Title: Top Independent in Panacea, FL - Expedia.com [Panacea Travel Guide](https://expedia.com/Panacea.dx3000431554)[Hotels in Panacea](https://expedia.com/Panacea-Hotels.d3000431554.Travel-Guide-Hotels)[Vacation Rentals in Panacea](https://expedia.com/Panacea-Vacation-Rentals.d3000431554.Travel-Guide-VacationRentals)[Flights to Panacea](https://expedia.com/Cheap-Flights-To-Panacea.d3000431554.Travel-Guide-Flights)[Car Rentals in Panacea](https://expedia.com/Car-Rentals-In-Panacea.d3000431554.Car-Rental-Guide)[Panacea Vacation Packages](https://expedia.com/Panacea.d3000431554.Destination-Travel-Guides) ![Sunset over a lake at Panacea, northern Florida, USA | NONE |](https://images.trvl-media.com/place/3000431554/82102cb8-9bdc-4f33-be26-bab6063d4ccd.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/3000431554/82102cb8-9bdc-4f33-be26-bab6063d4ccd.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Mar 6 - Mar 7](https://www.expedia.com/Hotel-Search?regionId=3000431554&startDate=2026-03-06&endDate=2026-03-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 7 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=3000431554&startDate=2026-03-07&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=3000431554&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=3000431554&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FPanacea-Hotels-Independent.0-0-d3000431554--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FPanacea-Hotels-Independent.0-0-d3000431554--bIndependent.Travel-Guide-Filter-Hotels) ## Top Panacea Hotel Reviews ![PRIVATE LUXURY BEACHFRONT HOME!](https://images.trvl-media.com/lodging/56000000/55370000/55361200/55361115/6cd29c9b_y.jpg) ### PRIVATE LUXURY BEACHFRONT HOME! 10/10 Excellent "We had a great time, the place was wonderful and had everything we needed right there for us. We would come again!" [](https://expedia.com/Panacea-Hotels-NEW-5-Bedroom-5-Bathroom-Beachfront-Home-With-Views-From-Every-Room.h55361115.Hotel-Information) ![Hideaway Beach Cottage on waterfront with amazing views.](https://images.trvl-media.com/lodging/89000000/89000000/88994400/88994349/8441415a_y.jpg) ### Hideaway Beach Cottage on waterfront with amazing views. 10/10 Excellent "It was a super place and we enjoyed it very much. we may return next year." [](https://expedia.com/Panacea-Hotels-Hideaway-Beach-Cottage-On-Waterfront-With-Amazing-Views.h88994349.Hotel-Information) ![Alligator Point "Old Florida” Beachfront Cottage ](https://images.trvl-media.com/lodging/35000000/34590000/34581200/34581134/2c943c28_y.jpg) ### Alligator Point "Old Florida” Beachfront Cottage 10/10 Excellent "Wendy is THE BEST host. Her cottage is so warm and welcoming and she is the most caring host I have have the pleasure of encountering. She supplies everything and anything you need to be relaxed and comfortable, the cottage is spotless and the location is perfect for our fur family. This was our second stay and we cannot wait until next year!" [](https://expedia.com/Panacea-Hotels-Charming-Alligator-Point-Old-Florida-Beach-Cottage.h34581134.Hotel-Information) ![Private Beachfront w/ Sauna, Hottub, Golf Cart, Kayaks, Paddle Boards & Bikes +](https://images.trvl-media.com/lodging/108000000/107290000/107284100/107284077/5342dafe_y.jpg) ### Private Beachfront w/ Sauna, Hottub, Golf Cart, Kayaks, Paddle Boards & Bikes + 8/10 Good "Host was very accommodating" [](https://expedia.com/Panacea-Hotels-Private-Beachfront-W-Golf-Cart.h107284077.Hotel-Information) ![BEACHFRONT! VIEWS! Pet Friendly! Fenced Yard! Perfect Summer Getaway!](https://images.trvl-media.com/lodging/28000000/27130000/27128700/27128696/e0dfec7c_y.jpg) ### BEACHFRONT! VIEWS! Pet Friendly! Fenced Yard! Perfect Summer Getaway! 10/10 Excellent "beautiful property!" [](https://expedia.com/Panacea-Hotels-BEACHFRONT-May-31-June-7-Just-Came-Available-10-Discount-Fenced-Yard-Pets.h27128696.Hotel-Information) ![Beach Getaway Just Refreshed, Sleeps 8 <4 br> EV level 2 charging- views](https://images.trvl-media.com/lodging/88000000/87140000/87136300/87136285/563d846f_y.jpg) ### Beach Getaway Just Refreshed, Sleeps 8 <4 br> EV level 2 charging- views 10/10 Excellent "We had Great communication throughout this booking. The owner (Host) was very quick to respond and very helpful. My family and I throughly enjoyed our stay. I highly recommend. " [](https://expedia.com/Panacea-Hotels-Beach-Getaway-Just-Refreshed.h87136285.Hotel-Information) ![The Panacea Motel](https://images.trvl-media.com/lodging/96000000/95080000/95072000/95071987/7ddc9d09_y.jpg) ### The Panacea Motel 10/10 Excellent "The rooms are decorated cute. Comfortable beds and they make check in and check out very simple. This is a great area to go fish and meet nice people." [](https://expedia.com/Panacea-Hotels-The-Panacea-Motel.h95071987.Hotel-Information) ![Oceanfront on a Private Beach-Hot Tub-Beautifully Remodeled-Dog Friendly Beach](https://images.trvl-media.com/lodging/99000000/98480000/98476700/98476634/29730e55_y.jpg) ### Oceanfront on a Private Beach-Hot Tub-Beautifully Remodeled-Dog Friendly Beach 10/10 Excellent "The best place ever! I would give them a 12 out of 10 if I could. The hosts are great to deal with., quick response and super nice people - and no I am not an old friend or relative! House is immaculate, with all the little extras like baggies, chip clips, extra toothbrushes, toothpaste, doggie doo bags. Let alone the bikes, kayaks, fishing equipment, extra towels and my favorite - a vacuum! And it's a dyson. I can't tell you the number of longer term stays we've been in that have no vacuum, or one that is a POS. Beautiful view, sunsets and privacy from beach walkers. Quiet setting, sweet neighbors next door and good restaurants that require a fifteen minute drive, but are good. The Trident and Hamaknockers stand out in our book. We will return and recommend this place to anyone who will listen." [](https://expedia.com/Panacea-Hotels-Oceanfront-Private-Beach-Beautifully-Decorated-Remodeled-On-121-Acres.h98476634.Hotel-Information) ![Ochlockonee Bay Waterfront Home 200 ft pier 1st floor over looking the bay](https://images.trvl-media.com/lodging/107000000/106380000/106377800/106377762/82e3e83b_y.jpg) ### Ochlockonee Bay Waterfront Home 200 ft pier 1st floor over looking the bay 10/10 Excellent "Vert nice house, very clean and confortable , perfect for relax and fish on the dock, amazing fish, really nice host....ty nancy " [](https://expedia.com/Panacea-Hotels-Waterfront-Home-200-Ft-Pier1st-Floor.h106377762.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Ochlockonee Bay Hotels ](https://www.expedia.com/Ochlockonee-Bay-Hotels.d553248635975855809.Travel-Guide-Hotels) - [Hotels near USS Mohawk CGC Veterans Memorial Reef ](https://www.expedia.com/USS-Mohawk-CGC-Veterans-Memorial-Reef-Hotels.0-l553248621561885546-0.Travel-Guide-Filter-Hotels) - 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