Mayo Vacations from $481

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The Latest Mayo vacation packages

Price found within the past 48 hours. Click for updated prices.
Hilton Greenville

Hilton Greenville

3.5 out of 5
Price was $573, price is now $481 per person
$481
per person
Jan 16 - Jan 19
found 18 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Greenville (GSP)
8.2/10 Very Good! (1,004 reviews)
Can use a little updating but overall good location.

Reviewed on Dec 5, 2025

Horizon Inn & Suites

Horizon Inn & Suites

2 out of 5
Price was $1,331, price is now $994 per person
$994
per person
Jan 16 - Jan 19
found 16 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Greenville (GSP)
4.6/10 (222 reviews)
There was drugs and people all over the place nasty area, we didn’t feel safe

Reviewed on Nov 25, 2025

Comfort Inn & Suites Greer - Greenville

Comfort Inn & Suites Greer - Greenville

2.5 out of 5
Price was $598, price is now $503 per person
$503
per person
Feb 5 - Feb 8
found 6 hours ago
Roundtrip non-stop flight included
Detroit (DTT) to Greenville (GSP)
8.6/10 Excellent! (711 reviews)
Heat didn't work, but staff quickly gave us another room and a little upgraded.

Reviewed on Dec 4, 2025

The Bleckley Inn

The Bleckley Inn

3.5 out of 5
Price was $765, price is now $653 per person
$653
per person
Jan 16 - Jan 19
found 16 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Greenville (GSP)
9.8/10 Exceptional! (405 reviews)
Cleanest hotel I've ever seen, nicest staff I've ever encountered, and the coolest rooms you can find in Anderson. My suite had a full kitchen, living area, and had a really impressive atmosphere. A lovely place to stay

Reviewed on Nov 29, 2025

Hotel Hartness

Hotel Hartness

4 out of 5
Price was $677, price is now $581 per person
$581
per person
Jan 16 - Jan 19
found 18 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Greenville (GSP)
9.8/10 Exceptional! (613 reviews)
Incredible hotel and property! We were extremely impressed!

Reviewed on Dec 3, 2025

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Mayo Hotel Deals

ECHO Suites Extended Stay by Wyndham Spartanburg

ECHO Suites Extended Stay by Wyndham Spartanburg

2 out of 5
490 W Blackstock Road Spartanburg SC
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $84 total per night from Dec 8 to Dec 9
$84 total
Dec 8 - Dec 9
Total with taxes and fees
8/10 Very Good! (284 reviews)
Room was Clean and the Staff was very Friendly. I usually stay at regular hotels so the feel of the Entry and lobby area felt cold and not very inviting. Some warmth to the common areas would go a long way. I did notice the sound of individuals walking in the Rooms above me where very noticeable ...

Reviewed on Dec 4, 2025

ECHO Suites Extended Stay by Wyndham Spartanburg
Spartanburg Marriott

Spartanburg Marriott

3.5 out of 5
299 North Church Street Spartanburg SC
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $141 total per night from Dec 14 to Dec 15
$141 total
Dec 14 - Dec 15
Total with taxes and fees
8.6/10 Excellent! (1,016 reviews)
The staff was very helpful. Room was comfortable and clean. Breakfast was well prepared.

Reviewed on Nov 29, 2025

Spartanburg Marriott
Comfort Suites At WestGate Mall

Comfort Suites At WestGate Mall

2.5 out of 5
458 West Blackstock Road Spartanburg SC
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $109 total per night from Jan 1 to Jan 2
$109 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
8.2/10 Very Good! (1,001 reviews)
Evening Staff was lifeless. There was no fresh water to drink.

Reviewed on Dec 3, 2025

Comfort Suites At WestGate Mall
See all 439 properties in Mayo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Mayo Vacation Packages

Mayo Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Greenville-Spartanburg Intl. Airport (GSP)
Population
1,600

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Frequently asked questions

How much does a Mayo vacation package cost?
Offering great value package deals from $481 on Expedia, you'll be surprised at how little a vacation to Mayo costs! Expedia's packages make travel planning easier and save you more.
What are the cheapest months to go to Mayo?
You can usually find lower prices and greater availability in December, January and February. Take a look at our cheap Mayo vacation packages and you could land some excellent off-season deals.
How many days is enough for Mayo?
Typically, a handful of days is enough to see the main attractions during your Mayo vacation. However, if you'd like to have time to relax or take day trips, think about extending your itinerary.
How to find the best Mayo package deals?
Begin your search for a Mayo package deal by entering your preferred trip dates and destination under our "Packages" tab. Then add a few filters, like "Popular locations" and "Amenities," to tailor the results to your exact style. You can also sort by "Package discount" and browse offers that come with unbeatable savings. If you don't find the perfect Mayo package deal right away, simply change your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Mayo getaway off to a flying start.
Is it cheaper to book a Mayo vacation as a package?
You can enjoy significant savings on your next Mayo break by booking a personalized vacation package. Check the "Package" heading, then select your travel dates and destination to view the best flight and hotel prices. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may land a better deal.
When to book a vacation package to Mayo?
If you've got your Mayo travel dates finalized, book as soon as you can to snap up some terrific deals. With Expedia, you can typically reserve some flights up to one year ahead of time. Prefer spur-of-the-moment getaways? Our last-minute deals are great for traveling on a whim.
Does Expedia offer Book Now, Pay Later Mayo vacation packages?
If you're anything like us, you love traveling but are not a fan of the big price tag that can come with it. That's why we've created Book Now, Pay Later vacations. With the help of online lender Affirm, you can break down the total cost of your Mayo trip across 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can secure cheap vacation packages with payment plans as soon as you see them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.