Find Adults Only Resorts & Hotels in Northeast Missouri, MO from $73

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Top Northeast Missouri Adults Only Resorts & Hotels

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Recommended hotels in Northeast Missouri

Quality Inn & Suites Hannibal West

2.5 star property
Hannibal
8.0 out of 10, Very Good, (1001)
"Very nice place to stay during a snow storm. "
United States
Teresa
$79 nightly
The price is $92
Jan 2 - Jan 3, 2026
Total with taxes and fees
Quality Inn & Suites Hannibal West

Holiday Inn Express & Suites Wentzville St Louis West by IHG

2.5 star property
Wentzville
9.4 out of 10, Exceptional, (832)
"Excellent location, very clean and comfortable, great hot breakfast, and amazing staff!"
United States
Shannon
$110 nightly
The price is $132
Jan 2 - Jan 3, 2026
Total with taxes and fees
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Pear Tree Inn St. Louis Airport

2.5 star property
St. Ann
9.4 out of 10, Exceptional, (2752)
"The room was clean and staff were very friendly."
United States
Denise
$90 nightly
The price is $106
Dec 13 - Dec 14
Total with taxes and fees
Pear Tree Inn St. Louis Airport

Sleep Inn & Suites Hannibal West

2.5 star property
Hannibal
9.6 out of 10, Exceptional, (1003)
"Great area"
United States
kelvin
$101 nightly
The price is $117
Dec 28 - Dec 29
Total with taxes and fees
Sleep Inn & Suites Hannibal West

Depot Inn and Suites

3.5 star property
La Plata
9.8 out of 10, Exceptional, (613)
"Fantastic stay, highly recommended .... will definitely be coming back."
United States
Chad
$85 nightly
The price is $93
Dec 28 - Dec 29
Total with taxes and fees
Depot Inn and Suites

Super 8 by Wyndham Kirksville-University Area

2.5 star property
Kirksville
9.0 out of 10, Wonderful, (141)
"All the above! Good place overall. "
United States
Michael
$65 nightly
The price is $73
Dec 8 - Dec 9
Total with taxes and fees
Super 8 by Wyndham Kirksville-University Area

The Wildwood Hotel

3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1601)
"The hotel was amazing from the staff to the rooms. Great location as well. Definitely recommend this place if traveling! "
United States
Brandi
$89 nightly
The price is $104
Dec 10 - Dec 11
Total with taxes and fees
The Wildwood Hotel

Hampton Inn St. Charles St. Peters

2.5 star property
St. Charles
8.0 out of 10, Very Good, (1005)
"Great breakfast, clean room, hot tub!"
United States
Tony
$87 nightly
The price is $100
Dec 14 - Dec 15
Total with taxes and fees
Hampton Inn St. Charles St. Peters

Hilton Garden Inn St. Louis/O'Fallon MO

3.0 star property
O'Fallon
8.8 out of 10, Excellent, (714)
"Clean room, quiet"
United States
Laura
$87 nightly
The price is $103
Dec 22 - Dec 23
Total with taxes and fees
Hilton Garden Inn St. Louis/O'Fallon MO

Courtyard by Marriott St. Louis Chesterfield

3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (575)
"Very clean hotel with great staff "
United States
brad
$89 nightly
The price is $104
Dec 26 - Dec 27
Total with taxes and fees
Courtyard by Marriott St. Louis Chesterfield
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Northeast Missouri

Discover top Northeast Missouri attractions

Northeast Missouri offers a delightful blend of natural beauty and cultural experiences that appeal to the discerning traveler. Start your adventure in Hannibal, the beloved hometown of Mark Twain, where you can explore the Mark Twain Boyhood Home and Museum, and take a scenic riverboat cruise on the Mississippi River, soaking in the stunning views and rich history. For outdoor enthusiasts, Thousand Hills State Park near Kirksville is a must-visit, featuring picturesque hiking trails and opportunities for fishing and camping, all surrounded by serene landscapes. If you're seeking a taste of local culture, don't miss the quaint town of Mexico, MO, where you can visit the historic downtown area filled with charming boutiques and cafes. For family fun, the annual Missouri State Fair in Sedalia is a vibrant gathering showcasing local agriculture, crafts, and live entertainment, perfect for creating lasting memories. Lastly, consider staying in the cozy town of Columbia, home to the University of Missouri, where you can find a range of top hotels that provide attentive service and quick access to attractions. These hotels often feature family-friendly amenities and unique local touches, ensuring a comfortable and enjoyable experience as you explore the region.

Top Northeast Missouri Hotel Reviews

Frequently asked questions

How much do adults-only hotels in Northeast Missouri cost?
Adults-only properties in Northeast Missouri come in a variety of prices depending on the amenities provided and the type of room you book. Whatever you decide on, you can get all the youngster-free tranquility you need at a price that doesn't break the bank.
Are there any adult-only all-inclusive resorts in Northeast Missouri?
Unfortunately, there aren't any adult-only all inclusive stays in Northeast Missouri — but Expedia has other options which are sure to have you falling head over heels. The Lodge At Grant's Trail comes with all you need for a perfect romantic getaway in St. Louis. A terrace and wedding services are just two of the many perks on offer. Or, book a room at Drury Inn & Suites St. Louis Brentwood, where you and your soulmate are guaranteed a perfect stay. Also located in St. Louis, amenities here include a staffed front desk and windsurfing.
What is there to do in Northeast Missouri near my adults-only hotel?
Whatever you're interested in, there are many ways to spend your time in Northeast Missouri. If you're vacationing in St. Louis, be sure to look around Fox Theater, St. Louis Aquarium at Union Station and Anheuser-Busch Brewery. Basing yourself in Hannibal? Planters Barn Theater, Bluff City Theater and Mark Twain Boyhood Home and Museum are among the best sights here.
How can I find cheap adults-only hotels in Northeast Missouri?
With Expedia's convenient filter tool, getting your hands on cheap adults-only hotels in Northeast Missouri is easy. Simply refine your search by amenities, budget and star rating to discover stays that'll make your wallet smile.
From what age can you stay in an adult-only hotel in Northeast Missouri?
It varies, but usually it's 16, 18 or 21 years old. Rules may be different from one property to the next, so check the fine print of the adult-only resort or hotel in Northeast Missouri you're considering. Whether you're planning a few days away with your friends or a romantic escape for two, Expedia's adult-only stays are all about stress-free, kid-free good times.
Are all adult-only resorts all-inclusive in Northeast Missouri?
If you're yearning for a hassle-free vacation, an adult-only all-inclusive resort delivers a generous helping of rest and relaxation. To discover what's available in Northeast Missouri, enter your dates of travel and then click on the "all-inclusive" filter. Keep on the lookout for stays listed as "adults only." Click on the properties you'd like to view to find out what you can expect for your money. The rate usually includes the room, food and drinks, on-site activities and daily entertainment.
Why book your adults-only hotel in Northeast Missouri with Expedia?
Expedia has an impressive selection of adults-only hotels at economical rates in Northeast Missouri. Take advantage of our search filters to choose how much you're willing to spend and then sort the price from lowest to highest. Whether you're planning a couples escape or want to party with friends, we'll help you find an ideal space.
When is the best time to stay at an adult-only all-inclusive resort in Northeast Missouri?
The best time to book an adult-only all-inclusive resort in Northeast Missouri depends on a few factors, the first one being the weather. Also consider whether you prefer to experience the excitement of peak season, when demand for hotels and flights is high, or the off-season when things slow down a bit more. Weigh up your personal travel style and budget before locking in your dream adult-only escape that comes with the works!
Can I cancel or change my adult-only resort booking?
It is possible to cancel or change your booking, but check the details in your itinerary or visit Expedia's Trips portal to learn what rules apply. Whether you have to pay a fee depends on the type of adult-only resort or hotel booking you made. Haven't locked in your Northeast Missouri getaway yet? Look for adult-only hotels that allow a full refund — because even the best plans can go awry!

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