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Featured Panama Luxury Hotels

See all 522 Hotels in Panama
Trump International Hotel and Tower Panama

Trump International Hotel and Tower Panama

Calle Punta Colon, Punta Pacifica, Panama City
5.0 out of 5.0
4.4 out of 5 (1,078 reviews)
Great Stay!Amazing views from the balcony and great room stocked with everything you could need. Very comfortable beds. The infinity pool overlooking the ocean was the highlight!
  Jan 19, 2018

$215

$215
Bristol Panama

Bristol Panama

Avenida Aquilino de La Guardia, Panama City
5.0 out of 5.0
4.6 out of 5 (417 reviews)
A great hotel in Panama City!We felt pampered at the Bristol! The location was great, the room was superb, the beds were wonderful, the breakfast was really good in a beautiful setting - we really felt that we were on holidays at the Bristol. We could not find fault with anything and would go back anytime, if just for the hotel ...
  Jan 18, 2018

$169

$169
Waldorf Astoria Panama

Waldorf Astoria Panama

47th St. & Uruguay Street, Panama City
5.0 out of 5.0
4.4 out of 5 (423 reviews)
Very nice hotelIt was great. Very comfortable room. Room service was very good. Staff is super friendly. Check in was super quick
  Jan 19, 2018

$149

$149
American Trade Hotel

American Trade Hotel

Plaza Herrera Casco Viejo, Panama City
5.0 out of 5.0
4.6 out of 5 (114 reviews)
Lovely and ultra comfortable hotel in the heart of Old Town.
  Nov 27, 2017

$246

$246
Sortis Hotel, Spa & Casino, Autograph Collection

Sortis Hotel, Spa & Casino, Autograph Collection

56 y 57 East Street, Obarrio, Panama City
5.0 out of 5.0
4.4 out of 5 (240 reviews)
Great hotel and great stay This is a great hotel - obarrio is not the most centrally located if you want touristic places but it’s definitely close enough to be convenient and far enough away to not feel like you’re staying in a touristy place. The hotel is big and has tons of things - very nice. The only issue I had was that ...
  Jan 5, 2018

$159

$159
Hilton Panama

Hilton Panama

Balboa Ave. and Aquilino De La Guardia, Panama City
5.0 out of 5.0
4.5 out of 5 (257 reviews)
A dream hotelGreat room and a view. Nice top of the line bathroom and bed. The Gym was a dream for any Gym lover
  Jan 17, 2018

$149

$149
Hard Rock Hotel Panama Megapolis

Hard Rock Hotel Panama Megapolis

Ave. Balboa al lado de Multicentro, Panama City
5.0 out of 5.0
4.3 out of 5 (2,223 reviews)
Entertaining hotelExcellent stay. Would recommend hotel. Very nice pool area and great on premise bars. Restaurant staff was very attentative and friendly. Particularly a young waitress by the name of Andrea. She made sure my fiancée and l had an excellent dining experience.
  Jan 20, 2018

$150

$150
Manrey Boutique Hotel

Manrey Boutique Hotel

Calle Uruguay y Calle 48, Panama City
5.0 out of 5.0
3.8 out of 5 (252 reviews)
Service is goodGreat location for night life. Several Discos and nice restruant walking distance.
  Oct 19, 2015
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

Av. Balboa con Calle 53, Panama City
4.0 out of 5.0
4.4 out of 5 (122 reviews)
Panama stayWe stayed at the hotel for 3 nights. Overall it was a very nice stay. Staff,room,location and breakfast were wonderful. Taking better care of little things as quality and quantity of toiletries would make it better
  Jan 20, 2018

$124

$124
Wyndham Panama Albrook Mall

Wyndham Panama Albrook Mall

Ave. Marginal, Corregimiento de Ancon, Panama City
4.5 out of 5.0
4.5 out of 5 (737 reviews)
Perfect location and more.At first I was hesitant to stay in a hotel connected to a mall. But when I looked at the location and quality of this hotel, the choice was obvious. The staff were all wonderful--very cheerful and helpful except the tours and translator lady about whom I will talk more later. The rooms were spacious, ...
  Jan 21, 2018

$97

$97
DoubleTree by Hilton Hotel Panama City

DoubleTree by Hilton Hotel Panama City

Via Espana, Federico Boyd & Bella Vista, Panama City
4.5 out of 5.0
4.1 out of 5 (1,465 reviews)
Party next door Waited half and hour after informing staff about noise and smoking from next door and nothing. Had to go down in person for second request. That helped but party started again at 2 am so again security was contacted and we asked security if they could move us and waited. Nothing. Eventually went ...
  Jan 16, 2018

$58

$58
Metro Hotel Panama

Metro Hotel Panama

Via Veneto, Calle D El Cangrejo, Panama City
4.0 out of 5.0
3.8 out of 5 (278 reviews)
100% recomendadosEl hotel se encuentra en el puro centro de la Ciudad de Panamá. A escaso 100 mtrs de la estación del Metro, como también del área comercial. El personal del hotel muy amable, servicial. La calidad de las habitaciones, muy buenas y el desayudo incluido, muy rico,
  Dec 29, 2017

$44

$44
Villa Palma Boutique Hotel

Villa Palma Boutique Hotel

Calle 1era, Panama City
4.5 out of 5.0
4.3 out of 5 (59 reviews)
Upscale boutique hotel It's our second time staying at this hotel. It has a great roof top. lounge. Rooms are cute and staff were very friendly and helpful.
  Jan 7, 2018

$119

$119
Radisson Summit Hotel and Golf Panama

Radisson Summit Hotel and Golf Panama

Omar Torrijos Ave, Paraiso
4.5 out of 5.0
4.3 out of 5 (747 reviews)
Quiet out of city place close to cityGood hiking trails and wildlife all around. Great modern hotel but needs a bit of tlc re eindow cleaning etc
  Jan 12, 2018

$76

$76
Global Hotel Panama

Global Hotel Panama

Calle 54 Este y Samuel Lewis, Panama City
4.5 out of 5.0
4.6 out of 5 (141 reviews)
Comfortable and economical This hotel is in the financial district, so no beach views. It is very comfortable, with a wonderful staff. The restaurant in the hotel is very good, but there are several others within walking distance. The waterfront is also within walking distance, but taxis and Ubers are plentiful and easy.
  Jan 10, 2018

$95

$95
Crowne Plaza Panama Airport

Crowne Plaza Panama Airport

Ave. Domingo Diaz, Tocumen
4.5 out of 5.0
4.2 out of 5 (546 reviews)
Nicer than I expected. I thought this hotel would be a typical utilitarian style place as it is near the airport. It is nicely designed and has all the amenities. Nice size pool with lots of comfy poolside seating. Lounge and restaurant was great too. Very friendly staff. Will definitely stay here again. Free airport shuttle ...
  Jan 22, 2018

$105

$105
Eurostars Panama City

Eurostars Panama City

Calle Ricardo Arias, Panama City
4.5 out of 5.0
4.1 out of 5 (512 reviews)
nice hotelnear to restaurants, self parking and clean rooms, perfect for a few days.
  Jan 16, 2018

$57

$57
RIU Plaza Panama

RIU Plaza Panama

Calle 50, Urb. Marbella, Panama City
4.0 out of 5.0
4.4 out of 5 (1,513 reviews)
Good hotel for business tripsA good hotel but the large Lobby and bar is very noisy when there is a group or music playing ...not a good hotel for an intimate quiet drink.
  Jan 21, 2018

$86

$86
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

Km 6 Road to Veracruz, Panama City
5.0 out of 5.0
4.1 out of 5 (288 reviews)
Very nice hotel with a friendly, helpful staff.This was my first stay in Panama City, so when I was looking for a hotel, I only had past experiences with other Westin properties as my guide and I was NOT disappointed! This is a very nice, clean, friendly place to stay. I would definitely go back again.
  Dec 19, 2017

$212

$212
Sercotel Panama Princess

Sercotel Panama Princess

Calle 53 Marbella y Avenida 5a B sur, Panama City
4.0 out of 5.0
3.9 out of 5 (372 reviews)
Pleasant and courtous restaurant staffAt check inn counter the lady was not too pleasant, but as general experience it is ok. I ask for the manager and the gentleman paid attention to my request about some deficiencies as cleanliness and bad condition of the furniture. I understand it is a new administration and they has the chance to ...
  Jan 10, 2018

$56

$56
Map

Recently booked Luxury Hotels in Panama

Wyndham Panama Albrook Mall
4.5 out of 5.0
Last booking: 14 minutes ago
The Westin Playa Bonita Panama
5.0 out of 5.0
Last booking: 23 minutes ago
Radisson Summit Hotel and Golf Panama
4.5 out of 5.0
Last booking: 53 minutes ago
Hyatt Place Panama City/Downtown
4.0 out of 5.0
Last booking: 1 hour ago
Hostal Boquete
2.5 out of 5.0
Last booking: 2 hours ago
The Golden Frog Inn
2.5 out of 5.0
Last booking: 2 hours ago
Bristol Panama
5.0 out of 5.0
Last booking: 2 hours ago
Crowne Plaza Panama Airport
4.5 out of 5.0
Last booking: 2 hours ago
Plaza Paitilla Inn Hotel
3.5 out of 5.0
Last booking: 3 hours ago

A few days away keeps your worries at bay, so plan a vacation in Panama and prepare to feel fancy-free. Exquisite eats, interesting points of interest, and the chance to capture fantastic photos: these are just a few of the benefits of visiting Panama. Where else would you stay but a luxury accommodation? Extravagant experiences are right up your alley. While you're here, you'll also grab tickets to the most popular performances, devour delicious food, and eye-guzzle the most noteworthy attractions . Book your luxury hotel in Panama on Expedia.com today, and your blissful getaway is off to a fantastic start.

Plan a Luxury Panama Vacation

If you need any proof that Panama is full of wonderful things to do, you should know that plenty of folks love it enough to live here. Whether you’re looking to spend your vacation dining on fine seasonal food or browsing art galleries in Panama, you'll never be disappointed. Panama is full of outstanding hotels as well as fantastic food, so you can count on a spectacular stay. Book early to get a room with a view!

An upscale vacation is the perfect opportunity to indulge in art, culture, and spa treatments. When you save big by booking on Expedia.com, you can enjoy it all. Thanks to our incredible prices on hotels, your bucket list budget will always be intact. After an eventful day of seeing the sights, your luxury hotel is waiting with fine dining and upscale amenities. Take advantage of amenities like an incredible balcony view or hot tub before the day is over. The luxury hotels in Panama will lull you into a state of relaxation in no time.

Luxury Panama Hotels

There's no better time than now to book your getaway in Panama, and Expedia.com is here to make the process painless. Search through the wealth of ratings and reviews on dozens of hotels to find an accommodation that suits your needs. Luxury accommodations offer amenities like elegant suites and VIP services. Some of the city's luxury accommodations even feature gigantic penthouses, while others boast tennis courts or salt water pools. Book your dream hotel in Panama now, and soon you'll be soaking up luxury in style!