Title: Mayo Vacation Packages 2026 from $579 | Expedia.com [Hotels in Mayo](https://expedia.com/Mayo-Hotels.d553248634999378372.Travel-Guide-Hotels)[Vacation Rentals in Mayo](https://expedia.com/Mayo-Vacation-Rentals.d553248634999378372.Travel-Guide-VacationRentals)[Car Rentals in Mayo](https://expedia.com/Car-Rentals-In-Mayo.d553248634999378372.Car-Rental-Guide) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_packages.jpeg?impolicy=fcrop&w=1200&h=300&q=medium) # Mayo Vacations from $579 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## The Latest Mayo vacation packages Price found within the past 48 hours. Click for updated prices. ![Landing Apartments - Lyman](https://images.trvl-media.com/lodging/120000000/119750000/119742800/119742739/6cf81d68_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Landing Apartments - Lyman $579 per person Jun 5 - Jun 8 found 1 day ago Roundtrip non-stop flight included Boston (BOS) to Greenville (GSP) No reviews ![Hotel Hartness](https://images.trvl-media.com/lodging/90000000/89690000/89689300/89689223/91df3d0d_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Hartness $791 per person Jun 19 - Jun 23 found 1 day ago Roundtrip non-stop flight included Boston (BOS) to Greenville (GSP) 9.8/10 Exceptional! (668 reviews) Relaxing and beautiful property with many areas to explore, inside& out. Reviewed on Mar 25, 2026 ![Hilton Greenville](https://images.trvl-media.com/lodging/1000000/30000/23200/23172/8017eeff_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hilton Greenville $705 per person Jun 19 - Jun 23 found 1 day ago Roundtrip non-stop flight included Boston (BOS) to Greenville (GSP) 8.2/10 Very Good! (1,012 reviews) Property was very clean throughout stay. Very convenient to getting on/off highway. Minutes from downtown Reviewed on Mar 25, 2026 ![Landing Apartments Greer - Sugar Creek](https://images.trvl-media.com/lodging/125000000/124260000/124255300/124255207/fa902843_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Landing Apartments Greer - Sugar Creek $585 per person Jun 5 - Jun 8 found 1 day ago Roundtrip non-stop flight included Boston (BOS) to Greenville (GSP) No reviews ![Grand Bohemian Lodge Greenville, Autograph Collection](https://images.trvl-media.com/lodging/72000000/71770000/71762700/71762652/6f048029_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Grand Bohemian Lodge Greenville, Autograph Collection Greenville Downtown $1,273 per person Jun 19 - Jun 23 found 1 day ago Roundtrip non-stop flight included Boston (BOS) to Greenville (GSP) 9.6/10 Exceptional! (460 reviews) Beautiful and comfortable! We loved it and wish we could have stayed longer than one night! Reviewed on Mar 20, 2026 Don't see what you're looking for? See all available trips from Columbus to Mayo [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-04-28/2026-05-05/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=GSP&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## Mayo Hotel Deals ![Comfort Suites At WestGate Mall](https://images.trvl-media.com/lodging/3000000/2660000/2654400/2654329/1ada0475_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Comfort Suites At WestGate Mall 458 West Blackstock Road Spartanburg SC Fully refundable $85 nightly $94 total Apr 26 - Apr 27 Total with taxes and fees 8.2/10 Very Good! (1,002 reviews) AC kept the room cold. Reviewed on Mar 23, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F26%2F2026&endDate=4%2F27%2F2026&selected=2654329&PinnedHotelID=2654329&HadPinnedHotel=true®ionId=553248634999378372) ![Best Western Spartanburg Northwest](https://images.trvl-media.com/lodging/1000000/20000/19800/19764/d02ac737_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Best Western Spartanburg Northwest 110 Mobile Dr Spartanburg SC $88 nightly $98 total Apr 1 - Apr 2 Total with taxes and fees 8.2/10 Very Good! (862 reviews) Price was competitive. Clean but worn. Bed was not comfortable. Reviewed on Mar 24, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F1%2F2026&endDate=4%2F2%2F2026&selected=19764&PinnedHotelID=19764&HadPinnedHotel=true®ionId=553248634999378372) ![Sleep Inn Spartanburg Southwest](https://images.trvl-media.com/lodging/1000000/50000/42900/42867/d8fe2964_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Sleep Inn Spartanburg Southwest 501 South Blackstock Rd Spartanburg SC Fully refundable $63 nightly $70 total Apr 19 - Apr 20 Total with taxes and fees 6/10 (573 reviews) TV was not working properly Remote battery was dead. Room was not cleaned by House keeping. Room was cleaned with products I brought from home. No access to hotel Wi-Fi Reviewed on Mar 17, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F19%2F2026&endDate=4%2F20%2F2026&selected=42867&PinnedHotelID=42867&HadPinnedHotel=true®ionId=553248634999378372) [See all 471 properties in Mayo](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F29%2F2026&endDate=3%2F30%2F2026®ionId=553248634999378372) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Mayo Vacation Packages ## Mayo Essential Information | Language | English | | --------------- | ------------------------------------------ | | Currency | U.S dollars | | Closest Airport | Greenville-Spartanburg Intl. Airport (GSP) | | Population | 1,600 | ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.com/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.com/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.com/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.com/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ![Gay Friendly Vacations](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) LGBTQ Friendly Vacations [](https://expedia.com/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ_Friendly%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2017/07/05/170615_Adventure_1320_2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Adventure Vacations [](https://expedia.com/lp/theme-vacations/adventure-vacations?rfrr=editorial.Adventure_Vacations.click) ![Vacations in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.com/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/honeymoon_hawaii.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Honeymoon Vacations [](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Mountain Vacations [](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Fishing Vacations [](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Adults Only Vacations [](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Waterpark Vacations [](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Scuba Diving Vacations [](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Yoga Vacations [](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Cheap Vacations [](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Solo Vacations [](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click) ## Frequently asked questions ### How much does a Mayo vacation package cost? ### What are the cheapest months to go to Mayo? ### How many days is enough for Mayo? ### How to find the best Mayo package deals? ### Is it cheaper to book a Mayo vacation as a package? ### When to book a vacation package to Mayo? ### Does Expedia offer Book Now, Pay Later Mayo vacation packages? \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app