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Our top choices for Santa Ana hotels

Hotel Rio Grande

Hotel Rio Grande
3.0 star property
Magangué
2.0 out of 10, (1 review)
"bien"
Colombia
Luis
$36 nightly
The price is $36
Mar 29 - Mar 30
Hotel Rio Grande

LA CANDELARIA ROOM HOUSE

LA CANDELARIA ROOM HOUSE
3.0 star property
Magangué
$55 nightly
The price is $55
Feb 27 - Feb 28
LA CANDELARIA ROOM HOUSE

La Casa Amarilla

La Casa Amarilla
3.0 star property
Mompos
8.8 out of 10, Excellent, (50 reviews)
"Very nice hotel"
Mexico
Jorge
$70 nightly
The price is $70
Feb 27 - Feb 28
La Casa Amarilla

Hotel Archangelus

Hotel Archangelus
3.0 star property
Mompos
10.0 out of 10, Exceptional, (1 review)
"Absolutely delightful! The staff were helpful and pleasant, the room was well appointed, and the breakfast served was delicious. This was my favorite accommodation during my week in Colombia and I highly recommend it."
United States
Andrea
$113 nightly
The price is $113
Feb 27 - Feb 28
Hotel Archangelus

Albarrada Hotel Boutique

Albarrada Hotel Boutique
3.0 star property
Mompos
10.0 out of 10, Exceptional, (2 reviews)
Albarrada Hotel Boutique

LITERATIUM

LITERATIUM
3.0 star property
Mompos
9.2 out of 10, Wonderful, (13 reviews)
"Lovely stay, excellent staff, calm environment, and good breakfast :)"
Canada
Jennifer
$84 nightly
The price is $84
Feb 27 - Feb 28
LITERATIUM

San Rafael

San Rafael
3.5 star property
Mompos
9.8 out of 10, Exceptional, (24 reviews)
"Very good hotel, staff is great and well located"
United States
Richard
$137 nightly
The price is $137
Feb 27 - Feb 28
San Rafael

Hotel Casa Isabelita

Hotel Casa Isabelita
3.0 star property
Mompos
8.8 out of 10, Excellent, (3 reviews)
"Good price, friendly staff, look location (short walk to the best parts of Mompox), AC in room worked well (Mompox is pretty hot)"
United States
Cormac
Hotel Casa Isabelita

Portal de la Marquesa

Portal de la Marquesa
3.5 star property
Mompos
9.0 out of 10, Wonderful, (133 reviews)
"Amazing staff and beautiful location. We love it I will be back in November :-)"
United States
Jaime
$94 nightly
The price is $94
Feb 27 - Feb 28
Portal de la Marquesa

Hotel Casa Evan

Hotel Casa Evan
2.0 star property
Mompos
8.0 out of 10, Very Good, (1 review)
Hotel Casa Evan

BOHEMIA HOTEL BOUTIQUE

BOHEMIA HOTEL BOUTIQUE
2.5 star property
Mompos
6.0 out of 10, (2 reviews)
"Muy buenas instalaciones. El servicio fue perfecto desde la Gerente del hotel, Lina, como Daniela y Don Juan. Muchas gracias por el servicio"
Colombia
Juan Pablo
$106 nightly
The price is $106
Feb 27 - Feb 28
BOHEMIA HOTEL BOUTIQUE

Hotel Jardines Evans By Geh Suites

Hotel Jardines Evans By Geh Suites
3.0 star property
Mompos
4.0 out of 10, (1 review)
"Hotel modesto, personal muy amable, pero MUY CARO por lo que ofrece, "
Colombia
enric
Hotel Jardines Evans By Geh Suites

Hotel Central

Hotel Central
3.0 star property
Magangué
$40 nightly
The price is $40
Mar 5 - Mar 6
Hotel Central

Hotel Santa Bárbara Mompox

Hotel Santa Bárbara Mompox
2.0 star property
Mompos
$44 nightly
The price is $44
Mar 5 - Mar 6
Hotel Santa Bárbara Mompox

Hotel Boutique Casa Gerar Filigrana

Hotel Boutique Casa Gerar Filigrana
3.0 star property
Mompos
$86 nightly
The price is $86
Feb 27 - Feb 28
Hotel Boutique Casa Gerar Filigrana

La Gloria Hotel by BespokeColombia

La Gloria Hotel by BespokeColombia
3.5 star property
Mompos
9.4 out of 10, Exceptional, (43 reviews)
"Nice staff and rooms. "
United States
Carlos
$109 nightly
The price is $109
Feb 27 - Feb 28
La Gloria Hotel by BespokeColombia

Bioma Boutique Hotel

Bioma Boutique Hotel
3.0 star property
Mompos
9.4 out of 10, Exceptional, (58 reviews)
"Amazing staff, very helpful, good breakfast, room was clean and the hotel is beautiful."
Canada
Maria
Bioma Boutique Hotel

Hotel Palmas del Rio Mompox

Hotel Palmas del Rio Mompox
3.0 star property
Mompos
$33 nightly
The price is $33
Feb 27 - Feb 28
Hotel Palmas del Rio Mompox
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

What is the best area to stay in Santa Ana?
The best area to stay in Santa Ana is the historic city center, especially around the Plaza de la Constitución.

This area is the heart of Santa Ana, characterized by its historic architecture and pedestrian-friendly streets. The Plaza de la Constitución is a central gathering point, surrounded by significant landmarks like the Santa Ana Cathedral and the Municipal Palace. You'll find many local eateries and shops within easy walking distance. Couples looking for a culturally rich experience will appreciate the convenience of exploring the city's main attractions on foot from here.

For travelers who prefer a quieter setting with convenient access to amenities, the neighborhoods just outside the immediate city center, such as those near the city's main avenues, offer a good balance. These areas often feature modern accommodations and are well-connected by public transport, making it easy to reach the historic center while enjoying a more residential feel.
When is the best time to go to Santa Ana?
For most visitors, the best time to go to Santa Ana is during the dry season, which runs from December to April.

During these months, you'll experience sunny days and lower humidity, making it ideal for exploring the city and its surroundings comfortably. The average daily temperatures are pleasant, typically ranging from the mid-70s to low 80s Fahrenheit (24-29°C). This period is superb for outdoor activities like visiting the historic center or taking a boat trip on the Magdalena River.

Travelers looking for a quieter experience might consider the shoulder months of November or May. While there might be occasional rain showers, these months generally offer good weather with fewer crowds, and you might find slightly better value on accommodations.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Santa Ana.
How can I save on a Santa Ana hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Santa Ana hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Santa Ana hotel?
Prices for hotels in Santa Ana often vary, but you can find a great deal from $36 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.