Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Midtown East Business Hotels

See all 118 Hotels in Midtown East
The Lexington New York City, Autograph Collection

The Lexington New York City, Autograph Collection

511 Lexington Ave at 48th St., New York
4.0 out of 5.0
4.0 out of 5 (1,108 reviews)
sight seeing excursionMy husband and I were in NYC for a totally tourist type trip this time. They let us check in early as long as we were ok with a room on the 3rd floor. The room did not have a view, but it was also incredibly quiet, which was perfect for us. I've been to NYC several times and had room with great views ...
  Sep 15, 2017

$188

$188
The Roosevelt Hotel, New York City

The Roosevelt Hotel, New York City

45 E 45th Street, New York
4.0 out of 5.0
3.6 out of 5 (9,745 reviews)
Classy hotel, central NYC Stylish and classy hotel. fab location for sightseeing and theatre etc. Walk to Time Square 5 mins, Grand Central Stn 2 mins. Stuffy reception staff but all the other staff were really helpful and friendly. Rooms at the back and lower floors can be noisy, we asked to be moved to quieter room.
  Sep 24, 2017

$170

$170
Pod 51

Pod 51

230 E 51st St, New York
3.0 out of 5.0
4.1 out of 5 (4,970 reviews)
Gem in the middle of NYC Adorable bijou room, youthful european styling, impeccably clean, quiet street, no breakfast but great variry of local eateries . Did not have an opportunity to check out ADA compliance but this is often a concern when travelling with family
  Sep 24, 2017

$105

$105
Waldorf Astoria New York

Waldorf Astoria New York

301 Park Avenue, New York
4.5 out of 5.0
4.2 out of 5 (4,089 reviews)
Lovely old hotel in need of refurbishingEnjoyed our stay especially as the Waldorf Astoria is closing
  Mar 9, 2017
The Kimberly Hotel & Suites

The Kimberly Hotel & Suites

145 E 50th St, New York
4.0 out of 5.0
4.5 out of 5 (855 reviews)
Great locationThe location was one of the best possible. Many of our excursions began within walking distance of the hotel. Many other sites are close enough to walk and those that are not are accessible by subway. There were many subway routes with access within walking distance. There are also restaurants and ...
  Sep 18, 2017

$251

$251
Dylan Hotel NYC

Dylan Hotel NYC

52 E 41st St, New York
4.0 out of 5.0
3.5 out of 5 (55 reviews)
Great hotel, central location This hotel is 10-12mins walk from Times Square, 2 mins walk from Grand Central. Set on a quiet street. The hotel room was clean and the shower powerful. Spacious for a NYC hotel room. I would def book again.
  Sep 21, 2017

$239

$239
The Court - A St Giles Hotel

The Court - A St Giles Hotel

130 East 39th Street, New York
4.0 out of 5.0
3.9 out of 5 (683 reviews)
Great location, walking distance to Grand Central Terminal
  Sep 21, 2017

$269

$269
Hilton Garden Inn New York/Manhattan-Midtown East

Hilton Garden Inn New York/Manhattan-Midtown East

206 East 52nd Street, New York
3.5 out of 5.0
4.2 out of 5 (294 reviews)
Great location, typicalOverall, I like this hotel. The window air conditioner was a little noisy, the shower was a little rough in regulating hot and cold but overall, its worth the money.
  Sep 22, 2017

$203

$203
The Tuscany - A St Giles Signature Hotel

The Tuscany - A St Giles Signature Hotel

120 E 39th Street, New York
4.0 out of 5.0
4.5 out of 5 (412 reviews)
Luxury Hotel in ManhattanLOVE the staff! Very helpful with my accommodations, traveling, recommendations for shopping & cafes, and absolutely wonderful about taking care of you. I had the most beautiful room with an incredibly beautiful and functional bathroom. Egyptian sheets. No room service, but great carry in options. ...
  Sep 19, 2017

$369

$369
Lotte New York Palace

Lotte New York Palace

455 Madison Ave, New York
4.5 out of 5.0
4.6 out of 5 (2,301 reviews)
Very classy hotel well situatedNice facilities, beautiful hotel, excellent staff. Rooms with view of downtown, calm and clean
  Sep 23, 2017

$409

$409
Map

Recently booked Business Hotels in Midtown East

Courtyard by Marriott New York City Manhattan Midtown East
3.5 out of 5.0
Last booking: 1 minute ago
Hotel 32 32
4.0 out of 5.0
Last booking: 19 minutes ago
Pod 51
3.0 out of 5.0
Last booking: 20 minutes ago
Pod 39
3.0 out of 5.0
Last booking: 24 minutes ago
Omni Berkshire Place
4.5 out of 5.0
Last booking: 27 minutes ago
The Kimberly Hotel & Suites
4.0 out of 5.0
Last booking: 37 minutes ago
The Roosevelt Hotel, New York City
4.0 out of 5.0
Last booking: 50 minutes ago
The Lexington New York City, Autograph Collection
4.0 out of 5.0
Last booking: 1 hour ago
The Court - A St Giles Hotel
4.0 out of 5.0
Last booking: 1 hour ago

Pocket Guide: Business Hotels in Midtown East

Search for hotels in Midtown East on Expedia. You can easily find your hotels in Midtown East using one of the methods below:

  • View our selection of featured hotels in Midtown East
  • Use the map to find hotels in the Midtown East neighborhood you prefer
  • Use the filters to see hotels in a specific area of Midtown East, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Midtown East
  • Enter your travel dates to view the best deals on hotels in Midtown East - while they last