Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Port Saint Lucie Luxury Hotels

See all 107 Hotels in Port Saint Lucie
Residence Inn by Marriott Port St. Lucie

Residence Inn by Marriott Port St. Lucie

1920 Sw Fountainview Blvd, Port Saint Lucie
3.0 out of 5.0
4.6 out of 5 (118 reviews)
smelled like mildewOnly one problem it smelled like mildew we thought it might because the AC was not on when came in. Turned AC and left for about two hours came back and the smell was still there. Was going to let the front desk know the next day since it was late when we got back, but the hurricane was coming and ...
  Sep 17, 2017

$114

$114
Hilton Garden Inn at PGA Village / Port St. Lucie

Hilton Garden Inn at PGA Village / Port St. Lucie

8540 Commerce Centre Dr, Port Saint Lucie
3.0 out of 5.0
4.6 out of 5 (111 reviews)
Very nice. Check in was quick and easy. Staff was very helpful. Hotel was Clean. Room were very nice.
  Sep 11, 2017

$94

$94
Homewood Suites by Hilton Port Saint Lucie-Tradition

Homewood Suites by Hilton Port Saint Lucie-Tradition

10301 Sw Innovation Way, Port Saint Lucie
3.0 out of 5.0
4.7 out of 5 (265 reviews)
Nice hotel, but the room smelled awful. The hotel was nice and the staff great. However, my room had the most awful smell. The first day, I accidentally walked over a huge wet area on the floor. Upon investigating, I put my hand on it and what I smelled was comparable to rotten fish. I went to the desk and they promptly had someone come ...
  Aug 20, 2017

$93

$93
Hampton Inn Suites Port St Lucie, West

Hampton Inn Suites Port St Lucie, West

155 SW Peacock Blvd, Port Saint Lucie
2.5 out of 5.0
4.4 out of 5 (155 reviews)
Ceo of a limo company. I traveled a lot for business. Location and cleanliness of the hotel is very important. Hampton Inn was very clean, the staff extremely funny helpful and reiable.
  Aug 30, 2017

$79

$79
Map

Recently booked Luxury Hotels in Port Saint Lucie

Hilton Garden Inn at PGA Village / Port St. Lucie
3.0 out of 5.0
Last booking: 3 hours ago
Residence Inn by Marriott Port St. Lucie
3.0 out of 5.0
Last booking: 5 hours ago
Best Western Port St. Lucie
2.5 out of 5.0
Last booking: 7 hours ago
Holiday Inn Express Suites West
2.5 out of 5.0
Last booking: 10 hours ago
Perfect Drive Vacation Rentals
3.5 out of 5.0
Last booking: 13 hours ago
Hampton Inn Suites Port St Lucie, West
2.5 out of 5.0
Last booking: 15 hours ago

A few days away keeps your worries at bay, and Port Saint Lucie is the best place to visit. Tremendous activities, divine eats, and the most stunning photo opportunities: these are just a few of the benefits of visiting Port Saint Lucie. You'll treat yourself to the city's best food, get in line to check out the coolest points of interest, and grab tickets to the most exciting shows. Of course, you'll book a room at a luxury hotel! Sampling the finer things in life is just your speed, so get your elegant hotel in Port Saint Lucie on Expedia.com right now and start your vacation off on the right (well-dressed) foot.

Plan a Luxury Port Saint Lucie Vacation

If you need any proof that Port Saint Lucie is teeming with an incredible assortment of activities, you should know that plenty of folks love it enough to have set down roots. Whether you’re looking to spend your vacation dining on the best regional fare or exploring museums in Port Saint Lucie, you'll never be disappointed. Port Saint Lucie is full of dreamy hotels on top of appealing attractions, so you can count on a remarkable stay. Crowds have doubled in the last year, and hotel rooms may go fast--book early!

Any 5-star getaway is your chance to live your best life, including eating at 5-star restaurants and getting VIP seats. When you save big by booking on Expedia.com, it's all at your fingertips. Thanks to our great prices on hotels, you can always afford to investigate the region's most interesting sights. After many hours of exploring the city, your luxury suite awaits. Don't fall asleep before making use of your room's luxury bath products or sipping on a glass of fine wine. The luxury rooms and suites in Port Saint Lucie will render you into a state of tranquility before you know it.

Luxury Port Saint Lucie Hotels

It's that time; you're ready to get swept away in Port Saint Lucie, and Expedia.com is here to save the day. Search through the bounty of real traveler reviews on spectacular hotels and then book your ideal room in minutes. 5-Star hotels treat you right, offering things like high end bath amenities and private kitchens. Some of the city's luxury accommodations even feature gigantic penthouses, while others offer tennis courts or salt water pools. Use our mobile booking app to choose the ideal 5-star hotel in Port Saint Lucie, and prepare for the experience of a lifetime!