Mission District Vacations from $425
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Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Hotel EPIK
Downtown San Francisco
Save 100% on your flight
Price was $734, price is now $425 per person
$425
per person
Feb 15 - Feb 22
found 1 day ago
Roundtrip flight included
Mesa (AZA) to San Francisco (SFO)
7/10 Good! (517 reviews)
Very small room and lots of street noise but served its purpose!
Reviewed on Jan 10, 2026
Bay Landing San Francisco Airport Hotel
Ingold - Milldale
Save 100% on your flight
Price was $943, price is now $510 per person
$510
per person
Feb 15 - Feb 22
found 1 day ago
Roundtrip flight included
Mesa (AZA) to San Francisco (SFO)
9/10 Wonderful! (4,699 reviews)
Room was clean. Staff was nice. Amenities were good. Breakfast was wonderful.
Reviewed on Jan 12, 2026
SF Central Hotel
South of Market
Save 100% on your flight
Price was $870, price is now $474 per person
$474
per person
Feb 15 - Feb 22
found 1 day ago
Roundtrip flight included
Mesa (AZA) to San Francisco (SFO)
6.2/10 (862 reviews)
No parking needed. The facility looked decent on the outside, but very dated and run down on the inside. It's a place to sleep for the night. The Becks motel/hotel in the Castro was a much better experience. Some older hotels just have that lived in look.
Reviewed on Oct 26, 2025
Hotel Riu Plaza Fisherman's Wharf
Fisherman's Wharf
Save 100% on your flight
Price was $1,094, price is now $603 per person
$603
per person
Feb 15 - Feb 22
found 1 day ago
Roundtrip flight included
Mesa (AZA) to San Francisco (SFO)
9/10 Wonderful! (7,092 reviews)
Very good service and clean 👍
Reviewed on Jan 14, 2026
Treehouse Hotel Silicon Valley
Save 100% on your flight
Price was $1,948, price is now $1,165 per person
$1,165
per person
Mar 31 - Apr 5
found 1 day ago
Roundtrip flight included
Los Angeles (QLA) to San Francisco (SFO)
9.6/10 Exceptional! (59 reviews)
Love this hotel! Beautiful rooms, super comfy bed, great restaurant! It’s all I need 😃😃😃
Reviewed on Dec 19, 2025
Where to stay in Mission District
Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Union Square
4/5(5,164 area reviews)
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
Mission District Hotel Deals
Hotel Riu Plaza Fisherman's Wharf
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
$142 nightly
The price is $168 total per night from Feb 10 to Feb 11
$168 total
Feb 10 - Feb 11
Total with taxes and fees
8.8/10 Excellent! (7,250 reviews)
Overall wonderful experience. Staff was great, room was great.. a little cold but housekeeping brought up an extra blanket and i was perfect. Outdoor fireplaces were lovely. Great location so close to pier 39.
Reviewed on Jan 10, 2026
Hilton San Francisco Financial District
750 Kearny St San Francisco CA
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $152 total per night from Jan 16 to Jan 17
$152 total
Jan 16 - Jan 17
Total with taxes and fees
8.6/10 Excellent! (2,281 reviews)
Room was very clean, staff was super helpful and courteous!
Reviewed on Jan 14, 2026
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $149 total per night from Jan 25 to Jan 26
$149 total
Jan 25 - Jan 26
Total with taxes and fees
8.8/10 Excellent! (5,117 reviews)
the toilet was leaking on floor, no room safe, the hot tub was out of order
Reviewed on Jan 13, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Mission District
Mission Dolores Park
Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.
Balmy Alley
Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the acclaimed art scene and fascinating museums in this vibrant area.
Mission San Francisco de Asís
Learn about the local history of San Francisco when you spend time at Mission San Francisco de Asís. Visit the shops and notable monuments in this vibrant area.
Things to do
California Academy of Sciences Daytime Admission
$49
per adult
86% of travellers recommend
Alcatraz Visit with Night Option and SF Bay Cruise
$139
per adult
96% of travellers recommend
San Francisco City Lights Cruise (2-hours)
$58
per adult
94% of travellers recommend
Explore a world of travel with Expedia
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- Vacation Homes in Church St & 24th St Stop
- Hotels near Market St & Dolores St Stop
- Hotels near Anchor Brewing Company
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- B&B in Church St & 14th St Stop
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- Hotels near U.S. Mint
- Hotels near Duboce Ave & Church St Stop
- Hotels near Emergence Healing Arts Studio
- Hotels near Bill Graham Civic Auditorium
- Gay friendly Hotels in Castro District
- Hotels near Castro Street
- San Francisco Vacations
- Hua Zang Si
- Marsh Theater
- Mission Dolores Park
- SF Armory
- Mission San Francisco de Asís
- Galería de la Raza
- Castro Street
- 22nd St Hill
- Visit Downtown San Francisco
- Fouladi Projects
- San Francisco City Hall
- U.S. Mint
- Visit Mission Dolores
- Castro Theatre
- Harvey Milk Plaza
- San Francisco Zen Center
- Louise Davies Symphony Hall
- Noe Valley Vacations
- The Promenade
- Bill Graham Civic Auditorium
- Randall Museum
- Nobby Clarke Mansion
- Visit Castro District
- Randall Junior Museum
- Golden Gate Model Railroad Club
- Mission Creek Park
- Corona Heights Park
- War Memorial Opera House
- Orpheum Theatre
- Civic Center Plaza
- Vulcan Steps
- McLellan Botanicals
- Painted Ladies
- San Francisco Federal Building
- Kite Hill Open Space
- Asian Art Museum of San Francisco
- United Nations Plaza
- California State Building
- Alamo Square
- Haight Street
- Chase Center
- Van Ness Avenue
- Visit Bernal Heights
- Twin Peaks
- Academy of Art University
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.