Santa Maria Centro Vacations

Book a Hotel + Flight or Car together to unlock savings

Plan, book, travel with confidence
Better together
Save up to $2,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Your Santa Maria Centro Vacation

Choose one of our vacation packages to Santa Maria Centro and immerse yourself in the delights of this interesting neighborhood. Especially renowned for its shopping, your next epic adventure begins right here. Can't wait to see the sights during your trip to Santa Maria Centro? Pencil in a visit to nearby attractions such as Royal Plaza Shopping, Historical and Cultural Museum of the Franciscan Sisters and Vicente Pallotti Museum. Expedia can help turn your ideal Santa Maria Centro vacation into reality, whatever your budget or travel plans.

Where to stay in Santa Maria Centro

Find the best Santa Maria Centro areas and neighborhoods for the activities you enjoy most. Learn more about Santa Maria Centro

Uglione

When in Uglione, you can plan a visit to Vicente Pallotti Museum and Medianeira Memorial, some noteworthy sights in the nearby area.

Santa Maria Centro Hotel Deals

Hotel Dom Rafael Premium

R. Cel. Ernesto Becker, 1816 Santa Maria RS

Fully refundableReserve now, pay when you stay

$53 nightly

$55 total

Jul 12 - Jul 13

Total with taxes and fees

9.2/10 Wonderful! (261 reviews)

"Restaurant and bar on property is a plus"

Reviewed on May 14, 2026

Hotel Dom Rafael Executivo

Avenida Rio Branco Santa Maria RIA

Fully refundableReserve now, pay when you stay

$39 nightly

$41 total

Jul 12 - Jul 13

Total with taxes and fees

Altadomo Hotel

Benjamin Constant, 1209 Santa Maria RS

Get rates

See all 20 properties in Santa Maria Centro

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.