Luxury in Santee

Santee Luxury Hotels & Resorts $47

Search over 1,000,000 properties worldwide and 550 airlines worldwide.

No Expedia cancellation fee to change or cancel almost any hotel reservation.

Search over a million flights, hotels, packages, and more

Featured Santee Luxury Hotels

Red Roof Inn Santee
2 out of 5
9091 Old Hwy 6, Santee, SC
Free CancellationReserve now, pay when you stay
$54
per night
Oct 15 - Oct 16
2.9/5 (304 reviews)

"It was clean and near many options for food and gas. Also it was right off the interstate which was convenient."…"

Reviewed on Jul 20, 2019

Red Roof Inn Santee
Comfort Inn & Suites Santee
2.5 out of 5
221 Britain St, Santee, SC
Free CancellationReserve now, pay when you stay
$84
per night
Oct 21 - Oct 22
3.9/5Very Good! (450 reviews)

"Area was quiet, rooms were clean and nice. Hotel staff very helpful in finding things to do and places to eat in the area. They led me to my new favorite restaurant Antonio's"…"

Reviewed on Sep 30, 2019

Comfort Inn & Suites Santee
Clarion Inn Santee I-95
2.5 out of 5
123 Mall Street, Santee, SC
Free CancellationReserve now, pay when you stay
$62
per night
Oct 20 - Oct 21
2.9/5 (226 reviews)

"This Clarion Inn is better than most of the mid-priced motels on I-95. Room is large, CLEAN and comfortable. What really sets this place apart, as others have noted, is the excellent staff."…"

Reviewed on Oct 5, 2019

Clarion Inn Santee I-95
Econo Lodge
2 out of 5
9112 Old 6 Highway, Santee, SC
Free CancellationReserve now, pay when you stay
$47
per night
Oct 28 - Oct 29
3.1/5 (247 reviews)

"Basic and inexpensive with a friendly helpful staff. Everything was in good working order, will definitely stay there again."…"

Reviewed on Aug 22, 2019

Econo Lodge
Don't see what you're looking for?
See all available properties in Santee
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Searching for a great accommodation for your luxury trip to Santee? Use Expedia to help you arrange a flight to Columbia, SC (CAE-Columbia Metropolitan) airport, and then choose from a variety of places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to find what you'd like to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Santee has to offer. During your visit, you might want to enjoy the restaurants and coffee shops which Santee is known for.

When to Visit Santee

Here's what you can expect the weather to be like while you are staying in Santee:

  • Hottest months: July, August, June, and September, with an average temperature of 92°F
  • Coldest months: January, December, February, and March, with an average temperature of 36°F
  • Driest months: November, April, October, and May, with an average rainfall of 3.40 inches
  • Rainiest months: August, June, July, and March, with an average rainfall of 5.35 inches

Exploring Santee

Enjoy all that Santee has to offer and visit Santee Outlets, Lake Marion, and Santee State Park. If you have extra time while you’re in the area, you might want to see Foxboro Golf Club and Wyboo Golf Club.

Other things that make Santee special are the:
  • Restaurants
  • Golfing
  • Cafés
  • Fishing
  • Excursions
  • Coffee

More trip options

Recently Booked Luxury Hotels in Santee

Travelers Loved These Luxury Hotels