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Featured San Francisco Independent Hotels

See all 525 Hotels in San Francisco
Hotel Whitcomb

Hotel Whitcomb

1231 Market St, San Francisco
3.5 out of 5.0
3.3 out of 5 (8,237 reviews)
Decent Hotel I have stayed here a dozen times in the past 3 years. It’s affordable and provides a nice place to … - 

$105

$105
Hotel Zoe San Francisco

Hotel Zoe San Francisco

425 North Point, San Francisco
4.0 out of 5.0
4.2 out of 5 (5,632 reviews)
San Francisco Get-A-Way We traveled to San Francisco with another couple as a last minute "Get-A-Way". The Hotel was extrem … - 

$140

$140
Sheraton Fisherman's Wharf Hotel

Sheraton Fisherman's Wharf Hotel

2500 Mason St, San Francisco
4.0 out of 5.0
3.8 out of 5 (3,919 reviews)
Nice hotel It was confortable and very clean! Close to the beach and many attractions - 

$149

$149
Clift

Clift

495 Geary St, San Francisco
4.5 out of 5.0
4.1 out of 5 (3,441 reviews)
Clean but needs to join the digital age. No charging ports, broken floor lamp switch, extra “facility charge” that reeks of extra add-on air … - 

$159

$159
Hyatt Regency San Francisco Airport

Hyatt Regency San Francisco Airport

1333 Bayshore Hwy, Burlingame
4.5 out of 5.0
4.0 out of 5 (3,252 reviews)
Room condition is good,need better foods for breakfast. Environment is good and I like the bed, ver … - 

$99

$99
Larkspur Landing South San Francisco - An All-Suite Hotel

Larkspur Landing South San Francisco - An All-Suite Hotel

690 Gateway Blvd, South San Francisco
3.5 out of 5.0
4.1 out of 5 (1,916 reviews)
Nice hotel. Convenient location. We found the room to be very clean and the location of the hotel served us well as we visited relat … - 

$93

$93
Hotel Nikko San Francisco

Hotel Nikko San Francisco

222 Mason St, San Francisco
4.5 out of 5.0
4.3 out of 5 (6,518 reviews)
My best hotel experience in San Francisco! Stayed in the imperial rooms, but the others are just as comfortable and beautiful. The bathrooms w … - 

$157

$157
Hyatt Regency San Francisco

Hyatt Regency San Francisco

5 Embarcadero Center, San Francisco
4.0 out of 5.0
4.3 out of 5 (3,168 reviews)
Andy at ceck in provided World class service to me andy family - 

$159

$159
The Westin St. Francis San Francisco on Union Square

The Westin St. Francis San Francisco on Union Square

335 Powell Street, San Francisco
4.5 out of 5.0
4.2 out of 5 (4,374 reviews)
Very Beautiful Hotel Perfect Location. Wonderful views. Outstanding service. - 

$158

$158
Palace Hotel, a Luxury Collection Hotel, San Francisco

Palace Hotel, a Luxury Collection Hotel, San Francisco

2 New Montgomery St, San Francisco
5.0 out of 5.0
4.5 out of 5 (3,030 reviews)
Comfortable hotel I love staying at the Palace Hotel. The beds and pillows are so comfortable and the rooms are spaci … - 

$167

$167
Pier 2620 Hotel Fisherman's Wharf

Pier 2620 Hotel Fisherman's Wharf

2620 Jones Street, San Francisco
4.0 out of 5.0
4.2 out of 5 (4,087 reviews)
We will definitely be back! Bill was absolutely wonderful checking us in. This is our second time here and definitely will not … - 

$161

$161
Holiday Inn San Francisco-Fisherman's Wharf

Holiday Inn San Francisco-Fisherman's Wharf

1300 Columbus Ave, San Francisco
3.5 out of 5.0
3.9 out of 5 (4,991 reviews)
Close to the wharf The hotel is within walking distance of Fisherman’s Wharf. There are two buildings. We were in the … - 

$126

$126
Grand Hyatt San Francisco Union Square

Grand Hyatt San Francisco Union Square

345 Stockton St, San Francisco
4.5 out of 5.0
4.4 out of 5 (3,344 reviews)
Good Location Clean hotel with a great staff and a very good location. Union Square is a great place for shopping - 

$169

$169
Fairmont San Francisco

Fairmont San Francisco

950 Mason Street Atop Nob Hill, San Francisco
5.0 out of 5.0
4.5 out of 5 (3,843 reviews)
Great hotel in beautiful San Francisco. Only downside is that you have to walk up a big hill! - 

$199

$199
Handlery Union Square Hotel

Handlery Union Square Hotel

351 Geary St, San Francisco
4.0 out of 5.0
4.0 out of 5 (4,153 reviews)
SF Nostalgia We loved staying here, brought back many memories of old times living in SF! Hotel stay was great i … - 

$129

$129
Serrano Hotel

Serrano Hotel

405 Taylor St, San Francisco
4.5 out of 5.0
4.0 out of 5 (4,481 reviews)
Great boutique style hotel blocks from union squar I’ve been staying here for 12 years and now they are renovating the hotel after so long and it’s wo … - 

$138

$138
The Park Central San Francisco

The Park Central San Francisco

50 3rd St, San Francisco
4.5 out of 5.0
4.3 out of 5 (5,873 reviews)
Thanksgiving in the city Took the family to the city for a get away thanksgiving weekend. Very nice hotel but expect to pay … - 

$114

$114
Hotel Zephyr

Hotel Zephyr

250 Beach Street, San Francisco
4.0 out of 5.0
4.2 out of 5 (2,385 reviews)
This is my second time at the Zepher nice room clean. Good location. SF Wharf. - 

$161

$161
Bay Landing San Francisco Airport Hotel

Bay Landing San Francisco Airport Hotel

1550 Bayshore Hwy, Burlingame
3.5 out of 5.0
4.5 out of 5 (3,663 reviews)
Good Hotel by the Airport Nice, quiet room. Spacious. Nice staff who quickly fulfilled my request for a bathtub rubber mat. B … - 

$112

$112
Hotel Focus SFO

Hotel Focus SFO

111 Mitchell Ave, South San Francisco
3.5 out of 5.0
3.1 out of 5 (375 reviews)
Nice and clean It’s was close to everything. Very neat and clean. - 

$89

$89
Map

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Independent San Francisco Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in San Francisco, California. Known for well-appointed rooms and friendly, personalized service, each of the top Independent San Francisco hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some San Francisco Independent locations may even offer extra little benefits and discounts for frequent travelers.