Mission District Vacations from $298
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Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages
Hotel Riu Plaza Fisherman's Wharf
Reviewed on Jan 24, 2026
1 Hotel San Francisco
Reviewed on Jan 15, 2026
Treehouse Hotel Silicon Valley
Reviewed on Dec 19, 2025
Where to stay in Mission District
Union Square
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
Mission District Hotel Deals
Holiday Inn Golden Gateway by IHG
Nice hotel
Reviewed on Jan 21, 2026
Hotel Riu Plaza Fisherman's Wharf
Clean, excellent location great breakfasts and nice staff ! Not a new hotel
Reviewed on Jan 24, 2026
Hilton San Francisco Financial District
Great clean room, staff was friendly and so helpful. 10/10 service. Would stay here again!
Reviewed on Jan 22, 2026
Discover the most popular places to visit in Mission District
Mission Dolores Park
Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.
Balmy Alley
Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the acclaimed art scene and fascinating museums in this vibrant area.
Mission San Francisco de Asís
Learn about the local history of San Francisco when you spend time at Mission San Francisco de Asís. Visit the shops and notable monuments in this vibrant area.
Things to do
California Academy of Sciences Daytime Admission
Alcatraz Visit with Night Option and SF Bay Cruise
San Francisco City Lights Cruise (2-hours)
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- San Francisco Vacations
- Hua Zang Si
- Marsh Theater
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- SF Armory
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- Galería de la Raza
- Castro Street
- 22nd St Hill
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- San Francisco Federal Building
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- Alamo Square
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- Van Ness Avenue
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- Academy of Art University