Mission District Vacations from $244
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Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Union Square Plaza Hotel
Union Square
Save 100% on your flight
Price was $446, price is now $244 per person
$244
per person
Dec 25 - Dec 30
found 1 day ago
Roundtrip flight included
Los Angeles (LAX) to San Francisco (SFO)
7.2/10 Good! (1,002 reviews)
Staff was nice! The room was a bit dirty, one of the rooms had something like sugar or salt under the glass part of a table that just wasn’t cleaned up. It seemed like the only thing regularly cleaned was the bed which was nice. The parking is terrible, the place they say they is the wrong address!!! I would choose a better option if i was staying in SF again.
Reviewed on Oct 17, 2025
Fitzgerald Hotel
Union Square
Save 100% on your flight
Price was $685, price is now $336 per person
$336
per person
Dec 25 - Dec 31
found 1 day ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
7.8/10 Good! (466 reviews)
It was great breakfast dont know about lsundry room
Reviewed on Oct 21, 2025
Bay Landing San Francisco Airport Hotel
Price was $790, price is now $390 per person
$390
per person
Dec 25 - Dec 31
found 1 day ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
9/10 Wonderful! (4,600 reviews)
breakfast very good; service very good; shuttle good; prefer it to be around the clock…staff friendly, helpful… location good, safe; appreciate the Bayshore pathway behind the hotels…kitchen staff works hard to keep food on display; it’s rude of hotel guests to leave their plates, glasses and mess behind on the tables for staff to clean up… there are no signs indicating that guests should clean up after themselves but really they should be observant and be courteous to the kitchen staff…. overall, a wonderful stay
Reviewed on Oct 23, 2025
The Phoenix Hotel
Downtown San Francisco
Save 100% on your flight
Price was $727, price is now $377 per person
$377
per person
Dec 25 - Dec 31
found 1 day ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
9/10 Wonderful! (1,005 reviews)
Sad to see this place closing down
Reviewed on Oct 12, 2025
Hotel Riu Plaza Fisherman's Wharf
Fisherman's Wharf
Save 100% on your flight
Price was $959, price is now $525 per person
$525
per person
Dec 25 - Dec 31
found 1 day ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
9/10 Wonderful! (7,008 reviews)
Good location. Upgraded from queen to king at check-in. Breakfast was much more than usual hotel offering and the staff worked very hard to keep it replenished and hot. Rooms could use more soundproofing- loud above, and could hear conversation in next room. Bed was comfortable. I’m Loved the seating areas with fire pits out front! Lobby bar bartender was slow and not very friendly or welcoming, so that was a bummer. But overall a good stay!
Reviewed on Oct 24, 2025
Where to stay in Mission District
Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Union Square
4/5(5,164 area reviews)
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
Mission District Hotel Deals
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave, San Francisco, CA
Fully refundable
$123 nightly
The price is $145 total per night from Nov 23 to Nov 24
$145 total
Nov 23 - Nov 24
Total with taxes and fees
8.8/10 Excellent! (4,707 reviews)
I enjoyed my stay — the hotel had a welcoming atmosphere and the amenities were nice. The room was spacious and the bed was comfortable. The only thing that stood out was that it wasn’t quite as clean as I expected (a bit of dust and a few missed spots). Other than that, it was a good experience, ...
Reviewed on Oct 20, 2025
Hilton San Francisco Financial District
750 Kearny St, San Francisco, CA
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $125 total per night from Oct 30 to Oct 31
$125 total
Oct 30 - Oct 31
Total with taxes and fees
8.6/10 Excellent! (1,908 reviews)
It was a pleasant, modern hotel experience. There was little hassle involved in any of the process and it was a great San Francisco location.
Reviewed on Oct 19, 2025
Best Western Plus Grosvenor Airport Hotel
380 S Airport Boulevard, South San Francisco, CA
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $113 total per night from Nov 7 to Nov 8
$113 total
Nov 7 - Nov 8
Total with taxes and fees
8.4/10 Very Good! (1,646 reviews)
Yes
Reviewed on Oct 20, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Mission District
Mission Dolores Park
Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.
San Francisco Public Library
After visiting San Francisco Public Library, make a plan to see the other sights and activities in San Francisco. Discover the entertainment choices and shops in this vibrant area.
Balmy Alley
Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene and fascinating museums in this vibrant area.
Things to do
California Academy of Sciences Daytime Admission
$49
per adult
84% of travellers recommend
Alcatraz Visit with Night Option and SF Bay Cruise
$139
per adult
92% of travellers recommend
California Sunset Cruise (2-hours)
$58
per adult
94% of travellers recommend
Explore a world of travel with Expedia
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- San Francisco Vacations
- Hua Zang Si
- Marsh Theater
- Mission Dolores Park
- SF Armory
- Mission San Francisco de Asís
- Galería de la Raza
- Castro Street
- 22nd St Hill
- Visit Downtown San Francisco
- Fouladi Projects
- San Francisco City Hall
- U.S. Mint
- Visit Mission Dolores
- Castro Theatre
- Harvey Milk Plaza
- San Francisco Zen Center
- Louise Davies Symphony Hall
- Noe Valley Vacations
- The Promenade
- Bill Graham Civic Auditorium
- Randall Museum
- Nobby Clarke Mansion
- Visit Castro District
- Randall Junior Museum
- Golden Gate Model Railroad Club
- Mission Creek Park
- Corona Heights Park
- War Memorial Opera House
- Orpheum Theatre
- Civic Center Plaza
- Vulcan Steps
- McLellan Botanicals
- Painted Ladies
- San Francisco Federal Building
- Kite Hill Open Space
- Asian Art Museum of San Francisco
- United Nations Plaza
- California State Building
- Alamo Square
- Haight Street
- Chase Center
- Van Ness Avenue
- Visit Bernal Heights
- Twin Peaks
- Academy of Art University
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.