Mission District Vacations from $249

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Your Mission District Vacation

Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.

The Latest Mission District Vacation Packages

Price found within the past 48 hours. Click for updated prices.
SOMA Park Inn – Civic Center

SOMA Park Inn – Civic Center

2 out of 5
Downtown San Francisco
Save 100% on your flight
Price was $425, price is now $249 per person
$249
per person
Sep 11 - Sep 14
found 2 days ago
Roundtrip flight included
Los Angeles (LAX) to San Francisco (SFO)
7/10 Good! (1,005 reviews)
Parking is by far the biggest perk here. The room was clean and staff was helpful. Pretty good overall.

Reviewed on Jul 8, 2026

Treehouse Hotel Silicon Valley

Treehouse Hotel Silicon Valley

5 out of 5
Price was $2,323, price is now $1,384 per person
$1,384
per person
Sep 23 - Sep 28
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to San Francisco (SFO)
9.6/10 Exceptional! (112 reviews)
This is a great place for a staycation. I really enjoyed the beer garden and Woodfire pizzas they served. I will definitely go back and visit again.

Reviewed on Jul 12, 2026

The Westin St. Francis San Francisco on Union Square

The Westin St. Francis San Francisco on Union Square

4.5 out of 5
Union Square
Save 100% on your flight
Price was $839, price is now $507 per person
$507
per person
Oct 1 - Oct 4
found 22 hours ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
8.8/10 Excellent! (2,322 reviews)
The classic San Francisco! Where should I begin?? Everything was so immaculate! Service flawless; Rooms were perfectly clean and beds were perfectly comfortable. Of course the hotel is old but boy they have maintained it so well ! Its right at Union Square so you already won in terms of location! Its central to everything and you can pick and choose any of the public transportation modes that SFO provides right outside of the hotel. We loved it and will definitely come back again.

Reviewed on Jul 13, 2026

San Francisco Proper Hotel

San Francisco Proper Hotel

4.5 out of 5
Downtown San Francisco
Save 100% on your flight
Price was $925, price is now $574 per person
$574
per person
Sep 24 - Sep 28
found 1 day ago
Roundtrip flight included
San Diego (SAN) to San Francisco (SFO)
8.8/10 Excellent! (866 reviews)
The neighborhood is not ideal, lots of drug houses nearby. Sad to see.

Reviewed on Jul 13, 2026

The Grove Inn

The Grove Inn

3 out of 5
Western Addition
Save 100% on your flight
Price was $1,123, price is now $720 per person
$720
per person
Oct 1 - Oct 4
found 19 hours ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
9.2/10 Wonderful! (719 reviews)
The room is basic but clean and a good size for SF. The staff was very nice and welcoming.

Reviewed on Jul 14, 2026

Where to stay in Mission District

Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
A marina with various boats docked, including a yellow and white boat named 'Golden Gate'.

Fisherman's Wharf

1 out of top 10 points of interest in this area

Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.

Find hotels in Fisherman's Wharf

Mission District Hotel Deals

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
$167 nightly
The price is $196 total per night from Jul 20 to Jul 21
$196 total
Jul 20 - Jul 21
Total with taxes and fees
9/10 Wonderful! (7,593 reviews)
"Great location. Great free breakfast. Friendly staff."

Reviewed on Jul 14, 2026

Hotel Riu Plaza Fisherman's Wharf
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
$155 nightly
The price is $182 total per night from Jul 19 to Jul 20
$182 total
Jul 19 - Jul 20
Total with taxes and fees
9/10 Wonderful! (5,980 reviews)
"Great place to stay. It’s clean. Everyone is very polite and lots of places to eat. But make sure your room is not next to the elevators. Other than that it was a great stay"

Reviewed on Jul 15, 2026

Holiday Inn Golden Gateway by IHG
Hyatt Regency San Francisco

Hyatt Regency San Francisco

4 out of 5
5 Embarcadero Center San Francisco CA
$238 nightly
The price is $280 total per night from Jul 17 to Jul 18
$280 total
Jul 17 - Jul 18
Total with taxes and fees
9.2/10 Wonderful! (2,378 reviews)
"Check in was weird since you need to go up 2 floors. For valet parking its $95 a day... which seems insane. So we parked a block over at a parking garage for $45 overnight. The hotel it self is nice and clean. But we made the mistake of getting a drink at the bar in the lobby. 2 drinks costs $50 ..."

Reviewed on Jul 14, 2026

Hyatt Regency San Francisco
See all 4,492 properties in Mission District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Mission District attractions

A park with people sitting on the grass, a school building, and a cityscape in the background.

Mission Dolores Park

9.4/10 (3 reviews)
Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.
See properties

Things to do

California Academy of Sciences General Admission

California Academy of Sciences Daytime Admission

$55
per adult
86% of travellers recommend
California Academy of Sciences Daytime Admission
Official Alcatraz Island Prison Tour with Free App Audio Packages

Official Alcatraz Inside Prison Tour with Free App Audio Packages

$86
per adult
100% of travellers recommend
Official Alcatraz Inside Prison Tour with Free App Audio Packages
San Francisco City Lights Cruise

California Sunset Cruise (2-hours)

$58
per adult
94% of travellers recommend
California Sunset Cruise (2-hours)
See all activities in San Francisco

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.