Title: Top Independent in Panacea, FL - Expedia.com [Panacea Travel Guide](https://expedia.com/Panacea.dx3000431554)[Hotels in Panacea](https://expedia.com/Panacea-Hotels.d3000431554.Travel-Guide-Hotels)[Vacation Rentals in Panacea](https://expedia.com/Panacea-Vacation-Rentals.d3000431554.Travel-Guide-VacationRentals)[Flights to Panacea](https://expedia.com/Cheap-Flights-To-Panacea.d3000431554.Travel-Guide-Flights)[Car Rentals in Panacea](https://expedia.com/Car-Rentals-In-Panacea.d3000431554.Car-Rental-Guide)[Panacea Vacation Packages](https://expedia.com/Panacea.d3000431554.Destination-Travel-Guides) ![Sunset over a lake at Panacea, northern Florida, USA | NONE |](https://images.trvl-media.com/place/3000431554/82102cb8-9bdc-4f33-be26-bab6063d4ccd.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/3000431554/82102cb8-9bdc-4f33-be26-bab6063d4ccd.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Mar 4 - Mar 5](https://www.expedia.com/Hotel-Search?regionId=3000431554&startDate=2026-03-04&endDate=2026-03-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 5 - Mar 6](https://www.expedia.com/Hotel-Search?regionId=3000431554&startDate=2026-03-05&endDate=2026-03-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=3000431554&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=3000431554&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FPanacea-Hotels-Independent.0-0-d3000431554--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FPanacea-Hotels-Independent.0-0-d3000431554--bIndependent.Travel-Guide-Filter-Hotels) ## Top Panacea Hotel Reviews ![BEACHFRONT! VIEWS! Pet Friendly! Fenced Yard! Perfect Summer Getaway!](https://images.trvl-media.com/lodging/28000000/27130000/27128700/27128696/e0dfec7c_y.jpg) ### BEACHFRONT! VIEWS! Pet Friendly! Fenced Yard! Perfect Summer Getaway! 10/10 Excellent "beautiful property!" [](https://expedia.com/Panacea-Hotels-BEACHFRONT-May-31-June-7-Just-Came-Available-10-Discount-Fenced-Yard-Pets.h27128696.Hotel-Information) ![Beach Getaway Just Refreshed, Sleeps 8 <4 br> EV level 2 charging- views](https://images.trvl-media.com/lodging/88000000/87140000/87136300/87136285/0a0672a1_y.jpg) ### Beach Getaway Just Refreshed, Sleeps 8 <4 br> EV level 2 charging- views 10/10 Excellent "We had Great communication throughout this booking. The owner (Host) was very quick to respond and very helpful. My family and I throughly enjoyed our stay. I highly recommend. " [](https://expedia.com/Panacea-Hotels-Beach-Getaway-Just-Refreshed.h87136285.Hotel-Information) ![The Panacea Motel](https://images.trvl-media.com/lodging/96000000/95080000/95072000/95071987/f641ddea_y.jpg) ### The Panacea Motel 10/10 Excellent "The rooms are decorated cute. Comfortable beds and they make check in and check out very simple. This is a great area to go fish and meet nice people." [](https://expedia.com/Panacea-Hotels-The-Panacea-Motel.h95071987.Hotel-Information) ![Private Beachfront w/ Sauna, Hottub, Golf Cart, Kayaks, Paddle Boards & Bikes +](https://images.trvl-media.com/lodging/108000000/107290000/107284100/107284077/5342dafe_y.jpg) ### Private Beachfront w/ Sauna, Hottub, Golf Cart, Kayaks, Paddle Boards & Bikes + 10/10 Excellent "Host was very responsive and helpful. The home was filled with amenities to make the stay pleasant." [](https://expedia.com/Panacea-Hotels-Private-Beachfront-W-Golf-Cart.h107284077.Hotel-Information) ![Best deal at Alligator Point](https://images.trvl-media.com/lodging/34000000/33490000/33486800/33486730/f2e6bb56_y.jpg) ### Best deal at Alligator Point 10/10 Excellent "The house was great fun with the pool table, the bed was comfy and the sunsets were outstanding. Lots of room for our motorcycle trailer and truck." [](https://expedia.com/Panacea-Hotels-Best-Deal-At-Alligator-Point.h33486730.Hotel-Information) ![Oceanfront on a Private Beach-Hot Tub-Beautifully Remodeled-Dog Friendly Beach](https://images.trvl-media.com/lodging/99000000/98480000/98476700/98476634/9da6b804_y.jpg) ### Oceanfront on a Private Beach-Hot Tub-Beautifully Remodeled-Dog Friendly Beach 10/10 Excellent "The best place ever! I would give them a 12 out of 10 if I could. The hosts are great to deal with., quick response and super nice people - and no I am not an old friend or relative! House is immaculate, with all the little extras like baggies, chip clips, extra toothbrushes, toothpaste, doggie doo bags. Let alone the bikes, kayaks, fishing equipment, extra towels and my favorite - a vacuum! And it's a dyson. I can't tell you the number of longer term stays we've been in that have no vacuum, or one that is a POS. Beautiful view, sunsets and privacy from beach walkers. Quiet setting, sweet neighbors next door and good restaurants that require a fifteen minute drive, but are good. The Trident and Hamaknockers stand out in our book. We will return and recommend this place to anyone who will listen." [](https://expedia.com/Panacea-Hotels-Oceanfront-Private-Beach-Beautifully-Decorated-Remodeled-On-121-Acres.h98476634.Hotel-Information) ![PRIVATE LUXURY BEACHFRONT HOME!](https://images.trvl-media.com/lodging/56000000/55370000/55361200/55361115/c761bdff_y.jpg) ### PRIVATE LUXURY BEACHFRONT HOME! 10/10 Excellent "We are a family of 11 adults from Boston, CT, NYC, & TX who gathered for a 4-day reunion and visit elderly grandparents at St Teresa. Nikki’s place was magical! From the moment we stepped inside we were bowled over by the views, spaciousness and cleanliness of the home, and a kitchen & dining space that is perfect for our “tribe.” Nikki has decorated and equipped the home so beautifully and thoughtfully! For a mid-February stay, the weather was perfect. We got to experience one dramatic storm and then beautiful warm weather perfect for long walks on the beach in jeans and t-shirts. Having a grill was so great for a celebration dinner as our youngest son proposed to his girlfriend there on the beach. Nikki went the extra mile to put us in contact with a professional photographer (Jenna Reichert) who came by for family photos. I wholeheartedly give this stunning home a thousand stars — Thank you Nikki! " [](https://expedia.com/Panacea-Hotels-NEW-5-Bedroom-5-Bathroom-Beachfront-Home-With-Views-From-Every-Room.h55361115.Hotel-Information) ![Hideaway Beach Cottage on waterfront with amazing views.](https://images.trvl-media.com/lodging/89000000/89000000/88994400/88994349/8441415a_y.jpg) ### Hideaway Beach Cottage on waterfront with amazing views. 10/10 Excellent "The view was the incredible. Many little details to show care - beach toys, beach towels, blankets, dog bowl, etc. " [](https://expedia.com/Panacea-Hotels-Hideaway-Beach-Cottage-On-Waterfront-With-Amazing-Views.h88994349.Hotel-Information) ![ Charming Alligator Point "Old Florida” Beach Cottage ](https://images.trvl-media.com/lodging/35000000/34590000/34581200/34581134/2c943c28_y.jpg) ### Charming Alligator Point "Old Florida” Beach Cottage 10/10 Excellent "The cottage is perfectly clean and furnished with many cozy touches as well as beautiful art. Wendy is one of the most friendly and welcoming hosts of any place where we've visited. What we enjoy the most about the house is the location in a quiet, non-crowded area away from traffic, with only the birds and sea life surrounding us. The view of sunrise and sunset from the screened porch is beyond compare!" [](https://expedia.com/Panacea-Hotels-Charming-Alligator-Point-Old-Florida-Beach-Cottage.h34581134.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Ochlockonee Bay Hotels ](https://www.expedia.com/Ochlockonee-Bay-Hotels.d553248635975855809.Travel-Guide-Hotels) - [Hotels near USS Mohawk CGC Veterans Memorial Reef ](https://www.expedia.com/USS-Mohawk-CGC-Veterans-Memorial-Reef-Hotels.0-l553248621561885546-0.Travel-Guide-Filter-Hotels) - [Medart Hotels ](https://www.expedia.com/Medart-Hotels.d553248635975866185.Travel-Guide-Hotels) - [Hotels near Ochlockonee River State Park ](https://www.expedia.com/Ochlockonee-River-State-Park-Hotels.0-l553248621532653556-0.Travel-Guide-Filter-Hotels) - [Sopchoppy Hotels ](https://www.expedia.com/Sopchoppy-Hotels.d6355340.Travel-Guide-Hotels) - [Cabin Rentals in Sopchoppy ](https://www.expedia.com/Sopchoppy-Cabins.d6355340-aaCabins.Travel-Guide-Accommodation) - [Motels in Sopchoppy ](https://www.expedia.com/Sopchoppy-Motels.d6355340-aaMotels.Travel-Guide-Accommodation) - 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