Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Top San Francisco Neighborhoods for Business Hotels

Union Square
83 hotels

The Mosser

2.5 out of 5.0
from

$195

South of Market
25 hotels

Hotel Whitcomb

3.5 out of 5.0
from

$189

Featured San Francisco Business Hotels

See all 500 Hotels in San Francisco
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

424 Clay St, San Francisco
4.0 out of 5.0
4.1 out of 5 (1,408 reviews)
sometimes employee staff make all the differencei had some billing issues; Sarbi at the hotel took care of them and that made all the difference. Based on her excellent work, i would recommend the hotel.
  Sep 24, 2017

$161

$161
Pullman San Francisco Bay

Pullman San Francisco Bay

223 Twin Dolphin Dr, Redwood City
4.0 out of 5.0
4.2 out of 5 (1,248 reviews)
Amazing hotel and great breakfast and friendly staff
  Sep 20, 2017

$143

$143
Parc 55 San Francisco - A Hilton Hotel

Parc 55 San Francisco - A Hilton Hotel

55 Cyril Magnin St, San Francisco
4.0 out of 5.0
4.2 out of 5 (4,309 reviews)
Good location. No more than a 12-15 min cab ride to most area's such as the Bay, shopping and dining. Found the people more than happy to help with suggestions for great dining and activities all within a short cab ride. The hotel staff were also very friendly and ready to help with any of our questions. The cons. ...
  Sep 23, 2017

$218

$218
San Francisco Marriott Marquis

San Francisco Marriott Marquis

780 Mission Street, San Francisco
4.0 out of 5.0
4.4 out of 5 (1,642 reviews)
Large modern hotel located centrallyVery efficient hotel where everything worked and staff were helpful. An easy walk to Union Square and most major stores and also near cable car terminus.
  Sep 23, 2017

$199

$199
Hotel Nikko San Francisco

Hotel Nikko San Francisco

222 Mason St, San Francisco
4.0 out of 5.0
4.3 out of 5 (2,753 reviews)
Excellent service great location near everything Will stay again.
  Sep 22, 2017

$194

$194
Marriott Courtyard San Francisco Downtown

Marriott Courtyard San Francisco Downtown

299 2nd St, San Francisco
3.5 out of 5.0
4.3 out of 5 (566 reviews)
Great hotel, great location! Especially liked the fire pits outside of their bar.
  Sep 23, 2017

$197

$197
Serrano Hotel

Serrano Hotel

405 Taylor St, San Francisco
4.0 out of 5.0
3.9 out of 5 (1,613 reviews)
Nice hotel! This place was absolutely beautiful on the inside and out. We were informed however that they are renovating soon, so everything will look completely different after October. Lovely service as well as location.
  Sep 25, 2017

$228

$228
The Park Central San Francisco

The Park Central San Francisco

50 3rd St, San Francisco
4.0 out of 5.0
4.2 out of 5 (2,608 reviews)
Close to Union Square and ChinatownConcierge helped me with a tour of Yosemite. I did not like the way I wait in line for a clerk at check-in but Starwood folks get to jump in line. It was too obvious and made the hotel look rude.
  Sep 15, 2017

$199

$199
Le Meridien San Francisco

Le Meridien San Francisco

333 Battery St, San Francisco
4.0 out of 5.0
4.5 out of 5 (1,140 reviews)
Nice hotel close to piersCheck in was easy and fast. My room, including chair, was comfortable and modern with a workspace area I used on and off. Quite a few eateries of all types nearby, though I grabbed a beer at the 333 bar in the hotel lobby - a really pleasant establishment. Close to shopping too. Neighborhood is safe ...
  Sep 23, 2017

$267

$267
DoubleTree by Hilton Berkeley Marina

DoubleTree by Hilton Berkeley Marina

200 Marina Blvd, Berkeley
3.5 out of 5.0
3.9 out of 5 (924 reviews)
Great hotel right on the harbor! The staff was so awesome and helpful! If we ever get back to the area that is where we would stay! Best cookies in town!
  Sep 19, 2017

$213

$213
Map

Recently booked Business Hotels in San Francisco

Good Hotel
2.5 out of 5.0
Last booking: 10 minutes ago
San Francisco Marriott Marquis
4.0 out of 5.0
Last booking: 10 minutes ago
Mithila Hotel
2.0 out of 5.0
Last booking: 11 minutes ago
The Beach House Hotel Half Moon Bay
3.5 out of 5.0
Last booking: 12 minutes ago
Days Inn San Francisco Lombard
2.0 out of 5.0
Last booking: 13 minutes ago
Stanford Court San Francisco
4.0 out of 5.0
Last booking: 15 minutes ago
Hotel Triton
3.0 out of 5.0
Last booking: 18 minutes ago
Hotel Carlton, a Joie de Vivre Boutique Hotel
3.0 out of 5.0
Last booking: 18 minutes ago
Hotel Zeppelin San Francisco
4.0 out of 5.0
Last booking: 34 minutes ago

San Francisco Business Hotel Information

Be business savvy on your next romp in Fog City.

  • Stay at a place with meeting rooms on site
  • Use the convenient mobile booking options during a busy work day
  • Take advantage of the lowest rates around

As much as you’d like to spend your days in San Francisco leisurely strolling through Fisherman’s Wharf, window-shopping in Union Square, and feeling like a rebel at Alcatraz, you’re in town for business.

Don’t let meetings and conferences put a damper on your stay in the City by the Bay, and book a business hotel instead. Your accommodations will have everything you need for a productive work trip. Many business hotels in San Francisco provide all the amenities, from a desk in your room and a coffee pot to fuel your late-night cram session to around-the-clock concierge service.

Large Space

Many business hotels offer large meeting rooms in San Francisco, which you can rent out for conferences and seminars. These spacious facilities are ideal for everything from teambuilding activities to big sale presentations. When it comes to hosting a huge event, don’t overlook the venues at your accommodation.

Small Space

These business hotels also provide smaller-scale rooms that double as deposition space and day offices. Prepare your speech or strategize with your colleagues in the convenient coworking areas at your hotel during your stay. What’s more, these Wi-Fi hotels offer teleconferencing tools, whiteboards, and presentation amenities, too.

Leave your negotiation skills in the boardroom. When you book an executive business hotel in San Francisco right here on Expedia, you’ll get the best deals without any debate. We offer the lowest prices on business hotels in San Francisco, so you can spend your money on souvenir shopping in Chinatown instead of on your accommodations. Taking advantage of prices this low? Well, that’s just being a good businessman.