Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Panama Independent Hotels

See all 525 Hotels in Panama
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Vía Tocumen, Tocumen
4.5 out of 5.0
4.0 out of 5 (1,876 reviews)
Nice hotel Everything was great, except the airport charter was to run every 30 min, but we had to wait for 1h … - 

$100

$100
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

Italy Avenue, Punta Paitilla, Panama City
4.0 out of 5.0
3.9 out of 5 (635 reviews)
Nice hotel. Close to a mall and restaurants. Very clean . Staff was helpful. A little Spanish is very helpful. Only frontline workers speak engl … - 

$75

$75
Central Hotel Panama

Central Hotel Panama

Plaza de la Independencia Casco Viejo, Panama City
4.5 out of 5.0
4.3 out of 5 (74 reviews)
in the new old town the old town is being all fixed up! old world hotel ... - 

$167

$167
The Saba Hotel

The Saba Hotel

Panama Internacional zone,Argentina Ave, Panama City
4.0 out of 5.0
4.1 out of 5 (216 reviews)
Staff Very nice and helpful staff. Great location to Albrook airport - 

$47

$47
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

Av. Balboa con Calle 53, Panama City
4.5 out of 5.0
4.4 out of 5 (130 reviews)
Awesome experience Had a great stay and Maxine, Gilbert ( Gil) and Edwardo (Eddie) were awesome. Maxine arranged for u … - 

$127

$127
Playa Blanca Beach Resort All Inclusive

Playa Blanca Beach Resort All Inclusive

115 Km Via Interamericana, Rio Hato
3.5 out of 5.0
3.5 out of 5 (345 reviews)
Hotel is legendary and in good condition I like it all because they offer free buffet and respectful staff - 

$180

$180
Veneto Hotel & Casino

Veneto Hotel & Casino

Eusebio A Morales Ave And Via Veneto Str, Panama City
3.0 out of 5.0
3.3 out of 5 (1,378 reviews)
Decent hotel. Heart of the city Very safe with 24 hour police. In the heart of the city, with Manolos across the street. (One of th … - 

$60

$60
Principe Hotel and Suites

Principe Hotel and Suites

Via Argentina, Panama city
3.0 out of 5.0
4.2 out of 5 (273 reviews)
Good restaurant Unable to join wifi. I called the desk for help but none arrived as promised - 

$50

$50
Hotel Coral Suites

Hotel Coral Suites

Calle D El Cangrejo, Panama City
4.0 out of 5.0
4.3 out of 5 (384 reviews)
Good Price and Great Location A group of 10 reserved rooms for a trip to the theater in Panama City. We all agreed this is a very … - 

$61

$61
Hotel El Parador

Hotel El Parador

Eusebio Morales Ave, Panama City
3.5 out of 5.0
3.0 out of 5 (271 reviews)
Nice hotel and good location It was ok, it's near of a subway station, and a lot of restaurants. - 

$34

$34
Global Hotel Panama

Global Hotel Panama

Calle 54 Este y Samuel Lewis, Panama City
4.0 out of 5.0
4.6 out of 5 (149 reviews)
Beautiful hotel! This is just such a lovely hotel. My husband and I accidentally booked it for the wrong night. We s … - 

$95

$95
Royal Decameron Golf, Beach Resort and Villas All Inclusive

Royal Decameron Golf, Beach Resort and Villas All Inclusive

KM 115 Carretera, Rio Hato
3.5 out of 5.0
3.6 out of 5 (557 reviews)
Very pleasant experience We were nervous about this place given all the bad reviews, but ended up having a great time and ar … - 

$262

$262
American Trade Hotel

American Trade Hotel

Plaza Herrera Casco Viejo, Panama City
4.5 out of 5.0
4.7 out of 5 (118 reviews)
Central Location in Old Town This beautifully renovated hotel is an icon of the glory days of old. It is well situated in the ar … - 

$260

$260
Gamboa Rainforest Resort

Gamboa Rainforest Resort

Corregimiento de Cristobal, IA 5, Gamboa
3.5 out of 5.0
3.8 out of 5 (243 reviews)
Attractive tropical hotel We checked in and were assigned a room on the first floor. When we arrived at the room there were p … - 

$179

$179
Hotel Ciudad De David

Hotel Ciudad De David

Calle D Norte, Avenida 2da Este, David
4.0 out of 5.0
4.6 out of 5 (254 reviews)
Most yeye spot in david Great newly built hotel in david's center, near the main park. The hotel offers a little gym, sauna … - 

$78

$78
Hotel Centroamericano

Hotel Centroamericano

Avenida Ecuador y Justo Arosemena, Panama City
3.5 out of 5.0
3.7 out of 5 (358 reviews)
Nice location, nice. Location, location , location, location, location location location, location - 

$32

$32
Hotel Casa Panamá

Hotel Casa Panamá

Avenida Eloy Alfaro y Calle 11, Panama City
4.5 out of 5.0
3.5 out of 5 (108 reviews)
Great boutique hotel near the old town. This was a great place for my layover. It's a very cute boutique hotel close to the old area of tow … - 

$91

$91
DeVille Hotel Boutique

DeVille Hotel Boutique

50 street and Beatriz M. De Cabal, Panama City
4.5 out of 5.0
4.2 out of 5 (295 reviews)
Close to downtown very convenient Quiet older boutique hotel the basics but nice large room with vaulted ceiling - 

$50

$50
The Executive Hotel

The Executive Hotel

Calle 52, Panama City
4.0 out of 5.0
4.1 out of 5 (70 reviews)
Excellent location Walking distance of shops and restaurants. Highly recommended. - 

$66

$66
Hotel Palma Royale

Hotel Palma Royale

Calle 3ra, Bocas Town, Bocas del Toro
4.0 out of 5.0
4.1 out of 5 (36 reviews)
Good hotel close to everything in town My friend and I stayed here three nights and enjoyed our stay. The hotel was clean and roomy. We ha … - 

$85

$85
Map

Recently booked Panama hotels

The Saba Hotel
4.0 out of 5.0
Last booking: 1 hour ago
Riande Aeropuerto Hotel & Casino
4.5 out of 5.0
Last booking: 1 hour ago
Occidental Panamá City
4.5 out of 5.0
Last booking: 1 hour ago
Veneto Hotel & Casino
3.0 out of 5.0
Last booking: 2 hours ago
The Buenaventura Golf & Beach Resort Panama, Autograph Collection
5.0 out of 5.0
Last booking: 2 hours ago
TRYP by Wyndham Panamá Centro
4.0 out of 5.0
Last booking: 2 hours ago
Zebulo Hostel
2.5 out of 5.0
Last booking: 3 hours ago
Las Americas Golden Tower Panama
4.5 out of 5.0
Last booking: 3 hours ago
Wyndham Panama Albrook Mall
4.5 out of 5.0
Last booking: 3 hours ago

Independent Panama Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in Panama, Panama. Known for well-appointed rooms and friendly, personalized service, each of the top Independent Panama hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Panama Independent locations may even offer extra little benefits and discounts for frequent travelers.