Mission District Vacations from $639
Book a Hotel + Flight or Car together to unlock savings
Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages
Price found within the past 48 hours. Click for updated prices.
SF Plaza Hotel
Union Square
Save 100% on your flight
Price was $959, price is now $639 per person
$639
per person
Mar 8 - Mar 13
found 23 hours ago
Roundtrip flight included
Boston (BOS) to San Francisco (SFO)
6.4/10 (1,001 reviews)
Decent hotel but quite old and needs updating, floor was creaky, and front desk staff could be more attentive
Reviewed on Jan 13, 2026
The Grove Inn
Western Addition
Save 100% on your flight
Price was $1,659, price is now $1,032 per person
$1,032
per person
Mar 8 - Mar 13
found 23 hours ago
Roundtrip flight included
Boston (BOS) to San Francisco (SFO)
9.2/10 Wonderful! (670 reviews)
The spot/location was perfect. The building was iconic. The room was spacious and clean. It is simple and quaint.
Reviewed on Jan 30, 2026
Hotel Riu Plaza Fisherman's Wharf
Fisherman's Wharf
Save 100% on your flight
Price was $1,353, price is now $906 per person
$906
per person
Mar 8 - Mar 13
found 23 hours ago
Roundtrip flight included
Boston (BOS) to San Francisco (SFO)
9/10 Wonderful! (7,092 reviews)
My room was spotless, the bed sooo comfy and the room was so quiet, I slept like a baby. The entire hotel staff was attentive, professional and eager to make guests feel comfortable. The breakfast buffet was top notch! It is rare to see this variety of breakfast items. There surely was something for everyone, even the most discriminating palates. I would definitely book this hotel again should I return to San Francisco.
Reviewed on Feb 4, 2026
Bay Landing San Francisco Airport Hotel
Ingold - Milldale
Price was $956, price is now $647 per person
$647
per person
Apr 12 - Apr 17
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to San Francisco (SFO)
9/10 Wonderful! (4,699 reviews)
Room was very clean and comfortable. Bed was extra comfortable as staff went above and beyond to make sure I was happy.
Reviewed on Feb 3, 2026
1 Hotel San Francisco
Downtown San Francisco
Save 100% on your flight
Price was $3,137, price is now $2,145 per person
$2,145
per person
Apr 18 - Apr 24
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Francisco (SFO)
9.2/10 Wonderful! (470 reviews)
My husband and I really enjoyed our stay.
Reviewed on Jan 15, 2026
Where to stay in Mission District
Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Union Square
4/5(5,164 area reviews)
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
Mission District Hotel Deals
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $149 total per night from Feb 9 to Feb 10
$149 total
Feb 9 - Feb 10
Total with taxes and fees
8.8/10 Excellent! (5,227 reviews)
The only reason it's not 5 stars is that the "grab and go" breakfast was very poor. Everything else was great.
Reviewed on Feb 2, 2026
Hotel Riu Plaza Fisherman's Wharf
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
$154 nightly
The price is $181 total per night from Feb 10 to Feb 11
$181 total
Feb 10 - Feb 11
Total with taxes and fees
8.8/10 Excellent! (7,308 reviews)
Comfy beds. Short walk to Pier 39. Safe surroundings. Fire pits. Quiet.
Reviewed on Feb 1, 2026
Hilton San Francisco Financial District
750 Kearny St San Francisco CA
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $134 total per night from Feb 22 to Feb 23
$134 total
Feb 22 - Feb 23
Total with taxes and fees
8.6/10 Excellent! (2,367 reviews)
Savvy, clean, sleek in a very clean China town. I love the cars a aialbe to pick you up and drop off as part of the guest services. The breakfast was not buffet style but still covered side orders of fruit and drinks. It was a good deal to have it connected with your room purchase. The view was breathe ...
Reviewed on Feb 2, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Mission District
Mission Dolores Park
Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.
Mission San Francisco de Asís
Learn about the local history of San Francisco when you spend time at Mission San Francisco de Asís. Visit the shops and notable monuments in this vibrant area.
Balmy Alley
Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the acclaimed art scene and fascinating museums in this vibrant area.
Things to do
California Academy of Sciences Daytime Admission
$49
per adult
86% of travellers recommend
Alcatraz Visit with Night Option and SF Bay Cruise
$139
per adult
94% of travellers recommend
Explore a world of travel with Expedia
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- Hotels near Hua Zang Si
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- Hotels near Clarion Alley
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- Hotels near 16th Street Mission Station
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- Hotels near San Francisco Public Library
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- Hotels near Mission Dolores
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- Hotels near Mission San Francisco de Asís
- Hotels near Hosfelt Gallery
- Hotels near Galería de la Raza
- Hotels near 22nd St Hill
- Hotels near Oracle Park
- Hotels near Union Square
- Vacation Homes in Church St & 24th St Stop
- Hotels near Market St & Dolores St Stop
- Hotels near Anchor Brewing Company
- Hotels near Castro District
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- Hotels near Market St & Buchanan St Stop
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- Hotels near Market St & Laguna St Stop
- B&B in Church St & 14th St Stop
- Hotels near Market St & Sanchez St Stop
- Hotels near SOMArts
- Hotels near Church St & Clipper St Stop
- Hotels near U.S. Mint
- Hotels near Duboce Ave & Church St Stop
- Hotels near Emergence Healing Arts Studio
- Hotels near Bill Graham Civic Auditorium
- Gay friendly Hotels in Castro District
- Hotels near Castro Street
- San Francisco Vacations
- Hua Zang Si
- Marsh Theater
- Mission Dolores Park
- SF Armory
- Mission San Francisco de Asís
- Galería de la Raza
- Castro Street
- 22nd St Hill
- Visit Downtown San Francisco
- Fouladi Projects
- San Francisco City Hall
- U.S. Mint
- Visit Mission Dolores
- Castro Theatre
- Harvey Milk Plaza
- San Francisco Zen Center
- Louise Davies Symphony Hall
- Noe Valley Vacations
- The Promenade
- Bill Graham Civic Auditorium
- Randall Museum
- Nobby Clarke Mansion
- Visit Castro District
- Randall Junior Museum
- Golden Gate Model Railroad Club
- Mission Creek Park
- Corona Heights Park
- War Memorial Opera House
- Orpheum Theatre
- Civic Center Plaza
- Vulcan Steps
- McLellan Botanicals
- Painted Ladies
- San Francisco Federal Building
- Kite Hill Open Space
- Asian Art Museum of San Francisco
- United Nations Plaza
- California State Building
- Alamo Square
- Haight Street
- Chase Center
- Van Ness Avenue
- Visit Bernal Heights
- Twin Peaks
- Academy of Art University
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.