United States of America may have travel restrictions in place, including self-quarantine, due to COVID-19.

Find out moreOpens in new tab or window

Find Non-Smoking Hotels in Florida Keys from $104

Search over 1 million properties and 550 airlines worldwide

Members save 10% more on select hotels, cars, activities and vacation rentals. Sign up.

Free cancellation on most hotels. Because flexibility matters.

Top Florida Keys Non-Smoking Hotels

(#7) WATERFRONT 4BR/OWN PRIVATE HEATED/COOLED PRIVATE POOL, FREE DOCK!!
4.9/5Exceptional! (45 reviews)
Great Location!! Awesome customer service

"We rented for a group of 8 for New Years! Jessieca and her team were awesome to work with even with some of our special requests. The location, house and pool provided were great and would highly recommend!"…"

Reviewed on Jan 15, 2020

(#7) WATERFRONT 4BR/OWN PRIVATE HEATED/COOLED PRIVATE POOL, FREE DOCK!!
Waterfront 4br/own Private Heated/cooled Pool, Free Dock!!
4.9/5Exceptional! (54 reviews)
Paradise

"Great quick communication, attentive to details and our needs. Jessieca was very kind. We loved the house and property and hope to go back again! It was clean and Covid friendly, even had signs on the beach to stay 6 feet apart and Lysol chairs, we felt safe and were able to relax with our ..."…"

Reviewed on Nov 29, 2020

Waterfront 4br/own Private Heated/cooled Pool, Free Dock!!
Almond Tree Inn
3.5 out of 5
512 Truman Ave, Key West, FL
Free CancellationReserve now, pay when you stay
The price is $168 per night from Dec 3 to Dec 4
4.8/5Exceptional! (986 reviews)

"Perfect location. Quaint room. Staff went above and beyond. Also, had the pool to ourselves one day. I would definitely recommend staying here!"…"

Reviewed on Dec 1, 2020

Almond Tree Inn
You could be seeing lower prices

You could be seeing lower prices

With member prices, you could save 10% or more right now on thousands of properties.
Coconut Bay Resort Key Largo
2 out of 5
97770 Overseas Hwy, Key Largo, FL
The price is $145 per night from Dec 7 to Dec 8
4.7/5Exceptional! (96 reviews)
Stop scrolling-Stay here it's great!!!!!

"Can't wait to go back! The only thing missing, other than daily maid service (understandable w/covid) is ice. I get it's the keys. Fishing or not, everyone has coolers! I simply wanted ice in a glass so I could kick back, and enjoy a cold beverage under the palm trees. The property is absolutly charming. ..."…"

Reviewed on Aug 31, 2020

Coconut Bay Resort Key Largo
Courtyard by Marriott Marathon Florida Keys
3 out of 5
2146 Overseas Hwy, Marathon, FL
Free CancellationReserve now, pay when you stay
The price is $118 per night from Dec 6 to Dec 7
4.7/5Exceptional! (742 reviews)

"Excellent property in a good place, nice staff , everything was very good according to the circumstances of the new normality”..."…"

Reviewed on Nov 29, 2020

Courtyard by Marriott Marathon Florida Keys
Award Winning Home Next to Lighthouse! Newly Updated Private Pool, Gated Parking
4.7/5Exceptional! (3 reviews)
More than we could have ever dreamed! This house is amazing!

"Hands down our greatest vacation rental/hotel experience ever! We had a wonderful vacation in this lovely home. What a fantastic location! We were within walking distance to almost everything. As soon as we walked in the door we knew that we had made the right choice. The house is very charming, ..."…"

Reviewed on Apr 10, 2018

Award Winning Home Next to Lighthouse! Newly Updated Private Pool, Gated Parking
Azul del Mar
3.5 out of 5
104300 Overseas Highway, Key Largo, FL
The price is $199 per night from Dec 4 to Dec 5
4.5/5Wonderful! (272 reviews)

"Quiet, laid back small resort. Very well maintained outside and in. Landscaping was very well maintained even after a recent storm. Room clean and spacious. Although a bit sparse in decor, you had everything you needed small coffee pot, dishes, microwave and dish washer."…"

Reviewed on Nov 18, 2020

Azul del Mar
Azul Key West
3.5 out of 5
907 Truman Avenue, Key West, FL
Get Rates
4.5/5Wonderful! (718 reviews)

"Great stay !! Only downside was the noisy AC unit, other than that my stay was a great one, highly recommended !"…"

Reviewed on Aug 3, 2020

Azul Key West
Bluegreen Vacations Hammocks at Marathon, an Ascend Resort
2.5 out of 5
1688 Overseas Hwy, Marathon, FL
Get Rates
4.5/5Wonderful! (116 reviews)

"We loved the location of the property and we also loved the entertainment/singer provided by lounge."…"

Reviewed on Feb 20, 2020

Bluegreen Vacations Hammocks at Marathon, an Ascend Resort
Condo 2 br, Ocean View From Balcony, Pets Welcome
4.5/5Wonderful! (22 reviews)
Great Stay In Key West

"We loved the condo it was clean and perfect size for our group of 5. Our only complaint is the beds were a little uncomfortable."…"

Reviewed on Aug 3, 2020

Condo 2 br, Ocean View From Balcony, Pets Welcome
Kimpton Fitch Lodge
3.5 out of 5
1030 Eaton St, Key West, FL
Free Cancellation
The price is $120 per night from Dec 3 to Dec 4
4.4/5Wonderful! (9 reviews)

"First off the people who work there are amazing. The location is perfect. You can walk everywhere but that gets tiring quickly in the heat. My suggestion rent scooters immediately & you will get around with ease. The room (I had #4) felt like home, extremely well designed & thought out. If you’re ..."…"

Reviewed on Nov 4, 2020

Kimpton Fitch Lodge
Amara Cay Resort
3.5 out of 5
80001 Overseas Hwy, Islamorada, FL
Free CancellationReserve now, pay when you stay
The price is $169 per night from Dec 3 to Dec 4
4.4/5Wonderful! (971 reviews)

"Very pleasant place and professional staff. Best Thanksgiving turkey ever!"…"

Reviewed on Nov 29, 2020

Amara Cay Resort
Best Western Hibiscus Motel
2.5 out of 5
1313 Simonton Street, 1313, Key West, FL
Get Rates
4.3/5Excellent! (483 reviews)

"We asked for a different room as the first one they gave us had a very dirty carpet."…"

Reviewed on Jul 23, 2019

Best Western Hibiscus Motel
Bayside Inn Key Largo
3 out of 5
99490 Overseas Hwy, Key Largo, FL
Free Cancellation
The price is $120 per night from Dec 10 to Dec 11
4.2/5Excellent! (335 reviews)

"Beautiful place. Thai restaurant on property. Starbucks next door"…"

Reviewed on Nov 30, 2020

Bayside Inn Key Largo
Fairfield Inn and Suites by Marriott Key West
3 out of 5
2400 N Roosevelt Blvd, Key West, FL
Free CancellationReserve now, pay when you stay
The price is $129 per night from Dec 9 to Dec 10
4.1/5Very Good! (961 reviews)

"The property is so well laid out. Beautiful pool. Great tiki bar. Great lobby."…"

Reviewed on Nov 2, 2020

Fairfield Inn and Suites by Marriott Key West
Courtyard by Marriott Key West Waterfront
3 out of 5
3031-41 N Roosevelt Blvd, Key West, FL
Free CancellationReserve now, pay when you stay
The price is $113 per night from Dec 13 to Dec 14
4.1/5Very Good! (962 reviews)

"Tons of free parking on-site and beautiful newly-renovated modern rooms in building C. Quiet and comfortable. Perfect"…"

Reviewed on Nov 24, 2020

Courtyard by Marriott Key West Waterfront
24 North Hotel Key West
4 out of 5
3820 North Roosevelt Boulevard, Key West, FL
Free CancellationReserve now, pay when you stay
The price is $104 per night from Dec 3 to Dec 4
4/5Very Good! (1,403 reviews)

"Great place, amenities and staff Awesome location"…"

Reviewed on Nov 30, 2020

24 North Hotel Key West
Courtyard by Marriott Key Largo
3 out of 5
99751 Overseas Hwy, Key Largo, FL
Free CancellationReserve now, pay when you stay
The price is $127 per night from Dec 8 to Dec 9
4/5Very Good! (863 reviews)

"Location was perfect, I like the Pool and Restaurant near location."…"

Reviewed on Oct 1, 2020

Courtyard by Marriott Key Largo
1800 Atlantic Suites
3 out of 5
1800 Atlantic Blvd, Key West, FL
Get Rates
3.9/5Good! (115 reviews)
Great view of ocean and nice location

"The 3 sliding glass doors lead to the balcony, great view, nice swimming pool, located between 2 beaches. Easy Uber access. However, the washer and dryer are noisy, slow and low capacity. The oven does not hold a temperature and pizzas burn up. The unit is a little dated. I would stay at the property ..."…"

Reviewed on Jul 24, 2020

1800 Atlantic Suites
Chesapeake Beach Resort
2.5 out of 5
83409 Overseas Hwy, Islamorada, FL
Free CancellationReserve now, pay when you stay
The price is $145 per night from Dec 7 to Dec 8
3.5/5Good! (924 reviews)

"We really enjoyed our stay! No issues that I can think of. I’m sure when renovations have been finished this will be an awesome place to stay any time of year! Unbeatable customer service ( they reached out daily to see if I need anything). Love love love this place!!!"…"

Reviewed on Oct 23, 2020

Chesapeake Beach Resort
Don't see what you're looking for?
We've got more Non-Smoking Hotels. Find the right one for you.
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Pocket Guide: Non-Smoking Hotels in Florida Keys

Search for hotels in Florida Keys on Expedia. You can easily find your hotels in Florida Keys using one of the methods below:

  • View our selection of featured hotels in Florida Keys
  • Use the map to find hotels in the Florida Keys neighborhood you prefer
  • Use the filters to see hotels in a specific area of Florida Keys, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Florida Keys
  • Enter your travel dates to view the best deals on hotels in Florida Keys - while they last

More trip options