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Featured Orangeburg Luxury Hotels

See all 60 Hotels in Orangeburg
Red Roof Inn Santee

Red Roof Inn Santee

9091 Old Hwy 6, Santee
2.0 out of 5.0
2.8 out of 5 (170 reviews)
Great Please tight off I-95This really is a nice place. Nothing fancy, however it does have everything for your basic needs. The staff is friendly and helpful. Breakfast is included which includes hot and cold items.
 Traveler Mar 28, 2016

$59

$59
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

221 Britain St, Santee
2.5 out of 5.0
3.8 out of 5 (303 reviews)
Pleasant, clean hotel...nice staffThe only suggestions I can make is that this hotel needs a little repair. It looks like that is happening as the 3rd floor was under repair.
  Jan 15, 2018

$99

$99
Baymont Inn & Suites Orangeburg North

Baymont Inn & Suites Orangeburg North

3583 Saint Matthews Rd, Orangeburg
3.0 out of 5.0
3.9 out of 5 (518 reviews)
Not what I was expectingWhen my boyfriend and I first drove in the lot it was nothing fancy. Looked like a regular motel with the exception of a new sign for the building. We walked in and was directed to our room. We walked outside and found it on our own. We ended up waking past an ice and snack machine. Both not in the ...
  Oct 19, 2015

$78

$78
Knights Inn Santee

Knights Inn Santee

249 Britain Street, Santee
2.0 out of 5.0
2.9 out of 5 (404 reviews)
Nice location just off hwyNice staff and good breakfast great location I have nothing else to say but keep up the good work this was are 4th stay when traveling to Florida
  Jan 4, 2018

$59

$59
Whitten Inn

Whitten Inn

123 Mall Street, Santee
2.5 out of 5.0
2.5 out of 5 (105 reviews)
OK for an Overnight StopWe booked two rooms since we were a family of 6. We stopped here on our way down to Orlando. It's not a fancy hotel but it suited the need to just rest to continue our journey from NJ. The room was clean which is the most important thing. The room did not have any toiletries, you had to ask the front ...
 Judi Aug 5, 2014
Econo Lodge

Econo Lodge

9112 Old 6 Highway, Santee
2.5 out of 5.0
3.1 out of 5 (218 reviews)
Convenient and cleanThis motel was easily accessible from 95 on our way to Pennsylvania from Florida. I stayed the night with my husband and two boys and we found it to be very comfortable and clean. We parked right outside of our door which made it easy to access our luggage. Breakfast was a bonus. It's not fancy, ...
 Jessica Apr 6, 2015
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Recently booked Luxury Hotels in Orangeburg

Hampton Inn & Suites Orangeburg
2.5 out of 5.0
Last booking: 2 hours ago
Orangeburg - Days Inn South
2.0 out of 5.0
Last booking: 9 hours ago
Baymont Inn & Suites Orangeburg North
3.0 out of 5.0
Last booking: 11 hours ago
Hampton Inn Santee I-95
3.0 out of 5.0
Last booking: 12 hours ago
Red Roof Inn Santee
2.0 out of 5.0
Last booking: 18 hours ago
Baymont Inn And Suites Orangeburg
2.5 out of 5.0
Last booking: 18 hours ago
Knights Inn Santee
2.0 out of 5.0
Last booking: 18 hours ago
Whitten Inn
2.5 out of 5.0
Last booking: 20 hours ago
Comfort Inn & Suites
3.0 out of 5.0
Last booking: 33 hours ago

A few days away keeps your stress at bay, especially when you're enjoying a stay in Orangeburg. Brilliant activities, exquisite eats, and the most breathtaking photo opportunities: these are just some of the reasons to take a trip to Orangeburg. You'll grab tickets to the most popular performances, devour spectacular cuisine, and marvel at the top monuments and landmarks in the region. Naturally, you'll stay at a luxury hotel! Sampling the finer things in life is just your speed, so get your upscale hotel in Orangeburg on Expedia.com today, and your relaxing getaway is off to a good start.

Plan a Luxury Orangeburg Vacation

If you doubt that Orangeburg is full of amazing things to do, you should know that plenty of folks are happy to call it home. Whether you’re looking to spend your vacation dining on fine seasonal food or browsing art galleries in Orangeburg, you'll never be disappointed. Orangeburg is full of impressive hotels on top of appealing attractions, so you can count on a spectacular stay. Book well in advance to get the best room!

An upscale vacation is your chance to live your best life, including eating at 5-star restaurants and getting VIP tickets. When you save big by booking on Expedia.com, you never have to limit yourself. Thanks to our hotel deals, you'll still have a healthy budget for the most indulgent and intriguing things to do. After a day of exploring the city, your luxury accommodations will welcome you back to extravagant amenities. Before you drift off to dreamland, order a glass of wine to your room and revel in your successful day. The luxury accommodations in Orangeburg will soothe you into a state of relaxation as soon as you check in.

Luxury Hotels in Orangeburg

There's no better time than right now to book a hotel in Orangeburg, and Expedia.com is here to help. Search through the bounty of real traveler reviews on more than a dozen hotels and then book your ideal room in minutes. Luxury accommodations offer amenities like elegant suites and VIP services. Some of the city's luxury accommodations even feature impeccable penthouses, while others have reinvigorating spa treatments. Book your dream hotel in Orangeburg now, and prepare for the experience of your life!