A beach with black volcanic rocks, clear turquoise water, and a distant shoreline with buildings.

Santa Cruz Island Vacations from $518

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Top destinations in Santa Cruz Island

The Latest Santa Cruz Island Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • Aug 21 - Aug 24

    Galapagos Native + Flight

    Puerto Ayora
    3 nights
    3.0 star property
    7.8/10 - Good (96 reviews)
    Roundtrip Guayaquil (GYE) - Santa Cruz Island (GPS)
    GYE - GPSNonstop GPS - GYENonstop
    $679
    $518
    per traveler
    found 1 day ago
    Galapagos Native
  • Aug 21 - Aug 24

    BAY VIEW HOUSE + Flight

    Puerto Ayora
    3 nights
    3.5 star property
    10/10 - Exceptional (6 reviews)
    "I had a wonderful stay at this Bay View House  in the Galápagos Islands. The location was excellent, with easy access to local attractions, restaurants, and the waterfront. The hotel was very clean, well-maintained, and comfortable. The staff was friendly and helpful throughout my stay. The rooms were spacious, quiet, and nicely furnished, making it a great place to relax after a day of exploring. I highly recommend this hotel to anyone visiting the Galápagos."
    Reviewed June 9, 2026
    Roundtrip Guayaquil (GYE) - Santa Cruz Island (GPS)
    GYE - GPSNonstop GPS - GYENonstop
    $786
    $577
    per traveler
    found 1 day ago
    BAY VIEW HOUSE
  • Aug 21 - Aug 24

    Hotel Albemarle Galapagos Beachfront + Flight

    Puerto Villamil
    3 nights
    3.5 star property
    9.0/10 - Wonderful (109 reviews)
    "Right on the beach! Exactly what we expected. Beautiful view— great staff."
    Reviewed July 12, 2026
    Roundtrip Guayaquil (GYE) - Santa Cruz Island (GPS)
    GYE - GPSNonstop GPS - GYENonstop
    $971
    $715
    per traveler
    found 1 day ago
    Hotel Albemarle Galapagos Beachfront
  • Aug 21 - Aug 24

    Blu Galapagos Sustainable Waterfront Lodge + Flight

    Puerto Ayora
    3 nights
    4.0 star property
    8.8/10 - Excellent (131 reviews)
    Roundtrip Guayaquil (GYE) - Santa Cruz Island (GPS)
    GYE - GPSNonstop GPS - GYENonstop
    $930
    $699
    per traveler
    found 1 day ago
    Blu Galapagos Sustainable Waterfront Lodge
  • Oct 11 - Oct 15

    Hotel Flamingo + Flight

    Puerto Ayora
    3 nights
    3.5 star property
    8.8/10 - Excellent (122 reviews)
    "Un lugar muy bonito y céntrico súper bien ubicado para cualquier actividad, únicamente deben cuidar el tema del ruido, pero en balance súper recomendado, el desayuno delicioso y variado tipo buffet, la piscina es muy bonita se ve que lo están mejorando vale la pena la visita"
    Reviewed July 6, 2026
    Roundtrip Boston (BOS) - Santa Cruz Island (GPS)
    BOS - GPS2 stops GPS - BOS2 stops
    $1,422
    $1,088
    per traveler
    found 1 day ago
    Hotel Flamingo

Discover the most popular places to visit in Santa Cruz Island

What to do in Santa Cruz Island

Santa Cruz Island Hotel Deals

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Things to do in Santa Cruz Island

Santa Cruz Island offers an exciting blend of outdoor adventures and stunning scenery. Visitors can enjoy day trips, educational excursions, and kayak tours, as well as surf landings for some thrilling water sports. Don't miss the chance to relax at picturesque picnic spots, making the most of your vacation in this beautiful part of the Galápagos.

Shopping

Discover the vibrant Mercado de Santa Cruz, where you can find local crafts, souvenirs, and fresh produce. For a more modern experience, visit the Galería La Lobería, featuring various shops and eateries, perfect for picking up unique gifts and enjoying local cuisine.

Recreation

On Santa Cruz Island, the Galápagos Spa offers rejuvenating massages and holistic wellness treatments amidst breathtaking landscapes. Experience the serene ambiance at the Tortuga Bay Retreat, where yoga sessions and meditation classes promote relaxation and mindfulness while surrounded by nature's beauty.

Adventure

Explore the Charles Darwin Research Station to learn about conservation efforts and see giant tortoises up close. For an adrenaline rush, go snorkeling at Tortuga Bay, where you can swim alongside vibrant marine life and enjoy the stunning beach scenery.

Nightlife

The nightlife in Santa Cruz Island is vibrant and diverse. Start your evening at La Panga Restaurant for fresh seafood, then head to The Galapagos Microbrewery for local craft beers. For dancing, check out the lively atmosphere at the nightclub, where you can groove to Latin music late into the night.

Find the best attractions near Santa Cruz Island

Santa Cruz Island in the Galápagos offers an incredible adventure for outdoor enthusiasts and nature lovers. With its stunning caves, natural features, and nature reserves, visitors can explore a variety of eco-friendly attractions. Key points of interest include Santa Rosa Island and Scorpion Anchorage, making it a perfect destination for those seeking unique experiences amidst breathtaking scenery.

  • Los Gemelos Sinkholes: These impressive sinkholes, located about 4 miles from Santa Cruz Island, are a fascinating natural wonder. Formed by volcanic activity, they offer unique geological features surrounded by lush vegetation, providing an ideal spot for photography and exploration.
  • Rancho Primicias: Situated 7 miles away from Santa Cruz Island, this adventurous cave experience invites you to explore its intriguing formations. The outdoor vibes here promise excitement and a chance to connect with nature while observing the local wildlife.
  • Rancho El Manzanillo: Just 6 miles from Santa Cruz Island, this eco-friendly nature reserve is perfect for outdoor enthusiasts. With its emphasis on conservation, you can enjoy hiking trails and learn about the unique ecosystems of the Galápagos.

Best time to go to Santa Cruz Island

The best time to visit Santa Cruz Island can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around Santa Cruz Island falls in March, when visitor numbers are average and weather is mostly sunny with light rain. The coolest average temperature around Santa Cruz Island falls in September, visitor numbers are slightly high and weather is mostly cloudy with no rain.

Tips to save on your trip to Santa Cruz Island

  • Combine your flights, hotels and car rentals on Expedia—bundling can result in significant savings.
  • Consider traveling during the off-peak season (typically January to February and September) for more affordable package holidays to Santa Cruz Island.
  • Use the Price per traveler filter on Expedia to find a package deal that suits your budget.
  • Check the VIP Access properties filter to discover outstanding hotels with added member perks at select properties.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.