Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured San Francisco Independent Hotels

See all 526 Hotels in San Francisco
Hotel Whitcomb

Hotel Whitcomb

1231 Market St, San Francisco
3.5 out of 5.0
3.1 out of 5 (3,220 reviews)
Close to the action My friend and I were going to a concert at Bill Graham Auditorium. It is 1 1/2 blocks away. It is e … - 

$149

$149
Hotel Zoe San Francisco

Hotel Zoe San Francisco

425 North Point, San Francisco
4.0 out of 5.0
4.2 out of 5 (2,382 reviews)
Beautiful room. The most comfortable bed of the whole trip. Pretty close to the pier. Parking was v … - 

$209

$209
Hotel Nikko San Francisco

Hotel Nikko San Francisco

222 Mason St, San Francisco
4.0 out of 5.0
4.3 out of 5 (2,783 reviews)
Had a great stay at the Hotel Nikko. We stayed in a Junior Suite on the 20th floor. The bed was so … - 

$176

$176
Serrano Hotel

Serrano Hotel

405 Taylor St, San Francisco
3.9 out of 5 (1,638 reviews)
The staff was excellent and very accommodating! The hotel was not in the best location. - 

$178

$178
Hotel Zephyr

Hotel Zephyr

250 Beach Street, San Francisco
3.5 out of 5.0
4.1 out of 5 (916 reviews)
Excellent location for Fisherman's Wharf area of the city. - 

$169

$169
Pier 2620 Hotel Fisherman's Wharf

Pier 2620 Hotel Fisherman's Wharf

2620 Jones Street, San Francisco
3.5 out of 5.0
4.2 out of 5 (1,963 reviews)
Great hotel, friendly staff and good breakfast Everything about this hotel met our expectations - helpful and friendly staff, nice room, close to … - 

$178

$178
The Westin St. Francis San Francisco on Union Square

The Westin St. Francis San Francisco on Union Square

335 Powell Street, San Francisco
4.0 out of 5.0
4.1 out of 5 (1,838 reviews)
Actually only unpleasing thing was the super noisy AC. It was impossible to rest or watch TV, talk … - 

$259

$259
Grand Hyatt San Francisco Union Square

Grand Hyatt San Francisco Union Square

345 Stockton St, San Francisco
4.0 out of 5.0
4.3 out of 5 (1,387 reviews)
Very nice hotel. Great location too. Check-in was very quick. Front desk person was able to find a nice room facing Union Square for us … - 

$209

$209
Palace Hotel, a Luxury Collection Hotel, San Francisco

Palace Hotel, a Luxury Collection Hotel, San Francisco

2 New Montgomery St, San Francisco
5.0 out of 5.0
4.5 out of 5 (1,545 reviews)
Close to everything! The lobby was very elegant and fancy and the amenities in the room are almost complete (no tootbrus … - 

$255

$255
Handlery Union Square Hotel

Handlery Union Square Hotel

351 Geary St, San Francisco
3.5 out of 5.0
3.9 out of 5 (1,605 reviews)
Central, great location We had a great stay in the hotel. Very pleased with service provided. Hotel is centrally located an … - 

$179

$179
San Francisco Marriott Marquis

San Francisco Marriott Marquis

780 Mission Street, San Francisco
4.0 out of 5.0
4.4 out of 5 (1,663 reviews)
Very accommodating -- lovely hotel -- great loca We had a great stay. Everyone was nice. Our flight was very delayed and we got into hotel very late … - 

$161

$161
Argonaut Hotel - a Noble House Hotel

Argonaut Hotel - a Noble House Hotel

495 Jefferson St, San Francisco
4.5 out of 5.0
4.6 out of 5 (2,972 reviews)
Nice hotel close to attractions. Arrived early but was allowed to check in. Great staff, very helpful. - 

$202

$202
Hyatt Regency San Francisco Airport

Hyatt Regency San Francisco Airport

1333 Bayshore Hwy, Burlingame
4.0 out of 5.0
4.0 out of 5 (1,281 reviews)
Close to airport Very accommodating / I was moved to a room closer to the elevator- I was with my elderly parents. T … - 

$149

$149
Fairmont San Francisco

Fairmont San Francisco

950 Mason Street Atop Nob Hill, San Francisco
5.0 out of 5.0
4.4 out of 5 (2,070 reviews)
It was about the journey Had a wonderful stay just what the doctor ordered - 

$254

$254
Hotel Focus SFO

Hotel Focus SFO

111 Mitchell Ave, South San Francisco
3.0 out of 5.0
3.3 out of 5 (77 reviews)
Exterior of hotel was not great. Our room had brand new beds. Everything was very clean. The vanity … - 

$107

$107
Sheraton Fisherman's Wharf Hotel

Sheraton Fisherman's Wharf Hotel

2500 Mason St, San Francisco
4.0 out of 5.0
3.9 out of 5 (2,455 reviews)
Definitely a nice hotel to make our stay more enjoyable. Very close to Fishermans Warf and most oth … - 

$189

$189
La Quinta Inn San Francisco Airport North

La Quinta Inn San Francisco Airport North

20 Airport Blvd, South San Francisco
2.5 out of 5.0
3.4 out of 5 (947 reviews)
Under Construction and a Bit Scary Couldn't find the lobby, it was in a converted hotel room. Construction everywhere and the location … - 

$95

$95
Monarch Hotel

Monarch Hotel

1015 Geary St, San Francisco
2.0 out of 5.0
3.0 out of 5 (1,073 reviews)
Trip to San Fran A nice older hotel with great staff. We appreciated being close to the bus lines! It was clean. Our … - 

$101

$101
San Francisco Marriott Union Square

San Francisco Marriott Union Square

480 Sutter Street, San Francisco
4.3 out of 5 (774 reviews)
New rooms Stayed for five days. I was on 25th, and my room was brand new including a bathroom. Service was gr … - 

$199

$199
Holiday Inn San Francisco-Fisherman's Wharf

Holiday Inn San Francisco-Fisherman's Wharf

1300 Columbus Ave, San Francisco
3.5 out of 5.0
3.9 out of 5 (1,856 reviews)
Great Location First off this hotel has 2 locations a block apart. I was not made aware of which hotel we were sta … - 

$160

$160
Map

Recently booked San Francisco hotels

The Westin St Francis San Francisco on Union Square
4.0 out of 5.0
Last booking: 3 minutes ago
Hotel 32One
3.0 out of 5.0
Last booking: 7 minutes ago
Clift
4.0 out of 5.0
Last booking: 10 minutes ago
White Swan Inn
3.5 out of 5.0
Last booking: 11 minutes ago
SF Plaza Hotel
2.5 out of 5.0
Last booking: 12 minutes ago
Inn on Broadway
2.5 out of 5.0
Last booking: 13 minutes ago
Grand Hyatt San Francisco Union Square
4.0 out of 5.0
Last booking: 13 minutes ago
Days Inn San Francisco Lombard
2.0 out of 5.0
Last booking: 13 minutes ago
Days Inn Redwood City
2.0 out of 5.0
Last booking: 14 minutes ago

Independent San Francisco Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in San Francisco, California. Known for well-appointed rooms and friendly, personalized service, each of the top Independent San Francisco hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some San Francisco Independent locations may even offer extra little benefits and discounts for frequent travelers.