
Santa Cruz Island Vacations from $439
Book a Hotel + Flight or Car together to unlock savings
Photo by Sig
- Plan, book, travel with confidence
Better together
Save up to $1,045 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
The Latest Santa Cruz Island vacation packages
Price found within the past 48 hours. Click for updated prices.


Angermeyer Waterfront Inn
Price was $779, price is now $536 per person
$536
per person
Oct 31 - Nov 3
found 16 hours ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
9.4/10 Exceptional! (118 reviews)
Staff was very friendly and professional. They helped us with everything we asked for.
Reviewed on Jul 4, 2025

La Casa de Marita
Price was $798, price is now $566 per person
$566
per person
Oct 31 - Nov 3
found 16 hours ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
9/10 Wonderful! (97 reviews)
We had a lovely night stay here. You’re on an island so some ants and bugs can be expected. This isn’t The Four Seasons so if you were looking for that you would be disappointed. What you will find staff willing to go above and beyond like Jonathan, who made our stay lovely. Love that you could just walk to the beach right behind the property. The peace and tranquillity you will find here is unmatched. I think this is the best place to stay on the island. We will definitely be returning.
Reviewed on May 14, 2025

Mi Playa Galapagos Beachfront
Price was $2,945, price is now $2,107 per person
$2,107
per person
Oct 24 - Oct 31
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Isla Baltra (GPS)
8.8/10 Excellent! (5 reviews)
Beautiful view, close to restaurants bars and restaurants.
The owner was very nice, breakfast was wonderful.
Really luxury place. We miss that place..
Reviewed on May 11, 2023

Hotel Isamar Galapagos Beachfront
Price was $749, price is now $538 per person
$538
per person
Oct 31 - Nov 3
found 16 hours ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
9/10 Wonderful! (58 reviews)
We had a wonderful time! Breakfast was absolutely delicious, and we also enjoyed an amazing dinner during our stay. The cocktails were delicious and perfectly made. The staff provided excellent recommendations for things to do on Isabela Island, which really enhanced our experience. We truly appreciated the warm hospitality. The location right by the ocean was perfect, and everything was clean and well maintained.
Highly recommended!
Jenny , Pam and Rafael
Reviewed on Jul 22, 2025
Don't see what you're looking for?
See all available trips from Columbus to Santa Cruz Island
View all tripsDiscover the most popular places to visit in Santa Cruz Island

Tortuga Bay Beach
If a restful vacation is part of your travel plans, Tortuga Bay Beach might be the perfect place to seek out during your trip to Bella Vista. While you're in the area, wander around the parks.

El Garrapatero Beach
Why not spend a carefree afternoon at El Garrapatero Beach during your travels in El Cascajo? While you're in the area, wander around the parks.

Las Ninfas Lagoon
Commune with nature and explore the great outdoors at Las Ninfas Lagoon during your travels in Puerto Ayora. While you're here, you can savor the top-notch restaurants.
What to do in Santa Cruz Island

Full Day Tour Pinzon Island + La Fe/Las Palmas - Snorkeling & Fishing
$169
per adult

Tour of the city to Isabela + Tintoreras from Santa Cruz
$256
per adult
Santa Cruz Island Hotel Deals

Hotel Fiesta
Calle Moises Brito y Juan Montalvo, Puerto Ayora, Galapagos
Fully refundableReserve now, pay when you stay
$155 nightly
The price is $155 total per night from Aug 22 to Aug 23
$155 total
Aug 22 - Aug 23
9/10 Wonderful! (355 reviews)
"Great place for the money"
Reviewed on Aug 13, 2025

Hotel Cucuve
Charles Binford 083 y Ave Charles Darwin, Puerto Ayora
$216 nightly
The price is $238 total per night from Aug 20 to Aug 21
$238 total
Aug 20 - Aug 21
9.8/10 Exceptional! (257 reviews)
Great hotel in Puerto Ayuro
"Excellent location, clean, friendly, and great breakfast. Highly recommend. Only caveat- the outdoor area on the water shown in photos is actually a couple blocks from the rest of the hotel. Not a big deal, but I was surprised."
Reviewed on Aug 2, 2025

Hotel el descanso del Guia
Calle Delfin, Barrio el Mirador, Puerto Ayora, Galapagos
$72 nightly
The price is $72 total per night from Sep 8 to Sep 9
$72 total
Sep 8 - Sep 9
8.8/10 Excellent! (162 reviews)
"Beautiful and spacious family room. Good breakfast and the staff is courteous. I highly recommend this hotel."
Reviewed on Aug 14, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More vacations you might like
Explore a world of travel with Expedia
Explore a world of travel with Expedia
- Bellavista Hotels
- B&B in Bellavista
- Galápagos Hotels
- Resorts & Hotels with Spas in Galápagos
- Honeymoon Resorts & in Galápagos
- Family Hotels in Galápagos
- Hotel Wedding Venues Hotels in Galápagos
- Luxury Hotels in Galápagos
- Hostels in Galápagos
- Hotels with Tennis Courts in Galápagos
- Villas in Galápagos
- Beach Hotels in Galápagos
- Apartments in Galápagos
- Green Hotels in Galápagos
- Vacation Homes in Galápagos
- Historic Hotels in Galápagos
- Cheap Hotels in Galápagos
- Hotels with Suites in Galápagos
- Romantic Hotels in Galápagos
- Oceanfront Hotels in Galápagos
- Pet-friendly Hotels in Galápagos
- Guest Houses in Galápagos
- Hotels with a View in Galápagos
- Hotels with Free Breakfast in Galápagos
- Hotels with a Gym in Galápagos
- B&B in Galápagos
- Lodges in Galápagos
- Hotels with Air Conditioning in Galápagos
- Cabin Rentals in Galápagos
- Boutique Hotels in Galápagos
- Hotels with an Outdoor Pool in Galápagos
- Santa Rosa Hotels
- 4 Star Hotels in Santa Rosa
- Puerto Ayora Hotels
- Hotels with Tennis Courts in Puerto Ayora
- Hotels with Free Airport Shuttle in Puerto Ayora
- Hotels with Laundry Facilities in Puerto Ayora
- Hotels with Restaurants in Puerto Ayora
- Apartments in Puerto Ayora
- B&B in Puerto Ayora
- Cheap Hotels in Puerto Ayora
- Luxury Hotels in Puerto Ayora
- Beach Hotels in Puerto Ayora
- Hostels in Puerto Ayora
- Oceanfront Hotels in Puerto Ayora
- Hotels with a Gym in Puerto Ayora
- Honeymoon Resorts & in Puerto Ayora
- Gay friendly Hotels in Puerto Ayora
- Lodges in Puerto Ayora
- Hotels with a Pool in Puerto Ayora
- Hotel with a Concierge Hotels in Puerto Ayora
- Romantic Hotels in Puerto Ayora
- Hotels with Childcare in Puerto Ayora
- Hotels near Charles Darwin Research Station
- Hotels near Malecon
- Hotels near Academy Bay
- Hotels near Playa de los Alemanes
- Hotels near Las Grietas
- El Cascajo Hotels
- Hotels near El Garrapatero Beach
- Hotels near South Plaza Island
- Bellavista Vacations
- Galápagos Vacations
- Visit Bellavista
- All inclusive Vacation Packages Galápagos
- Santa Rosa Vacations
- Visit Galápagos
- Luxury Vacation Packages Galápagos
- Visit Santa Rosa
- Rancho Primicias
- Puerto Ayora Vacations
- Visit Puerto Ayora
- Charles Darwin Research Station
- Malecon
- Academy Bay
- Playa de los Alemanes
- Las Grietas
- Tortuga Bay Beach
- El Cascajo Vacations
- El Garrapatero Beach
- Visit El Cascajo
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.