Mission District Vacations from $651

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Your Mission District Vacation

Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.

The Latest Mission District Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Handlery Union Square Hotel

Handlery Union Square Hotel

3.5 out of 5
Union Square
Save 100% on your flight
Price was $975, price is now $651 per person
$651
per person
Jun 12 - Jun 16
found 1 day ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
8.8/10 Excellent! (2,922 reviews)
We booked this hotel because of the pool but it was out of order for our stay. The rooms were cramped. AC didn’t work. Would not recommend

Reviewed on Mar 18, 2026

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
Fisherman's Wharf
Save 100% on your flight
Price was $1,445, price is now $906 per person
$906
per person
Jun 12 - Jun 16
found 1 day ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
9/10 Wonderful! (7,413 reviews)
The breakfast buffet, common areas and amenities were all great, as was the staff! Location was convenient to the streetcar and wharf areas - would stay again!

Reviewed on Mar 21, 2026

The Huntington Hotel

The Huntington Hotel

5 out of 5
Downtown San Francisco
Save 100% on your flight
Price was $4,065, price is now $2,601 per person
$2,601
per person
May 31 - Jun 7
found 1 day ago
Roundtrip flight included
Dallas (DAL) to San Francisco (SFO)
No reviews
The Grove Inn

The Grove Inn

3 out of 5
Western Addition
Save 100% on your flight
Price was $2,076, price is now $1,369 per person
$1,369
per person
May 15 - May 19
found 1 day ago
Roundtrip flight included
Los Angeles (LAX) to San Francisco (SFO)
9.2/10 Wonderful! (695 reviews)
Cute boutique style lodge. Rooms were nice, great area, and easy to check in and out. Provided list of local restaurants and amenities around the area.

Reviewed on Mar 7, 2026

Beacon Grand, A Union Square Hotel

Beacon Grand, A Union Square Hotel

4 out of 5
Union Square
Save 100% on your flight
Price was $1,443, price is now $963 per person
$963
per person
Jun 12 - Jun 16
found 1 day ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
9.2/10 Wonderful! (1,941 reviews)
Staff nice until we were yelled at by vallet because of filming some tv show. We were rushed and we had two infants to unload while traffic proceeded as vallet and manager yelled at us to hurry. We will most likely not recommend.

Reviewed on Mar 21, 2026

Where to stay in Mission District

Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Vibrant activity in Union Square, San Francisco with palm trees and bustling city life

Union Square

4/5(5,185 area reviews)

Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.

Find hotels in Union Square

Mission District Hotel Deals

Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $155 total per night from Apr 12 to Apr 13
$155 total
Apr 12 - Apr 13
Total with taxes and fees
9/10 Wonderful! (5,427 reviews)
Everything was horrible and I was overcharged

Reviewed on Mar 20, 2026

Holiday Inn Golden Gateway by IHG
Handlery Union Square Hotel

Handlery Union Square Hotel

3.5 out of 5
351 Geary St San Francisco CA
Fully refundableReserve now, pay when you stay
$137 nightly
The price is $161 total per night from Apr 6 to Apr 7
$161 total
Apr 6 - Apr 7
Total with taxes and fees
8.8/10 Excellent! (2,922 reviews)
The staff was very helpful and patient with our needs. The room was nice.

Reviewed on Mar 21, 2026

Handlery Union Square Hotel
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $214 total per night from Apr 12 to Apr 13
$214 total
Apr 12 - Apr 13
Total with taxes and fees
9/10 Wonderful! (7,363 reviews)
The breakfast buffet, common areas and amenities were all great, as was the staff! Location was convenient to the streetcar and wharf areas - would stay again!

Reviewed on Mar 21, 2026

Hotel Riu Plaza Fisherman's Wharf
See all 4,939 properties in Mission District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Mission District

Mission Dolores Park showing picnicing and a park as well as a small group of people

Mission Dolores Park

Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.

Mission Dolores Park
Mission San Francisco de Asís was founded 29 June 1776 by Padre Francisco Palóu and Padre Pedro Benito Cambón. The mission is named for Saint Francis of Assisi. The current site was picked in 1782 because of the harsh conditions at the original mission. It is considered to be the oldest intact building in San Francisco. The Mission is located in the San Francisco Mission District at the corner of 16th and Dolores Streets. #Details #golden #troveontuesday #Trovember

Mission San Francisco de Asís

Learn about the local history of San Francisco when you spend time at Mission San Francisco de Asís. Visit the notable monuments and shops in this vibrant area.

Mission San Francisco de Asís
Balmy Alley which includes outdoor art

Balmy Alley

Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the fascinating museums and acclaimed theater scene in this vibrant area.

Balmy Alley

Things to do

California Academy of Sciences General Admission

California Academy of Sciences Daytime Admission

$49
per adult
86% of travellers recommend
California Academy of Sciences Daytime Admission
Alcatraz Island Prison Tour Package

Official Alcatraz Island Prison Tour with Free App Audio Packages

$86
per adult
100% of travellers recommend
Official Alcatraz Island Prison Tour with Free App Audio Packages
San Francisco: Skip-the-Line 1-Hour Bay Cruise by Boat

San Francisco: Skip-the-Line 1-Hour Bay Cruise by Boat

$38
per adult
94% of travellers recommend
San Francisco: Skip-the-Line 1-Hour Bay Cruise by Boat
See all activities in San Francisco

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.