Mission District Vacations from $554
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Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages
Price found within the past 48 hours. Click for updated prices.
The Marker Union Square San Francisco
Union Square
Save 100% on your flight
Price was $869, price is now $554 per person
$554
per person
May 28 - Jun 2
found 1 day ago
Roundtrip flight included
Mesa (AZA) to San Francisco (SFO)
9.2/10 Wonderful! (1,203 reviews)
Staff was friendly and welcoming 24/7. I never had to open any door myself in the lobby. I felt safe and it was clean. Location isn’t noisy at all. Probably the best hotel I’ve ever stayed in for an exceptional price.
Reviewed on Mar 23, 2026
Hotel Riu Plaza Fisherman's Wharf
Fisherman's Wharf
Save 100% on your flight
Price was $1,198, price is now $677 per person
$677
per person
May 28 - Jun 2
found 1 day ago
Roundtrip flight included
Mesa (AZA) to San Francisco (SFO)
9/10 Wonderful! (7,413 reviews)
Well appointed rooms and very clean and tidy. Excellent breakfast. Good location right at Fisherman's Wharf. Views were limited, but the rooms were light and airy.
Reviewed on Mar 24, 2026
Bay Landing San Francisco Airport Hotel
Ingold - Milldale
Save 100% on your flight
Price was $949, price is now $559 per person
$559
per person
May 28 - Jun 2
found 1 day ago
Roundtrip flight included
Mesa (AZA) to San Francisco (SFO)
9/10 Wonderful! (4,822 reviews)
Very clean rooms a great view of SFO and planes landings if you are a aviation enthusiasts.
Reviewed on Mar 24, 2026
The Grove Inn
Western Addition
Save 100% on your flight
Price was $1,551, price is now $963 per person
$963
per person
May 14 - May 18
found 4 hours ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
9.2/10 Wonderful! (695 reviews)
Cute boutique style lodge. Rooms were nice, great area, and easy to check in and out. Provided list of local restaurants and amenities around the area.
Reviewed on Mar 7, 2026
1 Hotel San Francisco
Downtown San Francisco
Save 100% on your flight
Price was $1,506, price is now $960 per person
$960
per person
May 15 - May 18
just found
Roundtrip flight included
Mesa (AZA) to San Francisco (SFO)
9.2/10 Wonderful! (516 reviews)
This hotel used to be my favorite, now it lost it’s charm, the place needs renovation.
Reviewed on Mar 24, 2026
Where to stay in Mission District
Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Union Square
4/5(5,226 area reviews)
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
Mission District Hotel Deals
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $155 total per night from Apr 12 to Apr 13
$155 total
Apr 12 - Apr 13
Total with taxes and fees
9/10 Wonderful! (5,439 reviews)
Excellent city view (worth the price). Great location on Nob Hill. Ideal for family stay. Extortion pricing in the lobby machines and mini-store (($8.00 for a 4 oz. bottle of Pepto-Bismal, $10.60 for one bottle of cold beer!!). Just do your shopping in the surrounding shops...
Reviewed on Mar 24, 2026
Handlery Union Square Hotel
351 Geary St San Francisco CA
Fully refundableReserve now, pay when you stay
$148 nightly
The price is $174 total per night from Mar 28 to Mar 29
$174 total
Mar 28 - Mar 29
Total with taxes and fees
8.8/10 Excellent! (2,936 reviews)
This hotel is central to everywhere we want to go in SF! Plus, we feel safe in this neighbourhood. We love the atmosphere at Union Square, and BART is close by for our trips out to the suburbs. The staff are always friendly and helpful. Our room was nice and clean, and our room requests were met ...
Reviewed on Mar 24, 2026
Hotel Riu Plaza Fisherman's Wharf
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
$173 nightly
The price is $203 total per night from Apr 12 to Apr 13
$203 total
Apr 12 - Apr 13
Total with taxes and fees
9/10 Wonderful! (7,391 reviews)
Well appointed rooms and very clean and tidy. Excellent breakfast. Good location right at Fisherman's Wharf. Views were limited, but the rooms were light and airy.
Reviewed on Mar 24, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Mission District
Mission Dolores Park
Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.
Mission San Francisco de Asís
Learn about the local history of San Francisco when you spend time at Mission San Francisco de Asís. Visit the notable monuments and shops in this vibrant area.
Balmy Alley
Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the fascinating museums and acclaimed theater scene in this vibrant area.
Things to do
Official Alcatraz Island Prison Tour with Free App Audio Packages
$86
per adult
100% of travellers recommend
California Academy of Sciences Daytime Admission
$49
per adult
86% of travellers recommend
Alcatraz Visit with Night Option and SF Bay Cruise
$139
per adult
94% of travellers recommend
Explore a world of travel with Expedia
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- San Francisco Vacations
- Hua Zang Si
- Marsh Theater
- Mission Dolores Park
- Sf Armory
- Mission San Francisco de Asís
- Galería de la Raza
- Castro Street
- 22nd St Hill
- Visit Downtown San Francisco
- Fouladi Projects
- San Francisco City Hall
- U.s. Mint
- Visit Mission Dolores
- Castro Theatre
- Harvey Milk Plaza
- San Francisco Zen Center
- Louise Davies Symphony Hall
- Noe Valley Vacations
- The Promenade
- Bill Graham Civic Auditorium
- Randall Museum
- Nobby Clarke Mansion
- Visit Castro District
- Randall Museum
- Golden Gate Model Railroad Club
- Mission Creek Park
- Corona Heights Park
- War Memorial Opera House
- Orpheum Theatre
- Civic Center Plaza
- Vulcan Steps
- Mclellan Botanicals
- Painted Ladies
- San Francisco Federal Building
- Kite Hill Open Space
- Asian Art Museum of San Francisco
- United Nations Plaza
- California State Building
- Alamo Square
- Haight Street
- Chase Center
- Van Ness Avenue
- Visit Bernal Heights
- Twin Peaks
- Academy of Art University
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.