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Florida Keys Hotels

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Featured Florida Keys Independent Hotels

See all 389 Hotels in Florida Keys
Key West Escapes - Luxury Yoga Vacations

Key West Escapes - Luxury Yoga Vacations

Tropical Street, Key West
4.0 out of 5.0
Santa Maria Suites

Santa Maria Suites

1401 Simonton St, Key West
4.0 out of 5.0
4.8 out of 5 (364 reviews)
beautiful! Room was like an apartment rather than a hotel. Top notch all the way! I'm spoiled now - … - 

$399

$399
Cheeca Lodge & Spa

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82, Islamorada
4.0 out of 5.0
4.4 out of 5 (644 reviews)
Wedding We had our wedding there. Went off without a flaw. Would do the same in a beartbeat. Thank you ! - 

$143

$143
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

2600 Overseas Hwy, Marathon
4.0 out of 5.0
4.5 out of 5 (462 reviews)
Nice hotel but staff could be a little better. Nice hotel on Route 1 and on the beach. Facilities are well maintained, but desk did not tell us th … - 

$349

$349
Key West Yacht Life

Key West Yacht Life

Key West Harbour Yacht Club Stock Island, Key West
4.0 out of 5.0
Oceans Edge Key West Hotel & Marina

Oceans Edge Key West Hotel & Marina

5950 Peninsular Avenue, Key West
3.5 out of 5.0
4.4 out of 5 (80 reviews)
Nice and clean, staff not so good. Place is new, nice and very clean and the room was kept neat but was not happy to see that bed shee … - 

$193

$193
The Gardens Hotel

The Gardens Hotel

526 Angela Street, Key West
4.0 out of 5.0
4.8 out of 5 (115 reviews)
Best breakfast... Great location , friendly staff. Parking was limited - 

$187

$187
Map

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Independent Florida Keys Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in Florida Keys, Florida. Known for well-appointed rooms and friendly, personalized service, each of the top Independent Florida Keys hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Florida Keys Independent locations may even offer extra little benefits and discounts for frequent travelers.