Beginning of main content

Panama City Resorts & Spas

Search Flights

Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Panama City Hotels

Search Flight + Hotel

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Panama City Resorts & Hotels with Spas

See all 154 Hotels in Panama City
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

Km 6 Road to Veracruz, Panama City
5.0 out of 5.0
4.2 out of 5 (128 reviews)
Wonderful Ocean ViewsA society wedding during our stay was like a free fashion show!
  Jul 8, 2017

$149

$149
Eurostars Panama City

Eurostars Panama City

Calle Ricardo Arias, Panama City
4.0 out of 5.0
3.9 out of 5 (125 reviews)
Elegant hotel. Love the room. spacious room. very clean. with view we enjoy our stay and will go back on our next trip
  Jul 18, 2017

$60

$60
Trump Ocean Club International Hotel and Tower Panama

Trump Ocean Club International Hotel and Tower Panama

Calle Punta Colon, Punta Pacifica, Panama City
5.0 out of 5.0
4.3 out of 5 (386 reviews)
Pretty good hotel in Panama CityI always stay at the Trump when visiting Panama City on business. The Hotel location is great with easy access to main roads and some pretty good malls. Room size is very good and they are nice if you have to stay in to do a little work. Design is modern and different from your typical hotel. Staff ...
  Jul 19, 2017

$149

$149
Veneto Hotel & Casino

Veneto Hotel & Casino

Eusebio A Morales Ave And Via Veneto Str, Panama City
3.5 out of 5.0
3.1 out of 5 (485 reviews)
Nice location, friendly staffI was worried after booking and then reading the reviews but I was pleasantly surprised. Hotel is in a great location and staff are very friendly. I got extra towels within 15 minutes of check in. Rooms were cleaned daily and breakfast was excellent. There are a couple of things that need work like ...
  Jul 13, 2017

$56

$56
TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro

Via Veneto, El Cangrejo Bellavista, Panama City
3.5 out of 5.0
4.3 out of 5 (311 reviews)
A pleasant surprise!I thoroughly enjoyed my stay at the TRYP by Wyndham Panama Centro. Excellent location and within walking distance of good restaurants and transportation. The facility is very well-kept and does not have the feel of a big and impersonal hotel, quite the contrary. The room was most comfortable, clean, ...
  Jul 19, 2017

$59

$59
Sortis Hotel, Spa & Casino, Autograph Collection

Sortis Hotel, Spa & Casino, Autograph Collection

56 y 57 East Street, Obarrio, Panama City
4.5 out of 5.0
4.4 out of 5 (68 reviews)
Great Hotel and Casino in Panama City ObarrioThis is a great and modern hotel in a convenient location in the city. The staff are friendly and will provide any kind of assistance you may need. A casino is attached to the hotel and has a good vibe. It wasn't smoke filled and everything was clean. My only complaint would be the selection and ...
  Jul 16, 2017

$125

$125
Bristol Panama

Bristol Panama

Avenida Aquilino de La Guardia, Panama City
5.0 out of 5.0
4.5 out of 5 (153 reviews)
Great hotel and staff..Great hotel and staff. Walking distance to everything we needed. I would definitely stay again.
  Jul 14, 2017

$129

$129
Hard Rock Hotel Panama Megapolis

Hard Rock Hotel Panama Megapolis

Ave. Balboa al lado de Multicentro, Panama City
4.5 out of 5.0
4.1 out of 5 (727 reviews)
Very active hotelThere is s lot to do at this hotel. The nightlife is full of energy. The view from the 62 floor at night was incredible.
  Jul 6, 2017

$138

$138
Radisson Decapolis Panama City

Radisson Decapolis Panama City

Avenida Balboa Con Multicentro, Panama City
4.0 out of 5.0
4.4 out of 5 (251 reviews)
4 Day trip to Panama cityHotel is well located within a short taxi ride to casco Antigua and the canal. Right next door to shopping. Complimentary breakfast is the best my wife and I have had and over the last 30 years we have travelled extensively. Never ate in hotel other than breakfast as there are numerous restaurants ...
  Jul 18, 2017

$98

$98
RIU Plaza Panama

RIU Plaza Panama

Calle 50, Urb. Marbella, Panama City
4.0 out of 5.0
4.3 out of 5 (484 reviews)
perfect, staff, food, room very clean - nice location
  Jul 23, 2017

$88

$88
Map

Recently booked Panama City hotels

Novotel Panama City
4.0 out of 5.0
Last booking: 3 hours ago
Hotel Costa Inn
3.0 out of 5.0
Last booking: 5 hours ago
Bristol Panama
5.0 out of 5.0
Last booking: 6 hours ago
Continental Hotel & Casino
4.0 out of 5.0
Last booking: 7 hours ago
The Westin Playa Bonita Panama
5.0 out of 5.0
Last booking: 7 hours ago
Ramada Plaza Panama Punta Pacifica
4.0 out of 5.0
Last booking: 7 hours ago
Hotel Coral Suites
3.5 out of 5.0
Last booking: 8 hours ago
TRYP by Wyndham Panamá Centro
3.5 out of 5.0
Last booking: 9 hours ago
Las Americas Golden Tower Panama
4.0 out of 5.0
Last booking: 10 hours ago

Panama City Resorts & Spa Travel Guide

Pamper Yourself with a Spa Day in Panama City

Take a deep breath and let yourself relax. Take the opportunity for a weekend where you can have all your worries melt away in Panama City. If you are looking for extravagant hotel or budget-friendly selections, we can help you find the ideal location to stay. Pack up your suitcase and not your worries to initiate your pressure-free vacation.

Book a Panama City Spa Vacation that Won't Break the Bank

Once you've checked-in to your Panama City hotel then you can check-out from your worries for a bit. Unwind and stretch out for a bit. After that you can schedule your first appointment to indulge yourself at a nearby spa. After you've indulged yourself by getting a massage treatment, relaxing in the steam room, or taking it easy by the pool, you can put on your explorer's hat and uncover the hidden gems of Panama City. Discovering hip cafes, eclectic boutiques, or a scenic view can be one of the many highlights of your vacation. If you're not sure where to begin, ask your hotel's concierge to get a feel for what Panama City has to offer. There is no better source than a local to point you to an exciting evening out or to a cafe to sip a few cocktails at and socialize. Wherever you end up, just be sure to hang loose. Your spa sabbatical shouldn't be anything but exceptionally relaxing.

When you are ready to find the best hotel in Panama City for your spa break, book through Expedia and envision all the ways you are going to relax.