
Mission District Vacations from $249
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Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages

SOMA Park Inn – Civic Center
Reviewed on Jul 8, 2026

Treehouse Hotel Silicon Valley
Reviewed on Jul 12, 2026

The Westin St. Francis San Francisco on Union Square
Reviewed on Jul 13, 2026

San Francisco Proper Hotel
Reviewed on Jul 13, 2026

The Grove Inn
Reviewed on Jul 14, 2026
Where to stay in Mission District

Fisherman's Wharf
Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.
Mission District Hotel Deals

Hotel Riu Plaza Fisherman's Wharf
"Great location. Great free breakfast. Friendly staff."
Reviewed on Jul 14, 2026

Holiday Inn Golden Gateway by IHG
"Great place to stay. It’s clean. Everyone is very polite and lots of places to eat. But make sure your room is not next to the elevators. Other than that it was a great stay"
Reviewed on Jul 15, 2026

Hyatt Regency San Francisco
"Check in was weird since you need to go up 2 floors. For valet parking its $95 a day... which seems insane. So we parked a block over at a parking garage for $45 overnight. The hotel it self is nice and clean. But we made the mistake of getting a drink at the bar in the lobby. 2 drinks costs $50 ..."
Reviewed on Jul 14, 2026
Stay near popular Mission District attractions
Things to do

California Academy of Sciences Daytime Admission

Official Alcatraz Inside Prison Tour with Free App Audio Packages

California Sunset Cruise (2-hours)
Explore a world of travel with Expedia
- Old St. Mary's Cathedral
- Golden Gate Theatre
- Kezar Stadium
- Golden Gate Park
- San Francisco Zoo
- Painted Ladies
- Fouladi Projects
- Dragon's Gate
- Van Ness Avenue
- San Francisco Public Library
- Saints Peter and Paul Church
- De Young Museum
- Fisherman's Wharf Vacations
- Balmy Alley
- Crissy Field
- Lombard Street
- Mrs. Doubtfire House
- Telephone Pioneers Communication Museum
- San Francisco Museum of Modern Art
- St. Patrick Catholic Church
- Mission Creek Park
- Grace Cathedral
- Civic Center Vacations
- Civic Center Plaza
- Mission San Francisco de Asís
- Mission Dolores Park
- Embarcadero Center
- San Francisco African American Historical and Cultural Society
- Transamerica Pyramid
- Musée Mécanique
- The Fillmore
- Greek Theater
- Lotta's Fountain
- Orpheum Theatre
- Sf Masonic Auditorium
- Ghirardelli Chocolate Experience
- Westfield San Francisco Centre
- Twin Peaks
- San Francisco Vacations
- Golden Gate Bridge
- Pier 39
- Shn Curran Theatre
- San Francisco City Hall
- Yerba Buena Gardens
- Chase Center
- Sutro Tower
- San Francisco Botanical Garden
- Palace Hotel
- Westin St Francis Hotel Glass Elevators
- United Nations Plaza
- Sf Armory
- Yerba Buena Center for the Arts
- South Beach Vacations
- Bill Graham Civic Auditorium
- Haight-Ashbury Vacations
- Yerba Buena Ice Skating Center
- 450 Sutter Building
- San Francisco Federal Building
- Magowan's Infinite Mirror Maze
- Columbus Tower
- California Academy of Sciences
- Cathedral of Saint Mary of the Assumption
- 555 California Street
- Uss Pampanito
- 22nd St Hill
- Children's Creativity Museum
- Clarion Alley
- Maiden Lane
- Anchor Brewing Company
- Moscone Convention Center
- Walter S. Johnson Park
- Asian Art Museum of San Francisco
- Conservatory of Flowers
- American Conservatory Theater
- Museum of Craft and Folk Art
- Ucsf Medical Center at Mount Zion
- Morrison Planetarium
- Ghirardelli Square
- Muir Woods National Monument
- Aquarium of the Bay
- Alamo Square
- Ripley's Believe It Or Not Museum
- Grateful Dead House
- Palace of Fine Arts
- Academy of Art University
- The Regency Ballroom
- San Francisco Zen Center
- San Francisco Maritime National Historical Park
- Full House House
- Union Square Vacations
- Walt Disney Family Museum
- Japanese Tea Garden
- San Francisco Mint
- Pacific-Union Club
- Baker Beach
- St. Mary Square
- Alcatraz Island
- Coit Tower
- Warfield Theatre

























