
Mission District Vacations from $554
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $1,045 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages

The Marker Union Square San Francisco
Reviewed on Mar 23, 2026

Hotel Riu Plaza Fisherman's Wharf
Reviewed on Mar 24, 2026

Bay Landing San Francisco Airport Hotel
Reviewed on Mar 24, 2026

The Grove Inn
Reviewed on Mar 7, 2026

1 Hotel San Francisco
Reviewed on Mar 24, 2026
Where to stay in Mission District

Union Square
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
Mission District Hotel Deals

Holiday Inn Golden Gateway by IHG
Excellent city view (worth the price). Great location on Nob Hill. Ideal for family stay. Extortion pricing in the lobby machines and mini-store (($8.00 for a 4 oz. bottle of Pepto-Bismal, $10.60 for one bottle of cold beer!!). Just do your shopping in the surrounding shops...
Reviewed on Mar 24, 2026

Handlery Union Square Hotel
This hotel is central to everywhere we want to go in SF! Plus, we feel safe in this neighbourhood. We love the atmosphere at Union Square, and BART is close by for our trips out to the suburbs. The staff are always friendly and helpful. Our room was nice and clean, and our room requests were met ...
Reviewed on Mar 24, 2026

Hotel Riu Plaza Fisherman's Wharf
Well appointed rooms and very clean and tidy. Excellent breakfast. Good location right at Fisherman's Wharf. Views were limited, but the rooms were light and airy.
Reviewed on Mar 24, 2026
Discover the most popular places to visit in Mission District

Mission Dolores Park
Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.

Mission San Francisco de Asís
Learn about the local history of San Francisco when you spend time at Mission San Francisco de Asís. Visit the notable monuments and shops in this vibrant area.

Balmy Alley
Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the fascinating museums and acclaimed theater scene in this vibrant area.
Things to do

Official Alcatraz Island Prison Tour with Free App Audio Packages

California Academy of Sciences Daytime Admission

Alcatraz Visit with Night Option and SF Bay Cruise
Explore a world of travel with Expedia
- San Francisco Hotels
- Cheap Hotels in San Francisco
- Hotels with Free Airport Shuttle in San Francisco
- Hotels near Downtown San Francisco
- Hotels near Hua Zang Si
- Hotels near Southern Exposure
- Hotels near Clarion Alley
- Hotels near Women's Building
- Hotels near Victoria Theatre
- Hotels near Marsh Theater
- Hotels near 16th Street Mission Station
- Motels in 16th Street Mission Station
- Hotels near San Francisco Public Library
- Hotels near 24th Street Mission Station
- Hotels near Ratio 3
- Hotels near Mission Dolores Park
- Hotels near Balmy Alley
- Hotels near SF Armory
- Hotels near Mission High School
- Hotels near Mission Dolores
- Hotels near Right Of Way/Liberty St Stop
- Hotels near Mission San Francisco de Asís
- Hotels near Hosfelt Gallery
- Hotels near Galería de la Raza
- Hotels near 22nd St Hill
- Hotels near Oracle Park
- Hotels near Union Square
- Vacation Homes in Church St & 24th St Stop
- Hotels near Market St & Dolores St Stop
- Hotels near Anchor Brewing Company
- Hotels near Castro District
- Hotels near Church Street Station
- Hotels near Market St & Buchanan St Stop
- Hotels near Market St & Guerrero St Stop
- Hotels near Market St & Laguna St Stop
- B&B in Church St & 14th St Stop
- Hotels near Market St & Sanchez St Stop
- Hotels near SOMArts
- Hotels near Church St & Clipper St Stop
- Hotels near U.S. Mint
- Hotels near Duboce Ave & Church St Stop
- Hotels near Emergence Healing Arts Studio
- Hotels near Bill Graham Civic Auditorium
- Gay friendly Hotels in Castro District
- Hotels near Castro Street
- San Francisco Vacations
- Hua Zang Si
- Marsh Theater
- Mission Dolores Park
- Sf Armory
- Mission San Francisco de Asís
- Galería de la Raza
- Castro Street
- 22nd St Hill
- Visit Downtown San Francisco
- Fouladi Projects
- San Francisco City Hall
- U.s. Mint
- Visit Mission Dolores
- Castro Theatre
- Harvey Milk Plaza
- San Francisco Zen Center
- Louise Davies Symphony Hall
- Noe Valley Vacations
- The Promenade
- Bill Graham Civic Auditorium
- Randall Museum
- Nobby Clarke Mansion
- Visit Castro District
- Randall Museum
- Golden Gate Model Railroad Club
- Mission Creek Park
- Corona Heights Park
- War Memorial Opera House
- Orpheum Theatre
- Civic Center Plaza
- Vulcan Steps
- Mclellan Botanicals
- Painted Ladies
- San Francisco Federal Building
- Kite Hill Open Space
- Asian Art Museum of San Francisco
- United Nations Plaza
- California State Building
- Alamo Square
- Haight Street
- Chase Center
- Van Ness Avenue
- Visit Bernal Heights
- Twin Peaks
- Academy of Art University






















