Mission District Vacations from $362
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Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages
Price found within the past 48 hours. Click for updated prices.
1 Hotel San Francisco
Downtown San Francisco
Save 100% on your flight
Price was $2,704, price is now $1,565 per person
$1,565
per person
Mar 5 - Mar 11
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Francisco (SFO)
9.2/10 Wonderful! (470 reviews)
My husband and I really enjoyed our stay.
Reviewed on Jan 15, 2026
Montage Healdsburg
Save 100% on your flight
Price was $1,666, price is now $972 per person
$972
per person
Feb 26 - Mar 1
found 1 day ago
Roundtrip flight included
Los Angeles (LAX) to San Francisco (SFO)
9.6/10 Exceptional! (113 reviews)
Clean room, kind and helpful staff. Nice ambiance in vineyard.
Reviewed on Nov 30, 2025
Hotel Riu Plaza Fisherman's Wharf
Fisherman's Wharf
Price was $632, price is now $424 per person
$424
per person
Feb 20 - Feb 23
found 2 days ago
Roundtrip flight included
Boston (BOS) to San Francisco (SFO)
9/10 Wonderful! (7,092 reviews)
Staff was just less than courteous, the room standard a disappointment shower. Water pressure is joke not the mention the small sink. Water pressure was just a drip. But the buffet made up for the disappointing stay. Should we stay here again, hmm maybe not. The zephyr and the holiday inn, I think is the best option next time.
Reviewed on Jan 20, 2026
Where to stay in Mission District
Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Union Square
4/5(5,164 area reviews)
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
Mission District Hotel Deals
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $140 total per night from Jan 25 to Jan 26
$140 total
Jan 25 - Jan 26
Total with taxes and fees
8.8/10 Excellent! (5,147 reviews)
The staff made me feel welcome & quickly addressed any issue I had.
Reviewed on Jan 19, 2026
Hotel Riu Plaza Fisherman's Wharf
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
$142 nightly
The price is $168 total per night from Feb 10 to Feb 11
$168 total
Feb 10 - Feb 11
Total with taxes and fees
8.8/10 Excellent! (7,288 reviews)
The room and facility were very nice and clean. All the staff I came in contact with were very friendly and helpful. The Bell cap was excellent. The location was excellent for walking to the wharf.
Reviewed on Jan 19, 2026
Hilton San Francisco Financial District
750 Kearny St San Francisco CA
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $116 total per night from Feb 15 to Feb 16
$116 total
Feb 15 - Feb 16
Total with taxes and fees
8.6/10 Excellent! (2,303 reviews)
Room was clean. Amenities were okay (there was a small fridge; AC was very cold; and the workstation in the room was large and provided a good view). Would have liked some robes and slippers, which were not included in the room amenities. Furthermore, the coffee machine was not plugged in initially, ...
Reviewed on Jan 17, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Mission District
Mission Dolores Park
5/5(1 review)
Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.
Balmy Alley
Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the acclaimed art scene and fascinating museums in this vibrant area.
Mission San Francisco de Asís
Learn about the local history of San Francisco when you spend time at Mission San Francisco de Asís. Visit the shops and notable monuments in this vibrant area.
Things to do
California Academy of Sciences Daytime Admission
$49
per adult
86% of travellers recommend
Alcatraz Visit with Night Option and SF Bay Cruise
$139
per adult
94% of travellers recommend
San Francisco City Lights Cruise (2-hours)
$58
per adult
94% of travellers recommend
Explore a world of travel with Expedia
- San Francisco Hotels
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- Hotels near Downtown San Francisco
- Hotels near Hua Zang Si
- Hotels near Southern Exposure
- Hotels near Clarion Alley
- Hotels near Women's Building
- Hotels near Victoria Theatre
- Hotels near Marsh Theater
- Hotels near 16th Street Mission Station
- Motels in 16th Street Mission Station
- Hotels near San Francisco Public Library
- Hotels near 24th Street Mission Station
- Hotels near Ratio 3
- Hotels near Mission Dolores Park
- Hotels near Balmy Alley
- Hotels near SF Armory
- Hotels near Mission High School
- Hotels near Mission Dolores
- Hotels near Right Of Way/Liberty St Stop
- Hotels near Mission San Francisco de Asís
- Hotels near Hosfelt Gallery
- Hotels near Galería de la Raza
- Hotels near 22nd St Hill
- Hotels near Oracle Park
- Hotels near Union Square
- Vacation Homes in Church St & 24th St Stop
- Hotels near Market St & Dolores St Stop
- Hotels near Anchor Brewing Company
- Hotels near Castro District
- Hotels near Church Street Station
- Hotels near Market St & Buchanan St Stop
- Hotels near Market St & Guerrero St Stop
- Hotels near Market St & Laguna St Stop
- B&B in Church St & 14th St Stop
- Hotels near Market St & Sanchez St Stop
- Hotels near SOMArts
- Hotels near Church St & Clipper St Stop
- Hotels near U.S. Mint
- Hotels near Duboce Ave & Church St Stop
- Hotels near Emergence Healing Arts Studio
- Hotels near Bill Graham Civic Auditorium
- Gay friendly Hotels in Castro District
- Hotels near Castro Street
- San Francisco Vacations
- Hua Zang Si
- Marsh Theater
- Mission Dolores Park
- SF Armory
- Mission San Francisco de Asís
- Galería de la Raza
- Castro Street
- 22nd St Hill
- Visit Downtown San Francisco
- Fouladi Projects
- San Francisco City Hall
- U.S. Mint
- Visit Mission Dolores
- Castro Theatre
- Harvey Milk Plaza
- San Francisco Zen Center
- Louise Davies Symphony Hall
- Noe Valley Vacations
- The Promenade
- Bill Graham Civic Auditorium
- Randall Museum
- Nobby Clarke Mansion
- Visit Castro District
- Randall Junior Museum
- Golden Gate Model Railroad Club
- Mission Creek Park
- Corona Heights Park
- War Memorial Opera House
- Orpheum Theatre
- Civic Center Plaza
- Vulcan Steps
- McLellan Botanicals
- Painted Ladies
- San Francisco Federal Building
- Kite Hill Open Space
- Asian Art Museum of San Francisco
- United Nations Plaza
- California State Building
- Alamo Square
- Haight Street
- Chase Center
- Van Ness Avenue
- Visit Bernal Heights
- Twin Peaks
- Academy of Art University
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.