Mission District Vacations from $308

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

    Rest easy

    Plan, book, and manage your trip all in one place

Your Mission District Vacation

Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.

The Latest Mission District Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Fitzgerald Hotel
Bay Landing San Francisco Airport Hotel
Hotel Riu Plaza Fisherman's Wharf
1 Hotel San Francisco
Appellation Healdsburg

Where to stay in Mission District

Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District

Mission District Hotel Deals

Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave, San Francisco, CA
Fully refundable
$112 nightly
The price is $132 total per night from Nov 2 to Nov 3
$132 total
Nov 2 - Nov 3
Total with taxes and fees
8.8/10 Excellent! (4,659 reviews)
"Nice view in corner room"

Reviewed on Oct 7, 2025

Holiday Inn Golden Gateway by IHG
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St, San Francisco, CA
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $147 total per night from Nov 9 to Nov 10
$147 total
Nov 9 - Nov 10
Total with taxes and fees
8.6/10 Excellent! (1,848 reviews)
"Clean and awesome"

Reviewed on Oct 6, 2025

Hilton San Francisco Financial District
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St, San Francisco, CA
Fully refundableReserve now, pay when you stay
$158 nightly
The price is $186 total per night from Nov 2 to Nov 3
$186 total
Nov 2 - Nov 3
Total with taxes and fees
8.8/10 Excellent! (6,957 reviews)
"Amazing experience"

Reviewed on Oct 9, 2025

Hotel Riu Plaza Fisherman's Wharf
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Mission District

Things to do

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.