Mission District Vacations from $518
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $1,045 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Bay Landing San Francisco Airport Hotel
Ingold - Milldale
Price was $723, price is now $518 per person
$518
per person
Jun 24 - Jun 26
found 1 day ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
9/10 Wonderful! (4,822 reviews)
Great free breakfast and free parking. Close to the airport. Cons small double beds would have preferred queens. Comforters could use an upgrade many loose threads.
Reviewed on Mar 30, 2026
1 Hotel San Francisco
Downtown San Francisco
Save 100% on your flight
Price was $1,456, price is now $968 per person
$968
per person
Jun 24 - Jun 26
found 1 day ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
9.2/10 Wonderful! (516 reviews)
Everything was beyond great!
Reviewed on Mar 30, 2026
Hotel Riu Plaza Fisherman's Wharf
Fisherman's Wharf
Save 100% on your flight
Price was $756, price is now $519 per person
$519
per person
May 23 - May 26
found 1 day ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
9/10 Wonderful! (7,413 reviews)
Fist time staying here and will stay here again . Friendly staff and easy parking access
Reviewed on Mar 29, 2026
Montage Healdsburg
Price was $6,196, price is now $4,264 per person
$4,264
per person
Jun 7 - Jun 14
found 13 hours ago
Roundtrip flight included
New York (NYC) to San Francisco (SFO)
9.6/10 Exceptional! (131 reviews)
This hotel was amazing. Like a cabin in the woods. Beautiful property, room, and location. Exceptional service.
Reviewed on Mar 4, 2026
Where to stay in Mission District
Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Union Square
4/5(5,226 area reviews)
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
Mission District Hotel Deals
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $155 total per night from Apr 12 to Apr 13
$155 total
Apr 12 - Apr 13
Total with taxes and fees
9/10 Wonderful! (5,472 reviews)
Great staff
Reviewed on Mar 30, 2026
Handlery Union Square Hotel
351 Geary St San Francisco CA
Fully refundableReserve now, pay when you stay
$149 nightly
The price is $176 total per night from Apr 1 to Apr 2
$176 total
Apr 1 - Apr 2
Total with taxes and fees
8.8/10 Excellent! (2,953 reviews)
Ac is okay, pillow was given 3, but rather soft. Overall good location, good and decent hotel, but whenever nearby room door is closed, the air will make a loud sound to my door too. So when chambermaid is cleaning up rooms around mine, it will be endless slamming sound on my door too.
Reviewed on Mar 30, 2026
Hotel Riu Plaza Fisherman's Wharf
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
$167 nightly
The price is $196 total per night from Apr 12 to Apr 13
$196 total
Apr 12 - Apr 13
Total with taxes and fees
9/10 Wonderful! (7,391 reviews)
Daily breakfast was a 10 plus
Reviewed on Mar 30, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Mission District
Mission Dolores Park
Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.
Mission San Francisco de Asís
Learn about the local history of San Francisco when you spend time at Mission San Francisco de Asís. Visit the notable monuments and shops in this vibrant area.
Balmy Alley
Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the fascinating museums and acclaimed theater scene in this vibrant area.
Things to do
California Academy of Sciences Daytime Admission
$49
per adult
86% of travellers recommend
Official Alcatraz Island Prison Tour with Free App Audio Packages
$86
per adult
100% of travellers recommend
Alcatraz Visit with Night Option and SF Bay Cruise
$139
per adult
94% of travellers recommend
Explore a world of travel with Expedia
- San Francisco Hotels
- Cheap Hotels in San Francisco
- Hotels with Free Airport Shuttle in San Francisco
- Hotels near Downtown San Francisco
- Hotels near Hua Zang Si
- Hotels near Southern Exposure
- Hotels near Clarion Alley
- Hotels near Women's Building
- Hotels near Victoria Theatre
- Hotels near Marsh Theater
- Hotels near 16th Street Mission Station
- Motels in 16th Street Mission Station
- Hotels near San Francisco Public Library
- Hotels near 24th Street Mission Station
- Hotels near Ratio 3
- Hotels near Mission Dolores Park
- Hotels near Balmy Alley
- Hotels near SF Armory
- Hotels near Mission High School
- Hotels near Mission Dolores
- Hotels near Right Of Way/Liberty St Stop
- Hotels near Mission San Francisco de Asís
- Hotels near Hosfelt Gallery
- Hotels near Galería de la Raza
- Hotels near 22nd St Hill
- Hotels near Oracle Park
- Hotels near Union Square
- Vacation Homes in Church St & 24th St Stop
- Hotels near Market St & Dolores St Stop
- Hotels near Anchor Brewing Company
- Hotels near Castro District
- Hotels near Church Street Station
- Hotels near Market St & Buchanan St Stop
- Hotels near Market St & Guerrero St Stop
- Hotels near Market St & Laguna St Stop
- B&B in Church St & 14th St Stop
- Hotels near Market St & Sanchez St Stop
- Hotels near SOMArts
- Hotels near Church St & Clipper St Stop
- Hotels near U.S. Mint
- Hotels near Duboce Ave & Church St Stop
- Hotels near Emergence Healing Arts Studio
- Hotels near Bill Graham Civic Auditorium
- Gay friendly Hotels in Castro District
- Hotels near Castro Street
- San Francisco Vacations
- Hua Zang Si
- Marsh Theater
- Mission Dolores Park
- Sf Armory
- Mission San Francisco de Asís
- Galería de la Raza
- Castro Street
- 22nd St Hill
- Visit Downtown San Francisco
- Fouladi Projects
- San Francisco City Hall
- U.s. Mint
- Visit Mission Dolores
- Castro Theatre
- Harvey Milk Plaza
- San Francisco Zen Center
- Louise Davies Symphony Hall
- Noe Valley Vacations
- The Promenade
- Bill Graham Civic Auditorium
- Randall Museum
- Nobby Clarke Mansion
- Visit Castro District
- Randall Museum
- Golden Gate Model Railroad Club
- Mission Creek Park
- Corona Heights Park
- War Memorial Opera House
- Orpheum Theatre
- Civic Center Plaza
- Vulcan Steps
- Mclellan Botanicals
- Painted Ladies
- San Francisco Federal Building
- Kite Hill Open Space
- Asian Art Museum of San Francisco
- United Nations Plaza
- California State Building
- Alamo Square
- Haight Street
- Chase Center
- Van Ness Avenue
- Visit Bernal Heights
- Twin Peaks
- Academy of Art University
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.