Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 590,000 properties worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Recently booked Panama hotels

Wyndham Panama Albrook Mall
4.0 out of 5.0
Last booking: 29 minutes ago
Novotel Panama City
4.0 out of 5.0
Last booking: 38 minutes ago
Veneto Hotel & Casino
2.5 out of 5.0
Last booking: 53 minutes ago
Occidental Panamá City
4.0 out of 5.0
Last booking: 54 minutes ago
Hotel Ciudad De David
3.5 out of 5.0
Last booking: 1 hour ago
RIU Plaza Panama
4.0 out of 5.0
Last booking: 1 hour ago
Sercotel Panama Princess
3.5 out of 5.0
Last booking: 1 hour ago
Albrook Inn
3.0 out of 5.0
Last booking: 1 hour ago
TRYP by Wyndham Panamá Centro
3.5 out of 5.0
Last booking: 2 hours ago

Independent Panama Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in Panama, Panama. Known for well-appointed rooms and friendly, personalized service, each of the top Independent Panama hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Panama Independent locations may even offer extra little benefits and discounts for frequent travelers.