Florida may have travel restrictions in place due to COVID-19.

Find Non-Smoking Hotels in Gainesville, FL from $49

Search over 1 million properties and 550 airlines worldwide

Members save 10% more on select hotels, cars, activities and vacation rentals. Sign up.

Free cancellation on most hotels. Because flexibility matters.

Top Gainesville Non-Smoking Hotels

Huge Pool Home: Perfect for Families With Pets
4.9/5Exceptional! (50 reviews)
Great location

"We stayed here while some work was being done on our house. It was a great location and perfect for our dogs. There is a nice back yard and good walking areas. The neighborhood was quiet and convenient to shopping. Check in/ out was very easy."…"

Reviewed on Nov 16, 2020

Huge Pool Home: Perfect for Families With Pets
Drury Inn & Suites Gainesville
3 out of 5
4000 Southwest 40th Blvd, Gainesville, FL
Free CancellationReserve now, pay when you stay
The price is $81 per night from Dec 8 to Dec 9
4.8/5Exceptional! (1,511 reviews)

"Enjoyed our stay. Very clean and the dinner and drinks was a great perk."…"

Reviewed on Nov 29, 2020

Drury Inn & Suites Gainesville
Sweetwater Branch Inn
3.5 out of 5
625 East University Avenue, Gainesville, FL
The price is $109 per night from Jan 3 to Jan 4
4.7/5Exceptional! (330 reviews)

"This is a charming inn kept in the style of the Victorian era. Because we were arriving late we were called and given excellent instructions on how to check in after hours. This was a wonderful departure from the ordinary."…"

Reviewed on Nov 30, 2020

Sweetwater Branch Inn
You could be seeing lower prices

You could be seeing lower prices

With member prices, you could save 10% or more right now on thousands of properties.
Home2 Suites by Hilton Gainesville
2.5 out of 5
2115 Southwest 13th Street, Gainesville, FL
Free CancellationReserve now, pay when you stay
The price is $84 per night from Dec 4 to Dec 5
4.6/5Exceptional! (480 reviews)

"Clear and huge rooms, staff was very friendly and kind. Breakfast so light do to covid."…"

Reviewed on Nov 26, 2020

Home2 Suites by Hilton Gainesville
Residence Inn by Marriott Gainesville I-75
3 out of 5
3275 SW 40th Blvd, Gainesville, FL
Free CancellationReserve now, pay when you stay
The price is $94 per night from Dec 14 to Dec 15
4.5/5Wonderful! (512 reviews)
Clean hotel, great service with a bed of rocks

"We enjoyed our overall weekend stay here. The staff was friendly and hotel was clean and followed Covid guidelines. However the bed was extremely firm and uncomfortable to sleep in"…"

Reviewed on Aug 26, 2020

Residence Inn by Marriott Gainesville I-75
Hampton Inn & Suites Gainesville Downtown
2.5 out of 5
101 SE 1st Ave, Gainesville, FL
Free CancellationReserve now, pay when you stay
The price is $79 per night from Dec 6 to Dec 7
4.5/5Wonderful! (542 reviews)

"Room is great, was spacious and comfortable. The negative, no good plan for guest parking."…"

Reviewed on Oct 31, 2020

Hampton Inn & Suites Gainesville Downtown
DoubleTree by Hilton Gainesville
3.5 out of 5
3726 Sw 40th Blvd, Gainesville, FL
Free CancellationReserve now, pay when you stay
The price is $76 per night from Dec 17 to Dec 18
4.4/5Wonderful! (979 reviews)

"Great hotel with a great location. Nice, spacious rooms."…"

Reviewed on Nov 29, 2020

DoubleTree by Hilton Gainesville
Best Western Waldo Inn and Suites
2 out of 5
17230 Ne Us Highway 301, Waldo, FL
Free CancellationReserve now, pay when you stay
The price is $93 per night from Dec 11 to Dec 12
4.3/5Excellent! (290 reviews)

"Loved the Service and cleanliness of the hotel. Will be staying again."…"

Reviewed on Jun 17, 2020

Best Western Waldo Inn and Suites
SpringHill Suites by Marriott Gainesville
3 out of 5
4155 Sw 40th Blvd, Gainesville, FL
Free CancellationReserve now, pay when you stay
The price is $94 per night from Dec 14 to Dec 15
4.3/5Excellent! (963 reviews)

"The facility was clean, easy check-in. The room was clean, bed soft"…"

Reviewed on Nov 28, 2020

SpringHill Suites by Marriott Gainesville
Hilton University of Florida Conference Center Gainesville
3 out of 5
1714 SW 34th St, Gainesville, FL
Free CancellationReserve now, pay when you stay
The price is $84 per night from Dec 8 to Dec 9
4.3/5Excellent! (982 reviews)

"Great place to stay. Staff was very welcoming. Would stay their again."…"

Reviewed on Oct 10, 2020

Hilton University of Florida Conference Center Gainesville
Sleep Inn & Suites University/Shands
2.5 out of 5
4110 SW 40th Boulevard, Gainesville, FL
Free CancellationReserve now, pay when you stay
The price is $70 per night from Dec 7 to Dec 8
4.3/5Excellent! (990 reviews)

"This was a clean very nice motel.Price was good also."…"

Reviewed on Jul 4, 2020

Sleep Inn & Suites University/Shands
Courtyard by Marriott Gainesville
3 out of 5
3700 Sw 42nd St, Gainesville, FL
Free CancellationReserve now, pay when you stay
The price is $78 per night from Dec 7 to Dec 8
4.2/5Excellent! (401 reviews)

"Wonderful Stay"…"

Reviewed on Aug 20, 2020

Courtyard by Marriott Gainesville
Best Western Gateway Grand
3 out of 5
4200 NW 97th Blvd, Gainesville, FL
Free CancellationReserve now, pay when you stay
The price is $81 per night from Dec 6 to Dec 7
4.2/5Very Good! (989 reviews)

"Daily breakfast was very nice and a real time-saver We could have done without Harley Davidson across the street. Hotel staff were courteous and helpful."…"

Reviewed on Oct 19, 2020

Best Western Gateway Grand
TownePlace Suites by Marriott Gainesville Northwest
3 out of 5
7451 West Newberry Road, Gainesville, FL
Free CancellationReserve now, pay when you stay
The price is $99 per night from Dec 6 to Dec 7
4.1/5Very Good! (305 reviews)

"The weather was perfect the location was perfect wonderful staff very clean condition just a great stay."…"

Reviewed on Nov 28, 2020

TownePlace Suites by Marriott Gainesville Northwest
Red Roof Inn PLUS+ Gainesville
2.5 out of 5
3500 Southwest 42nd St, Gainesville, FL
Free CancellationReserve now, pay when you stay
The price is $63 per night from Dec 6 to Dec 7
4/5Very Good! (1,034 reviews)
Great Hotel to Stay at with Your Pet

"I Chose RED ROOF INN For 2 reasons : it was close to my daughter’s college residence in Gainesville AND I Brought my little dog to stay with us while we were up there. This hotel is not fancy but VERY CLEAN And I would definitely stay here again on my next trip to Gainesville."…"

Reviewed on Aug 30, 2020

Red Roof Inn PLUS+ Gainesville
Quality Inn University North I-75
2 out of 5
7516 Newberry Road/I-75, I-75 & SR 26 Exit 387, Gainesville, FL
Free CancellationReserve now, pay when you stay
The price is $65 per night from Dec 17 to Dec 18
3.8/5Good! (601 reviews)
Last minute stay

"One night stay got tired of driving so a last minute thing. But the room was very clean and the front desk lady was very nice. If I had any complaint it would be that when I went to get breakfast I was told I was suppose to have ordered it when we checked in, which I was not told or asked. They are ..."…"

Reviewed on Jul 14, 2020

Quality Inn University North I-75
Holiday Inn Gainesville - University Center
3 out of 5
1250 W University Ave, Gainesville, FL
Free Cancellation
The price is $76 per night from Dec 20 to Dec 21
3.8/5Good! (700 reviews)

"It was nice & close to event venue. However my room the ceiling needed fixing and the shower surround was cracked and needed replacing."…"

Reviewed on Nov 30, 2020

Holiday Inn Gainesville - University Center
Days Inn by Wyndham Gainesville
2.5 out of 5
920 Nw 69th Ter, Gainesville, FL
Free CancellationReserve now, pay when you stay
The price is $55 per night from Dec 10 to Dec 11
3.3/5 (982 reviews)

"The room was clean"…"

Reviewed on Aug 31, 2020

Days Inn by Wyndham Gainesville
Extended Stay America Gainesville - I-75
2.5 out of 5
3600 Sw 42nd St, Gainesville, FL
Free CancellationReserve now, pay when you stay
The price is $66 per night from Dec 10 to Dec 11
3.3/5 (996 reviews)

"I liked everything about the hotels And the employers"…"

Reviewed on May 10, 2020

Extended Stay America Gainesville - I-75
Americas Best Value Inn Alachua
2 out of 5
16100 NW US Highway 441, Alachua, FL
Free CancellationReserve now, pay when you stay
The price is $49 per night from Dec 6 to Dec 7
2.2/5 (184 reviews)

"We had a nice trip."…"

Reviewed on Aug 1, 2020

Americas Best Value Inn Alachua
Don't see what you're looking for?
We've got more Non-Smoking Hotels. Find the right one for you.
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Pocket Guide: Non-Smoking Hotels in Gainesville

Search for hotels in Gainesville on Expedia. You can easily find your hotels in Gainesville using one of the methods below:

  • View our selection of featured hotels in Gainesville
  • Use the map to find hotels in the Gainesville neighborhood you prefer
  • Use the filters to see hotels in a specific area of Gainesville, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Gainesville
  • Enter your travel dates to view the best deals on hotels in Gainesville - while they last

More trip options