Mission District Vacations from $329
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Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Bay Landing San Francisco Airport Hotel
Ingold - Milldale
Save 100% on your flight
Price was $499, price is now $329 per person
$329
per person
May 24 - May 27
found 1 day ago
Roundtrip flight included
Carlsbad (CLD) to San Francisco (SFO)
9/10 Wonderful! (4,833 reviews)
This may be the best airport hotel I’ve ever stayed at. The staff is very professional. The rooms are spacious and clean with a great view of San Francisco Bay, if you request it. And the airport shuttle is dependable. Highly recommend the Bay Landing Hotel.
Reviewed on Apr 3, 2026
Four Seasons Hotel San Francisco at Embarcadero
Downtown San Francisco
Save 100% on your flight
Price was $2,344, price is now $1,581 per person
$1,581
per person
May 23 - May 28
found 13 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to San Francisco (SFO)
9.6/10 Exceptional! (1,002 reviews)
We really enjoyed our stay! The view from the room was wonderful, and the bed was very comfortable — we slept great. Everything was very clean, and you can feel the high level of service. The staff was friendly and attentive. Special thanks to the kitchen — the food was excellent.
On the downside: the chair in the room was very uncomfortable.
Thank you
Reviewed on Mar 29, 2026
Hotel Riu Plaza Fisherman's Wharf
Fisherman's Wharf
Save 100% on your flight
Price was $611, price is now $412 per person
$412
per person
May 24 - May 27
found 1 day ago
Roundtrip flight included
Carlsbad (CLD) to San Francisco (SFO)
9/10 Wonderful! (7,351 reviews)
Hotel was clean and nice. Excellent breakfast selection, considering it was complementary, it was amazing. Particularly loved being a few minutes walk from Fisherman’s Wharf. I would recommend this hotel any day.
Reviewed on Apr 4, 2026
Bay Bridge Inn
Downtown San Francisco
Save 100% on your flight
Price was $672, price is now $455 per person
$455
per person
Jun 10 - Jun 14
found 9 hours ago
Roundtrip non-stop flight included
Dallas (DFW) to San Francisco (SFO)
7.6/10 Good! (1,009 reviews)
Close to where I needed to go. Rooms are clean and basic. Not the nicest area, a bit dark, but doesn’t feel unsafe.
Reviewed on Feb 18, 2026
Where to stay in Mission District
Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Fisherman's Wharf
1 out of top 10 points of interest in this area
4/5(39 area reviews)
Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.
Mission District Hotel Deals
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $155 total per night from Apr 12 to Apr 13
$155 total
Apr 12 - Apr 13
Total with taxes and fees
9/10 Wonderful! (5,503 reviews)
The room was not expected so small and parking own by hotel must be pay with tax $55 supposed to be is free because you are guess.
Reviewed on Apr 4, 2026
Handlery Union Square Hotel
351 Geary St San Francisco CA
Fully refundableReserve now, pay when you stay
$131 nightly
The price is $154 total per night from Apr 11 to Apr 12
$154 total
Apr 11 - Apr 12
Total with taxes and fees
8.8/10 Excellent! (2,954 reviews)
Room needs a renovation.
Reviewed on Apr 4, 2026
Hotel Riu Plaza Fisherman's Wharf
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
$167 nightly
The price is $196 total per night from Apr 12 to Apr 13
$196 total
Apr 12 - Apr 13
Total with taxes and fees
9/10 Wonderful! (7,386 reviews)
Breakfast was very good. Did not use pool. Person checking me in spoke very poor English.
Reviewed on Apr 4, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Mission District
Mission Dolores Park
Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.
Mission San Francisco de Asís
Learn about the local history of San Francisco when you spend time at Mission San Francisco de Asís. Visit the notable monuments and shops in this vibrant area.
Balmy Alley
Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the fascinating museums and acclaimed theater scene in this vibrant area.
Things to do
Official Alcatraz Island Prison Tour with Free App Audio Packages
$86
per adult
100% of travellers recommend
California Academy of Sciences Daytime Admission
$49
per adult
86% of travellers recommend
Alcatraz Visit with Night Option and SF Bay Cruise
$139
per adult
94% of travellers recommend
Explore a world of travel with Expedia
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- San Francisco Vacations
- Hua Zang Si
- Marsh Theater
- Mission Dolores Park
- Sf Armory
- Mission San Francisco de Asís
- Galería de la Raza
- Castro Street
- 22nd St Hill
- Visit Downtown San Francisco
- Fouladi Projects
- San Francisco City Hall
- U.s. Mint
- Visit Mission Dolores
- Castro Theatre
- Harvey Milk Plaza
- San Francisco Zen Center
- Louise Davies Symphony Hall
- Noe Valley Vacations
- The Promenade
- Bill Graham Civic Auditorium
- Randall Museum
- Nobby Clarke Mansion
- Visit Castro District
- Randall Museum
- Golden Gate Model Railroad Club
- Mission Creek Park
- Corona Heights Park
- War Memorial Opera House
- Orpheum Theatre
- Civic Center Plaza
- Vulcan Steps
- Mclellan Botanicals
- Painted Ladies
- San Francisco Federal Building
- Kite Hill Open Space
- Asian Art Museum of San Francisco
- United Nations Plaza
- California State Building
- Alamo Square
- Haight Street
- Chase Center
- Van Ness Avenue
- Visit Bernal Heights
- Twin Peaks
- Academy of Art University
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.