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Featured San Francisco Independent Hotels

See all 521 Hotels in San Francisco
Hotel Whitcomb

Hotel Whitcomb

1231 Market St, San Francisco
4.0 out of 5.0
3.3 out of 5 (8,248 reviews)
Great location near BART and the city center. Visited sister and business appointments near city hall. - 

$105

$105
Hyatt Regency San Francisco Airport

Hyatt Regency San Francisco Airport

1333 Bayshore Hwy, Burlingame
4.5 out of 5.0
4.0 out of 5 (3,254 reviews)
Really Good Really nice hotel and every way except the flat pillows. We stayed two nights and had two rooms. My … - 

$99

$99
Sheraton Fisherman's Wharf Hotel

Sheraton Fisherman's Wharf Hotel

2500 Mason St, San Francisco
4.5 out of 5.0
3.8 out of 5 (3,923 reviews)
Nice hotel It was confortable and very clean! Close to the beach and many attractions - 

$127

$127
Clift

Clift

495 Geary St, San Francisco
4.0 out of 5.0
4.1 out of 5 (3,445 reviews)
Rooms could use a little updating. Lots of noise from street. Great staff - 

$159

$159
Hotel Nikko San Francisco

Hotel Nikko San Francisco

222 Mason St, San Francisco
4.5 out of 5.0
4.3 out of 5 (6,524 reviews)
Great review Very pleased with my stay @the hotel. Great room, comfortable, clean, staff was great. - 

$157

$157
Hyatt Regency San Francisco

Hyatt Regency San Francisco

5 Embarcadero Center, San Francisco
4.5 out of 5.0
4.3 out of 5 (3,168 reviews)
Nice hotel at Embarcadero The hotel is in a great location, where you go in a walking distance to the City sites. Cable car i … - 

$159

$159
The Westin St. Francis San Francisco on Union Square

The Westin St. Francis San Francisco on Union Square

335 Powell Street, San Francisco
4.5 out of 5.0
4.2 out of 5 (4,377 reviews)
Good. We stayed in the older side of the building but had a nice view if union square. It was clean but o … - 

$149

$149
Hotel Zoe San Francisco

Hotel Zoe San Francisco

425 North Point, San Francisco
4.5 out of 5.0
4.2 out of 5 (5,646 reviews)
Great stay The experience at Zoe was great, we were greeted with wine, and our room was so cute and comfy. The … - 

$149

$149
Palace Hotel, a Luxury Collection Hotel, San Francisco

Palace Hotel, a Luxury Collection Hotel, San Francisco

2 New Montgomery St, San Francisco
5.0 out of 5.0
4.5 out of 5 (3,031 reviews)
Best Hotel Ever Excellent hotel. Classic elegance. Attentive service. Great Location. Enough said. - 

$167

$167
Pier 2620 Hotel Fisherman's Wharf

Pier 2620 Hotel Fisherman's Wharf

2620 Jones Street, San Francisco
4.5 out of 5.0
4.2 out of 5 (4,093 reviews)
Great Hotel Loved this place. Clean, great breakfast and close to EVERYTHING. I did not hear any noise like oth … - 

$161

$161
Grand Hyatt San Francisco Union Square

Grand Hyatt San Francisco Union Square

345 Stockton St, San Francisco
4.5 out of 5.0
4.4 out of 5 (3,346 reviews)
Great hotel. Tougher city. This is a great hotel. The staff were great. Helpful accommodating and professional. But San Franci … - 

$169

$169
Holiday Inn San Francisco-Fisherman's Wharf

Holiday Inn San Francisco-Fisherman's Wharf

1300 Columbus Ave, San Francisco
4.0 out of 5.0
3.9 out of 5 (4,995 reviews)
Great location for fisherman’s wharf Busy fun weekend . Lots to see and do. Check out breakfast place called 8 am - 

$112

$112
Fairmont San Francisco

Fairmont San Francisco

950 Mason Street Atop Nob Hill, San Francisco
4.5 out of 5 (3,849 reviews)
Fairmont Hotel is an excellent hotel. Great bay views. Wonderful way to spend the holidays. - 

$199

$199
Handlery Union Square Hotel

Handlery Union Square Hotel

351 Geary St, San Francisco
4.0 out of 5.0
4.0 out of 5 (4,157 reviews)
SF Nostalgia We loved staying here, brought back many memories of old times living in SF! Hotel stay was great i … - 

$129

$129
Serrano Hotel

Serrano Hotel

405 Taylor St, San Francisco
4.5 out of 5.0
4.0 out of 5 (4,488 reviews)
Nice stay here at the Serrano Hotel in San Francisco!! - 

$138

$138
The Park Central San Francisco

The Park Central San Francisco

50 3rd St, San Francisco
4.5 out of 5.0
4.3 out of 5 (5,875 reviews)
Watch your wallet !!! When you book online, one this is erroneous about the stated price of the stay here. There is a hid … - 

$113

$113
Hotel Zephyr

Hotel Zephyr

250 Beach Street, San Francisco
3.5 out of 5.0
4.2 out of 5 (2,394 reviews)
Excellent Location Fantastic location, close to fisherman’s wharf, cable cars, walking distance to boat for Alcatraz t … - 

$161

$161
Bay Landing San Francisco Airport Hotel

Bay Landing San Francisco Airport Hotel

1550 Bayshore Hwy, Burlingame
3.5 out of 5.0
4.5 out of 5 (3,666 reviews)
the room is comfortable and clean close to the airport - 

$112

$112
Larkspur Landing South San Francisco - An All-Suite Hotel

Larkspur Landing South San Francisco - An All-Suite Hotel

690 Gateway Blvd, South San Francisco
3.5 out of 5.0
4.1 out of 5 (1,913 reviews)
Nice hotel. Convenient location. We found the room to be very clean and the location of the hotel served us well as we visited relat … - 

$93

$93
Hotel Focus SFO

Hotel Focus SFO

111 Mitchell Ave, South San Francisco
3.0 out of 5.0
3.1 out of 5 (381 reviews)
Comfortable hotel close to SFO Worked out well for our 9 hr layover. Clean, quiet, attentive staff and breakfast included. Shuttle … - 

$89

$89
Map

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Independent San Francisco Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in San Francisco, California. Known for well-appointed rooms and friendly, personalized service, each of the top Independent San Francisco hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some San Francisco Independent locations may even offer extra little benefits and discounts for frequent travelers.