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Featured Panama Independent Hotels

See all 466 Hotels in Panama
Los Mandarinos Boutique Spa and Hotel

Los Mandarinos Boutique Spa and Hotel

Calle Del Ciclo El Valle De Anton Cocle, El Valle de Anton
4.0 out of 5.0
3.8 out of 5 (45 reviews)
Great place Nice hotel with great restaurant. Can't wait to visit again. - 

$169

$169
DeVille Hotel Boutique

DeVille Hotel Boutique

50 street and Beatriz M. De Cabal, Panama City
4.0 out of 5.0
4.2 out of 5 (98 reviews)
Service level not what it used to be. Night manager doesn't speak English, area becomes more prostitute-infested at night which can make … - 

$50

$50
Nitro City Panama Action Sports Resort

Nitro City Panama Action Sports Resort

Paseo Andres Maduro, Punta Chame
4.0 out of 5.0
3.6 out of 5 (15 reviews)
It is a shame that some activities were unavailable. - 
Bocas del Mar Hotel

Bocas del Mar Hotel

Road to Boca Chica, Boca Chica
4.0 out of 5.0
4.9 out of 5 (29 reviews)
Very nice hotel with an amazing staff. We enjoyed our stay. Very relaxing place in a remote location. Certainly not touristy. Beautiful vi … - 

$159

$159
Red Frog Beach Island Resort

Red Frog Beach Island Resort

Isla Bastimentos, Isla Bastimentos
4.0 out of 5.0
4.3 out of 5 (29 reviews)
Amazing hotel resort in the middle of the paradise I have not the right words for that great hotel resort and experience in the middle of the nature. … - 

$130

$130
San Francisco Apartments

San Francisco Apartments

Punta Paitilla, Calle Ramón H Jurado, Panama City
4.0 out of 5.0
3.8 out of 5 (6 reviews)
Downtown Panama Our experience in Panama at San Francisco Apartments was exceptional. The one hiccup was a three ho … - 

$120

$120
Continental Hotel & Casino

Continental Hotel & Casino

Via España & Ricardo Arias Street, Panama City
4.0 out of 5.0
3.6 out of 5 (308 reviews)
Downtown Hotel Nice downtown hotel. Convenient location. Close to activities and restaurants. - 

$60

$60
Hotel Valle del Rio, S.A

Hotel Valle del Rio, S.A

Camino Valle Escondido, Boquete
4.0 out of 5.0
4.3 out of 5 (19 reviews)
Quiet, nice view to river and near to town Nice for families, kids had a great moment. Prices of restaurant could be more affordable - 

$123

$123
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Vía Tocumen, Tocumen
4.0 out of 5.0
3.8 out of 5 (623 reviews)
Nice, cozy and comfortable. Very close to airport. The staff from checking in/out to the cleaning people are very helpful and friendly. - 

$91

$91
Playa Tortuga Hotel Beach And Resort

Playa Tortuga Hotel Beach And Resort

Camino A Playa Bluff Y P Creek, Bocas Del Toro
4.0 out of 5.0
3.4 out of 5 (80 reviews)
Great hotel with wonderful employees i have had a fabulous time at the playa tortuga. The facilities are great. The rooms are great. The … - 

$106

$106
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Independent Panama Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in Panama, Panama. Known for well-appointed rooms and friendly, personalized service, each of the top Independent Panama hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Panama Independent locations may even offer extra little benefits and discounts for frequent travelers.