Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured San Angelo Luxury Hotels

See all 31 Hotels in San Angelo
Motel 6 San Angelo

Motel 6 San Angelo

311 N Bryant Blvd, San Angelo
2.0 out of 5.0
3.4 out of 5 (33 reviews)
WiFi access sucks after paying still didn't get heMy property got stolen, other than that wasn't to bad
  Sep 4, 2017

$44

$44
Quality Inn San Angelo

Quality Inn San Angelo

4613 S Jackson St, San Angelo
2.5 out of 5.0
3.8 out of 5 (8 reviews)
Comfortable My stay here was a great experience. Rooms are clean and bed was very comfortable. Staff was very nice and accommodating. Only complaint is that there is not much to choose from for breakfast. Would definitely stay here again.
  Sep 2, 2017

$47

$47
Clarion Hotel

Clarion Hotel

441 Rio Concho Drive, San Angelo
2.5 out of 5.0
3.9 out of 5 (219 reviews)
GlassesThe glasses were made of glass and the in room coffee cups we're ceramic. Not a huge deal, but so much nicer than plastic.
  Sep 22, 2017

$43

$43
Ramada Limited San Angelo

Ramada Limited San Angelo

2201 N Bryant Blvd, San Angelo
2.0 out of 5.0
2.8 out of 5 (28 reviews)
Front desk was very friendly, service was greatFront desk was very friendly, service was great room was very clean and the area was very safe. will be staying here again
  Jun 3, 2017

$54

$54
Map

Recently booked Luxury Hotels in San Angelo

Hampton Inn San Angelo
2.5 out of 5.0
Last booking: 7 hours ago
Holiday Inn Express Hotel & Suites San Angelo
2.5 out of 5.0
Last booking: 7 hours ago
SpringHill Suites by Marriott San Angelo
2.5 out of 5.0
Last booking: 8 hours ago
Courtyard San Angelo
3.0 out of 5.0
Last booking: 8 hours ago
Wingate By Wyndham San Angelo
3.5 out of 5.0
Last booking: 9 hours ago
Motel 6 San Angelo - South
1.5 out of 5.0
Last booking: 10 hours ago
Clarion Hotel
2.5 out of 5.0
Last booking: 11 hours ago
Motel 6 San Angelo
2.0 out of 5.0
Last booking: 12 hours ago
Hawthorn Suites By Wyndham San Angelo
2.5 out of 5.0
Last booking: 13 hours ago

When you crave some respite from your typical routine and you're ready to enjoy wide open spaces, look no further than San Angelo. As one of the most interesting destinations for people seeking a no-hassle trip, San Angelo is a great place to make memories. Marvelous activities, delicious eats, and some of the world’s most coveted photo opportunities: these are just some of the reasons to take a vacation to San Angelo. You'll snag seats to the most exciting shows, devour spectacular food, and get in line to check out the coolest points of interest. Where else would you stay but in a luxury hotel? Extravagant experiences are right up your alley, so get your luxury hotel in San Angelo on Expedia.com today, and your relaxing vacation is off to a good start.

Plan a Luxury San Angelo Vacation

If you doubt that San Angelo is full of brilliant things to do, keep in mind that 100,450 people love it enough to live here. Whether you’re looking to spend your vacation dining on fine seasonal food or browsing art galleries in San Angelo, you'll never be disappointed. San Angelo is full of comfy hotels as well as fantastic food, so it's no surprise that travelers often return. Book early to ensure you snag a room!

Any 5-star getaway is your chance to live your best life, including eating at 5-star restaurants and getting the VIP treatment. When you book your vacation on Expedia.com, the world is your oyster. Thanks to our hotel deals, your bucket list budget will still be intact. After a day of seeing the sights, your luxury accommodations will welcome you back to extravagant amenities. Before you go to bed, order a glass of wine to your room and sip on it at your leisure. The luxury accommodations in San Angelo will render you into a state of tranquility as soon as you check in.

Luxury Hotels in San Angelo

It's that time; you're prepared to get swept away in The End of the Rainbow, and Expedia.com is here to make the process painless. Browse the bounty of ratings and reviews on more than a dozen hotels and find the perfect vacation rental. Luxury accommodations offer amenities like spacious suites and VIP services. Some of the city's opulent accommodations even feature upscale penthouses, while others boast tennis courts or salt water pools. Book your luxury experience in San Angelo now, and before you know it you'll be getting pampered in paradise!