Mission District Vacations from $374
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Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages
Price found within the past 48 hours. Click for updated prices.
The Westin St. Francis San Francisco on Union Square
Union Square
Save 100% on your flight
Price was $589, price is now $374 per person
$374
per person
Apr 16 - Apr 18
found 1 day ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
8.8/10 Excellent! (2,399 reviews)
Clean room, very helpful staff. Nice old hotel with old Wood features and high ceilings. Comfortable bed.
Reviewed on Mar 2, 2026
Beacon Grand, A Union Square Hotel
Union Square
Save 100% on your flight
Price was $841, price is now $567 per person
$567
per person
May 4 - May 7
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Francisco (SFO)
9.2/10 Wonderful! (1,920 reviews)
I have stayed here twice and definitely will do so again. The location could not be better. Superb restaurants within walking distance, proximity to Chinatown, cable car stop right in front and comfortable, clean rooms. The best staff I've ever encountered. A classy and elegant hotel with a long history.
Reviewed on Mar 2, 2026
Cathedral Hill Hotel
Downtown San Francisco
Save 100% on your flight
Price was $701, price is now $472 per person
$472
per person
Apr 18 - Apr 25
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Francisco (SFO)
7.2/10 Good! (670 reviews)
Staff was very friendly, Parking Lot very secure, Room was very clean just had a weird smell
Reviewed on Feb 26, 2026
The Grove Inn
Western Addition
Save 100% on your flight
Price was $656, price is now $444 per person
$444
per person
May 24 - May 27
found 21 hours ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
9.2/10 Wonderful! (693 reviews)
We had a deluxe king room. The room was small and basic, but sparkly clean and had a very comfortable bed. We really liked the location. It was very central to everything we wanted to do.
Reviewed on Feb 12, 2026
1 Hotel San Francisco
Downtown San Francisco
Save 100% on your flight
Price was $811, price is now $554 per person
$554
per person
May 29 - May 31
found 1 day ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
9.2/10 Wonderful! (514 reviews)
Beautiful overall , this is not as complaint but the shower head in our bathroom didn’t have any water coming out
Reviewed on Feb 15, 2026
Where to stay in Mission District
Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Union Square
4/5(5,164 area reviews)
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
Mission District Hotel Deals
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $159 total per night from Mar 29 to Mar 30
$159 total
Mar 29 - Mar 30
Total with taxes and fees
9/10 Wonderful! (5,350 reviews)
Great
Reviewed on Mar 4, 2026
Hotel Riu Plaza Fisherman's Wharf
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
$182 nightly
The price is $214 total per night from Mar 18 to Mar 19
$214 total
Mar 18 - Mar 19
Total with taxes and fees
9/10 Wonderful! (7,359 reviews)
Everything was exceptional
Reviewed on Mar 4, 2026
Handlery Union Square Hotel
351 Geary St San Francisco CA
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $176 total per night from Apr 1 to Apr 2
$176 total
Apr 1 - Apr 2
Total with taxes and fees
8.8/10 Excellent! (2,894 reviews)
.
Reviewed on Mar 4, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Mission District
Mission Dolores Park
5/5(1 review)
Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.
Mission San Francisco de Asís
Learn about the local history of San Francisco when you spend time at Mission San Francisco de Asís. Visit the shops and notable monuments in this vibrant area.
Balmy Alley
Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the fascinating museums and acclaimed art scene in this vibrant area.
Things to do
Official Alcatraz Island Prison Tour with Free App Audio Packages
$86
per adult
100% of travellers recommend
California Academy of Sciences Daytime Admission
$49
per adult
86% of travellers recommend
Alcatraz Visit with Night Option and SF Bay Cruise
$139
per adult
94% of travellers recommend
Explore a world of travel with Expedia
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- San Francisco Vacations
- Hua Zang Si
- Marsh Theater
- Mission Dolores Park
- Sf Armory
- Mission San Francisco de Asís
- Galería de la Raza
- Castro Street
- 22nd St Hill
- Visit Downtown San Francisco
- Fouladi Projects
- San Francisco City Hall
- U.s. Mint
- Visit Mission Dolores
- Castro Theatre
- Harvey Milk Plaza
- San Francisco Zen Center
- Louise Davies Symphony Hall
- Noe Valley Vacations
- The Promenade
- Bill Graham Civic Auditorium
- Randall Museum
- Nobby Clarke Mansion
- Visit Castro District
- Randall Museum
- Golden Gate Model Railroad Club
- Mission Creek Park
- Corona Heights Park
- War Memorial Opera House
- Orpheum Theatre
- Civic Center Plaza
- Vulcan Steps
- Mclellan Botanicals
- Painted Ladies
- San Francisco Federal Building
- Kite Hill Open Space
- Asian Art Museum of San Francisco
- United Nations Plaza
- California State Building
- Alamo Square
- Haight Street
- Chase Center
- Van Ness Avenue
- Visit Bernal Heights
- Twin Peaks
- Academy of Art University
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.