Mission District Vacations from $244
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Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Bay Landing San Francisco Airport Hotel
Ingold - Milldale
Save 100% on your flight
Price was $422, price is now $244 per person
$244
per person
Jan 31 - Feb 3
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Francisco (SFO)
9/10 Wonderful! (4,699 reviews)
The front desk agent was very friendly and had a smile as she greeted me while checking in. Very pleasant person.
Reviewed on Dec 13, 2025
Treehouse Hotel Silicon Valley
Price was $7,968, price is now $4,156 per person
$4,156
per person
Feb 4 - Feb 9
found 1 day ago
Roundtrip non-stop flight included
Denver (DEN) to San Francisco (SFO)
9.6/10 Exceptional! (59 reviews)
It was a lovely, fun property with all of the nostalgia in the room you could ever ask for!
Reviewed on Dec 11, 2025
Comfort Inn and Suites San Francisco Airport North
The East Side
Save 100% on your flight
Price was $505, price is now $285 per person
$285
per person
Feb 20 - Feb 25
found 16 hours ago
Roundtrip flight included
Denver (DEN) to San Francisco (SFO)
7.8/10 Good! (1,001 reviews)
Water in the shower cane out brown.
The pipes were leaking and called to get them fixed they did fix them but they just left the mess therw kinda nasty
Reviewed on Nov 16, 2025
San Francisco Proper Hotel
Downtown San Francisco
Save 100% on your flight
Price was $920, price is now $523 per person
$523
per person
Jan 15 - Jan 19
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to San Francisco (SFO)
8.8/10 Excellent! (789 reviews)
Got an uprade and a glass of champagne
Reviewed on Dec 13, 2025
The Westin St. Francis San Francisco on Union Square
Union Square
Save 100% on your flight
Price was $717, price is now $411 per person
$411
per person
Feb 26 - Mar 1
found 10 hours ago
Roundtrip flight included
Denver (DEN) to San Francisco (SFO)
8.8/10 Excellent! (2,430 reviews)
Was just fab all around!
Reviewed on Dec 8, 2025
Where to stay in Mission District
Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Union Square
4/5(5,164 area reviews)
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
Mission District Hotel Deals
Hotel Riu Plaza Fisherman's Wharf
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
$157 nightly
The price is $185 total per night from Dec 17 to Dec 18
$185 total
Dec 17 - Dec 18
Total with taxes and fees
8.8/10 Excellent! (7,176 reviews)
Clean room in a very nice hotel. Hotel itself outside of the rooms was quite cool in temperature.
Reviewed on Dec 11, 2025
Fairmont San Francisco
950 Mason Street Atop Nob Hill San Francisco CA
Fully refundableReserve now, pay when you stay
$260 nightly
The price is $306 total per night from Dec 21 to Dec 22
$306 total
Dec 21 - Dec 22
Total with taxes and fees
9/10 Wonderful! (1,437 reviews)
⭐️⭐️⭐️⭐️⭐️ 5/5 — A Truly Magical Stay! I can’t say enough wonderful things about this beautiful hotel. From the moment we arrived, the service was exceptional—warm, attentive, and genuinely welcoming. Every staff member went above and beyond to make our stay feel special. But what absolutely stole ...
Reviewed on Dec 5, 2025
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $140 total per night from Dec 15 to Dec 16
$140 total
Dec 15 - Dec 16
Total with taxes and fees
8.8/10 Excellent! (4,957 reviews)
The entire experience was good.
Reviewed on Dec 12, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Mission District
Mission Dolores Park
5/5(1 review)
Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.
Mission San Francisco de Asís
Learn about the local history of San Francisco when you spend time at Mission San Francisco de Asís. Visit the notable monuments and shops in this vibrant area.
San Francisco Public Library
After visiting San Francisco Public Library, make a plan to see the other sights and activities in San Francisco. Discover the acclaimed theater scene and notable monuments in this vibrant area.
Things to do
California Academy of Sciences Daytime Admission
$49
per adult
86% of travellers recommend
San Francisco City Lights Cruise (2-hours)
$58
per adult
94% of travellers recommend
de Young Museum General Admission Ticket
$20
per adult
88% of travellers recommend
Explore a world of travel with Expedia
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- Hotels near Duboce Ave & Church St Stop
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- Hotels near Castro Street
- San Francisco Vacations
- Hua Zang Si
- Marsh Theater
- Mission Dolores Park
- SF Armory
- Mission San Francisco de Asís
- Galería de la Raza
- Castro Street
- 22nd St Hill
- Visit Downtown San Francisco
- Fouladi Projects
- San Francisco City Hall
- U.S. Mint
- Visit Mission Dolores
- Castro Theatre
- Harvey Milk Plaza
- San Francisco Zen Center
- Louise Davies Symphony Hall
- Noe Valley Vacations
- The Promenade
- Bill Graham Civic Auditorium
- Randall Museum
- Nobby Clarke Mansion
- Visit Castro District
- Randall Junior Museum
- Golden Gate Model Railroad Club
- Mission Creek Park
- Corona Heights Park
- War Memorial Opera House
- Orpheum Theatre
- Civic Center Plaza
- Vulcan Steps
- McLellan Botanicals
- Painted Ladies
- San Francisco Federal Building
- Kite Hill Open Space
- Asian Art Museum of San Francisco
- United Nations Plaza
- California State Building
- Alamo Square
- Haight Street
- Chase Center
- Van Ness Avenue
- Visit Bernal Heights
- Twin Peaks
- Academy of Art University
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.