Mission District Vacations from $354
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Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages
Price found within the past 48 hours. Click for updated prices.
SOMA Park Inn – Civic Center
Downtown San Francisco
Save 100% on your flight
Price was $564, price is now $354 per person
$354
per person
May 12 - May 17
found 1 day ago
Roundtrip flight included
Dallas (DFW) to San Francisco (SFO)
6.8/10 (1,002 reviews)
Nice place to stay. Very friendly staff.
Reviewed on Feb 1, 2026
1 Hotel San Francisco
Downtown San Francisco
Save 100% on your flight
Price was $2,447, price is now $1,580 per person
$1,580
per person
Jun 14 - Jun 17
found 19 hours ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
9.2/10 Wonderful! (525 reviews)
Everything was beyond great!
Reviewed on Mar 30, 2026
Four Seasons Hotel San Francisco at Embarcadero
Downtown San Francisco
Save 100% on your flight
Price was $2,339, price is now $1,524 per person
$1,524
per person
May 23 - May 28
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to San Francisco (SFO)
9.6/10 Exceptional! (1,002 reviews)
We really enjoyed our stay! The view from the room was wonderful, and the bed was very comfortable — we slept great. Everything was very clean, and you can feel the high level of service. The staff was friendly and attentive. Special thanks to the kitchen — the food was excellent.
On the downside: the chair in the room was very uncomfortable.
Thank you
Reviewed on Mar 29, 2026
Where to stay in Mission District
Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Fisherman's Wharf
1 out of top 10 points of interest in this area
4/5(39 area reviews)
Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.
Mission District Hotel Deals
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $155 total per night from Apr 12 to Apr 13
$155 total
Apr 12 - Apr 13
Total with taxes and fees
9/10 Wonderful! (5,500 reviews)
Breakfast was good, but thought it was included originally with stay. Also didnt know we had to pay for parking garage.
Reviewed on Apr 4, 2026
Handlery Union Square Hotel
351 Geary St San Francisco CA
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $155 total per night from Apr 9 to Apr 10
$155 total
Apr 9 - Apr 10
Total with taxes and fees
8.8/10 Excellent! (2,950 reviews)
The hotel is an older hotel that is well maintained. The staff is very nice, friendly, polite and helpful. My only negative is that their is no restaurant and the website has not been updated to reflect that fact.
Reviewed on Apr 4, 2026
Hotel Riu Plaza Fisherman's Wharf
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
$167 nightly
The price is $196 total per night from Apr 12 to Apr 13
$196 total
Apr 12 - Apr 13
Total with taxes and fees
9/10 Wonderful! (7,382 reviews)
The room was basic but clean, however the water pressure in the shower was horrible. Breakfast was amazing! The hotel is located in the center for good entertainment and restaurants and near the city bus station. Everyone was poliet.
Reviewed on Apr 4, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Mission District
Mission Dolores Park
5/5(1 review)
Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.
Mission San Francisco de Asís
Learn about the local history of San Francisco when you spend time at Mission San Francisco de Asís. Visit the notable monuments and shops in this vibrant area.
Balmy Alley
Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the fascinating museums and acclaimed theater scene in this vibrant area.
Things to do
Official Alcatraz Island Prison Tour with Free App Audio Packages
$86
per adult
100% of travellers recommend
California Academy of Sciences Daytime Admission
$49
per adult
86% of travellers recommend
Alcatraz Visit with Night Option and SF Bay Cruise
$139
per adult
94% of travellers recommend
Explore a world of travel with Expedia
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- San Francisco Vacations
- Hua Zang Si
- Marsh Theater
- Mission Dolores Park
- Sf Armory
- Mission San Francisco de Asís
- Galería de la Raza
- Castro Street
- 22nd St Hill
- Visit Downtown San Francisco
- Fouladi Projects
- San Francisco City Hall
- U.s. Mint
- Visit Mission Dolores
- Castro Theatre
- Harvey Milk Plaza
- San Francisco Zen Center
- Louise Davies Symphony Hall
- Noe Valley Vacations
- The Promenade
- Bill Graham Civic Auditorium
- Randall Museum
- Nobby Clarke Mansion
- Visit Castro District
- Randall Museum
- Golden Gate Model Railroad Club
- Mission Creek Park
- Corona Heights Park
- War Memorial Opera House
- Orpheum Theatre
- Civic Center Plaza
- Vulcan Steps
- Mclellan Botanicals
- Painted Ladies
- San Francisco Federal Building
- Kite Hill Open Space
- Asian Art Museum of San Francisco
- United Nations Plaza
- California State Building
- Alamo Square
- Haight Street
- Chase Center
- Van Ness Avenue
- Visit Bernal Heights
- Twin Peaks
- Academy of Art University
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.