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Our top choices for Santa Fe hotels

A spacious indoor dining area with multiple tables and chairs, large windows offering a view of palm trees and greenery outside.
A modern office space with a reception desk, several chairs, a large window, and a colorful abstract painting on the wall.
A lobby with a patterned carpet, two green armchairs, a white sofa, a small round table with a plant, and framed artwork on the wall.
A Holiday Inn Express & Suites hotel with a modern design, multiple floors, and a parking lot.

1. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Alachua
United States
Tobias
$106 nightly
$119 total
Oct 5 - Oct 6
Total with taxes and fees
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
A modern kitchen area with a central counter, various food stations, and a chalkboard menu.
A reception desk with a "Welcome to the Sun Shine State" sign, a "Treats" sign, and a minibar area with a "Hilton" sign.
A hotel room with two beds, a desk, a chair, a TV, and a couch.

2. Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
Alachua
United States
Pamela
$106 nightly
$119 total
Oct 4 - Oct 5
Total with taxes and fees
Hampton Inn & Suites Alachua I-75
A swimming pool with a 5 ft 8 in depth marker, surrounded by lounge chairs and red umbrellas, with a fence and trees in the background.
A fitness center with treadmills, exercise bikes, and weights.
A two-story motel with a covered entrance, a parking lot, and a clear sky.
A modern hotel lobby with a reception desk, seating area, and a wall-mounted television.

3. Clarion Pointe Alachua - Gainesville Area

Clarion Pointe Alachua - Gainesville Area
Alachua
United States
María Teresa
$65 nightly
$73 total
Oct 18 - Oct 19
Total with taxes and fees
Clarion Pointe Alachua - Gainesville Area
A cozy restaurant with wooden beams, yellow walls, and a bar area with coffee machines.
A swimming pool with lounge chairs and umbrellas, a covered seating area, and a multi-story building with balconies.
A hotel room with a bed, a desk with a chair, a television, a mirror, and a wardrobe.
A reception desk with a sign reading "Quality by Choice Hotels," surrounded by various reptile decorations.

4. Quality Inn Alachua - Gainesville Area

Quality Inn Alachua - Gainesville Area
Alachua
United States
Deborah
$76 nightly
$85 total
Oct 18 - Oct 19
Total with taxes and fees
Quality Inn Alachua - Gainesville Area
A large, multi-story hotel with a central courtyard, palm trees, and an American flag.
A spacious dining area with multiple tables and chairs, a kitchen area with a coffee station, and large windows allowing natural light.
A living room with a brown leather sofa, a glass-top coffee table, and a framed picture on the wall.
A spacious lobby with a large painting, a fireplace, a piano, and multiple seating areas.

5. Best Western Gateway Grand

Best Western Gateway Grand
Gainesville
United States
Jason
$93 nightly
$104 total
Sep 28 - Sep 29
Total with taxes and fees
Best Western Gateway Grand
A modern hotel with a prominent 'La Quinta' sign, a covered entrance, and a well-maintained outdoor area with a parking lot.
A hotel reception area with directional signs for elevators, floor 1, pool restrooms, and business center.
A modern lounge area with a flat-screen TV, a fireplace, teal and brown seating, patterned carpet, and a wall-mounted clock.
A modern kitchen with blue-tiled walls, stainless steel appliances, and a central island.

6. La Quinta by Wyndham Gainesville

La Quinta by Wyndham Gainesville
Gainesville
United States
Elizabeth
$96 nightly
$108 total
Sep 28 - Sep 29
Total with taxes and fees
La Quinta by Wyndham Gainesville
A hotel room with a bed, bedside tables, a desk, a chair, a mirror, and a window.
A reception area with a counter, a computer, and a bulletin board with pamphlets.
A building with a Coca-Cola vending machine, a window with a 'OPEN' sign, and a red awning.
A bathroom with a large mirror, a sink, and a towel rack.

7. Palms Garden Inn

Palms Garden Inn
Lake City
United States
Sherry
$63 nightly
$71 total
Oct 5 - Oct 6
Total with taxes and fees
Palms Garden Inn
A hotel room with two beds, a desk, a chair, and a television.
A bathroom with a white sink, mirror, and towel rack.
A large, empty parking lot with marked parking spaces and a few trees in the background.
A motel with a two-story structure, a covered front entrance, and a parking lot with several cars.

8. Royal Inn

Royal Inn
Alachua
United States
Alec
$80 nightly
$90 total
Sep 28 - Sep 29
Total with taxes and fees
Royal Inn
A stone water feature with cascading water, surrounded by a brick wall and greenery.
A covered outdoor area with a paved walkway leading to a seating area, surrounded by greenery and a clear sky.
A neatly arranged bedroom with a bed, bedside lamps, a TV, and a mirror.
A spacious living area with a wooden floor, a blue sofa, a round coffee table, and a ceiling fan.

9. BlueGem Motel

BlueGem Motel
High Springs
United States
Wesley
$98 nightly
$110 total
Sep 29 - Sep 30
Total with taxes and fees
BlueGem Motel
A room with a wooden ceiling, two beds with patterned bedding, a desk, and a chair.
A stone outdoor seating area with a table and benches, a trash bin, and a building in the background.
A bedroom with a bed, a chair, a dresser, a ceiling fan, a window with blinds, and a wall-mounted air conditioner.
A row of motel buildings with a fire hydrant and trees in front.

10. High Springs Country Inn

High Springs Country Inn
High Springs
United States
Luis
$72 nightly
$81 total
Sep 29 - Sep 30
Total with taxes and fees
High Springs Country Inn
A modern breakfast area with labeled dispensers for yogurt, eggs, and milk, a coffee machine, and a chalkboard menu.
A Holiday Inn Express building with a modern design, featuring multiple windows and a flat roof.
An outdoor patio with tables and chairs, a stone wall, and a view of a street with trees and buildings.
A hotel room with two beds, a TV, a desk, and a chair.

11. Holiday Inn Express Starke by IHG

Holiday Inn Express Starke by IHG
Starke
United States
Judy
$110 nightly
$122 total
Oct 4 - Oct 5
Total with taxes and fees
Holiday Inn Express Starke by IHG
A multi-story hotel with a central entrance, palm trees, and a clear sky.
A spacious hotel lobby with a modern staircase, a seating area with a sofa and chairs, and a dining area in the background.
A hotel room with a bed, a desk, a television, a sofa, and artwork on the wall.
A hotel room with a wooden floor, a red armchair, a beige sofa, a TV, and framed artwork on the wall.

12. Country Inn & Suites by Radisson, Gainesville, FL

Country Inn & Suites by Radisson, Gainesville, FL
Gainesville
United States
sherry
$88 nightly
$99 total
Oct 4 - Oct 5
Total with taxes and fees
Country Inn & Suites by Radisson, Gainesville, FL
A hotel entrance with a covered driveway, flag poles, and a well-lit facade.
A modern dining area with a wooden table, four chairs, and a fireplace.
A spacious lobby with a reception desk, seating areas, and potted plants.
A grocery store interior with shelves stocked with snacks, beverages, and packaged goods.

13. Hilton Garden Inn Gainesville

Hilton Garden Inn Gainesville
Gainesville
United States
jose
$89 nightly
$101 total
Sep 28 - Sep 29
Total with taxes and fees
Hilton Garden Inn Gainesville
A modern kitchen with a flat-screen TV, a microwave, and a coffee maker on a wooden cabinet. There is a window with a view of a green landscape.
A living room with a grey sofa, a wooden coffee table, and a framed horse picture on the wall.
A kitchen with a green refrigerator, a wooden countertop, a black kettle, and a wooden cutting board.
A narrow kitchen with a wooden ceiling, a green refrigerator, and a wooden countertop.

14. Vista Verde Farm Retreat

Vista Verde Farm Retreat
Lake City
United States
Stacy
$161 nightly
$182 total
Oct 12 - Oct 13
Total with taxes and fees
Vista Verde Farm Retreat
A swimming pool with a metal ladder, surrounded by a white fence and green chairs.
A refrigerated display case with beverages and snacks, and a shelf with bottled water and other beverages.
A living room with a curved sofa, a wooden cabinet, and a fish tank.
A hotel room with a bed, a sofa, a coffee table, and a small table with a lamp.

15. Best Western Waldo Inn and Suites

Best Western Waldo Inn and Suites
Waldo
United States
Ana Laura
$136 nightly
$153 total
Oct 5 - Oct 6
Total with taxes and fees
Best Western Waldo Inn and Suites
A modern bar area with wooden bar stools, pendant lighting, and artwork on the walls.
A hotel reception desk with a wooden panel design, a digital kiosk, and a "Welcome to the Sun Shine State" sign.
A hotel hallway with carpeted floors, doors on both sides, and overhead lighting.
A hotel room with a kitchenette, a bed, a desk with a chair, and a bathroom.

16. Hampton Inn Gainesville

Hampton Inn Gainesville
Gainesville
United States
Charles
$87 nightly
$98 total
Oct 4 - Oct 5
Total with taxes and fees
Hampton Inn Gainesville
A reception area with a desk, two chairs, framed pictures, and a sign for Days Inn.
A Days Inn by Wyndham sign with a sunburst logo, a blue arch, and a clear sky.

17. Days Inn by Wyndham Gainesville Hospital/University Area

Days Inn by Wyndham Gainesville Hospital/University Area
Gainesville
United States
Andrew
$60 nightly
$68 total
Sep 28 - Sep 29
Total with taxes and fees
Days Inn by Wyndham Gainesville Hospital/University Area
An outdoor patio with wicker furniture, stone walls, and a barbecue grill.
A modern hotel room with a flat-screen TV, a dining area with a table and chairs, a kitchenette, and a wardrobe with hanging space.
A modern dining area with a wooden table, blue upholstered chairs, and pendant lighting.
A modern living room with a sectional sofa, a standing lamp, a large window with sheer curtains, a flat-screen TV, and a built-in air conditioning unit.

18. TownePlace Suites by Marriott Gainesville Northwest

TownePlace Suites by Marriott Gainesville Northwest
Gainesville
United States
Tanya
$105 nightly
$118 total
Sep 30 - Oct 1
Total with taxes and fees
TownePlace Suites by Marriott Gainesville Northwest
A room with two beds, a TV, and a door.
A bathroom with a toilet, sink, and mirror.
A covered corridor with a row of parked cars on one side and a building with blue trim on the other.
A hotel room with a bed, a TV mounted on the wall, a remote control on a table, and a door leading to another room.

19. Soho Inn Waldo

Soho Inn Waldo
Waldo
United States
Brandie
$60 nightly
$68 total
Sep 28 - Sep 29
Total with taxes and fees
Soho Inn Waldo
A modern living room with a fireplace, comfortable seating, a flat-screen TV, and a large window.
A fire pit area surrounded by stone tiles, with a metal fence in the background.
A hotel room with a bed, a desk, a chair, a sofa, and a window.
A modern hotel lobby with a long dining table, multiple seating areas, and a large window with curtains.

20. Comfort Suites Gainesville near University

Comfort Suites Gainesville near University
Gainesville
United States
thomas
$81 nightly
$92 total
Oct 18 - Oct 19
Total with taxes and fees
Comfort Suites Gainesville near University
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Top Santa Fe Hotel Reviews

HOM Hotel Gainesville, SureStay Collection by Best Western

HOM Hotel Gainesville, SureStay Collection by Best Western

10/10 Excellent
"room was clean, staff were helpful no issues personally"
Omar 4-night trip
Posted 2 hours ago
HOM Hotel Gainesville, SureStay Collection by Best Western
Country Inn & Suites by Radisson, Gainesville, FL

Country Inn & Suites by Radisson, Gainesville, FL

10/10 Excellent
"All good"
Sidney 1-night trip
Posted 2 hours ago
Country Inn & Suites by Radisson, Gainesville, FL
Hilton University of Florida Conference Center Gainesville

Hilton University of Florida Conference Center Gainesville

10/10 Excellent
"Only thing I didn’t like was the breakfast vouchers that essentially cover nothing so don’t feel like you’re getting any perk all I really want you to do is go down and buy their breakfast"
John 1-night trip
Posted 5 hours ago
Hilton University of Florida Conference Center Gainesville
Red Roof Inn PLUS+ Gainesville

Red Roof Inn PLUS+ Gainesville

10/10 Excellent
"Clean and safe good bedding good staff."
Jeff 1-night trip
Posted 1 day ago
Red Roof Inn PLUS+ Gainesville
Comfort Suites Gainesville near University

Comfort Suites Gainesville near University

8/10 Good
"Good breakfast but the trash bins by the elevators weren't cleaned out regularly and therefore smelled a bit funky."
Amanda 2-night trip
Posted 2 days ago
Comfort Suites Gainesville near University

More cheap stays in Santa Fe

Red Roof Inn PLUS+ Gainesville

Red Roof Inn PLUS+ Gainesville

3500 Southwest 42nd St Gainesville FL
$60 nightly
$68 total
Oct 1 - Oct 2
Total with taxes and fees
7.4/10 Good! (1,328 reviews)
Red Roof Inn PLUS+ Gainesville
Days Inn by Wyndham Gainesville University I-75

Days Inn by Wyndham Gainesville University I-75

920 Nw 69th Ter Gainesville FL
$72 nightly
$81 total
Sep 30 - Oct 1
Total with taxes and fees
5.8/10 (1,005 reviews)
Days Inn by Wyndham Gainesville University I-75
HOM Hotel Gainesville, SureStay Collection by Best Western

HOM Hotel Gainesville, SureStay Collection by Best Western

3905 Sw 43Rd St Gainesville FL
$72 nightly
$82 total
Oct 4 - Oct 5
Total with taxes and fees
8.6/10 Excellent! (2,144 reviews)
HOM Hotel Gainesville, SureStay Collection by Best Western
Sleep Inn & Suites University/Shands

Sleep Inn & Suites University/Shands

4110 SW 40th Boulevard Gainesville FL
$81 nightly
$91 total
Oct 18 - Oct 19
Total with taxes and fees
Sleep Inn & Suites University/Shands
Comfort Suites Gainesville near University

Comfort Suites Gainesville near University

2603 SW 13TH STREET Gainesville FL
$81 nightly
$92 total
Oct 18 - Oct 19
Total with taxes and fees
9.2/10 Wonderful! (1,504 reviews)
Comfort Suites Gainesville near University
Comfort Inn Gainesville - University Area

Comfort Inn Gainesville - University Area

3440 SW 40th Blvd Gainesville FL
$81 nightly
$92 total
Oct 18 - Oct 19
Total with taxes and fees
8.2/10 Very Good! (1,101 reviews)
Comfort Inn Gainesville - University Area

Hotels in Santa Fe with star-rating

Frequently asked questions

What's the best place for a stay in Santa Fe?
Located 18.6 mi (30 km) from the heart of Santa Fe, Drury Inn & Suites Gainesville is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Sleep Inn & Suites University/Shands and Country Inn & Suites by Radisson, Gainesville, FL. See all available top hotels, or vacation rentals in Santa Fe.
What are some of the best vacation rentals in Santa Fe?
Private Resort-Style Oasis, Pool, Lanai & Court – Backyard Paradise w/ BBQ: This vacation home rental outside of Santa Fe is located in the city center and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a dishwasher, a stovetop, and a microwave, so you can cook with friends or family. See all vacation rentals in Santa Fe.
If I need to cancel my hotel reservation in Santa Fe, will I receive a refund?
Yes, most hotel bookings are fully refundable if cancelled before the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you have a non-refundable reservation, you might still have the option to cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Fe.
Where can I learn more about changing or cancelling my trip to Santa Fe?
To access more information about picking new dates or cancelling your trip to Santa Fe, go to https://www.expedia.com/service/.
What is staying in Santa Fe like?
Travelers to Santa Fe will find plenty to explore and enjoy. There are 802 hotels and other accommodations in the surrounding area. Find out more about Santa Fe.
What are the top places to visit in Santa Fe?
Places to visit in the wider area include O'Leno State Park, San Felasco Hammock Preserve State Park, and Devil's Milhopper Geological State Park. You'll also find Gainesville Raceway and Poe Springs Park in the area. Check out what more to see and do in Expedia's Santa Fe guide.
What's the seasonal weather like in Santa Fe?
The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 59°F. The rainiest months in Santa Fe are August, June, July, and September, with each month seeing an average of 7 inches of rainfall.

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