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Our top choices for Santa Cruz hotels

A swimming pool with tiled edges, surrounded by lounge chairs and palm trees.
A cobblestone path leading to a house with a tiled roof, surrounded by lush greenery and vibrant pink bougainvillea flowers.
A traditional wooden building with a sloped roof and a balcony.
A spacious indoor venue with high ceilings and natural light, featuring wooden tables and chairs, and various floral arrangements.

1. Autenthico Sajonia Hotel Aeropuerto

Autenthico Sajonia Hotel Aeropuerto
Rionegro
United States
Mabel Angela Frias
$26 nightly
$26 total
Oct 26 - Oct 27
Autenthico Sajonia Hotel Aeropuerto
A buffet with various fruits, vegetables, and beverages.
A bar area with a curved counter, shelves with bottles, and hanging wine glasses.
A person using a laptop in a hotel room with a bed, a chair, and a small table.
Exterior

2. ibis Medellin

ibis Medellin
El Poblado
United States
Yuliana
$58 nightly
$58 total
Nov 1 - Nov 2
ibis Medellin
A hotel room with two beds, a TV, a balcony with a city view, and artwork on the walls.
A reception area with a brick wall, wooden tables, wicker pendant lights, and a reception desk.
A multi-story building with a modern architectural design, featuring large windows and a brick facade.
A hotel room with a bed, a small table with chairs, a coffee maker, and a view of the city through the window.

3. Urbit Social Lofts

Urbit Social Lofts
Laureles
United States
Richard
$50 nightly
$50 total
Oct 19 - Oct 20
Urbit Social Lofts
A hotel sign with a sun emblem, a modern glass building, and flags.
A modern hotel lobby with a reception desk, seating area, and a view of the outdoors.
A neatly arranged bedroom with a bed, bedside table, and a desk with a chair.
A modern lobby with green sofas, a white coffee table, and a large potted plant.

4. La Quinta by Wyndham Medellin

La Quinta by Wyndham Medellin
San Diego
United States
Domingo
$84 nightly
$84 total
Oct 18 - Oct 19
La Quinta by Wyndham Medellin
A bedroom with a large bed, a chair, and a view through a glass door.
A garden pathway with various plants and a palm tree.
A modern glass structure with a roof, surrounded by a well-maintained lawn and trees.
A reception desk with a wooden finish, a logo, and a view of greenery outside.

5. Isak Hotel & Golf Airport

Isak Hotel & Golf Airport
Rionegro
Australia
Cristina
$80 nightly
$80 total
Oct 16 - Oct 17
Isak Hotel & Golf Airport
A woman in a black swimsuit sitting in a hot tub with a cityscape view through a glass railing.
A modern hotel room with a bed, a desk, a TV, and a balcony with a view.
An indoor cafe with brick walls, tables, chairs, and hanging plants.
A modern interior with a sofa, two armchairs, a coffee table, and a large potted plant.

6. Hotel Living 35 Suites by Growing Group

Hotel Living 35 Suites by Growing Group
La América
United States
Margarita
$40 nightly
$40 total
Oct 16 - Oct 17
Hotel Living 35 Suites by Growing Group
A modern bar with a long counter, shelves with decorative items, and a coffee machine.
A modern hotel lobby with a reception desk, seating area, and large windows.
A restaurant with multiple tables and chairs, large windows offering a view of mountains and cityscape, and indoor plants.
A swimming pool with a glass barrier, surrounded by high-rise buildings and greenery.

7. Novotel Medellín El Tesoro

Novotel Medellín El Tesoro
El Poblado
United States
Oscar
$146 nightly
$146 total
Nov 7 - Nov 8
Novotel Medellín El Tesoro
A reflective pool with a cityscape and mountains in the background.
A library with bookshelves, a ladder, a round table, and a potted plant.
A modern bedroom with a large bed, a bench, and a brick wall.
A modern lounge area with a sofa, chairs, and a coffee table.

8. Los Patios Cool Living

Los Patios Cool Living
Laureles
United States
Emilio
$64 nightly
$64 total
Oct 18 - Oct 19
Los Patios Cool Living
An outdoor patio area with wicker furniture, a brick floor, and a view of a building with large windows and indoor lighting.
A modern hotel entrance with a prominent sign reading "Fairfield by Marriott" and a staircase leading to the lobby.
A modern kitchen area with wooden cabinets, a countertop, and a fruit bowl.
A modern living area with a sofa, ottomans, and a dining area with chairs and a table.

9. Fairfield by Marriott Medellin Sabaneta

Fairfield by Marriott Medellin Sabaneta
Sabaneta
United States
Michael
$81 nightly
$81 total
Nov 1 - Nov 2
Fairfield by Marriott Medellin Sabaneta
A hotel room with a balcony overlooking a cityscape, a bed with patterned pillows, and a painting of a flower on the wall.
A bar area with a green wall, bar stools, and a counter with a bartender.
A modern hotel room with a large bed, a cityscape mural on the wall, a wooden headboard, and a walk-in closet.
A casino with multiple slot machines and chairs arranged in rows.

10. Hotel Dorado La 70

Hotel Dorado La 70
Laureles
United States
Gregson
$91 nightly
$91 total
Nov 15 - Nov 16
Hotel Dorado La 70
A rooftop pool area with a breakfast setup, including plates, cups, and juice.
A multi-story building with a brick facade, surrounded by lush greenery and other high-rise buildings.
A modern hotel room with a large bed, bedside tables, a sofa, and a view of the city through the window.
An outdoor patio area with tables and chairs, a large canopy, and a brick wall.

11. Hotel Dann Carlton Belfort Medellin

Hotel Dann Carlton Belfort Medellin
El Poblado
United States
Christian Alvarez
$82 nightly
$82 total
Oct 18 - Oct 19
Hotel Dann Carlton Belfort Medellin
A modern lounge area with a blue sofa, pendant lights, a refrigerator stocked with snacks, and a chalkboard wall with food illustrations.
A brick building with a sign reading "ibis budget."
A modern reception area with a black counter, a digital display, and a wall decorated with food and drink illustrations.
A modern interior with a blue sofa, a hanging chair, a vending machine, and a refrigerator stocked with beverages.

12. ibis budget Medellín Itagüí Metro

ibis budget Medellín Itagüí Metro
Itagüí
United States
Jose
$45 nightly
$45 total
Oct 30 - Oct 31
ibis budget Medellín Itagüí Metro
A modern bedroom with a large bed, a small table, and a chair.
A reception area with a modern design, featuring a white reception desk, a white sofa, and a mural of tropical plants.
A modern hotel room with a large bed, a desk with chairs, a TV, and a view of the outdoors.
A modern kitchen with a built-in island, wooden cabinets, and a bar stool.

13. Firenze Lofts

Firenze Lofts
La América
United States
Raecita
$49 nightly
$49 total
Nov 10 - Nov 11
Firenze Lofts
A modern interior with a wooden ceiling, a reception desk, and a display of baked goods.
Gift shop
A multi-story hotel with a prominent 'EUTOPIO' sign, featuring a modern architectural design with a mix of brick and glass facades, and balconies with greenery.
A modern hotel room with a large bed, a sitting area with a table and chairs, a large window with a view of buildings, and a hot tub.

14. Eutopiq Hotel

Eutopiq Hotel
Laureles
United States
Ramiro
$79 nightly
$79 total
Oct 18 - Oct 19
Eutopiq Hotel
A modern reception area with a glass door entrance, a reception desk, and seating arrangements.
A gym with exercise equipment, a punching bag, and a view of the city through large windows.
A modern living room with a round wooden coffee table, white chairs, a sofa, and a potted plant.
A modern building with a prominent corner design, large windows, and a patterned facade.

15. Arame Hotel

Arame Hotel
Envigado
United States
David
$66 nightly
$66 total
Nov 15 - Nov 16
Arame Hotel
A tall building with a modern design, featuring large windows and a sign that reads "SPRING SELECT EST 2025".
A restaurant with booths, tables, and chairs, featuring a modern design with plants and pendant lighting.
A rooftop terrace with potted plants, a tiled floor, and a cityscape view in the background.
A woman standing by a spa tub with a window and plants in the background.

16. Hotel Ryo 74B Suites by Growing Group

Hotel Ryo 74B Suites by Growing Group
Laureles
Canada
Neil
$40 nightly
$40 total
Oct 21 - Oct 22
Hotel Ryo 74B Suites by Growing Group
A multi-level outdoor pool area with tiered wooden structures, lounge chairs, and umbrellas.
A hotel room with a large bed, a wooden headboard, a bedside table, a mirror, and a view of the cityscape.
A hotel room with a wooden vanity, a bed, a large window with a mountain view, and a flat-screen TV mounted on the wall.
A modern reception area with a green sofa, a reception desk, and a large, circular ceiling light fixture.

17. Heiss Hotel By Jalo

Heiss Hotel By Jalo
El Poblado
United States
Mario
$66 nightly
$66 total
Oct 16 - Oct 17
Heiss Hotel By Jalo
A modern building entrance with glass doors, a wooden ceiling, and potted plants.
A building with a wooden lattice facade and a sign reading 'PERGAMINO.'
A modern hotel room with a large bed, bedside tables, a bench, a potted plant, and a sliding door closet.
A gym with wooden floors, weight racks, and exercise equipment.

18. The Cut Hotel

The Cut Hotel
El Poblado
United States
Arturo
$54 nightly
$54 total
Nov 8 - Nov 9
The Cut Hotel
A modern bedroom with a large bed, bedside table, and a view of trees through a window.
View from room
A modern living space with a central island, a dining area, and a kitchen.
A modern bathroom with a white toilet, a large sink, and a mirror above it. There are two bottles on the sink counter.

19. Soy Local Reserva Sajonia

Soy Local Reserva Sajonia
Rionegro
United States
Antonio
$68 nightly
$68 total
Oct 17 - Oct 18
Soy Local Reserva Sajonia
A modern outdoor bathroom with a hot tub, wooden benches, and string lights.
A modern bedroom with a large bed, a balcony with a glass door, and artwork on the walls.
A modern bedroom with a city view, a sofa, a bed with a yellow throw, and two bedside lamps.
A breakfast buffet setup with a toaster, a basket of toast, a milk dispenser, and yogurt containers.

20. Manila Hotel Boutique

Manila Hotel Boutique
El Poblado
United States
Robert Nigel
$54 nightly
$54 total
Nov 8 - Nov 9
Manila Hotel Boutique
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Top Santa Cruz Hotel Reviews

Hashtag 98 Hotel By Jalo

Hashtag 98 Hotel By Jalo

10/10 Excellent
"I always have a fantastic stay at this hotel! The staff is super friendly and welcoming every single time. The rooms are consistently clean and offer amazing views of El Poblado. I really appreciate the wide variety of breakfast options each morning, and the bed is exceptionally comfortable. The location couldn't be better—it's very central with plenty of great restaurants and shops just steps away. Highly recommended!"
ryan 6-night trip
Posted 3 hours ago
Hashtag 98 Hotel By Jalo
Calle Flora Hotel by Jalo

Calle Flora Hotel by Jalo

8/10 Good
"El hotel súper céntrico, estaba limpio y eran atentos los empleados"
Jamie 3-night trip
Posted 4 hours ago
Calle Flora Hotel by Jalo
Marquee Hotel

Marquee Hotel

10/10 Excellent
"Todo fue muy bonito y muy limpio el lugar y sus empleados mantienen muy bien ambiente"
XAVIER 5-night trip
Posted 9 hours ago
Marquee Hotel
Hotel BH El Poblado

Hotel BH El Poblado

8/10 Good
"El hotel está muy céntrico y accesible al Mall Santa Fe y acceso a diferentes medios de transporte , los chicos del Lobby en espacial Edwin muy amable y servicial. Las chicas del desayuno muy atentas ."
Liza M 5-night trip
Posted 21 hours ago
Hotel BH El Poblado
Dann Carlton Medellin Hotel

Dann Carlton Medellin Hotel

8/10 Good
"The breakfast was normal"
andres 4-night trip
Posted 22 hours ago
Dann Carlton Medellin Hotel
Laureles Selection Suites

Laureles Selection Suites

8/10 Good
"Overall, we had a pleasant stay at Laureles Suite Selection. The location was great, and the accommodations were comfortable. However, we believe there is room for improvement in the overall guest experience, particularly in staff attentiveness, communication, and responsiveness to guest needs. Despite a few inconveniences, we enjoyed our stay and would consider returning in the future."
Kimberly Marty Veronic 9-night trip
Posted 22 hours ago
Laureles Selection Suites
V Grand Hotel, a member of Radisson Individuals

V Grand Hotel, a member of Radisson Individuals

10/10 Excellent
"Llevo años quedándome en este hotel.Limpio ,personal atento.Buena Comida y la cama es una ricura.Lo recomiendo 200%"
Christian Omar Gonzalez 4-night trip
Posted 1 day ago
V Grand Hotel, a member of Radisson Individuals
Hotel Dorado La 70

Hotel Dorado La 70

10/10 Excellent
"Clean hotel i like the balcony"
Chenco Valentino 5-night trip
Posted 1 day ago
Hotel Dorado La 70
The Click Clack Hotel Medellin

The Click Clack Hotel Medellin

10/10 Excellent
"a 5 star experience, amazing vibes, walkable to a ton of bars / restaurants, would stay here again"
Matthew 3-night trip
Posted 1 day ago
The Click Clack Hotel Medellin

More cheap stays in Santa Cruz

Autenthico Sajonia Hotel Aeropuerto

Autenthico Sajonia Hotel Aeropuerto

Aeropuerto Jose Maria Cordova, Km 20 Rionegro Antioquia
$26 nightly
$26 total
Oct 26 - Oct 27
Autenthico Sajonia Hotel Aeropuerto
Hotel Casa Malibú

Hotel Casa Malibú

Calle 32F 66 c 57 Medellín Medellin
$26 nightly
$26 total
Oct 20 - Oct 21
4.8/10 (3 reviews)
Hotel Casa Malibú
Hostal Lleras Calle 8 - Hostel

Hostal Lleras Calle 8 - Hostel

Calle 8 # 37A - 59 Medellín Antioquia
$28 nightly
$28 total
Oct 19 - Oct 20
8.4/10 Very Good! (165 reviews)
Hostal Lleras Calle 8 - Hostel
Hotel Ofix - Laureles

Hotel Ofix - Laureles

79-86 Calle 44 Medellín
$31 nightly
$31 total
Oct 23 - Oct 24
Hotel Ofix - Laureles
Nakúa Stay + Work

Nakúa Stay + Work

8A-29 Cra. 34 Medellín Antioquia
$53 nightly
$53 total
Nov 15 - Nov 16
Nakúa Stay + Work
Masaya Medellin

Masaya Medellin

43a1 Cl. 8 Medellín Antioquia
$77 nightly
$77 total
Oct 20 - Oct 21
Masaya Medellin

Frequently asked questions

What is the best area to stay in Santa Cruz?
The best area to stay in Santa Cruz is the El Poblado district, particularly around Parque Lleras and the Golden Mile, as it offers a blend of upscale accommodations, dining, and entertainment options.El Poblado is known for its tree-lined streets, modern high-rises, and a wide selection of restaurants and cafes. Parque Lleras is a central square within El Poblado where many of the area's social activities are centered, while the Golden Mile (Milla de Oro) is a stretch of avenue known for its luxury hotels, shopping centers, and corporate offices. This area provides easy access to public transportation and is well-maintained.Couples often find El Poblado ideal due to its sophisticated dining experiences and lively evening scene. There are numerous restaurants offering various cuisines, from traditional Colombian to international dishes, and many establishments provide a pleasant ambiance for an evening out. The area's walkability also makes it convenient for exploring on foot.For travelers seeking a convenient base with high-quality amenities, El Poblado's Golden Mile is an excellent choice. Many hotels in this section offer modern facilities, including well-equipped fitness centers and business services.
When is the best time to go to Santa Cruz?
The best time to go to Santa Cruz, Antioquia, Colombia, is during the dry season, which runs from December to February and again from June to August. These months offer the most pleasant weather for exploring the region.During the dry season, you can expect less rainfall and more sunshine, making it ideal for outdoor activities like hiking, coffee farm tours, or simply enjoying the town's central plaza. The comfortable temperatures during these periods are particularly appealing for couples looking for a relaxed and scenic getaway.Travelers seeking a vibrant cultural experience might also consider visiting during local festivals, which often occur outside the dry season.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Santa Cruz.
How much is the nightly rate at a Santa Cruz hotel?
Prices for hotels in Santa Cruz often vary, but you can find a great deal from $26 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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