Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5
Start by selecting your hotel
Start by selecting your hotel
Start by selecting your hotel

Save up to $603 by booking Flight + Hotel.

Search 590,000 properties and 550 airlines worldwide.

Search over a million flights, hotels, packages, and more


Santa Fe Vacation Travel Guide

Accommodation in Santa Fe

Securing a great place to stay is a crucial component of any vacation. Hotel and accommodation options in Santa Fe itself are a little limited, so if you'd like to stay a few days, visit Expedia's easy-to-use Santa Fe hotel deals page right now for the latest listings and deals.

The Hotel Puerto Amarras and Hotel de Campo Colon are the best accommodations in and around Santa Fe.

It’s easy to book the getaway of your dreams when you search through our selection of Santa Fe vacations. Our goal? To create the perfect trip for you by providing the largest selection of vacation packages. Confidently book your getaway thanks to our trustworthy recommendations and verified consumer reviews from travelers just like you. Personalize your Santa Fe package with our myriad of hotel rooms and flight tickets, which help to create a vacation specifically for you. Simply sort through our selection and pick and choose the elements that best suit your preferences and price range.

Because we offer the best rates, you can book your travel reservations knowing you won’t find lower prices elsewhere. These discounts are so great, you’ll feel like you gained the title of the ultimate bargain hunter with our Santa Fe vacation package deals. Whether you’re looking to book multiple flights, stay at the fanciest hotel, or explore the hottest local attractions, you’ll find discounted travel arrangements within your budget right here. You shouldn’t have a care in the world when you go on vacation, so our discounts allow you to rest easy without giving your bank account a second thought. Save money on your vacation today and revel in your much-deserved getaway tomorrow.


Top Hotel Deals

See all 11 Hotels in Santa Fe
$95
InterTower Hotel

InterTower Hotel

San Jeronimo 2779, Santa Fe
4.0
of 5, from 38 reviews
4.5 out of 5.0

Located in the heart of Santa Fe, this spa hotel is within 1 mi (2 km) of Catedral Metropolitana, Plaza 25 de Mayo, and Nuestra Senora de los Milagros Church. Historical Provincial Museum and Ethnographic Museum are also within 1 mi (2 km).

Ambit Boulevard Hotel Boutique

Ambit Boulevard Hotel Boutique

Bv Galvez 1408, Santa Fe
4.1
of 5, from 11 reviews
4.0 out of 5.0

Situated in Santa Fe, this hotel is 1.1 mi (1.8 km) from National University of the Littoral and within 3 mi (5 km) of Nuestra Senora de los Milagros Church and Ethnographic Museum. Catedral Metropolitana and Historical Provincial Museum are also within 3 mi (5 km).

Hotel Hernandarias

Hotel Hernandarias

Rivadavia 2680, Santa Fe
3.5 out of 5.0

Situated in Santa Fe, this hotel is within 1 mi (2 km) of Nuestra Senora de los Milagros Church, Ethnographic Museum, and Catedral Metropolitana. Historical Provincial Museum and Plaza 25 de Mayo are also within 1 mi (2 km).

Hostal Santa Fe de la Veracruz

Hostal Santa Fe de la Veracruz

San Martin 2954, Santa Fe
3.8
of 5, from 75 reviews
3.5 out of 5.0

Located in the heart of Santa Fe, this hotel is within 1 mi (2 km) of Nuestra Senora de los Milagros Church, Plaza 25 de Mayo, and Catedral Metropolitana. Historical Provincial Museum and Ethnographic Museum are also within 1 mi (2 km).

$42
Hotel Bertaina

Hotel Bertaina

Hipólito Irigoyen 2255, Santa Fe City
1.0
of 5, from 1 reviews
3.5 out of 5.0

Situated in Santa Fe, this hotel is within 2 mi (3 km) of Nuestra Senora de los Milagros Church, Ethnographic Museum, and Catedral Metropolitana. Historical Provincial Museum and Plaza 25 de Mayo are also within 2 mi (3 km).

$92
Hotel Puerto Amarras

Hotel Puerto Amarras

Primero de Enero, no 27 - Dique II, Santa Fe
3.8
of 5, from 19 reviews
4.0 out of 5.0

Situated in Santa Fe, this hotel is within 2 mi (3 km) of Nuestra Senora de los Milagros Church, Ethnographic Museum, and Catedral Metropolitana. Historical Provincial Museum and Plaza 25 de Mayo are also within 2 mi (3 km).

$101
Hotel de Campo Colon

Hotel de Campo Colon

Autopista Santa Fe - Rosario / KM 153, Santa Fe
3.9
of 5, from 18 reviews
4.0 out of 5.0

Situated in Santa Fe, this spa hotel is within 9 mi (15 km) of April 15 Stadium, Brigadier General Estanislao Lopez Stadium, and Palacio de la Legislatura. Ethnographic Museum and Nuestra Senora de los Milagros Church are also within 12 mi (20 km).

$86
Gran Hotel Paraná

Gran Hotel Paraná

Urquiza 976, Paranà
4.0 out of 5.0

Situated in Parana, this hotel is steps from Plaza de Mayo, Parana Cathedral, and 3 de Feberero Municipal Theater. National University of the Littoral and Ethnographic Museum are also within 20 mi (32 km).