Title: Mesilla Vacation Rentals from $133: Search Short-Term Rentals | Expedia.com

[Mesilla Travel Guide](https://expedia.com/Mesilla.dx132684)[Hotels in Mesilla](https://expedia.com/Mesilla-Hotels.d132684.Travel-Guide-Hotels)[Flights to Mesilla](https://expedia.com/Cheap-Flights-To-Mesilla.d132684.Travel-Guide-Flights)[Car Rentals in Mesilla](https://expedia.com/Car-Rentals-In-Mesilla.d132684.Car-Rental-Guide)[Mesilla Vacation Packages](https://expedia.com/Mesilla.d132684.Destination-Travel-Guides)

![Red chile doorway Mesilla NM](https://images.trvl-media.com/place/132684/621c4b20-e7ee-452c-9495-0ec62a9d9908.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/132684/621c4b20-e7ee-452c-9495-0ec62a9d9908.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=132684&startDate=2026-04-17&endDate=2026-04-19&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 29 - May 31](https://www.expedia.com/Hotel-Search?regionId=132684&startDate=2026-05-29&endDate=2026-05-31&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Jun 26 - Jun 28](https://www.expedia.com/Hotel-Search?regionId=132684&startDate=2026-06-26&endDate=2026-06-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jul 24 - Jul 26](https://www.expedia.com/Hotel-Search?regionId=132684&startDate=2026-07-24&endDate=2026-07-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Mesilla vacation rentals

![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/120000000/119930000/119923800/119923794/bc0a9d00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/120000000/119930000/119923800/119923794/1aa64a21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/120000000/119930000/119923800/119923794/02adc68a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/120000000/119930000/119923800/119923794/7d2a99cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Las Cruces Home w/ Fenced Yard: Recently Remodeled

[](https://www.expedia.com/Las-Cruces-Home-W-Fenced-Yard-Recently-Remodeled.h119923794.Hotel-Information)

Las Cruces

10/10

Exceptional

(1 review)

"The host was thoughful. He provided all the information we needed and responded our questions really quickly. The house was clean and very well organized. This house had the best view at night. We will definitely visit again when we go Santa fe. 😊 "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Nam

$223 nightly

$256 total

Apr 1 - Apr 2

Total with taxes and fees

[](https://www.expedia.com/Las-Cruces-Home-W-Fenced-Yard-Recently-Remodeled.h119923794.Hotel-Information)

![House, 2 Bedrooms | Living area | Smart TV, streaming services](https://images.trvl-media.com/lodging/121000000/120410000/120402300/120402249/043ded28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House, 2 Bedrooms | Private kitchen | Fridge, oven, coffee/tea maker, toaster](https://images.trvl-media.com/lodging/121000000/120410000/120402300/120402249/6fad21b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House, 2 Bedrooms | Interior](https://images.trvl-media.com/lodging/121000000/120410000/120402300/120402249/a0826640.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House, 2 Bedrooms | Living area | Smart TV, streaming services](https://images.trvl-media.com/lodging/121000000/120410000/120402300/120402249/b70818bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Desert Haven Cozy 2-Bedroom Mobile Home Near NMSU 2 Home

[](https://www.expedia.com/Las-Cruces-Hotels-Desert-Haven-Cozy-2-Bedroom-Mobile-Home-Near-NMSU-2-Home.h120402249.Hotel-Information)

Las Cruces

$335 nightly

$383 total

Apr 5 - Apr 6

Total with taxes and fees

[](https://www.expedia.com/Las-Cruces-Hotels-Desert-Haven-Cozy-2-Bedroom-Mobile-Home-Near-NMSU-2-Home.h120402249.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-14&endDate=2026-04-15&regionId=132684&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Mesilla%2C+New+Mexico%2C+United+States+of+America&regionId=132684&latLong=32.270096%2C-106.800835&adults=2&startDate=2026-06-28&d1=2026-06-28&endDate=2026-07-01&d2=2026-07-01&lodging=VACATION_HOME)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Mesilla%2C+New+Mexico%2C+United+States+of+America&regionId=132684&latLong=32.270096%2C-106.800835&adults=2&startDate=2026-06-28&d1=2026-06-28&endDate=2026-07-01&d2=2026-07-01&lodging=COTTAGE)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Mesilla%2C+New+Mexico%2C+United+States+of+America&regionId=132684&latLong=32.270096%2C-106.800835&adults=2&startDate=2026-06-28&d1=2026-06-28&endDate=2026-07-01&d2=2026-07-01&lodging=APARTMENT)

Condos

[](https://www.expedia.com/Hotel-Search?destination=Mesilla%2C+New+Mexico%2C+United+States+of+America&regionId=132684&latLong=32.270096%2C-106.800835&adults=2&startDate=2026-06-28&d1=2026-06-28&endDate=2026-07-01&d2=2026-07-01&lodging=CONDO)

Villas

[](https://www.expedia.com/Hotel-Search?destination=Mesilla%2C+New+Mexico%2C+United+States+of+America&regionId=132684&latLong=32.270096%2C-106.800835&adults=2&startDate=2026-06-28&d1=2026-06-28&endDate=2026-07-01&d2=2026-07-01&lodging=VILLA)

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## Top Mesilla Hotel Reviews

![Hotel Encanto de Las Cruces](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/5b5c1a96_y.jpg)

### Hotel Encanto de Las Cruces

10/10 Excellent

"Everything was perfect. Such a beautiful place. Will definitely stay there again. "

[](https://expedia.com/Las-Cruces-Hotels-Hotel-Encanto-De-Las-Cruces.h21267.Hotel-Information)

![Casita Azul, Mesilla Plaza Only Steps Away](https://images.trvl-media.com/lodging/35000000/34210000/34201100/34201060/87c0ec68_y.jpg)

### Casita Azul, Mesilla Plaza Only Steps Away

10/10 Excellent

"Lovely location and decor."

[](https://expedia.com/Mesilla-Hotels-Casita-Azul.h34201060.Hotel-Information)

![Drury Inn & Suites Las Cruces](https://images.trvl-media.com/lodging/2000000/1730000/1723300/1723204/46263956_y.jpg)

### Drury Inn & Suites Las Cruces

4/10 Poor

"Check I was smooth and friendly. Room was clean and comfortable. Major downside was that my daughter found a black curly hair in her scrambled eggs. We were taking our bags out to the car and staff member came out and hock a loogie onto the sidewalk while taking out the trash. "

[](https://expedia.com/Las-Cruces-Hotels-Drury-Inn-Suites-Las-Cruces.h1723204.Hotel-Information)

![La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain](https://images.trvl-media.com/lodging/1000000/80000/75400/75365/e54f14db_y.jpg)

### La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain

6/10 Okay

"Carpet needed replacing throughout the hotel - the rooms and hallways."

[](https://expedia.com/Las-Cruces-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Las-Cruces-Organ-Mountain.h75365.Hotel-Information)

![Ramada Hotel & Conference Center by Wyndham Las Cruces](https://images.trvl-media.com/lodging/1000000/10000/3900/3871/1a82ee39_y.jpg)

### Ramada Hotel & Conference Center by Wyndham Las Cruces

8/10 Good

"The staff was very friendly and helpful. The room was spacious and clean. "

[](https://expedia.com/Las-Cruces-Hotels-Ramada-Hotel-Conference-Center-By-Wyndham-Las-Cruces.h3871.Hotel-Information)

![Comfort Inn & Suites Las Cruces Mesilla](https://images.trvl-media.com/lodging/2000000/1360000/1353900/1353805/518ac77c_y.jpg)

### Comfort Inn & Suites Las Cruces Mesilla

4/10 Poor

"Room had stains on curtains and bedding. Shower did not get hot. Roaches in the pool"

[](https://expedia.com/Las-Cruces-Hotels-Comfort-Inn-Suites-Las-Cruces-Mesilla.h1353805.Hotel-Information)

![Quality Inn & Suites Las Cruces - University Area](https://images.trvl-media.com/lodging/1000000/50000/43200/43177/04c2427f_y.jpg)

### Quality Inn & Suites Las Cruces - University Area

2/10 Terrible

"I absolutely do not recommend this property. I arrived late on a Friday night, and was assigned and occupied room. When I notified the desk and they gave me another room, that one was occupied as well. By this time it was 10 o’clock at night, and the guest staying in the second room was angry. Understandably so. It put me in a very uncomfortable and unsafe situation. When I refuse to try a third room and request requested a refund, my request was not honored. It’s been two days, and I have not yet heard from the daytime manager. Very, very disappointed."

[](https://expedia.com/Las-Cruces-Hotels-Quality-Inn-Suites-Las-Cruces-University-Area.h43177.Hotel-Information)

![Hampton Inn & Suites Las Cruces I-25](https://images.trvl-media.com/lodging/2000000/1670000/1665200/1665185/fc08ee64_y.jpg)

### Hampton Inn & Suites Las Cruces I-25

6/10 Okay

"Swimming pool was very cold. Front desk staff not very friendly. "

[](https://expedia.com/Las-Cruces-Hotels-Hampton-Inn-Suites-Las-Cruces-I-25.h1665185.Hotel-Information)

![Days Inn by Wyndham Las Cruces](https://images.trvl-media.com/lodging/1000000/20000/15100/15035/b4a415ed_y.jpg)

### Days Inn by Wyndham Las Cruces

10/10 Excellent

"Yes, excellent!!"

[](https://expedia.com/Las-Cruces-Hotels-Days-Inn-By-Wyndham-Las-Cruces.h15035.Hotel-Information)

## Find out more about Mesilla

**Everything you need to know about Mesilla vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Mesilla vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Mesilla vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Mesilla vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Mesilla. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Mesilla in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $133 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Mesilla rentals**

At Expedia, we put the best Mesilla vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Mesilla rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Mesilla vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Mesilla. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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- [Vacation Homes in Mesilla ](https://expedia.com/Mesilla-Private-Vacation-Homes.d132684-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Apartments in Mesilla ](https://expedia.com/Mesilla-Apartments.d132684-aaApartments.Travel-Guide-Accommodation)
- [Cottages in Mesilla ](https://expedia.com/Mesilla-Cottages.d132684-aaCottages.Travel-Guide-Accommodation)
- [Condo Rentals in Mesilla ](https://expedia.com/Mesilla-Condos.d132684-aaCondos.Travel-Guide-Accommodation)
- [Villas in Mesilla ](https://expedia.com/Mesilla-Villas.d132684-aaVillas.Travel-Guide-Accommodation)
- [Guest Houses in Mesilla ](https://expedia.com/Mesilla-Guest-Houses.d132684-aaGuestHouses.Travel-Guide-Accommodation)
- [Motels in Mesilla ](https://expedia.com/Mesilla-Motels.d132684-aaMotels.Travel-Guide-Accommodation)
- [Farmstay in Mesilla ](https://expedia.com/Mesilla-Agritourism.d132684-aaAgritourism.Travel-Guide-Accommodation)

## Frequently asked questions

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### What’s there to see and do in Mesilla?

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General

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