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Featured Panama Luxury Hotels

See all 495 Hotels in Panama
Trump International Hotel and Tower Panama

Trump International Hotel and Tower Panama

Calle Punta Colon, Punta Pacifica, Panama City
5.0 out of 5.0
4.3 out of 5 (406 reviews)
Excellent Very well located. Friendly staff. Easy to check in. Quiet and well organized.
  Sep 18, 2017

$149

$149
American Trade Hotel

American Trade Hotel

Plaza Herrera Casco Viejo, Panama City
4.5 out of 5.0
4.6 out of 5 (47 reviews)
Excellent location in Casco Viejo. Stayed for a couple of nights. The building is beautiful and very well maintained. The restaurant is very good. Only issue is the curch bells early Sunday morning. Walking distance to best restaurants in Casco Viejo.
  Sep 4, 2017

$197

$197
Dreams Delight Playa Bonita Panama - All Inclusive

Dreams Delight Playa Bonita Panama - All Inclusive

KM 7, Camino a Veracruz, Playa Bonita
4.0 out of 5.0
3.8 out of 5 (69 reviews)
Nice hotel in relatively secluded locationThe hotel itself is very nice. The rooms are large and clean. The location is nice in that you can only see one other hotel. Not your typical beach with one resort after another. The beach is okay. In high tide, there is very sand. The sand has a lot of shells and rocks - beach shoes are recommended. ...
  Aug 23, 2017

$227

$227
Hotel Riu Playa Blanca - All Inclusive

Hotel Riu Playa Blanca - All Inclusive

Finca 43.668, Rio Hato
3.5 out of 5.0
3.8 out of 5 (245 reviews)
We're dying to go backThe hotel may not be the newest in the area but it definitely has everything you need to have a great time. The room was more than comfortable and the food was excellent too. I highly recomend it
  Sep 20, 2017
Laguna Azul Eco Lodge

Laguna Azul Eco Lodge

Isla Popa, Punta Laurel
4.0 out of 5.0
Sortis Hotel, Spa & Casino, Autograph Collection

Sortis Hotel, Spa & Casino, Autograph Collection

56 y 57 East Street, Obarrio, Panama City
4.5 out of 5.0
4.4 out of 5 (70 reviews)
Hotel with amazing extras Loved the hotel and all that it came with. A few glitches at the pool and spa that bothered me. Upon check I expressed my issues, they didn't seem to care.
  Sep 8, 2017

$105

$105
Global Hotel Panama

Global Hotel Panama

Calle 54 Este y Samuel Lewis, Panama City
4.0 out of 5.0
4.5 out of 5 (46 reviews)
Nice Hotel & Amazing customer service by Katrin.Miss. Katrin was our amazing travel coordinator and her team made our stay increíble. Highly recommend it and we can't Thank enough the hotel staff and Miss. Katrin.
  Sep 12, 2017

$90

$90
Crowne Plaza Panama Airport

Crowne Plaza Panama Airport

Ave. Domingo Diaz, Tocumen
4.0 out of 5.0
4.3 out of 5 (157 reviews)
It's a good hotel close to airport I Hav been staying here before with everything included breakfast lunch n dinner but this time I was charged same price but nothing included that's what was embarrassing
  Sep 6, 2017

$103

$103
Hotel Central Boquete

Hotel Central Boquete

Calle Principal, Boquete
2.5 out of 5.0
3.5 out of 5 (4 reviews)
Nice small family run hotel just outside of townThe weather was terrible when I stayed in this hotel & so it felt a bit chillier than it probably is. The room I stayed in was a single with a single bed & was very small but was fine as I only had one bag. The attached private bathroom was a good size and clean with plenty of amenities & clean towels. ...
  Jan 13, 2017

$37

$37
Novotel Panama City

Novotel Panama City

Calle Jose I. Fabrega y Thais de Pons, Panama City
4.0 out of 5.0
4.2 out of 5 (261 reviews)
Nice stayIf you are staying in Panama city for 1 night or more, you wont regret to stay at Novotel. A French franchise hotel, clean, modern and near everything, including the financial district in Panama.
  Sep 20, 2017

$62

$62
Map

Recently booked Luxury Hotels in Panama

Playa Tortuga Hotel Beach And Resort
4.0 out of 5.0
Last booking: 10 minutes ago
Principe Hotel and Suites
3.0 out of 5.0
Last booking: 13 minutes ago
Waldorf Astoria Panama
5.0 out of 5.0
Last booking: 17 minutes ago
Plaza Paitilla Inn Hotel
3.5 out of 5.0
Last booking: 20 minutes ago
Trump Ocean Club International Hotel and Tower Panama
5.0 out of 5.0
Last booking: 23 minutes ago
The Executive Hotel
3.5 out of 5.0
Last booking: 29 minutes ago
Hyatt Place Panama City/Downtown
3.5 out of 5.0
Last booking: 52 minutes ago
Express Inn Panama International Airport Hostel
1.5 out of 5.0
Last booking: 1 hour ago
Hotel Valle Verde
2.5 out of 5.0
Last booking: 1 hour ago

A few days away keeps your worries at bay, so plan a vacation in Panama and prepare to feel fancy-free. Exquisite eats, interesting points of interest, and the chance to capture fantastic photos: these are just a few of the benefits of visiting Panama. Where else would you stay but a luxury accommodation? Extravagant experiences are right up your alley. While you're here, you'll also grab tickets to the most popular performances, devour delicious food, and eye-guzzle the most noteworthy attractions . Book your luxury hotel in Panama on Expedia.com today, and your blissful getaway is off to a fantastic start.

Plan a Luxury Panama Vacation

If you need any proof that Panama is full of wonderful things to do, you should know that plenty of folks love it enough to live here. Whether you’re looking to spend your vacation dining on fine seasonal food or browsing art galleries in Panama, you'll never be disappointed. Panama is full of outstanding hotels as well as fantastic food, so you can count on a spectacular stay. Book early to get a room with a view!

An upscale vacation is the perfect opportunity to indulge in art, culture, and spa treatments. When you save big by booking on Expedia.com, you can enjoy it all. Thanks to our incredible prices on hotels, your bucket list budget will always be intact. After an eventful day of seeing the sights, your luxury hotel is waiting with fine dining and upscale amenities. Take advantage of amenities like an incredible balcony view or hot tub before the day is over. The luxury hotels in Panama will lull you into a state of relaxation in no time.

Luxury Panama Hotels

There's no better time than now to book your getaway in Panama, and Expedia.com is here to make the process painless. Search through the wealth of ratings and reviews on dozens of hotels to find an accommodation that suits your needs. Luxury accommodations offer amenities like elegant suites and VIP services. Some of the city's luxury accommodations even feature gigantic penthouses, while others boast tennis courts or salt water pools. Book your dream hotel in Panama now, and soon you'll be soaking up luxury in style!