Title: Mayesville Vacation Packages 2026 from $728 | Expedia.com

[Mayesville Travel Guide](https://expedia.com/Mayesville.dx3000456025)[Hotels in Mayesville](https://expedia.com/Mayesville-Hotels.d3000456025.Travel-Guide-Hotels)[Vacation Rentals in Mayesville](https://expedia.com/Mayesville-Vacation-Rentals.d3000456025.Travel-Guide-VacationRentals)[Flights to Mayesville](https://expedia.com/Cheap-Flights-To-Mayesville.d3000456025.Travel-Guide-Flights)[Car Rentals in Mayesville](https://expedia.com/Car-Rentals-In-Mayesville.d3000456025.Car-Rental-Guide)

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# Mayesville Vacations from $728

## Book a Hotel + Flight or Car together to unlock savings

- ##  
Plan, book, travel with confidence
- ###  
Better together  
Save up to $1,045 when you book a flight and hotel together\*
- ###  
Find the right fit  
With over 300,000 hotels worldwide, it's easy to create a perfect package
- ###  
Rest easy  
Plan, book, and manage your trip all in one place

## The Latest Mayesville vacation packages

Price found within the past 48 hours. Click for updated prices.

![Americas Best Value Inn Bishopville](https://images.trvl-media.com/lodging/1000000/30000/27700/27650/26fb3d06_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Americas Best Value Inn Bishopville

$728

per person

Apr 3 - Apr 10

found 1 day ago

Roundtrip non-stop flight included

New York (JFK) to Florence (FLO)

7.2/10 Good! (89 reviews)

The room smelled clean, looked clean and I found no bed bugs. To look at it, we were not sure about our choice. But the wife and I were very pleased. If in the area, we will definitely stay there again.

Reviewed on Oct 27, 2025

![Springhill Suites by Marriott Cheraw](https://images.trvl-media.com/lodging/90000000/89930000/89925000/89924960/3922a50b_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Springhill Suites by Marriott Cheraw

$1,034

per person

Apr 3 - Apr 10

found 1 day ago

Roundtrip non-stop flight included

New York (JFK) to Florence (FLO)

9.4/10 Exceptional! (267 reviews)

The room was fined but unfortunately the TV did not work and after several attempts from the maintenance man, Mr. Gary Cash, who was went above and beyond to get the TV to work it did not. The front desk did offer to change our room but we just said we were tired and just wanted to rest. So we were charged for a full night without the convenience of entertainment.

Reviewed on Jan 27, 2026

![Hyatt Place Florence Downtown](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c29c3321_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Hyatt Place Florence Downtown

$910

per person

Apr 3 - Apr 10

found 1 day ago

Roundtrip non-stop flight included

New York (JFK) to Florence (FLO)

8.8/10 Excellent! (1,001 reviews)

Clean and spacious room.

Reviewed on Jan 27, 2026

![TownePlace Suites by Marriott Florence](https://images.trvl-media.com/lodging/11000000/10630000/10620800/10620701/4140d9d6_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### TownePlace Suites by Marriott Florence

$893

per person

Apr 3 - Apr 10

found 1 day ago

Roundtrip non-stop flight included

New York (JFK) to Florence (FLO)

9/10 Wonderful! (681 reviews)

yes the room was clean and staff was good

Reviewed on Feb 12, 2026

![Comfort Inn & Suites Florence Center Area](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Comfort Inn & Suites Florence Center Area

$882

per person

Apr 3 - Apr 10

found 1 day ago

Roundtrip non-stop flight included

New York (JFK) to Florence (FLO)

9.2/10 Wonderful! (1,145 reviews)

Breakfast was very simple and not tasty. Rooms a little dated with thin walls you could hear next door guests.

Reviewed on Feb 12, 2026

Don't see what you're looking for?

See all available trips from Columbus to Mayesville

[View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-14/2026-03-21/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=FLO&NumRoom=1&NumAdult=2&NumChild=0&paandie=true)

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## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

[Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_3000456025)

## Mayesville Hotel Deals

![Woodspring Suites Sumter Near Shaw Afb](https://images.trvl-media.com/lodging/114000000/113640000/113638700/113638614/ffe51947_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Woodspring Suites Sumter Near Shaw Afb

2715 Broad Street Sumter SC

Fully refundableReserve now, pay when you stay

$104 nightly

$116 total

Feb 15 - Feb 16

Total with taxes and fees

8/10 Very Good! (164 reviews)

Young lady was very friendly and helpful

Reviewed on Feb 9, 2026

[](https://expedia.com/Hotel-Search?startDate=2%2F15%2F2026&endDate=2%2F16%2F2026&selected=113638614&PinnedHotelID=113638614&HadPinnedHotel=true&regionId=3000456025)

![SureStay Hotel by Best Western Manning](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/e6b95688_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

SureStay Hotel by Best Western Manning

2816 Paxville Highway Manning SC

Fully refundableReserve now, pay when you stay

$89 nightly

$99 total

Feb 15 - Feb 16

Total with taxes and fees

8.4/10 Very Good! (1,006 reviews)

Clean, modern room

Reviewed on Feb 6, 2026

[](https://expedia.com/Hotel-Search?startDate=2%2F15%2F2026&endDate=2%2F16%2F2026&selected=569301&PinnedHotelID=569301&HadPinnedHotel=true&regionId=3000456025)

![Hyatt Place Sumter / Downtown](https://images.trvl-media.com/lodging/23000000/22520000/22514800/22514748/dfc7158d_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hyatt Place Sumter / Downtown

18 N Main St Sumter SC

$164 nightly

$184 total

Mar 15 - Mar 16

Total with taxes and fees

9/10 Wonderful! (901 reviews)

Great job

Reviewed on Jan 27, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F15%2F2026&endDate=3%2F16%2F2026&selected=22514748&PinnedHotelID=22514748&HadPinnedHotel=true&regionId=3000456025)

[See all 76 properties in Mayesville](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F15%2F2026&endDate=2%2F16%2F2026&regionId=3000456025)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Find the Best Mayesville Vacation Packages

## Mayesville Essential Information

| Language        | English                         |
| --------------- | ------------------------------- |
| Currency        | U.S dollars                     |
| Closest Airport | Florence Regional Airport (FLO) |
| Population      | 730                             |

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## Frequently asked questions

### How much does a Mayesville vacation package cost?

### What are the cheapest months to go to Mayesville?

### How many days is enough for Mayesville?

### How to find the best Mayesville package deals?

### Is it cheaper to book a Mayesville vacation as a package?

### When to book a vacation package to Mayesville?

### Does Expedia offer Book Now, Pay Later Mayesville vacation packages?

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.

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