Santiago Vacations from $424

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Your Santiago Vacation

Enjoy the urban city of Santiago with a tailor-made Santiago vacation package and immerse yourself in all it can offer. From its rich history and cultural experiences to its lively atmosphere, prepare to fall for the unique charms of this vibrant destination. Parque Acuatico Italia Guadalupe Panama, Catedral of Santiago Apostol and Plaza Banconal are just some of the sights you'll want to see during your trip to Santiago. A few quick clicks is all it takes to put together the perfect Santiago vacation on Expedia.

The Latest Santiago vacation packages

Price found within the past 48 hours. Click for updated prices.
Villa Botero By Casa Mojito B&B

Villa Botero By Casa Mojito B&B

3 out of 5
Price was $643, price is now $424 per person
$424
per person
Nov 28 - Dec 1
found 3 hours ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
9.8/10 Exceptional! (60 reviews)
Host was excellent. Great communication and very helpful. The rooms were nice and great value.

Reviewed on Apr 18, 2025

Bambuda Bocas Town - Hostel

Bambuda Bocas Town - Hostel

2.5 out of 5
Price was $1,138, price is now $762 per person
$762
per person
Nov 15 - Nov 18
found 19 hours ago
Roundtrip non-stop flight included
New York (NYC) to Panama City (PTY)
8.4/10 Very Good! (42 reviews)
Have a great time! Beauyplaxe and the staff was so nice!

Reviewed on Jan 3, 2025

Hotel Finca Lerida

Hotel Finca Lerida

3 out of 5
Price was $1,163, price is now $783 per person
$783
per person
Nov 15 - Nov 18
found 19 hours ago
Roundtrip non-stop flight included
New York (NYC) to Panama City (PTY)
8.8/10 Excellent! (182 reviews)
The property is beautifully located on a coffee farm. The rooms are nice and bright. The restaurant is beautiful with outdoor seating with views of the mountain tops. The weather is prefect and you do not need an air conditioner. The staff were wonderful especially Luis.

Reviewed on Aug 8, 2025

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was $1,409, price is now $950 per person
$950
per person
Nov 27 - Dec 1
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (997 reviews)
The service was excellent, the staff very friendly and attentive at all times. The food was varied. The hotel was very clean. Highly recommended!!!

Reviewed on Oct 5, 2025

Valle Escondido Wellness Resort

Valle Escondido Wellness Resort

3.5 out of 5
Price was $1,190, price is now $812 per person
$812
per person
Nov 15 - Nov 18
found 20 hours ago
Roundtrip non-stop flight included
New York (NYC) to Panama City (PTY)
8.8/10 Excellent! (208 reviews)
We were warmly greeted by the staff. Roger was very friendly and gave us a good orientation of the grounds and facilities. We loved the place surrounded by lush trees and flowers with the mountains as a backdrop. Service was excellent not just by the reception staff but at the restaurant as well. On our last day, it was too early to have breakfast before we left so they made us a nice breakfast box each complete with freshly squeezed juice, a sandwich, banana bread and even fresh flowers!

Reviewed on Jul 27, 2025

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Discover the most popular places to visit in Santiago

Escuela Normal Juan Demostenes Arosemena

Explore the campus of Escuela Normal Juan Demostenes Arosemena, during your trip to Santiago. Stroll along the lakeside or visit the cathedral while you're in the area.

Escuela Normal Juan Demostenes Arosemena

Catedral of Santiago Apostol

Find out about the history of Santiago when you take a trip to Catedral of Santiago Apostol. Amble around the area's lakeside or visit its cathedral.

Catedral of Santiago Apostol

Plaza Banconal

You can find the perfect gifts to bring home at Plaza Banconal during your stay in Santiago. Stroll along the lakeside or visit the cathedral while you're in the area.

Plaza Banconal

Santiago Hotel Deals

Hotel Gran David

Hotel Gran David

3.5 out of 5
Vía Interamericana, Santiago, Veraguas
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $83 total per night from Oct 12 to Oct 13
$83 total
Oct 12 - Oct 13
Total with taxes and fees
8.4/10 Very Good! (333 reviews)
"Ok"

Reviewed on Aug 27, 2025

Hotel Gran David
HOTEL PLAZA COROTÚ

HOTEL PLAZA COROTÚ

2 out of 5
Carr. Panamericana, Santiago, Provincia de Veraguas
9/10 Wonderful! (19 reviews)
"They will wash and laundry for a reasonable fee."

Reviewed on Feb 24, 2025

Get rates
HOTEL PLAZA COROTÚ
Charming 2-bedroom house in amazing Santiago with AC, WiFi cable phone

Charming 2-bedroom house in amazing Santiago with AC, WiFi cable phone

2 out of 5
Santiago
Get rates
Charming 2-bedroom house in amazing Santiago with AC, WiFi cable phone
See all 13 properties in Santiago
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Santiago Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
45,400
Max Temp Winter
90ºF
Max Temp Summer
85ºF
Top Sights
Parque Acuatico Italia Guadalupe Panama, Catedral of Santiago Apostol and Parque Nacional Cerro Hoya

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Frequently asked questions

How much does a Santiago vacation package cost?
You can pick up a vacation package to this popular destination from $424 on Expedia. But how much your vacation to Santiago costs will depend on the length of stay, season and hotel choice.
What are the cheapest months to go to Santiago?
May, July and September are the best times to look for cheap Santiago vacation packages. Choosing to travel in less busy months means you can typically find reduced prices on accommodations and flights.
How many days is enough for Santiago?
With a well-organized itinerary, you can easily visit the main Santiago sights in a few days. But if you'd like to venture off the beaten track or go on day trips, think about booking your Santiago vacation for longer.
Is it worth booking a vacation package to Santiago?
Whether you're planning to visit attractions like Parque Acuatico Italia Guadalupe Panama and Catedral of Santiago Apostol, or eager to experience its top-notch shopping and culture, a Santiago vacation is sure to exceed your expectations. Book your getaway with Expedia and discover why Santiago is such a good vacation destination.
How to find the best Santiago package deals?
Start your search for a Santiago package deal by entering your destination and travel dates under our "Packages" tab. Then add some filters, like "Property type" and "Amenities," to fine-tune the results to your exact needs. You can also sort by "Package discount" and discover offers that come with huge savings. If you don't find the perfect Santiago package deal right away, simply switch up your dates and search again. Remember that deals are only available for a limited time, so book early and get your Santiago adventure underway.
Is it cheaper to book a Santiago vacation as a package?
An Expedia vacation package could land you significant savings when compared to arranging flights and accommodations separately. Better still, you can personalize your Santiago escape to match your exact needs. Choose your preferred flight time, select the hotel type and add a rental car. Browse our great deals to see how much you can save.
When to book a vacation package to Santiago?
Enjoy incredible discounts by reserving your flights ahead of time with Expedia. If being spontaneous is more your thing, take advantage of our last-minute deals for a spur-of-the-moment Santiago trip.
Does Expedia offer Book Now, Pay Later Santiago vacation packages?
Set off on your perfect escape to Santiago with our Book Now, Pay Later vacations. There's no need to scrimp and save or wait until the next payday — we've partnered with online lender Affirm to give you more flexibility and choice. Our vacation packages with payment plans mean you can spread the total cost across 3, 6 or 12 months. With no hidden or late payment fees, it's a breeze to stay on budget and snag great deals before they sell out.

Explore a world of travel with Expedia

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.