I chose this hotel for being in a walkable area, near Via Grand yet in close proximity to airport (20 minute cab ride). The hotel's facade is lovely to look at a distance when all lit up. Easy check-in, very helpful staff. Would stay again for a night or two if given a room closer to main elevators. I was traveling solo and the wing I was staying in has to be accessed by another elevator tucked away from the main area. The room was clean enough but some minor repairs needed such as peeling ceiling (very old hotel so that wasn't a big deal). The carpets in corridor were in dire need of a deep clean. Unfortunately, dirty carpeting on top of the long, desolate corridors gave me a creepy vibe.
I liked Hotel Santa Domingo overall but dont expect a modern, newly furnished 4 star hotel. Also, I'd highly suggest making a reservation for their rooftop dining on terrace overlooking the city. I was disappointed that the hostess in main lobby informed me they had no seating available..at all. Fortunately, there are dozens of restaurant choicea nearby.