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Florida Keys, FL Luxury Hotels

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Florida Keys Hotels

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Top Florida Keys Neighborhoods for Luxury Hotels

Key West
57 hotels
from

$127

Marathon
17 hotels

Kingsail Resort

2.0 out of 5.0
from

$119

Islamorada
15 hotels

Amara Cay Resort

3.5 out of 5.0
from

$184

Featured Florida Keys Luxury Hotels

See all 390 Hotels in Florida Keys
Amara Cay Resort

Amara Cay Resort

80001 Overseas Hwy, Islamorada
3.5 out of 5.0
4.2 out of 5 (459 reviews)
Long weekend getawayThis is a very nice resort. Very modern interior and very clean. A little high in price for the size of the room but everything in the Keys is overpriced. The plus side is even though it is pricey, you are getting an extremely clean and modern place. My only complaint is that both the inside and ...
  Jul 19, 2017

$184

$184
La Concha Hotel & Spa

La Concha Hotel & Spa

430 Duval St, Key West
3.5 out of 5.0
4.0 out of 5 (585 reviews)
3 nightsVery nice staff, attentive. We stayed on the new side of the hotel and we were pretty happy. There was a bird or some animal stuck in the AC pipes somewhere. It tapped all night long. The beds were ok, the pillows too soft. But this is nitpicking.
  Jul 22, 2017

$195

$195
The Marker Waterfront Resort Key West

The Marker Waterfront Resort Key West

200 William Street, Key West
4.0 out of 5.0
4.5 out of 5 (317 reviews)
Great Location Close to just about everything- the waterfront, restaurants- Mallory Square-bars. Adults only pool was a nice touch.
  Jul 21, 2017

$199

$199
Santa Maria Suites

Santa Maria Suites

1401 Simonton St, Key West
4.0 out of 5.0
4.8 out of 5 (365 reviews)
beautiful! Room was like an apartment rather than a hotel. Top notch all the way! I'm spoiled now - won't stay anywhere else.
  Jul 10, 2017

$399

$399
Cheeca Lodge & Spa

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82, Islamorada
4.0 out of 5.0
4.4 out of 5 (644 reviews)
WeddingWe had our wedding there. Went off without a flaw. Would do the same in a beartbeat. Thank you !
  Jul 16, 2017

$143

$143
Casa Marina Resort - A Waldorf Astoria Resort

Casa Marina Resort - A Waldorf Astoria Resort

1500 Reynolds Street, Key West
4.0 out of 5.0
4.1 out of 5 (967 reviews)
Perfect Getaway!We enjoyed every drop of our six-day stay. From the cheery welcome, to the beautiful backdrop, and even down to the virtual concierge; all our expectations were met and superceded. I can't understand why so many people posted such subpar reviews. We were half expecting a nightmare based on some of ...
  Jul 19, 2017

$279

$279
Little Palm Island Resort & Spa - A Noble House Resort

Little Palm Island Resort & Spa - A Noble House Resort

28500 Overseas Hwy, Little Torch Key
4.5 out of 5.0
4.9 out of 5 (23 reviews)
fabulous accommodation and staff...service is superb
  Jul 3, 2017

$790

$790
Kingsail Resort

Kingsail Resort

7050 Overseas Highway, Marathon
2.0 out of 5.0
3.3 out of 5 (514 reviews)
Decent motel with its own marinaThe motel was comfortable and it was nice to have the boat right in front of us in the water. The slips are very small; they do expect to get 2 boats in adjoining slips but there is no way that two will fit side by side. They also have fewer real slips than advertised and they cost $75 per night. ...
  Jul 3, 2017

$119

$119
The Gates Hotel Key West

The Gates Hotel Key West

3824 N Roosevelt Blvd, Key West
4.0 out of 5.0
4.3 out of 5 (300 reviews)
Clean, really nice staff.Very nice stay. The staff was very helpful. The hotel is very clean.
  Jul 13, 2017

$127

$127
Islander Resort, a Guy Harvey Outpost

Islander Resort, a Guy Harvey Outpost

82100 Overseas Highway, Islamorada
3.0 out of 5.0
4.2 out of 5 (655 reviews)
This is a real Keys experience. Wonderful property!
  Jul 16, 2017

$100

$100
Map

Recently booked Florida Keys hotels

Holiday Inn Express Hotel & Suites Marathon
2.5 out of 5.0
Last booking: 1 minute ago
Courtyard by Marriott Key West Waterfront
3.0 out of 5.0
Last booking: 1 minute ago
Artist House on Fleming
3.5 out of 5.0
Last booking: 8 minutes ago
Hampton Inn Key Largo Manatee Bay
2.5 out of 5.0
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Fairfield Inn & Suites Key West at The Keys Collection
2.5 out of 5.0
Last booking: 27 minutes ago
Parrot Key Hotel & Resort
4.0 out of 5.0
Last booking: 31 minutes ago
Ocean Key Resort - A Noble House Resort
4.0 out of 5.0
Last booking: 54 minutes ago
24 North Hotel Key West
3.5 out of 5.0
Last booking: 1 hour ago
Key Lime Inn - Key West
3.0 out of 5.0
Last booking: 1 hour ago

A few days away keeps your stress at bay, and Florida Keys is the best location to visit. Divine eats, fascinating sites, and the most stunning photo opportunities: these are just a few of the benefits of visiting Florida Keys. Where else would you stay but a luxury accommodation? Sampling the finer things in life is just your speed. While you're here, you'll also grab tickets to the most popular performances, treat yourself to decadent cuisine, and eye-guzzle the most noteworthy points of interest in the region. Book your upscale hotel in Florida Keys on Expedia.com right now and start your trip off on the right (well-dressed) foot.

5-Star Vacations in Florida Keys

It turns out plenty of folks have decided to have set down roots -- how is that for proof that Florida Keys is full of an exciting array of activities? Whether you’re looking to spend your vacation dining on haute cuisine or exploring museums in Florida Keys, you'll never be disappointed. Florida Keys is full of dreamy hotels in addition to friendly locals, so you can count on a marvelous stay. Book early to get a room with a view!

Your luxury vacation is the perfect opportunity to indulge in art, culture, and spa treatments. When you save big by booking on Expedia.com, it's all at your fingertips. Thanks to our hotel deals, you'll still have plenty of cash for the most fun and free-spirited things to do. After an eventful day of exploring the city, your luxury hotel is waiting with a wonderful meal and incredible amenities. Before you start counting sheep, order a glass of wine to your room and start planning tomorrow's adventure. The luxury hotels in Florida Keys will have you feeling the relaxation in no time.

Find Luxury Florida Keys Hotels Now

There's no better time than now to book a hotel in Florida Keys, and Expedia.com is here to make the process painless. Search through the abundance of reviews on dozens of hotels and then book your ideal room in minutes. Luxury accommodations offer amenities like elegant suites and concierge services. Many opulent accommodations in Florida Keys even feature impeccable suites, and it's not uncommon to enjoy a sauna and heated swimming pool in your hotel. Use our easy booking widget to choose an incredible 5-star hotel in Florida Keys, and prepare for the vacation of a lifetime!