Mission District Vacations from $491
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Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Jenner Inn
Save 100% on your flight
Price was $768, price is now $491 per person
$491
per person
Mar 25 - Mar 29
found 1 day ago
Roundtrip flight included
Seattle (SEA) to San Francisco (SFO)
8.8/10 Excellent! (968 reviews)
The Fort Ross room was perfect. Stayed with my son and daughter in law. The sofa bed was comfy. It was guiet, safe, and comfy. The kitchen is perfect. Small but it served our needs. Love the area and this Inn is lovely.
Reviewed on Jan 4, 2026
Hotel EPIK
Downtown San Francisco
Save 100% on your flight
Price was $2,095, price is now $1,138 per person
$1,138
per person
Mar 21 - Mar 28
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Francisco (SFO)
7/10 Good! (517 reviews)
This hotel is just ok , no friendly front desk at all , NO PARKING FOR GUEST , there is only valet parking extremely expensive and only for a certain time, rooms are really small and noisy. Areas around the hotel really poor , homeless everywhere, dirty streets all around!!! No recommend.
Reviewed on Jan 17, 2026
Lodge at Marconi
Save 100% on your flight
Price was $1,468, price is now $870 per person
$870
per person
Feb 18 - Feb 25
found 1 day ago
Roundtrip flight included
Seattle (SEA) to San Francisco (SFO)
9.2/10 Wonderful! (196 reviews)
Beautiful site and nature integrated design. Cozy and comfortable room and attentive staff.
Reviewed on Dec 1, 2025
Hotel Riu Plaza Fisherman's Wharf
Fisherman's Wharf
Save 100% on your flight
Price was $1,427, price is now $906 per person
$906
per person
Mar 8 - Mar 14
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Francisco (SFO)
9/10 Wonderful! (7,092 reviews)
Staff were very friendly from start to end. It was very easy to check in & the front desk staff were very helpful.
Although it is an older hotel the room & corridors were clean. The hotel is close to many attractions, stores & restaurants.
Reviewed on Jan 19, 2026
Where to stay in Mission District
Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Union Square
4/5(5,164 area reviews)
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
Mission District Hotel Deals
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave San Francisco CA
Fully refundable
$127 nightly
The price is $149 total per night from Jan 25 to Jan 26
$149 total
Jan 25 - Jan 26
Total with taxes and fees
8.8/10 Excellent! (5,146 reviews)
We were given a room with an amazing view on the 26th floor! Check in was easy and we were able to check in early. We wanted a drink at the bar, it was open yet, but the guy served us anyway. Parking garage was safe and easy to access as street parking was hard to find. The hotel and our room was ...
Reviewed on Jan 18, 2026
Hotel Riu Plaza Fisherman's Wharf
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
$142 nightly
The price is $168 total per night from Feb 10 to Feb 11
$168 total
Feb 10 - Feb 11
Total with taxes and fees
8.8/10 Excellent! (7,262 reviews)
Clean room, friendly staff, variety of break
Reviewed on Jan 14, 2026
Hilton San Francisco Financial District
750 Kearny St San Francisco CA
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $118 total per night from Feb 16 to Feb 17
$118 total
Feb 16 - Feb 17
Total with taxes and fees
8.6/10 Excellent! (2,303 reviews)
Room was clean. Amenities were okay (there was a small fridge; AC was very cold; and the workstation in the room was large and provided a good view). Would have liked some robes and slippers, which were not included in the room amenities. Furthermore, the coffee machine was not plugged in initially, ...
Reviewed on Jan 17, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Mission District
Mission Dolores Park
Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.
Balmy Alley
Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the acclaimed art scene and fascinating museums in this vibrant area.
Mission San Francisco de Asís
Learn about the local history of San Francisco when you spend time at Mission San Francisco de Asís. Visit the shops and notable monuments in this vibrant area.
Things to do
California Academy of Sciences Daytime Admission
$49
per adult
86% of travellers recommend
Alcatraz Visit with Night Option and SF Bay Cruise
$139
per adult
96% of travellers recommend
San Francisco City Lights Cruise (2-hours)
$58
per adult
94% of travellers recommend
Explore a world of travel with Expedia
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- San Francisco Vacations
- Hua Zang Si
- Marsh Theater
- Mission Dolores Park
- SF Armory
- Mission San Francisco de Asís
- Galería de la Raza
- Castro Street
- 22nd St Hill
- Visit Downtown San Francisco
- Fouladi Projects
- San Francisco City Hall
- U.S. Mint
- Visit Mission Dolores
- Castro Theatre
- Harvey Milk Plaza
- San Francisco Zen Center
- Louise Davies Symphony Hall
- Noe Valley Vacations
- The Promenade
- Bill Graham Civic Auditorium
- Randall Museum
- Nobby Clarke Mansion
- Visit Castro District
- Randall Junior Museum
- Golden Gate Model Railroad Club
- Mission Creek Park
- Corona Heights Park
- War Memorial Opera House
- Orpheum Theatre
- Civic Center Plaza
- Vulcan Steps
- McLellan Botanicals
- Painted Ladies
- San Francisco Federal Building
- Kite Hill Open Space
- Asian Art Museum of San Francisco
- United Nations Plaza
- California State Building
- Alamo Square
- Haight Street
- Chase Center
- Van Ness Avenue
- Visit Bernal Heights
- Twin Peaks
- Academy of Art University
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.