Beginning of main content

San Francisco Hotel Rooms at the Independent

Search Flights

Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

San Francisco Hotels

Search Flight + Hotel

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured San Francisco Independent Hotels

See all 493 Hotels in San Francisco
Serrano Hotel

Serrano Hotel

405 Taylor St, San Francisco
4.0 out of 5.0
3.9 out of 5 (1,511 reviews)
Nice hotel Stayed overnight. Very nice lady at front desk. Easy check in and out. The room was ok but they had … - 

$168

$168
Oceano Hotel and Spa

Oceano Hotel and Spa

280 Capistrano Road, Half Moon Bay
4.0 out of 5.0
4.4 out of 5 (267 reviews)
Wonderful relaxing accomadations Very clean well kept property, room was spacious and well equipped. We enjoyed our stay and will be … - 

$259

$259
Hotel G San Francisco

Hotel G San Francisco

386 Geary Street, San Francisco
4.0 out of 5.0
4.1 out of 5 (469 reviews)
Fantastic hotel in the heart of San Francisco. We loved our stay at Hotel G. From our communication before arrival, to the last day when we droppe … - 

$178

$178
Hotel Drisco

Hotel Drisco

2901 Pacific Avenue, San Francisco
4.0 out of 5.0
4.8 out of 5 (117 reviews)
Deluxe, luxury Hotel This is probably the nicest hotel that I've ever stayed in. It might be one of the nicest hotels in … - 
Casa Madrona Hotel & Spa

Casa Madrona Hotel & Spa

801 Bridgeway, Sausalito
3.5 out of 5.0
4.3 out of 5 (189 reviews)
Nice view Too many steps to get to room. Great view and nice suite. - 

$237

$237
Axiom Hotel San Francisco

Axiom Hotel San Francisco

28 Cyril Magnin Street, San Francisco
4.0 out of 5.0
4.4 out of 5 (146 reviews)
Prime location Lovely boutique hotel in the heart of Union Square - 

$182

$182
Villa Florence

Villa Florence

225 Powell St, San Francisco
4.0 out of 5.0
3.7 out of 5 (506 reviews)
Nice hotel. Great location. VERY loud! The construction work on the other side of our wall began at 6am sharp was HORRIBLE. The banging an … - 

$140

$140
Orchard Hotel

Orchard Hotel

665 Bush St, San Francisco
4.0 out of 5.0
4.6 out of 5 (802 reviews)
Great Location, Friendly/Helpful Staff Very comfortable, great staff, and great location. Excellent stay! - 

$179

$179
Orchard Garden Hotel

Orchard Garden Hotel

466 Bush St, San Francisco
4.0 out of 5.0
4.5 out of 5 (609 reviews)
Nice hotel just near by China town Location is very good to go to China town, Union square, etc. Even though it's located inside downt … - 

$179

$179
Cavallo Point

Cavallo Point

601 Murray Circle, Sausalito
4.5 out of 5.0
4.4 out of 5 (122 reviews)
Timeless Amazing location, huge green space, timeless feeing - 

$529

$529
Map

Recently booked San Francisco hotels

Best Western Plus El Rancho Inn
3.0 out of 5.0
Last booking: 2 minutes ago
Serrano Hotel
4.0 out of 5.0
Last booking: 3 minutes ago
Hotel Whitcomb
3.5 out of 5.0
Last booking: 10 minutes ago
Best Western Plus Americania
3.0 out of 5.0
Last booking: 11 minutes ago
The Tuscan, A Noble House Hotel
4.0 out of 5.0
Last booking: 11 minutes ago
Pier 2620 Hotel Fisherman's Wharf
3.5 out of 5.0
Last booking: 12 minutes ago
DoubleTree by Hilton Berkeley Marina
3.5 out of 5.0
Last booking: 12 minutes ago
The Scarlet Huntington Hotel
4.5 out of 5.0
Last booking: 12 minutes ago
Hotel Kabuki - a Joie de Vivre Boutique Hotel
3.5 out of 5.0
Last booking: 14 minutes ago

Independent San Francisco Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in San Francisco, California. Known for well-appointed rooms and friendly, personalized service, each of the top Independent San Francisco hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some San Francisco Independent locations may even offer extra little benefits and discounts for frequent travelers.