Mission District Vacations from $619
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Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Montage Healdsburg
Save 100% on your flight
Price was $2,080, price is now $1,176 per person
$1,176
per person
Feb 12 - Feb 15
found 1 day ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
9.6/10 Exceptional! (113 reviews)
Clean room, kind and helpful staff. Nice ambiance in vineyard.
Reviewed on Nov 30, 2025
Beacon Grand, A Union Square Hotel
Union Square
Save 100% on your flight
Price was $1,533, price is now $912 per person
$912
per person
Mar 3 - Mar 10
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to San Francisco (SFO)
9.2/10 Wonderful! (1,799 reviews)
Hotel was very nice, very spacious lobby and nice decoration during Christmas. Staff was very helpful and polite. We stayed on the 15th floor and the view was very enjoyable. Only "problem" was the room was not as big, however, it was very comfortable.
Reviewed on Dec 30, 2025
SF Central Hotel
South of Market
Save 100% on your flight
Price was $1,162, price is now $707 per person
$707
per person
Mar 15 - Mar 22
found 2 days ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to San Francisco (SFO)
6.2/10 (862 reviews)
No parking needed. The facility looked decent on the outside, but very dated and run down on the inside. It's a place to sleep for the night. The Becks motel/hotel in the Castro was a much better experience. Some older hotels just have that lived in look.
Reviewed on Oct 26, 2025
Treehouse Hotel Silicon Valley
Save 100% on your flight
Price was $2,005, price is now $1,233 per person
$1,233
per person
Mar 5 - Mar 10
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to San Francisco (SFO)
9.6/10 Exceptional! (59 reviews)
Love this hotel! Beautiful rooms, super comfy bed, great restaurant! It’s all I need 😃😃😃
Reviewed on Dec 19, 2025
Where to stay in Mission District
Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Union Square
4/5(5,164 area reviews)
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
Mission District Hotel Deals
Hotel Riu Plaza Fisherman's Wharf
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $159 total per night from Jan 5 to Jan 6
$159 total
Jan 5 - Jan 6
Total with taxes and fees
8.8/10 Excellent! (7,251 reviews)
Clean room comfortable bed and the breakfast buffet were great. It’s the holiday so it’s very busy and noisy. The walls are so thin that you can hear everything and it distrusted our sleep. And the people upstairs were stumping their feet. Good thing we were only there for 1 night.
Reviewed on Dec 29, 2025
Hilton San Francisco Financial District
750 Kearny St San Francisco CA
$89 nightly
The price is $105 total per night from Jan 8 to Jan 9
$105 total
Jan 8 - Jan 9
Total with taxes and fees
8.6/10 Excellent! (2,180 reviews)
Good spacious room. Very clean . Staff was very courteous. We had wonderful stay at Hilton Financial district SFO.
Reviewed on Dec 26, 2025
Fairmont San Francisco
950 Mason Street Atop Nob Hill San Francisco CA
$265 nightly
The price is $312 total per night from Jan 4 to Jan 5
$312 total
Jan 4 - Jan 5
Total with taxes and fees
9/10 Wonderful! (1,442 reviews)
It is a beautiful place to visit around the holidays, for he was a bit busy but still enjoyed our stay and the galleries inside, the Tonga Room, customer service was excellent and very kind From the lady checking us in to the valet , everyone was very helpful and cordial They make you feel like a ...
Reviewed on Dec 29, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Mission District
Mission Dolores Park
5/5(1 review)
Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.
Balmy Alley
Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the fascinating museums and acclaimed art scene in this vibrant area.
San Francisco Public Library
After visiting San Francisco Public Library, make a plan to see the other sights and activities in San Francisco. Discover the acclaimed theater scene and notable monuments in this vibrant area.
Things to do
California Academy of Sciences Daytime Admission
$49
per adult
86% of travellers recommend
Alcatraz Visit with Night Option and SF Bay Cruise
$139
per adult
96% of travellers recommend
San Francisco City Lights Cruise (2-hours)
$58
per adult
94% of travellers recommend
Explore a world of travel with Expedia
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- Vacation Homes in Church St & 24th St Stop
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- Hotels near Duboce Ave & Church St Stop
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- San Francisco Vacations
- Hua Zang Si
- Marsh Theater
- Mission Dolores Park
- SF Armory
- Mission San Francisco de Asís
- Galería de la Raza
- Castro Street
- 22nd St Hill
- Visit Downtown San Francisco
- Fouladi Projects
- San Francisco City Hall
- U.S. Mint
- Visit Mission Dolores
- Castro Theatre
- Harvey Milk Plaza
- San Francisco Zen Center
- Louise Davies Symphony Hall
- Noe Valley Vacations
- The Promenade
- Bill Graham Civic Auditorium
- Randall Museum
- Nobby Clarke Mansion
- Visit Castro District
- Randall Junior Museum
- Golden Gate Model Railroad Club
- Mission Creek Park
- Corona Heights Park
- War Memorial Opera House
- Orpheum Theatre
- Civic Center Plaza
- Vulcan Steps
- McLellan Botanicals
- Painted Ladies
- San Francisco Federal Building
- Kite Hill Open Space
- Asian Art Museum of San Francisco
- United Nations Plaza
- California State Building
- Alamo Square
- Haight Street
- Chase Center
- Van Ness Avenue
- Visit Bernal Heights
- Twin Peaks
- Academy of Art University
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.