Mission District Vacations from $780
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Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Nob Hill Hotel
Downtown San Francisco
Save 100% on your flight
Price was $1,194, price is now $780 per person
$780
per person
Jun 16 - Jun 20
found 1 day ago
Roundtrip non-stop flight included
Dallas (DFW) to San Francisco (SFO)
7.8/10 Good! (1,005 reviews)
The hotel was surprisingly in the good condition. Rooms were clean staff was friendly. Some things to consider, NO AC, and it can be a bit noisy at times since your on a semi busy st that’s near a hospital.
Reviewed on Apr 10, 2026
Fairmont Heritage Place, Ghirardelli Square
Fisherman's Wharf
Save 100% on your flight
Price was $6,204, price is now $3,578 per person
$3,578
per person
Jul 2 - Jul 7
found 23 hours ago
Roundtrip flight included
Dallas (DFW) to San Francisco (SFO)
9.4/10 Exceptional! (393 reviews)
Nothing but great things to say about this place! So much to do and see and staff is sooo nice and helpful.
Reviewed on Apr 5, 2026
1 Hotel San Francisco
Downtown San Francisco
Save 100% on your flight
Price was $3,430, price is now $2,112 per person
$2,112
per person
Jun 16 - Jun 20
found 1 day ago
Roundtrip non-stop flight included
Dallas (DFW) to San Francisco (SFO)
9.2/10 Wonderful! (525 reviews)
Amazing ambiance. Great staff and Daily Breakfast.
Reviewed on Apr 10, 2026
The Huntington Hotel
Downtown San Francisco
Save 100% on your flight
Price was $2,262, price is now $1,486 per person
$1,486
per person
Jun 23 - Jun 26
found 1 day ago
Roundtrip flight included
Carlsbad (CLD) to San Francisco (SFO)
10/10 Exceptional! (2 reviews)
After a long hiatus, the Hunington is back, and thanks to the owners and Ken Faulk, the property is as it was in 1980 but with the addition of a lobby bar and understated elegance in the all new rooms and interiors. The Big Four looks like it was never touched. I never imagined an old hotel that everyone loved could have been brought back so elegantly.
Reviewed on Mar 27, 2026
Hotel Riu Plaza Fisherman's Wharf
Fisherman's Wharf
Save 100% on your flight
Price was $1,697, price is now $1,127 per person
$1,127
per person
Jun 21 - Jun 25
found 1 day ago
Roundtrip flight included
Carlsbad (CLD) to San Francisco (SFO)
9/10 Wonderful! (7,351 reviews)
The property is a renovated hotel. Accoustic / popcorn ceilings, small bathrooms, thin walls & floors.You hear doors slamming above you and in the halls.I had to wear ear plugs because it was noisy. The staff was friendly. The breakfast was plentiful, but bland.The next trip to San Francisco I'll be checking out some other options.
Reviewed on Apr 14, 2026
Where to stay in Mission District
Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Fisherman's Wharf
1 out of top 10 points of interest in this area
4/5(39 area reviews)
Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.
Mission District Hotel Deals
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $155 total per night from Apr 19 to Apr 20
$155 total
Apr 19 - Apr 20
Total with taxes and fees
9/10 Wonderful! (5,557 reviews)
The view of the city was the highlight of this room! The staff were super friendly. Check in was smooth and efficient. Self-parking was easy. Rooms were decently sized. Beds are comfortable. Walking distance to the Regency Ballroom. Exactly what we needed for a quick overnight stay. Will absolutely ...
Reviewed on Apr 14, 2026
Handlery Union Square Hotel
351 Geary St San Francisco CA
Fully refundableReserve now, pay when you stay
$143 nightly
The price is $169 total per night from Apr 19 to Apr 20
$169 total
Apr 19 - Apr 20
Total with taxes and fees
8.8/10 Excellent! (3,012 reviews)
Very friendly staff great location
Reviewed on Apr 14, 2026
Hotel Riu Plaza Fisherman's Wharf
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
$173 nightly
The price is $203 total per night from Apr 20 to Apr 21
$203 total
Apr 20 - Apr 21
Total with taxes and fees
9/10 Wonderful! (7,413 reviews)
The property is a renovated hotel. Accoustic / popcorn ceilings, small bathrooms, thin walls & floors.You hear doors slamming above you and in the halls.I had to wear ear plugs because it was noisy. The staff was friendly. The breakfast was plentiful, but bland.The next trip to San Francisco I'll ...
Reviewed on Apr 14, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Mission District
Mission Dolores Park
Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.
Mission San Francisco de Asís
Learn about the local history of San Francisco when you spend time at Mission San Francisco de Asís. Visit the notable monuments and shops in this vibrant area.
Balmy Alley
Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene and fascinating museums in this vibrant area.
Things to do
Official Alcatraz Island Prison Tour with Free App Audio Packages
$86
per adult
100% of travellers recommend
California Academy of Sciences Daytime Admission
$49
per adult
86% of travellers recommend
Alcatraz Visit with Night Option and SF Bay Cruise
$139
per adult
94% of travellers recommend
Explore a world of travel with Expedia
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- San Francisco Vacations
- Hua Zang Si
- Marsh Theater
- Mission Dolores Park
- Sf Armory
- Mission San Francisco de Asís
- Galería de la Raza
- Castro Street
- 22nd St Hill
- Visit Downtown San Francisco
- Fouladi Projects
- San Francisco City Hall
- U.s. Mint
- Visit Mission Dolores
- Castro Theatre
- Harvey Milk Plaza
- San Francisco Zen Center
- Louise Davies Symphony Hall
- Noe Valley Vacations
- The Promenade
- Bill Graham Civic Auditorium
- Randall Museum
- Nobby Clarke Mansion
- Visit Castro District
- Randall Museum
- Golden Gate Model Railroad Club
- Mission Creek Park
- Corona Heights Park
- War Memorial Opera House
- Orpheum Theatre
- Civic Center Plaza
- Vulcan Steps
- Mclellan Botanicals
- Painted Ladies
- San Francisco Federal Building
- Kite Hill Open Space
- Asian Art Museum of San Francisco
- United Nations Plaza
- California State Building
- Alamo Square
- Haight Street
- Chase Center
- Van Ness Avenue
- Visit Bernal Heights
- Twin Peaks
- Academy of Art University
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.