Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 590,000 properties worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys Independent Hotels

See all 859 Hotels in Florida Keys
Oceans Edge Key West Resort, Hotel & Marina

Oceans Edge Key West Resort, Hotel & Marina

5950 Peninsular Avenue, Key West
    4.0 out of 5.0
     
     
    4.5 out of 5 (530 reviews)
    My boyfriend and I, also our dog were super happy with the room, the view, the service and everythi … - 

    Oceans Edge Key West Resort, Hotel & Marina$139

    Oceans Edge Key West Resort, Hotel & Marina$139
    Havana Cabana at Key West

    Havana Cabana at Key West

    3420 N. Roosevelt Blvd, Key West
      3.5 out of 5.0
       
       
      3.9 out of 5 (33 reviews)
      The pool and amenities were fantastic. The room was pretty standard. I wouldn't pay extra for the g … - 

      Havana Cabana at Key West$144

      Havana Cabana at Key West$144
      Bayside Inn Key Largo

      Bayside Inn Key Largo

      99490 Overseas Hwy, Key Largo
        2.5 out of 5.0
         
         
        3.0 out of 5 (1,804 reviews)
        The room location perfect room 101 room service was very poor - 

        Bayside Inn Key Largo$82

        Bayside Inn Key Largo$82
        Ibis Bay Beach Resort

        Ibis Bay Beach Resort

        3101 N. Roosevelt Blvd, Key West
          2.5 out of 5.0
           
           
          3.8 out of 5 (1,679 reviews)

          Ibis Bay Beach Resort$144

          Ibis Bay Beach Resort$144
          The Perry Hotel Key West

          The Perry Hotel Key West

          7001 Shrimp Road, Key West
            4.0 out of 5.0
             
             
            4.6 out of 5 (179 reviews)
            Very nice place. Clean room and very courteous and polite staff. Always with a smile. We liked it a … - 

            The Perry Hotel Key West$169

            The Perry Hotel Key West$169
            Margaritaville Key West Resort & Marina

            Margaritaville Key West Resort & Marina

            245 Front Street, Key West
              4.0 out of 5.0
               
               
              4.3 out of 5 (286 reviews)
              Beautiful room with ocean view. Only stayed one night. Mattresses aren’t the greatest but overall o … - 

              Margaritaville Key West Resort & Marina$232

              Margaritaville Key West Resort & Marina$232
              Marina Del Mar Resort and Marina

              Marina Del Mar Resort and Marina

              527 Caribbean Drive, Key Largo
                2.5 out of 5.0
                 
                 
                3.6 out of 5 (1,882 reviews)

                Marina Del Mar Resort and Marina$119

                Marina Del Mar Resort and Marina$119
                Albury Court Hotel - Key West

                Albury Court Hotel - Key West

                1030 Eaton St, Key West
                  3.0 out of 5.0
                   
                   
                  4.0 out of 5 (1,475 reviews)
                  Very nice and cozy. Excellent location to walk to everything. Short walk to "free" bus that does th … - 

                  Albury Court Hotel - Key West$169

                  Albury Court Hotel - Key West$169
                  Heron House - Adult Only

                  Heron House - Adult Only

                  512 Simonton St, Key West
                    3.5 out of 5.0
                     
                     
                    4.3 out of 5 (1,614 reviews)
                    Nice place close to everything - 

                    Heron House - Adult Only$119

                    Heron House - Adult Only$119
                    Skipjack Resort & Marina

                    Skipjack Resort & Marina

                    19 Sombrero Blvd, Marathon
                      3.0 out of 5.0
                       
                       
                      4.1 out of 5 (216 reviews)
                      Appears that repairs have been made after Irma and some still need to be done. Rooms are spacious w … - 

                      Skipjack Resort & Marina$159

                      Skipjack Resort & Marina$159
                      Amara Cay Resort

                      Amara Cay Resort

                      80001 Overseas Hwy, Islamorada
                        3.5 out of 5.0
                         
                         
                        4.3 out of 5 (1,297 reviews)

                        Amara Cay Resort$182

                        Amara Cay Resort$182
                        Creekside Inn Islamorada

                        Creekside Inn Islamorada

                        90611 Old Highway, Islamorada
                          2.5 out of 5.0
                           
                           
                          3.6 out of 5 (745 reviews)
                          Stay at Creekside Inn Nice stop on our way to Key West. Clean and comfortable for a reasonable price. - 

                          Creekside Inn Islamorada$116

                          Creekside Inn Islamorada$116
                          Silver Palms Inn

                          Silver Palms Inn

                          830 Truman Ave, Key West
                            3.5 out of 5.0
                             
                             
                            4.5 out of 5 (1,859 reviews)
                            Ample parking, quiet room (we had one on a side street) and very close to Duval Street. Loved the p … - 

                            Silver Palms Inn$139

                            Silver Palms Inn$139
                            Chesapeake Beach Resort

                            Chesapeake Beach Resort

                            83409 Overseas Hwy, Islamorada
                              2.5 out of 5.0
                               
                               
                              3.7 out of 5 (587 reviews)
                              didn't have beach access due to Hurricane Irma damage, but centrally located to restaurants and mod … - 

                              Chesapeake Beach Resort$111

                              Chesapeake Beach Resort$111
                              Heron House Court - Adult Only

                              Heron House Court - Adult Only

                              412 Frances St, Key West
                                3.0 out of 5.0
                                 
                                 
                                4.4 out of 5 (1,458 reviews)
                                Lovely! My husband and I very much enjoyed our stay at Heron House Court. The location is convenient to eve … - 

                                Heron House Court - Adult Only$129

                                Heron House Court - Adult Only$129
                                Seashell Motel & Key West Hostel

                                Seashell Motel & Key West Hostel

                                718 South Street, Key West
                                  1.5 out of 5.0
                                   
                                   
                                  2.8 out of 5 (712 reviews)
                                  Close to all the neat stuff. It is as advertised. Rooms have all you need but are barish.. would st … - 

                                  Seashell Motel & Key West Hostel$70

                                  Seashell Motel & Key West Hostel$70
                                  La Siesta Resort & Marina

                                  La Siesta Resort & Marina

                                  80241 Overseas Highway, Islamorada
                                    3.0 out of 5.0
                                     
                                     
                                    3.8 out of 5 (653 reviews)
                                    Every year i stay at la siesta and its just perfect the only thing is they closed down the jacuzzi … - 

                                    La Siesta Resort & Marina$194

                                    La Siesta Resort & Marina$194
                                    Tranquility Bay Beachfront Hotel and Resort

                                    Tranquility Bay Beachfront Hotel and Resort

                                    2600 Overseas Hwy, Marathon
                                      4.0 out of 5.0
                                       
                                       
                                      4.5 out of 5 (1,110 reviews)
                                      A lovely slice of paradise! The view can’t be beat. My second story patio seemed to be floating ove … - 

                                      Tranquility Bay Beachfront Hotel and Resort$169

                                      Tranquility Bay Beachfront Hotel and Resort$169
                                      Drop Anchor Resort and Marina

                                      Drop Anchor Resort and Marina

                                      84959 Overseas Highway, 222, Islamorada
                                        3.0 out of 5.0
                                         
                                         
                                        4.2 out of 5 (886 reviews)
                                        Vert cute motel with a waterfront area with a great view, plenty of seating. and a small pool. Our … - 

                                        Drop Anchor Resort and Marina$135

                                        Drop Anchor Resort and Marina$135
                                        Lime Tree Bay Resort

                                        Lime Tree Bay Resort

                                        68500 Overseas Hwy, Long Key
                                          3.5 out of 5.0
                                           
                                           
                                          4.1 out of 5 (666 reviews)

                                          Lime Tree Bay Resort$107

                                          Lime Tree Bay Resort$107
                                          Map

                                          Recently booked Florida Keys hotels

                                          Best Western Key Ambassador Resort Inn
                                          2.5 out of 5.0
                                          Last booking: 47 minutes ago
                                          The Marker Waterfront Resort Key West
                                          4.0 out of 5.0
                                          Last booking: 48 minutes ago
                                          24 North Hotel Key West
                                          4.0 out of 5.0
                                          Last booking: 1 hour ago
                                          Mangrove Marina and Resort Aqualodge Houseboats
                                          3.0 out of 5.0
                                          Last booking: 1 hour ago
                                          Albury Court Hotel - Key West
                                          3.0 out of 5.0
                                          Last booking: 1 hour ago
                                          Lighthouse Court Hotel - Key West
                                          3.5 out of 5.0
                                          Last booking: 2 hours ago
                                          Lime Tree Bay Resort
                                          3.5 out of 5.0
                                          Last booking: 2 hours ago
                                          Fairfield Inn and Suites by Marriott Key West
                                          3.5 out of 5.0
                                          Last booking: 2 hours ago
                                          Ibis Bay Beach Resort
                                          2.5 out of 5.0
                                          Last booking: 3 hours ago

                                          Independent Florida Keys Hotel Guide

                                          Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in Florida Keys, Florida. Known for well-appointed rooms and friendly, personalized service, each of the top Independent Florida Keys hotels guarantees an unparalleled level of comfort and quality.

                                          You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Florida Keys Independent locations may even offer extra little benefits and discounts for frequent travelers.