Beginning of main content

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.

Featured Santa Cruz Luxury Hotels

See all 77 Hotels in Santa Cruz
Los Tajibos Hotel And Convention Center

Los Tajibos Hotel And Convention Center

Ave. San Martin, #455, Santa Cruz
5.0 out of 5.0
4.3 out of 5 (61 reviews)
Great hotel in Santa CruzBusiness room are nice, good space to rest and work. Great location.
  Feb 23, 2017



Recently booked Luxury Hotels in Santa Cruz

Hotel LP Equipetrol
4.0 out of 5.0
Last booking: 24 hours ago
Buganvillas Hotel Suites & Spa
4.5 out of 5.0
Last booking: 28 hours ago

A few days away keeps your worries at bay, so book your trip to Santa Cruz and get ready to feel fancy-free. Brilliant experiences, divine eats, and some of the world’s most stunning photo opportunities: these are just some of the benefits of visiting Santa Cruz. You'll enjoy the most popular performances, treat yourself to decadent cuisine, and get in line to check out the coolest attractions. Where else would you stay but in a luxury hotel? Extravagant experiences are right up your alley, so get your elegant hotel in Santa Cruz on today and start your excursion off on the right (well-dressed) foot.

Book a Luxury Santa Cruz Vacation

If you need any proof that Santa Cruz is filled with an intoxicating array of activities, consider that plenty of folks choose to have set down roots. Whether you’re looking to spend your vacation dining on haute cuisine or browsing art galleries in Santa Cruz, you'll never be disappointed. Santa Cruz is full of outstanding hotels in addition to friendly locals, so it's no surprise that travelers often return. Book early to get the best room!

Any 5-star getaway begs for you to explore day spas, art, and local museums. When you save big by booking on, it's all at your fingertips. Thanks to our incredible prices on hotels, you can always afford to investigate the area's most intriguing activities. After an eventful day of sightseeing, your luxury accommodation awaits. Take advantage of amenities like a concierge or hot tub before the day is over. The luxury hotels in Santa Cruz will have you basking in relaxation in no time.

Luxury Hotels in Santa Cruz

When you’ve got your heart set on an upscale getaway in Santa Cruz, is here to help. Search through the bounty of real traveler reviews on fantastic hotels and find the perfect vacation rental. Luxury accommodations offer amenities like elegant suites and VIP services. Some of the city's 5-star accommodations even feature upscale penthouses, while others have exquisite in-room dining. Book your dream hotel in Santa Cruz now, and prepare for the experience of your life!