Find hotels in Santa Cruz from $24

Start date: Check-in selected.
To Date
End date: Check-out
  • Upfront pricing

    Our total price for your stay includes taxes and fees
  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santa Cruz hotels

Isak Hotel & Golf Airport

Isak Hotel & Golf Airport
3.0 star property
Rionegro
9.4 out of 10, Exceptional, (548)
"Great staff, good breakfast, very clean and conveniently located close to airport!"
Canada
Philippe
$69 nightly
The price is $69
Jan 3 - Jan 4, 2026
Isak Hotel & Golf Airport

Movich Hotel Las Lomas

Movich Hotel Las Lomas
4.0 star property
Rionegro
9.0 out of 10, Wonderful, (1007)
"Its a food hotel , perfectly "
United States
Roberto
$138 nightly
The price is $138
Jan 8 - Jan 9, 2026
Movich Hotel Las Lomas

Dann Carlton Medellin Hotel

Dann Carlton Medellin Hotel
4.5 star property
El Poblado
8.8 out of 10, Excellent, (1685)
"Excellent hotel , comfortable beds location is very convenient."
Canada
Ana
$78 nightly
The price is $78
Jan 12 - Jan 13, 2026
Dann Carlton Medellin Hotel

Hotel Santiago de Arma

Hotel Santiago de Arma
3.0 star property
Rionegro
9.2 out of 10, Wonderful, (914)
"Very clean room and very friendly staff."
United States
Redding
Hotel Santiago de Arma

Hotel Lagoon

Hotel Lagoon
3.5 star property
Rionegro
9.2 out of 10, Wonderful, (298)
"Nice property, very good food, very relaxing."
United States
Kevin
$123 nightly
The price is $123
Dec 25 - Dec 26
Hotel Lagoon

Hotel San Fernando Plaza

Hotel San Fernando Plaza
4.0 star property
El Poblado
9.2 out of 10, Wonderful, (1002)
"Amazing people and breakfast "
United States
Miguel
$105 nightly
The price is $105
Dec 26 - Dec 27
Hotel San Fernando Plaza

Calle Flora Hotel by Jalo

Calle Flora Hotel by Jalo
3.5 star property
El Poblado
9.2 out of 10, Wonderful, (314)
"Good place to stay"
United States
Obed
$73 nightly
The price is $73
Dec 25 - Dec 26
Calle Flora Hotel by Jalo

Hotel Park 10

Hotel Park 10
4.0 star property
El Poblado
9.2 out of 10, Wonderful, (1228)
"The staff was very friendly and helpful. "
United States
Jesus Cordova
$76 nightly
The price is $76
Dec 25 - Dec 26
Hotel Park 10

Hashtag 98 Hotel By Jalo

Hashtag 98 Hotel By Jalo
4.0 star property
El Poblado
9.2 out of 10, Wonderful, (1636)
"Excellent costumer service clean rooms great location "
United States
sandra
$71 nightly
The price is $71
Dec 25 - Dec 26
Hashtag 98 Hotel By Jalo

Heiss Hotel By Jalo

Heiss Hotel By Jalo
4.0 star property
El Poblado
9.2 out of 10, Wonderful, (1071)
"Clean rooms, comfortable bed, great staff, top location!"
United States
Josue
$70 nightly
The price is $70
Jan 19 - Jan 20, 2026
Heiss Hotel By Jalo

Hotel Attic 33

Hotel Attic 33
3.0 star property
Laureles
9.6 out of 10, Exceptional, (12)
"Was great, very recommended for a quick trip. "
United States
jorge
$49 nightly
The price is $49
Jan 11 - Jan 12, 2026
Hotel Attic 33

Travelers Rio Verde Living Suites

Travelers Rio Verde Living Suites
3.5 star property
Rionegro
8.4 out of 10, Very Good, (466)
"Good property. "
United States
Ruth Marcela
$67 nightly
The price is $67
Dec 26 - Dec 27
Travelers Rio Verde Living Suites

Novotel Medellín El Tesoro

Novotel Medellín El Tesoro
4.5 star property
El Poblado
9.4 out of 10, Exceptional, (1360)
"Great service from all the team at the hotel. "
United States
Marisol
$135 nightly
The price is $135
Dec 28 - Dec 29
Novotel Medellín El Tesoro

The Somos Central Hotel Poblado

The Somos Central Hotel Poblado
4.0 star property
El Poblado
9.0 out of 10, Wonderful, (247)
"Very good hotel, location, staff, breakfast and price."
United States
Luis
$65 nightly
The price is $65
Jan 15 - Jan 16, 2026
The Somos Central Hotel Poblado

The Click Clack Hotel Medellin

The Click Clack Hotel Medellin
5.0 star property
El Poblado
9.2 out of 10, Wonderful, (1074)
"Great hotel."
United States
Luz Alma
$205 nightly
The price is $205
Jan 20 - Jan 21, 2026
The Click Clack Hotel Medellin

Hotel Dann Carlton Belfort Medellin

Hotel Dann Carlton Belfort Medellin
4.0 star property
El Poblado
8.8 out of 10, Excellent, (1001)
"Beatiful hotel with impeccable service !"
United States
Miodrag
$70 nightly
The price is $70
Jan 12 - Jan 13, 2026
Hotel Dann Carlton Belfort Medellin

NH Collection Medellín Royal

NH Collection Medellín Royal
5.0 star property
El Poblado
9.2 out of 10, Wonderful, (1000)
"excellent location, friendly staff, excellent food."
United States
Felix
$101 nightly
The price is $101
Jan 18 - Jan 19, 2026
NH Collection Medellín Royal

Lettera Hotel

Lettera Hotel
3.5 star property
El Poblado
9.8 out of 10, Exceptional, (453)
"Excellent hotel and staff "
United States
Jose
$72 nightly
The price is $72
Jan 20 - Jan 21, 2026
Lettera Hotel

Manila Hotel Boutique

Manila Hotel Boutique
3.5 star property
El Poblado
9.2 out of 10, Wonderful, (252)
"Great stay"
United States
John
$54 nightly
The price is $54
Dec 25 - Dec 26
Manila Hotel Boutique

V Grand Hotel, a member of Radisson Individuals

V Grand Hotel, a member of Radisson Individuals
3.5 star property
El Poblado
9.2 out of 10, Wonderful, (1278)
"Excellent and a highly recommended place to stay. Great hospitality from staff."
United States
Miguel Angel Guzman
$94 nightly
The price is $94
Jan 14 - Jan 15, 2026
V Grand Hotel, a member of Radisson Individuals
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Santa Cruz Hotel Reviews

More cheap stays in Santa Cruz

Frequently asked questions

What is the best area to stay in Santa Cruz?
The best area to stay in Santa Cruz is the El Poblado district, particularly around Parque Lleras and the Golden Mile, as it offers a blend of upscale accommodations, dining, and entertainment options.

El Poblado is known for its tree-lined streets, modern high-rises, and a wide selection of restaurants and cafes. Parque Lleras is a central square within El Poblado where many of the area's social activities are centered, while the Golden Mile (Milla de Oro) is a stretch of avenue known for its luxury hotels, shopping centers, and corporate offices. This area provides easy access to public transportation and is well-maintained.

Couples often find El Poblado ideal due to its sophisticated dining experiences and lively evening scene. There are numerous restaurants offering various cuisines, from traditional Colombian to international dishes, and many establishments provide a pleasant ambiance for an evening out. The area's walkability also makes it convenient for exploring on foot.

For travelers seeking a convenient base with high-quality amenities, El Poblado's Golden Mile is an excellent choice. Many hotels in this section offer modern facilities, including well-equipped fitness centers and business services.
When is the best time to go to Santa Cruz?
The best time to go to Santa Cruz, Antioquia, Colombia, is during the dry season, which runs from December to February and again from June to August. These months offer the most pleasant weather for exploring the region.

During the dry season, you can expect less rainfall and more sunshine, making it ideal for outdoor activities like hiking, coffee farm tours, or simply enjoying the town's central plaza. The comfortable temperatures during these periods are particularly appealing for couples looking for a relaxed and scenic getaway.

Travelers seeking a vibrant cultural experience might also consider visiting during local festivals, which often occur outside the dry season.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Santa Cruz.
How can I save on a Santa Cruz hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Santa Cruz hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Santa Cruz hotel?
Prices for hotels in Santa Cruz often vary, but you can find a great deal from $24 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

Explore a world of travel with Expedia