Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys Independent Hotels

See all 508 Hotels in Florida Keys
Ibis Bay Beach Resort

Ibis Bay Beach Resort

3101 N. Roosevelt Blvd, Key West
2.5 out of 5.0
3.7 out of 5 (1,685 reviews)
Room cleanliness I stayed for 8 nights. My room was not touched by any hotel staff for 4 days. I add dirty room phot … - 

$143

$143
Hilton Garden Inn Key West,The Keys Collection

Hilton Garden Inn Key West,The Keys Collection

3850 N Roosevelt Blvd, Key West
3.5 out of 5.0
4.1 out of 5 (323 reviews)
Good Key West Lodging My wife and I were in Key West for the boat races and stayed at the Garden Inn. We used the shuttle … - 

$125

$125
Lime Tree Bay Resort

Lime Tree Bay Resort

68500 Overseas Hwy, Long Key
3.5 out of 5.0
4.1 out of 5 (500 reviews)
A welcome surprise We were on a motorcycle trip from Alabama just looking for a place to stay on the way to Key West. … - 

$116

$116
The Southernmost Inn-Adults Only

The Southernmost Inn-Adults Only

525 United Street, Key West
2.5 out of 5.0
4.1 out of 5 (834 reviews)
The hotel is very nice, with a good conditions and perfect location. However I would like to includ … - 

$169

$169
The Pelican Key Largo Cottages

The Pelican Key Largo Cottages

99340 Overseas Highway, Key Largo
2.0 out of 5.0
3.7 out of 5 (750 reviews)
Friendly staff It was a real pleasure staying there with very friendly staff. - 

$93

$93
Fairfield Inn & Suites by Marriott Key West, Keys Collection

Fairfield Inn & Suites by Marriott Key West, Keys Collection

3852 North Roosevelt Boulevard, Key West
3.0 out of 5.0
4.0 out of 5 (876 reviews)
Away from traffic and quiet breakfast was the best we have ever had stayed in a lot of high rated h … - 

$149

$149
24 North Hotel Key West

24 North Hotel Key West

3820 North Roosevelt Boulevard, Key West
4.0 out of 5.0
4.1 out of 5 (1,037 reviews)
Hotel has a great shuttle to Mallory Square! The hotel was nice. The shuttle was fantastic because we did not have to use our rental car the who … - 

$137

$137
La Concha Hotel & Spa

La Concha Hotel & Spa

430 Duval St, Key West
4.0 out of 5.0
4.1 out of 5 (1,861 reviews)
Top notch Staff The hotel common areas and staff are very good and helpful. I stopped to ask a question or two seve … - 

$195

$195
Hyatt Place Marathon Florida Keys

Hyatt Place Marathon Florida Keys

1996 Overseas Highway, Marathon
3.0 out of 5.0
4.5 out of 5 (1,325 reviews)
Negatives No beach and allow pets with little management control or actions. This was a difficult time after … - 

$161

$161
Silver Palms Inn

Silver Palms Inn

830 Truman Ave, Key West
3.5 out of 5.0
4.4 out of 5 (2,451 reviews)
Great downtown key hotel A very cozy and welcoming place to stay free parking and a breakfast were the main draw for our one … - 

$179

$179
The Gates Hotel Key West

The Gates Hotel Key West

3824 N Roosevelt Blvd, Key West
4.0 out of 5.0
4.3 out of 5 (1,062 reviews)
Nice hotel Excellent for travelers. Service is excellent. Bus schedule is provided. Front desk personnel very … - 

$164

$164
Margaritaville Key West Resort & Marina

Margaritaville Key West Resort & Marina

245 Front Street, Key West
4.0 out of 5.0
4.3 out of 5 (148 reviews)
Great time Hotel is very well located, service is good , restaurant is good - 

$161

$161
Hyatt Centric Key West Resort and Spa

Hyatt Centric Key West Resort and Spa

601 Front St, Key West
4.0 out of 5.0
4.5 out of 5 (1,287 reviews)
Overall, great property. Treated ourselves to a nice hotel for a last minute trip to Key West. The property was beautiful, r … - 

$239

$239
Pier House Resort & Spa

Pier House Resort & Spa

1 Duval St, Key West
4.0 out of 5.0
4.4 out of 5 (1,420 reviews)
Great hotel This is a great hotel and is conveniently located near all the fun things to see and do in Key West - 

$279

$279
Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection

97450 Overseas Highway, Key Largo
3.5 out of 5.0
4.7 out of 5 (94 reviews)
Short stay for our anniversary, but had a great time. Beautiful property and staff was very friendl … - 

$212

$212
Marina Del Mar Resort and Marina

Marina Del Mar Resort and Marina

527 Caribbean Drive, Key Largo
2.5 out of 5.0
3.6 out of 5 (2,044 reviews)
Nice view-Aging rooms The hotel has a nice location with a pretty view of the channel water from the balcony. There is a … - 

$119

$119
Captain Pip's at Knight's Key Inn

Captain Pip's at Knight's Key Inn

40 Kyle Way W, Marathon
3.0 out of 5.0
4.5 out of 5 (40 reviews)
Good for a night or two Nice clean efficiency unit. Newly renovated. A nice place to take a break half way through the Keys … - 

$109

$109
Amy Slate's Amoray Dive Resort

Amy Slate's Amoray Dive Resort

104250 Overseas Hwy, Key Largo
2.0 out of 5.0
3.9 out of 5 (887 reviews)
We enjoyed the premises. Very nice location with dive boat on the property. Did not dive with them … - 

$86

$86
Southwinds Motel

Southwinds Motel

1321 Simonton Street, Key West
2.0 out of 5.0
3.9 out of 5 (751 reviews)
Location central to amenities Reception staff was friendly and helpful, allowed us to have room ahead of deadline. The room was s … - 

$169

$169
Duval House

Duval House

815 Duval St, Key West
3.0 out of 5.0
4.2 out of 5 (669 reviews)
beautiful historic section of old town old historic place. so beautiful behind hotel. very private. like jungle living by pool. rooms are … - 

$189

$189
Map

Recently booked Florida Keys hotels

Holiday Inn Key Largo
3.0 out of 5.0
Last booking: 8 minutes ago
La Concha Hotel & Spa
3.5 out of 5.0
Last booking: 24 minutes ago
Seascape Tropical Inn
3.0 out of 5.0
Last booking: 26 minutes ago
Pier House Resort & Spa
4.0 out of 5.0
Last booking: 28 minutes ago
Sheraton Suites Key West
3.5 out of 5.0
Last booking: 39 minutes ago
Drop Anchor Resort and Marina
3.0 out of 5.0
Last booking: 54 minutes ago
Ocean Key Resort - A Noble House Resort
4.0 out of 5.0
Last booking: 59 minutes ago
Lighthouse Court Hotel - Key West
3.5 out of 5.0
Last booking: 1 hour ago
DoubleTree Resort by Hilton Grand Key - Key West
3.5 out of 5.0
Last booking: 1 hour ago

Independent Florida Keys Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in Florida Keys, Florida. Known for well-appointed rooms and friendly, personalized service, each of the top Independent Florida Keys hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Florida Keys Independent locations may even offer extra little benefits and discounts for frequent travelers.