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Featured San Francisco Independent Hotels

See all 528 Hotels in San Francisco
Hotel Whitcomb

Hotel Whitcomb

1231 Market St, San Francisco
3.5 out of 5.0
3.3 out of 5 (8,179 reviews)
Decent hotel very close to the BART station. Rolando at the front desk was very helpful. The front desk was busy with convention guests but he t … - 

$105

$105
Hotel Zoe San Francisco

Hotel Zoe San Francisco

425 North Point, San Francisco
4.0 out of 5.0
4.2 out of 5 (5,575 reviews)
Wonderful stay. Perfect location near Fisherman's Wharf. Everything was spot-on in our stay there. - 

$167

$167
Hotel Nikko San Francisco

Hotel Nikko San Francisco

222 Mason St, San Francisco
4.0 out of 5.0
4.3 out of 5 (6,469 reviews)
Love it here This is our second time at the NIkko in 3 months. Last time was with a client and this time just fo … - 

$176

$176
Hyatt Regency San Francisco

Hyatt Regency San Francisco

5 Embarcadero Center, San Francisco
4.0 out of 5.0
4.3 out of 5 (3,475 reviews)
Great San Francisco location Close to great outdoor spaces, the Ferry Building, restaurants and public transportation. The atriu … - 

$159

$159
Hotel Zephyr

Hotel Zephyr

250 Beach Street, San Francisco
3.5 out of 5.0
4.2 out of 5 (2,329 reviews)
Experience was great. The staff is the best. Everyone was so friendly and helpful. - 

$152

$152
Serrano Hotel

Serrano Hotel

405 Taylor St, San Francisco
4.0 out of 5.0
4.0 out of 5 (4,447 reviews)
A historic gem in a diverse neighborhood. Surprise fees for “urban taxes” of $26+ were laughable. Hotel is actively renovating, which will on … - 

$128

$128
Grand Hyatt San Francisco Union Square

Grand Hyatt San Francisco Union Square

345 Stockton St, San Francisco
4.0 out of 5.0
4.4 out of 5 (3,747 reviews)
very central - well priced, but nothing special check in / check ou definitely needs improvement, the set up is not very effective and especially t … - 

$169

$169
The Westin St. Francis San Francisco on Union Square

The Westin St. Francis San Francisco on Union Square

335 Powell Street, San Francisco
4.0 out of 5.0
4.2 out of 5 (5,221 reviews)
Great Anniversary Location This is a great location. The view in our room was of Union Square. I highly recommend getting this … - 

$158

$158
Pier 2620 Hotel Fisherman's Wharf

Pier 2620 Hotel Fisherman's Wharf

2620 Jones Street, San Francisco
4.0 out of 5.0
4.2 out of 5 (4,035 reviews)
Awesome location, good amenities. We had an awesome stay, it's close to the warf(a couple blocks away) and the cable car is right aro … - 

$152

$152
Sheraton Fisherman's Wharf Hotel

Sheraton Fisherman's Wharf Hotel

2500 Mason St, San Francisco
4.0 out of 5.0
3.9 out of 5 (5,405 reviews)
Convenient Close to Pier 39 Will definately stay again, walking distance to so many sight-seeing places. Clean, Safe and many l … - 

$149

$149
Hyatt Regency San Francisco Airport

Hyatt Regency San Francisco Airport

1333 Bayshore Hwy, Burlingame
4.0 out of 5.0
4.0 out of 5 (3,552 reviews)
Everything was great except for the bed, which was a bit hard for my liking. - 

$99

$99
Palace Hotel, a Luxury Collection Hotel, San Francisco

Palace Hotel, a Luxury Collection Hotel, San Francisco

2 New Montgomery St, San Francisco
5.0 out of 5.0
4.5 out of 5 (3,577 reviews)
Elegant and fantastic! Truly one of the best and luxurious hotels in San Francisco. - 

$191

$191
Handlery Union Square Hotel

Handlery Union Square Hotel

351 Geary St, San Francisco
3.5 out of 5.0
4.0 out of 5 (4,770 reviews)
We arrived early an they we very helpful in holding our luggage until check-in so we could see the … - 

$139

$139
Hotel Focus SFO

Hotel Focus SFO

111 Mitchell Ave, South San Francisco
3.0 out of 5.0
3.1 out of 5 (357 reviews)
Room was nice! Would recommend for a short affordable stay! - 

$89

$89
Argonaut Hotel - a Noble House Hotel

Argonaut Hotel - a Noble House Hotel

495 Jefferson St, San Francisco
4.5 out of 5.0
4.6 out of 5 (5,590 reviews)
Great location but..... Great hotel, great location and fantastic staff. Hotel was recently renovated and features nice roo … - 

$188

$188
Larkspur Landing South San Francisco - An All-Suite Hotel

Larkspur Landing South San Francisco - An All-Suite Hotel

690 Gateway Blvd, South San Francisco
3.0 out of 5.0
4.2 out of 5 (2,426 reviews)
Cozy Clean cozy quiet rooms.....only one thing wish the shower water pressure was stronger but stil love … - 

$84

$84
Holiday Inn San Francisco-Fisherman's Wharf

Holiday Inn San Francisco-Fisherman's Wharf

1300 Columbus Ave, San Francisco
3.5 out of 5.0
3.9 out of 5 (4,963 reviews)
It was an overall amazing experience. We got there from the airport at 9am and was just going to dr … - 

$105

$105
Stanford Court San Francisco

Stanford Court San Francisco

905 California Street, San Francisco
4.0 out of 5.0
4.2 out of 5 (3,212 reviews)
Perfect nob hill stay I came to San Francisco to see a show at the Masonic and this hotel was perfect walking distance aw … - 

$131

$131
San Francisco Marriott Marquis

San Francisco Marriott Marquis

780 Mission Street, San Francisco
4.0 out of 5.0
4.3 out of 5 (4,483 reviews)
Super nice, got upgraded from the 10th floor to the 31st floor! - 

$169

$169
San Francisco Marriott Union Square

San Francisco Marriott Union Square

480 Sutter Street, San Francisco
4.0 out of 5.0
4.4 out of 5 (2,391 reviews)
Staff was great! Staff was very courteous. Clean. Room felt a little small. - 

$179

$179
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Independent San Francisco Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in San Francisco, California. Known for well-appointed rooms and friendly, personalized service, each of the top Independent San Francisco hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some San Francisco Independent locations may even offer extra little benefits and discounts for frequent travelers.