Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Santiago Center Luxury Hotels

See all 223 Hotels in Santiago Center
Altiplanico Bellas Artes

Altiplanico Bellas Artes

Santo Domingo 526, Santiago
3.5 out of 5.0
4.6 out of 5 (226 reviews)
Great hotel and location! Best of all - breakfast was really nice and filling. Would highly recommend this hotel!
  Nov 16, 2017

$120

$120
Hotel Plaza San Francisco

Hotel Plaza San Francisco

Alameda 816, Santiago
4.0 out of 5.0
4.4 out of 5 (326 reviews)
Lovely hotel in a good locationWe had two nights at this hotel at the end of a three week holiday to South America.It was lovely to stay somewhere really nice and enjoy a little bit of luxury before the big trip home.
 Megan Oct 7, 2014

$157

$157
Hotel Vegas

Hotel Vegas

Londres 49, Santiago
3.0 out of 5.0
3.9 out of 5 (140 reviews)
Convenient LocationThe staff was very friendly and did what they could to help me with extra 1/2 day, phone calls, and more.Great location close to old downtown, plazas and government buildings. Close to bus, subway and restaurants.It is an old building with very small rooms but I was not expecting nor paying for luxury. ...
 Brent Mar 25, 2015

$73

$73
Hotel Panamericano

Hotel Panamericano

Teatinos 320, Santiago
3.0 out of 5.0
3.9 out of 5 (53 reviews)
Hotel in excellent locationI chose the hotel for its location in the historical center of Santiago where museums and interesting sites are easily walkable. The hotel is decent and comfortable, but don't expect luxury. It is very good value for the money. It has a tasty breakfast included in the price. The room was comfortable ...
 Jenny Jan 13, 2014

$106

$106
Map

Recently booked Luxury Hotels in Santiago Center

Hotel Plaza San Francisco
4.0 out of 5.0
Last booking: 11 hours ago
Apart Los Bosques
3.0 out of 5.0
Last booking: 11 hours ago
Lucía Suites
2.0 out of 5.0
Last booking: 27 hours ago
Galerías Hotel
4.0 out of 5.0
Last booking: 43 hours ago
Hotel Magnolia
3.5 out of 5.0
Last booking: 47 hours ago
Casanoble Hotel Boutique
3.5 out of 5.0
Last booking: 47 hours ago

Pocket Guide: Luxury Hotels in Santiago Center

Search for hotels in Santiago Center on Expedia. You can easily find your hotels in Santiago Center using one of the methods below:

  • View our selection of featured hotels in Santiago Center
  • Use the map to find hotels in the Santiago Center neighborhood you prefer
  • Use the filters to see hotels in a specific area of Santiago Center, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Santiago Center
  • Enter your travel dates to view the best deals on hotels in Santiago Center - while they last