Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 590,000 properties worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Panama Independent Hotels

See all 525 Hotels in Panama
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Vía Tocumen, Tocumen
4.5 out of 5.0

$94

$94
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

Italy Avenue, Punta Paitilla, Panama City
4.0 out of 5.0

$69

$69
Central Hotel Panama

Central Hotel Panama

Plaza de la Independencia Casco Viejo, Panama City
4.5 out of 5.0
The Saba Hotel

The Saba Hotel

Panama Internacional zone,Argentina Ave, Panama City
4.0 out of 5.0
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

Av. Balboa con Calle 53, Panama City
4.5 out of 5.0

$127

$127
Playa Blanca Beach Resort All Inclusive

Playa Blanca Beach Resort All Inclusive

115 Km Via Interamericana, Rio Hato
3.5 out of 5.0

$123

$123
Veneto Hotel & Casino

Veneto Hotel & Casino

Eusebio A Morales Ave And Via Veneto Str, Panama City
3.0 out of 5.0
Principe Hotel and Suites

Principe Hotel and Suites

Via Argentina, Panama city
3.0 out of 5.0
Hotel Coral Suites

Hotel Coral Suites

Calle D El Cangrejo, Panama City
4.0 out of 5.0
Hotel El Parador

Hotel El Parador

Eusebio Morales Ave, Panama City
3.5 out of 5.0
Global Hotel Panama

Global Hotel Panama

Calle 54 Este y Samuel Lewis, Panama City
4.0 out of 5.0
Royal Decameron Golf, Beach Resort and Villas All Inclusive

Royal Decameron Golf, Beach Resort and Villas All Inclusive

KM 115 Carretera, Rio Hato
3.5 out of 5.0

$262

$262
American Trade Hotel

American Trade Hotel

Plaza Herrera Casco Viejo, Panama City
4.5 out of 5.0
Gamboa Rainforest Resort

Gamboa Rainforest Resort

Corregimiento de Cristobal, IA 5, Gamboa
3.5 out of 5.0
Hotel Ciudad De David

Hotel Ciudad De David

Calle D Norte, Avenida 2da Este, David
4.0 out of 5.0

$78

$78
Hotel Centroamericano

Hotel Centroamericano

Avenida Ecuador y Justo Arosemena, Panama City
3.5 out of 5.0
Hotel Casa Panamá

Hotel Casa Panamá

Avenida Eloy Alfaro y Calle 11, Panama City
4.5 out of 5.0

$83

$83
DeVille Hotel Boutique

DeVille Hotel Boutique

50 street and Beatriz M. De Cabal, Panama City
4.5 out of 5.0
The Executive Hotel

The Executive Hotel

Calle 52, Panama City
4.0 out of 5.0
Hotel Palma Royale

Hotel Palma Royale

Calle 3ra, Bocas Town, Bocas del Toro
4.0 out of 5.0

Recently booked Panama hotels

Los Mandarinos Boutique Spa and Hotel
4.5 out of 5.0
Last booking: 26 minutes ago
Hyatt Place Panama City/Downtown
4.0 out of 5.0
Last booking: 33 minutes ago
Hotel Terranova
3.5 out of 5.0
Last booking: 40 minutes ago
The Westin Panama
4.5 out of 5.0
Last booking: 48 minutes ago
Nitro City Panama Action Sports Resort
4.5 out of 5.0
Last booking: 59 minutes ago
Dreams Delight Playa Bonita Panama - All Inclusive
4.5 out of 5.0
Last booking: 1 hour ago
Principe Hotel and Suites
3.0 out of 5.0
Last booking: 1 hour ago
RIU Plaza Panama
4.5 out of 5.0
Last booking: 1 hour ago
Riu Playa Blanca - All Inclusive
4.0 out of 5.0
Last booking: 2 hours ago

Pocket Guide: Independent Hotels in Panama

Search for hotels in Panama on Expedia. You can easily find your hotels in Panama using one of the methods below:

  • View our selection of featured hotels in Panama
  • Use the map to find hotels in the Panama neighborhood you prefer
  • Use the filters to see hotels in a specific area of Panama, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Panama
  • Enter your travel dates to view the best deals on hotels in Panama - while they last