Beginning of main content

location Santa Cruz is highly rated for Cafes and Shopping by 103 people

Search 590,000 properties worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Check prices on hotels in Santa Cruz

Best deal Best deal Feb 23 - Feb 25
Tonight Tonight Feb 21 - Feb 22
This weekend This weekend Feb 23 - Feb 25
Next weekend Next weekend Mar 2 - Mar 4

Top 10 Hotels in Santa Cruz

See all 79 Hotels in Santa Cruz
Marriott Santa Cruz de la Sierra

Marriott Santa Cruz de la Sierra

4to Anillo Entre Radial 23, Santa Cruz
4.5 out of 5.0
Last booking: 2 days ago
5.0 out of 5 (1 reviews)

Situated in Santa Cruz, this hotel is close to Ventura Mall, Santa Cruz Zoo, and Municipal Library. Also nearby are Arenal Park and Ethno-folkloric Museum.

$119

$119
Radisson Hotel Santa Cruz

Radisson Hotel Santa Cruz

Avenida Segunda 4, Santa Cruz
4.5 out of 5.0
Last booking: 4 hours ago
4.7 out of 5 (38 reviews)

Situated in Colinas del Urubo, this hotel is 2.8 mi (4.5 km) from Santa Cruz Zoo and within 6 mi (10 km) of Guembe Biocenter and Municipal Library. Arenal Park ...

$135

$135
Terranova Suites

Terranova Suites

7º Anillo 400 mts al Oeste de, Santa Cruz
4.0 out of 5.0
4.1 out of 5 (34 reviews)

Situated near the airport, this aparthotel is 2.9 mi (4.7 km) from Santa Cruz Zoo and within 6 mi (10 km) of Municipal Library and Arenal Park. La Recova Artisan ...

$61

$61
Los Tajibos Hotel And Convention Center

Los Tajibos Hotel And Convention Center

Ave. San Martin, #455, Santa Cruz
5.0 out of 5.0
Last booking: 18 hours ago
5 others viewing this property now
4.3 out of 5 (69 reviews)

Situated in Santa Cruz, this luxury hotel is within 2 mi (3 km) of Santa Cruz Zoo, Municipal Library, and Arenal Park. Ethno-folkloric Museum and Guarani Nandereko ...

$139

$139
Camino Real Hotel

Camino Real Hotel

Av. San Martín y 4to. Anillo, Santa Cruz
4.5 out of 5.0
Last booking: 1 day ago
2 others viewing this property now
4.2 out of 5 (163 reviews)

This family-friendly Santa Cruz hotel is located near the airport, within 3 mi (5 km) of Santa Cruz Zoo, La Recova Artisan Walk and Artecampo. Municipal Library ...

$129

$129
Casa Patio Hotel Boutique

Casa Patio Hotel Boutique

Av. Iberica Calle 5 #6, Santa Cruz
4.5 out of 5.0

Situated in Santa Cruz, this hotel is close to Ramon Tahuichi Aguilera Stadium, Artecampo, and Cine Center. Local attractions also include Blacutt Square and ...

$74

$74
Hotel LP Equipetrol

Hotel LP Equipetrol

Dr Victor Pinto, Equipetrol, Santa Cruz
4.0 out of 5.0
Last booking: 1 day ago
3.9 out of 5 (48 reviews)

Situated in the entertainment district, this hotel is 0.9 mi (1.4 km) from Santa Cruz Zoo and within 3 mi (5 km) of Municipal Library and Arenal Park. Ethno-folkloric ...

$69

$69
Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique

Pari, 70, Santa Cruz
3.5 out of 5.0
Last booking: 2 days ago
4.4 out of 5 (19 reviews)

Situated in Santa Cruz, this hotel is within a 10-minute walk of Sacred Art Museum, San Lorenzo Cathedral, and Franco Aleman Cultural Center. Plaza 24 de Septiembre ...

$54

$54
Buganvillas Hotel Suites & Spa

Buganvillas Hotel Suites & Spa

Av. Roca y Coronado No. 901, Santa Cruz
4.0 out of 5.0
Last booking: 5 days ago
2 others viewing this property now
3.6 out of 5 (35 reviews)

This family-friendly Santa Cruz hotel is located in the business district, within 3 mi (5 km) of Guarani Nandereko Nomai Art and Culture Center, Santa Cruz Zoo ...

$90

$90
Hotel Cortez

Hotel Cortez

Av. Cristobal de Mendoza 280, Santa Cruz
4.0 out of 5.0
4.4 out of 5 (17 reviews)

Situated in Santa Cruz, this hotel is within a 15-minute walk of Municipal Library and Arenal Park. Ethno-folkloric Museum and La Recova Artisan Walk are also ...

$121

$121
Map

Recent Reviews in Santa Cruz