-Adults Only
4.0 out of 5.0
Last booking: 4 hours ago
Key Lime Inn - Key West
3.0 out of 5.0
Last booking: 4 hours ago
Best Western Key Ambassador Resort Inn
3.0 out of 5.0
Last booking: 5 hours ago
The Gates Hotel Key West
4.5 out of 5.0
Last booking: 5 hours ago
Gilbert's Resort
2.5 out of 5.0
Last booking: 5 hours ago
The Caribbean Resort
4.0 out of 5.0
Last booking: 5 hours ago
Authors of Key West
3.5 out of 5.0
Last booking: 5 hours ago

Independent Florida Keys Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in Florida Keys, Florida. Known for well-appointed rooms and friendly, personalized service, each of the top Independent Florida Keys hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Florida Keys Independent locations may even offer extra little benefits and discounts for frequent travelers.