Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Port Saint Lucie Business Hotels

See all 160 Hotels in Port Saint Lucie
Residence Inn by Marriott Port St. Lucie

Residence Inn by Marriott Port St. Lucie

1920 Sw Fountainview Blvd, Port Saint Lucie
3.5 out of 5.0
4.7 out of 5 (492 reviews)
The front desk staff are super nice, the rooms are amazing. Definitely recommend this place.
  Nov 17, 2017

$109

$109
Holiday Inn Express Suites West

Holiday Inn Express Suites West

1601 NW Courtyard Circle, Port Saint Lucie
3.0 out of 5.0
4.4 out of 5 (429 reviews)
Some problemsI have stayed here four time before. This is the only time I have had some problems. 1) Wi-Fi not working most of the weekend 2) No room service on first day there. 3) Even after room service began - not as good as before. Missed many things to clean and fill.
  Oct 31, 2017

$93

$93
Holiday Inn Port St. Lucie

Holiday Inn Port St. Lucie

10120 S Federal Hwy, Port Saint Lucie
3.5 out of 5.0
3.8 out of 5 (397 reviews)
Staff nice. Common areas fine. Jets in tub don’t work. Toilet leaks. Ac gives off vinegar smell. Good location for our visit with family.
  Nov 22, 2017

$86

$86
Homewood Suites by Hilton Port Saint Lucie-Tradition

Homewood Suites by Hilton Port Saint Lucie-Tradition

10301 Sw Innovation Way, Port Saint Lucie
3.0 out of 5.0
4.7 out of 5 (1,033 reviews)
Great stay clean place, very comfortable feel for a extended stay hotel, updated bathrooms and kitchens make you feel right at home, their hot breakfast selection is also very good. If you like a simple breakfast every morning, good selection.
  Dec 5, 2017

$101

$101
Best Western Port St. Lucie

Best Western Port St. Lucie

7900 S US Highway 1, Port Saint Lucie
3.0 out of 5.0
4.2 out of 5 (409 reviews)
Comfortable Hotel was clean the room was comfortable and roomy. Hot tub was broke and internet was terrible but all in all I would stay here again.
  Dec 11, 2017

$90

$90
Hilton Garden Inn at PGA Village / Port St. Lucie

Hilton Garden Inn at PGA Village / Port St. Lucie

8540 Commerce Centre Dr, Port Saint Lucie
3.5 out of 5.0
4.5 out of 5 (500 reviews)
Awesome Friendly Professional Attentive Can’t ask for more
  Nov 24, 2017

$111

$111
SpringHill Suites Port St. Lucie

SpringHill Suites Port St. Lucie

2000 NW Courtyard Cir, Port Saint Lucie
3.5 out of 5.0
4.2 out of 5 (473 reviews)
Great locationWe stayed at this hotel on our way to Key West. The staff were friendly and efficient. The room was larger to accommodate a kitchen area. The bed was very comfortable. The location was packed with restaurants and stores, very convenient. We would stop here again.
  Dec 22, 2016

$190

$190
Hampton Inn Suites Port St Lucie, West

Hampton Inn Suites Port St Lucie, West

155 SW Peacock Blvd, Port Saint Lucie
3.0 out of 5.0
4.5 out of 5 (762 reviews)
Hotel location was prefect, close to everything. Hotel location was perfect, close to all shops, restaurants and Highways. The staff at the Hotel was very nice, made my check in smooth and easy. The check put process was even more pleasing. very nice place to stay and would definitely stay there again..
  Nov 20, 2017

$91

$91
Castle Pines Golf Villas

Castle Pines Golf Villas

2080 NW Courtyard Circle, Port Saint Lucie
4.0 out of 5 (94 reviews)
Nice condo but not really a 3 bedroomWe confirmed beforehand and when we checked in that we had a 3 bedroom condo with a king and two singles in each of the other two bedrooms sleeping 6 total in the bedrooms. It turned out there was only one single in each of the 2nd and 3rd bedrooms and the 3rd bedroom was really a small den with ...
  Dec 29, 2013
Mainstay Suites at PGA Village

Mainstay Suites at PGA Village

8501 Champions Way, Port Saint Lucie
2.5 out of 5.0
3.7 out of 5 (127 reviews)
I didn’t stay there a friend did because I couldn’t cancel the reservation. But I did see the staff and the room.
  Oct 15, 2017

$95

$95
Sheraton PGA Vacation Resort, Port St. Lucie

Sheraton PGA Vacation Resort, Port St. Lucie

8702 Champions Way, Port Saint Lucie
4.0 out of 5.0
4.4 out of 5 (274 reviews)
Basic VillaRooms are clean and basic. Nothing special, but not terrible.
  Dec 8, 2017

$129

$129
Sleep Inn at PGA Village

Sleep Inn at PGA Village

8501 Champions Way Building B, Port Saint Lucie
2.5 out of 5.0
3.8 out of 5 (40 reviews)
GreatRoom was clean . Breakfast was good. Staff was polite and attentive . Nice quiet location
  Jan 3, 2016
Map

Recently booked Business Hotels in Port Saint Lucie

Residence Inn by Marriott Port St. Lucie
3.5 out of 5.0
Last booking: 2 hours ago
Best Western Port St. Lucie
3.0 out of 5.0
Last booking: 3 hours ago
Sheraton PGA Vacation Resort, Port St. Lucie
4.0 out of 5.0
Last booking: 7 hours ago
Mainstay Suites at PGA Village
2.5 out of 5.0
Last booking: 10 hours ago
Hilton Garden Inn at PGA Village / Port St. Lucie
3.5 out of 5.0
Last booking: 11 hours ago
Hampton Inn Suites Port St Lucie, West
3.0 out of 5.0
Last booking: 15 hours ago
Holiday Inn Express Suites West
3.0 out of 5.0
Last booking: 26 hours ago
Holiday Inn Port St. Lucie
3.5 out of 5.0
Last booking: 45 hours ago
Homewood Suites by Hilton Port Saint Lucie-Tradition
3.0 out of 5.0
Last booking: 46 hours ago

Pocket Guide: Business Hotels in Port Saint Lucie

Search for hotels in Port Saint Lucie on Expedia. You can easily find your hotels in Port Saint Lucie using one of the methods below:

  • View our selection of featured hotels in Port Saint Lucie
  • Use the map to find hotels in the Port Saint Lucie neighborhood you prefer
  • Use the filters to see hotels in a specific area of Port Saint Lucie, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Port Saint Lucie
  • Enter your travel dates to view the best deals on hotels in Port Saint Lucie - while they last