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Featured San Francisco Independent Hotels

See all 522 Hotels in San Francisco
Hotel Whitcomb

Hotel Whitcomb

1231 Market St, San Francisco
4.0 out of 5.0
3.3 out of 5 (8,242 reviews)
Lovely hotel, not the best neighborhood at night The hotel itself is beautiful and clean. They have done a nice job preserving the antique charm. St … - 

$105

$105
Hotel Zoe San Francisco

Hotel Zoe San Francisco

425 North Point, San Francisco
4.5 out of 5.0
4.2 out of 5 (5,638 reviews)
Great STAFF - competitive rates - LOVE LOVE LOVE the location - 

$149

$149
Sheraton Fisherman's Wharf Hotel

Sheraton Fisherman's Wharf Hotel

2500 Mason St, San Francisco
4.5 out of 5.0
3.8 out of 5 (3,921 reviews)
Nice hotel It was confortable and very clean! Close to the beach and many attractions - 

$149

$149
Clift

Clift

495 Geary St, San Francisco
4.5 out of 5.0
4.1 out of 5 (3,441 reviews)
Clean but needs to join the digital age. No charging ports, broken floor lamp switch, extra “facility charge” that reeks of extra add-on air … - 

$159

$159
Hyatt Regency San Francisco Airport

Hyatt Regency San Francisco Airport

1333 Bayshore Hwy, Burlingame
4.0 out of 5 (3,253 reviews)
Really Good Really nice hotel and every way except the flat pillows. We stayed two nights and had two rooms. My … - 

$99

$99
Larkspur Landing South San Francisco - An All-Suite Hotel

Larkspur Landing South San Francisco - An All-Suite Hotel

690 Gateway Blvd, South San Francisco
3.5 out of 5.0
4.1 out of 5 (1,917 reviews)
Nice hotel. Convenient location. We found the room to be very clean and the location of the hotel served us well as we visited relat … - 

$93

$93
Hotel Nikko San Francisco

Hotel Nikko San Francisco

222 Mason St, San Francisco
4.5 out of 5.0
4.3 out of 5 (6,522 reviews)
Great central location Exceptionally friendly and competent staff from doorman to person delivering bottle opener promptly … - 

$157

$157
Hyatt Regency San Francisco

Hyatt Regency San Francisco

5 Embarcadero Center, San Francisco
4.5 out of 5.0
4.3 out of 5 (3,169 reviews)
Andy at ceck in provided World class service to me andy family - 

$159

$159
The Westin St. Francis San Francisco on Union Square

The Westin St. Francis San Francisco on Union Square

335 Powell Street, San Francisco
4.5 out of 5.0
4.2 out of 5 (4,375 reviews)
Very Beautiful Hotel Perfect Location. Wonderful views. Outstanding service. - 

$158

$158
Palace Hotel, a Luxury Collection Hotel, San Francisco

Palace Hotel, a Luxury Collection Hotel, San Francisco

2 New Montgomery St, San Francisco
5.0 out of 5.0
4.5 out of 5 (3,032 reviews)
Best Hotel Ever Excellent hotel. Classic elegance. Attentive service. Great Location. Enough said. - 

$167

$167
Pier 2620 Hotel Fisherman's Wharf

Pier 2620 Hotel Fisherman's Wharf

2620 Jones Street, San Francisco
4.2 out of 5 (4,091 reviews)
would recommend to friends. good location and friendly, helpful staff. We enjoyed our stay and would recommend this hotel. - 

$161

$161
Grand Hyatt San Francisco Union Square

Grand Hyatt San Francisco Union Square

345 Stockton St, San Francisco
4.5 out of 5.0
4.4 out of 5 (3,345 reviews)
Very friendly hotel staff. Helped my husband find our room .... Let us have a late checkout. - 

$169

$169
Holiday Inn San Francisco-Fisherman's Wharf

Holiday Inn San Francisco-Fisherman's Wharf

1300 Columbus Ave, San Francisco
4.0 out of 5.0
3.9 out of 5 (4,993 reviews)
Late check in was rough. Not a lot of communication and when we got to our room we were surprised t … - 

$126

$126
Fairmont San Francisco

Fairmont San Francisco

950 Mason Street Atop Nob Hill, San Francisco
5.0 out of 5.0
4.5 out of 5 (3,845 reviews)
Beautiful hotel in the Knob Hill area! The Fairmont Hotel San Fran is absolutely beautiful! So nicely decorated for the holidays. - 

$199

$199
Handlery Union Square Hotel

Handlery Union Square Hotel

351 Geary St, San Francisco
4.0 out of 5.0
4.0 out of 5 (4,157 reviews)
SF Nostalgia We loved staying here, brought back many memories of old times living in SF! Hotel stay was great i … - 

$129

$129
Serrano Hotel

Serrano Hotel

405 Taylor St, San Francisco
4.5 out of 5.0
4.0 out of 5 (4,486 reviews)
Quick check-in. Very nice and clean. Room was well decorated. - 

$138

$138
The Park Central San Francisco

The Park Central San Francisco

50 3rd St, San Francisco
4.5 out of 5.0
4.3 out of 5 (5,876 reviews)
Thanksgiving in the city Took the family to the city for a get away thanksgiving weekend. Very nice hotel but expect to pay … - 

$90

$90
Hotel Zephyr

Hotel Zephyr

250 Beach Street, San Francisco
3.5 out of 5.0
4.2 out of 5 (2,391 reviews)
Excellent Location Fantastic location, close to fisherman’s wharf, cable cars, walking distance to boat for Alcatraz t … - 

$161

$161
Bay Landing San Francisco Airport Hotel

Bay Landing San Francisco Airport Hotel

1550 Bayshore Hwy, Burlingame
3.5 out of 5.0
4.5 out of 5 (3,664 reviews)
Good Hotel by the Airport Nice, quiet room. Spacious. Nice staff who quickly fulfilled my request for a bathtub rubber mat. B … - 

$112

$112
Hotel Focus SFO

Hotel Focus SFO

111 Mitchell Ave, South San Francisco
3.5 out of 5.0
3.1 out of 5 (379 reviews)
Nice and clean It’s was close to everything. Very neat and clean. - 

$89

$89
Map

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Independent San Francisco Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in San Francisco, California. Known for well-appointed rooms and friendly, personalized service, each of the top Independent San Francisco hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some San Francisco Independent locations may even offer extra little benefits and discounts for frequent travelers.